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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | Approximating the stochastic knapsack problem: the benefit of adaptivity 显示文摘 | Dean B C Goemans M X Vondrak J | 2008 | Mathematics of Operations Research2008，33，： | 1 |
| 3 | Problem of smoothing observational data 11 显示文摘 | Vondrak J | 1977 | Bulletin of the Astronomical Institutes of Czechoslovakia1977，28，2： | 1 |
| 4 | Substrate switches, phenotypic innovations and allopatric speciation formed taxonomic diversity within the lichen genus Blastenia显示文摘Blastenia is a widely distributed lichen genus in Teloschistaceae.We reconstructed its phylogeny in order to test species delimitation and to find evolutionary drivers forming recent Blastenia diversity.The origin of Blastenia is dated to the early Tertiary period,but later diversification events are distinctly younger.We recognized 24 species(plus 2 subspecies)within 6 infrageneric groups.Each species strongly prefers a single type of substrate(17 species occur on organic substrates,7 on siliceous rock),and most infrageneric groups also show a clear substrate preference.All infrageneric groups tend to have the Mediterranean and Macaronesian distribution,but some epiphytic species have much larger geographic ranges and some evolved after a long distance dispersal outside the region.Chlorinated and nonchlorinated anthraquinone chemosyndromes co-occur in apothecia of most species,but the chemotype has been secondarily reduced in some lineages.One infrageneric group has a marked reduction in apothecial size,associated with a substrate shift to twigs.Only seven species have vegetative diaspores;they also produce apothecia but have smaller ascospores.Genome sizes(22-35 Mb in Blastenia)are significantly higher in epilithic species.Within-species genetic variation is low in widely distributed species but high in some epilithic species with small geographical ranges.New taxa are:B.afroalpina,B.anatolica,B.caucasica,B.gennargentuae,B.herbidella subsp.acidophila,B.lauri,B.monticola,B.palmae,B.psychrophila,B.purpurea,B.relicta,B.remota,B.xerothermica,and B.xerothermica subsp.macaronesica.New combinations are:B.festivella and B.subathallina;both names and B.catalinae are lectotypifed. | Jan Vondrak Ivan Frolov Jiri Kosnar Ulf Arup Tereza Veselska Gokhan Halici Jiri Malicek Ulrik Sochting | 2020 | Journal of Systematics and Evolution2020，58，3： | 1 |
| 5 | Lunar Reconnaissance Orbiter(LRO):observations for lunar exploration and science显示文摘 | Richard Vondrak John Keller Gordon Chin | 2010 | Space Science Reviews2010，150，1234： | 1 |
| 6 | 显示文摘 | Klapste B Vondrak J | 2002 | Electrochem Acta2002，47，： | 1 |
| 7 | 显示文摘 | Vondrak J Sedla i-ikovd M Velickd J | 2001 | Marinaci & Prygal 'A'2001，46，： | 1 |
| 8 | Thyroid gland disease in adult pa- tients with diabetes mellitus 显示文摘 | VondraK Vrbikova J Dvorakova K | 2005 | Minerva Endocrinol2005，30，4： | 1 |
| 9 | Problem of smoothing observational data Ⅱ显示文摘 | Vondrak J | 1977 | Bull Astron Inst Czech1977，28，： | 1 |
| 10 | Lunar Reconnaissance Orbiter (LRO) : observations for lunar exploration and science 显示文摘 | Vondrak R Keller J Chin G | 2010 | Space Science Reviews2010，150，14： | 1 |
| 11 | A Contribution to the Problem of Smoothing Observation- al Data显示文摘 | VONDRAK J | 1969 | Bull Astron Inst Czech1969，20，6： | 1 |
| 12 | CRRES electron and proton wide-angle spectrometer显示文摘 | NIGHTINGALE R W VONDRAK R R GAINES E E | 1992 | Journal of Spacecraft and Rockets1992，29，4： | 1 |
| 13 | Combined smoothing method and itsuse in combining earth orientation parameters easured by space techniques显示文摘 | VONDRAK J CEPEK A | 2000 | Astronrophys2000，147，： | 1 |
| 14 | Electrochemical absorption of hydrogen in transition metal oxide 显示文摘 | Vondrak J | 1984 | Electrochim Acta1984，29，9： | 1 |
| 15 | Plasmapheresis-induced cXinical improvement in a patient with steroid-resistant aephrotic syndrome due to podocin (NPHS2) gene mutation 显示文摘 | Skalova S Podhola M Vondrak K | 2010 | Acta Medica ( Hradec Kralove)2010，53，3： | 1 |
| 16 | DissolvableFilms for Flexible Product Format in Drug Delivery' 显示文摘 | Beth Vondrak Scott Barnhart | 2008 | Pharmaceutical Technology Suppiement2008，，： | 1 |
| 17 | The increase of stability of LixCoO2 electrodes of concentrated sodium显示文摘 | Bludska J Vondrak J Stopka P | 1992 | J Power Sources1992，39，： | 1 |
| 18 | Lunar Recon- naissance Orbiter(LRO) : Observations for Lunar Explo- ration and Science 显示文摘 | VONDRAK R KELLER J CHIN G | 2010 | Space Science Reviews2010，150，14： | 1 |
| 19 | Plasmapheresis-in- duced clinical improvement in a patient with steroid-resistant nephrotic syndrome due to podocin (NPHS2) gene mutati- on显示文摘 | Skdlovd S Podhola M Vondrak K | 2010 | Acta Medica2010，53，： | 1 |
| 20 | Laboratory studies and modelling of mesospheric iron chemistry显示文摘 | J.M.C. Plane D.E. Self T. Vondrak K.R.I. Woodcock | 2003 | Advances in Space Research2003，，5： | 1 |
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