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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 4 | The umbilical coiling index 显示文摘 | Strong TH Jr Jarles DL Vega JS | 1994 | Am J Obstet Gynecol1994，170，11： | 1 |
| 5 | Early calcification of the aortic mitroflow pericardial bioprosthesis in the elderly显示文摘 | Alvarez JR Sierra J Vega M | | 0，，05： | 1 |
| 6 | IL- 10Expression in Thyroid Glands: Protective or Harmful Role Against Thyroid Autoimmunity? 显示文摘 | Vilaplana JC Biro A | 1998 | Clinical & Experimental Immunology1998，113，1： | 1 |
| 7 | CTA4transcription factor mediates induction of nitrosative stress response in Candida albicans显示文摘 | Chiranand W McLeod I Zhou H Lynn JJ Vega LA Myers H Yates JR Lorenz MC Gustin MC | | 0，，： | 1 |
| 8 | Arthroscopic fixation of dis-placed tibial eminence fractures:a new growth plate-sparing method显示文摘 | Vega JR Irribarra LA Baar AK | 2008 | Arthroscopy2008，24，11： | 1 |
| 9 | Prospective phase Ⅱ study of rituximab with alternating cycles of hyper-CVAD and high-dose methotrexate with cytarabine for young patients with high-risk diffuse large B-cell lymphoma显示文摘 | Oki Y Westin JR Vega F | 2013 | Br J Haematol2013，163，5： | 1 |
| 10 | Delivery materials for siRNA therapeutics显示文摘 | Kanasty R Dorkin JR Vegas A | 2013 | Na Mater2013，12，11： | 1 |
| 11 | 显示文摘 | De la Vega JR Vilaplana JC Biro A | 1998 | Clin Exp Immunol1998，113，1： | 1 |
| 12 | The umbilical coiling index显示文摘 | Strong T H Jr Jarles D L Vega J S | 1994 | Am J Obstet Gynecol1994，170，： | 1 |
| 13 | Lymphomas involving the pleura:a clinicopathologic study of 34 cases diagnosed by pleural biopsy显示文摘 | Vega F Padula A Valbuena JR | 2006 | Arch Pathol Lab Med2006，130，： | 1 |
| 14 | The cytosolic O-acetylserine(thiol)lyase gene is regulated by heavy metals and can function in cadmium tolerance显示文摘 | Dominguez-Solis JR Gutierrez-Alcala G Vega JM | 2001 | J BiolChem2001，276，12： | 1 |
| 15 | Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction显示文摘 | Zurawski SM Vega F Jr Huyghe B | 1993 | EMBO J1993，12，7： | 1 |
| 16 | Differential metabolic adaptation to acute and long-term hypoxia in rat primary cortical astrocytes显示文摘 | Vega C R Sachleben L Jr Gozal D | 2006 | J Neurochem2006，97，3： | 1 |
| 17 | Differential metabolic adaptation to acute and long-term hypoxia in rat primary cortical astrocytes显示文摘 | Vega C Sachleben L Jr Gozal D | 2006 | Journal of Neurochemistry2006，97，3： | 1 |
| 18 | l)elive' materials for siRNA therapeutics 显示文摘 | Kanasty R Dorkin JR Vegas A | 2013 | N at Mater2013，12，11： | 1 |
| 19 | Behavioral and neurochemical responses in mice beating tumors submitted to social stress显示文摘 | Vegas O Beitia G Sá nchez-Martin JR | | 0，，1： | 1 |
| 20 | The umbilical coiling index显示文摘 | Strong T H Jr Jarles D L Vega J S | 1994 | Am J Obstet Gynecol1994，170，： | 1 |
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