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| 1 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 2 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 3 | Locus of control in relation to sex and nationalityz A cross cultural study 显示文摘 | Lee Victoria K Dengerink | 1992 | Journal of Cross-Cultural Psychology1992，23，4： | 1 |
| 4 | Optimal power and rate allocation for coded V-BLAST:Instantaneous optimi-zation显示文摘 | VICTORIA K SERGEY L | 2011 | IEEE Transactions on Communications2011，59，10： | 1 |
| 5 | Mouse DNA ‘fingerprints' : analysis of chromosome localization and germ-line stability of hypervariable loci in recombinant inbred strains显示文摘 | Alec J J Victoria W Robert K | 1987 | Nucleic Acids Research1987，15，7： | 1 |
| 6 | Functional polymorphism of the anpep gene increases promoter activity in the dahl salt-resistant rat显示文摘 | Douglas EH Victoria LM | 2007 | Hypertension2007，49，： | 1 |
| 7 | Toxic effect of surfactants and probable products of their biodegradation on methanogenesis in an anaerobic microbial community 显示文摘 | Victoria A S Kestutis S L Vasily K A | 1999 | Chemosphere1999，39，11： | 1 |
| 8 | Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases显示文摘 | Victoria E. Albrow Elizabeth L. Ponder Domenico Fasci Miklós Békés Edgar Deu Guy S. Salvesen Matthew Bogyo | 2011 | Chemistry & Biology2011，，6： | 1 |
| 9 | Comparison of convention and miniemulsion copolymerizations of acyrlic monomers using poly (vinyl alcohol) as the sole stabilizer 显示文摘 | Noma K Sudol E D Victoria L | 2004 | Macromolecules2004，，37： | 1 |
| 10 | Inducing differentiation of tramsformed cells with hybrid polar compounds: a cell cycle-dependent process 显示文摘 | Paul AM Victoria MR Hiroaki K | 1994 | PNAS1994，91，10： | 1 |
| 11 | Electronic structure of Ni2 MnIn for use in spin injection显示文摘 | Kilian K A Victoria R H | | 0，，09： | 1 |
| 12 | N- Hydroxybenzimidazole inhibitors of the transcription factor LcrF in yersinia: novel antivirulence agents 显示文摘 | Kim Oak K Garrity Lynne K Bartlett Victoria J | 2009 | Journal of Medicinal Chemistry2009，52，18： | 1 |
| 13 | ot-Syn suppression reverses synaptic and memory defects in amouse model of dementia with Lewy bodies显示文摘 | YOUNGSHIN L VICTORIA M K EDWARD B L | 2011 | J Neurosci2011，31，10： | 1 |
| 14 | Purification of zinc sulfate solutions from cobalt and nickel through activated cementation显示文摘 | Boyan S B Victoria V K Nikolai K K | 2004 | Hydrometallurgy2004，73，2： | 1 |
| 15 | Scientific and engineering advances from fusion materials R&D 显示文摘 | Zinkle S J Victoria M Abe K | 2002 | J Nucl Mater2002，，： | 1 |
| 16 | Rapid Identification of Known and New RNA Viruses from Animal Tissues显示文摘 | Victoria JG Kapoor A Dupuis K | 2008 | PLoS Pathog2008，4，10： | 1 |
| 17 | Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-APS): A review显示文摘 | Vijay K S Victoria L N Thomas M S | 2015 | Cytokine2015，71，1： | 1 |
| 18 | Effects of hand massage on comfort of nursing home residents显示文摘 | Kmharine K Victoria S Richard S | | 0，，02： | 1 |
| 19 | Ownership, board structure, and performance in continental Europe 显示文摘 | VICTORIA K | 2006 | The International Journal of Accounting2006，41，2： | 1 |
| 20 | Ownership, Board Structure, and Performance in Continental Europe显示文摘 | Victoria K | 2006 | The International Journal of Accounting2006，41，2： | 1 |
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