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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains显示文摘 | Virginia Aragon Marta Cerdà-Cuéllar Lorenzo Fraile Mark Mombarg Miquel Nofrarías Alexandre Olvera Marina Sibila David Solanes Joaquim Segalés | 2009 | Veterinary Microbiology2009，，3： | 2 |
| 3 | Effects of blood collection tubes, iucluding pediatric devices on 16 common immunoassays 显示文摘 | Wang S Virginia H O Altheia R | 2006 | Clin Chem2006，52，5： | 1 |
| 4 | Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels 显示文摘 | Virginia J Y Michael G O Amanda S | 2006 | Cancer Res2006，66，5： | 1 |
| 5 | Does the presence of hepatitis virus B and C influence the evolution of diffuse large B-cell lymphoma?显示文摘 | Judit Rubio Fernando Franco Antonio Sá nchez Blanca Cantos Miriam Mé ndez Virginia Calvo Constanza Maximiano David Perez Isabel Millá n Margarita Sá nchez-Beato Mariano Provencio | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 6 | Genetic Diversity of Fast-growing Rhizobia that Nodulate Soybean ( Glycine max L Merr) 显示文摘 | VIRGINIA G S ALCANTARA M JOSE M | 2003 | Arch Microbiol2003，180，： | 1 |
| 7 | Characterization of a bacteriocin-like substance produced by a vaginal lactobacillus salivarius strain显示文摘 | Virginia S O Aida A P Maria E N | 1999 | Appl Environ Microbiol1999，65，5： | 1 |
| 8 | Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma:a Gynecologic Oncology Group Study显示文摘 | Meenakshi S Richar JZ Virginia JF | 2007 | Gynecologic Oncology2007，106，： | 1 |
| 9 | Application of traffic simulation modeling for improved emergency preparedness planning显示文摘 | Virginia P S | 2007 | Management and Response in Urban planning and Development2007，133，1： | 1 |
| 10 | Carbon Isotopes Reveal Soil Organic Matter Dynamics Following arid Land Shrub Expansion显示文摘 | Connin S L Virginia R A Chamberlain C P | 1997 | Oecologia1997，110，： | 1 |
| 11 | Tumers syndrome 显示文摘 | Virginia S Elizabeth M | 2004 | N Engl J Med2004，351，12： | 1 |
| 12 | A phase Ⅱ and pharmacodynamic study of gefitinib in patients with rcfraetoty or recurrent epithelial ovarian cancer显示文摘 | Edwin M Meghan S Virginia K | 2007 | Cancer2007，109，7： | 1 |
| 13 | Neurotoxic effects and biomarkers of lead exposure显示文摘 | Talia S Yiming L Virginia B | 2009 | Rev Environ Health2009，24，1： | 1 |
| 14 | Knowledge creation processes in small innovative hi- tech firms显示文摘 | Martin S Virginia Bodolica | 2008 | Management Research News2008，31，11： | 1 |
| 15 | Confirmation of Gnathostoma binucleatum Almeyda - Artigas, 1991, advanced third - stage larvae in Tres Palos Lagoon, Mexico, by morphological and molecular data 显示文摘 | Elizabeth A Martinez S Virginia LR | 2005 | J Parasitol2005，91，4： | 1 |
| 16 | Airway stents显示文摘 | Cynt hia S Virginia Litle Jaime Yun | 2008 | Ann thorac Surg2008，85，： | 1 |
| 17 | From flower to fabric显示文摘 | VIRGINIA S | 2002 | Textile World2002，152，： | 1 |
| 18 | Effects of abscisic acid ongrowth, RNA metabolism* and respiration in germinatingbean axes显示文摘 | Virginia W Mary C Ian S | 1975 | Plant Physiology1975，56，： | 1 |
| 19 | The application of CE-MS in the trace analysis of environmental pollutants and food contaminants显示文摘 | VIRGINIA R R WILLIAM F S | 2009 | Electrophoresis2009，30，10： | 1 |
| 20 | Characterization of a bact eriocin-like substance produced by a vaginal Lactobacillus salivarius strain显示文摘 | VIRGINIA S O AIDA A P MARIA E N | 1999 | Appl Environ Microbiol1999，65，： | 1 |
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