|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Helicobacter pylori and Gastrointestinal Malignancies显示文摘 | Marino Venerito Riccardo Vasapolli Theodoros Rokkas Peter Malfertheiner | 2015 | Helicobacter2015，，： | 2 |
| 3 | Helicobacter pylori infection: selected aspects in clinical management显示文摘 | Peter Malfertheiner Marino Venerito Michael Selgrad | 2013 | Current Opinion in Gastroenterology2013，，6： | 2 |
| 4 | Dilemma between gastr-oprotection and cardiovascular preventior显示文摘 | Venerito M Kandulsk A Malfertheiner P | 2010 | Dtsch Med Wochen-schr2010，135，44： | 1 |
| 5 | Gastric cancer--epidemiologic and clinical aspects显示文摘 | Venerito M Nardone G Selgrad M | 2014 | Helicobacter2014，191，： | 1 |
| 6 | Preneoplastic Conditions in the Stomach: Always a Point of No Return显示文摘 | Venerito M Malfertheiner P | 2015 | Dig Dis2015，33，1： | 1 |
| 7 | The long-term effect of Helicobacter pylori eradication on COX-1/2,5-LOX and leukotriene receptors in patients with a risk gastritis phenotype-A link to gastric carcinogenesis显示文摘 | Venerito M Kuester D Wex T | 2008 | Cancer Lett2008，，270： | 1 |
| 8 | Feasibility of double-balloon enteroscopy-assisted chromoendoscopy of the small bowel in patients with familial adenomatous polyposis显示文摘 | K. M?nkemüller L. Fry M. Ebert M. Bellutti M. Venerito C. Knippig S. Rickes P. Muschke C. R?cken P. Malfertheiner | 2007 | Endoscopy2007，，01： | 1 |
| 9 | Dilemma betweengastroprotection and cardiovascular prevention显示文摘 | Venerito M Kandulski A Malfertheiner P | 2010 | Dtsch MedWochenschr2010，135，44： | 1 |
| 10 | Gastric cancer-epidemio- logic and chnical aspects 显示文摘 | Venerito M Nardone G Selgrad M | 2014 | Helicobacter2014，19，1： | 1 |
| 11 | Helicobaeter pylori infec- tion: selected aspects in clinical management显示文摘 | Malfertheiner P Venerito M Selgrad M | 2013 | Curr Opin Gastro- enterol2013，29，6： | 1 |
| 12 | Hepatobiliary and pancreatic:gallbladder varices显示文摘 | Venerito M Monkemuller K Malfertheiner P | 2006 | J Gastroenterol Hepatol2006，21，8： | 1 |
| 13 | Short-term/low-dose aspirin-induced duodenal erosions are not dependent on Helicobacter pylori infection,cyclooxygenase expression and prostaglandin E2 levels显示文摘 | Venerito M Treiber G Wex T | 2008 | Scand J Gastroenterol2008，43，7： | 1 |
| 14 | Dilemma between gas- troprotection arid cardiovascular prevention 显示文摘 | Venerito M Kandulski A Malfertheiner P | 2010 | Disch Med Wochenschr2010，135，44： | 1 |
| 15 | Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter py- lori infection显示文摘 | Venerito M Krieger T Ecker T | 2013 | Digestion2013，88，1： | 1 |
| 16 | Serological prevalence of Helicohacter pylori infection in Saxony-Anhah, Germany, in 2010 显示文摘 | Wex T Venerito M Kreutzer J | 2011 | Clin Vaccine Immunol2011，18，12： | 1 |
| 17 | Interaction of Helicobacter pylori in- fection and nonsteroidal anti-inflammatory drugs in gastric and duodenal ulcers显示文摘 | Venerito M Malfertheiner P | 2010 | Helicobacter2010，15，4： | 1 |
| 18 | Di- lemma between gastroprotection and cardiovas- cular prevention显示文摘 | Venerito M Kandulski A Malfertheiner P | 2010 | Dtsch Med Wochenschr2010，135，44： | 1 |
| 19 | Feasibility of double-balloon enteroscopy-assisted chromoendoscopy of the small bowel in patients with familial adenomatous polyposis显示文摘 | K. M?nkemüller L. Fry M. Ebert M. Bellutti M. Venerito C. Knippig S. Rickes P. Muschke C. R?cken P. Malfertheiner | 2007 | Endoscopy2007，，： | 1 |
| 20 | SJWD14082900001281显示文摘 | Marino Venerito Gerardo Nardone Michael Selgrad Theodoros Rokkas Peter Malfertheiner | 2014 | Helicobacter2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员