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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Male Breast Cancer:10-Year Experience at Mansoura University Hospital in Egypt显示文摘Objective Male breast cancer(MBC) is a rare disease representing less than 1%of all malignancies.The objective of the study is to report clinicopathological characteristics,treatment patterns,and outcomes of MBC in Mansoura University Hospital,Egypt. Methods This retrospective study focused on male breast cancer patients during 10 years(2000-2009).The studied variables were data regarding general characteristics of patients,treatment modalities and survival. Results The series included 37 patients(0.8%of all breast cancer).The median age was 57.7 years(range:26-86 years).The main clinical complaint was a mass beneath the areola in 94.5%of the cases.Most patients had a locally advanced disease.94.5%of tumors were invasive duct carcinomas.The treatment was essentially surgery in 91.8%,followed by adjuvant radiotherapy(in 89.2%), hormonal therapy(in 56.7%) and chemotherapy(in 91.8%).Follow-up period ranged from 6-115 months.Local recurrence occurred in 4 cases and metastasis in 11 cases.The 2-year and 5-year overall survival(OS) rates were 81.6%and 60.5%,respectively.The 2-year and 5-year disease-free survival(DFS) rates were 68.4%,and 52.6%,respectively.OS was not significantly affected by any of the studied parameters.Factors influencing DFS were:T stage(P=0.05),positive lymph nodes(P=0.043),metastasis(P=0.004),and chemotherapy (P=0.046). Conclusions MBC is a rare disease and often diagnosed at a locally advanced stage.The management of male and female breast carcinoma is identical.Future research for better understanding of this disease is needed to improve the management and prognosis of male breast cancer patients. | Wafaa El-Beshbeshi Engy M Abo-Elnaga | 2012 | Clinical oncology and cancer resexreh2012，9，1： | 2 |
| 3 | Insights for hepatitis C virus related hepatocellular carcinoma genetic biomarkers: Early diagnosis and therapeutic intervention显示文摘The current review explores the role of emerging molecular contributing factors in liver carcinogenesis on top of hepatitis C virus(HCV). Here we will try to discuss the role genetic and epigenetic factors in pathogenesis of hepatocellular carcinoma. Understanding the role of these factors will help in discovering the mystery of liver carcinogenesis on top of chronic HCV infection. Moreover, use of the studied molecular factors will provide the hepatologists with tailored diagnostic promising biomarkers and flatten the way for establishment of emerging molecular treatment based on exploring the molecular subscription of this aggressive liver cancer. | Wafaa M Ezzat Khalda Sayed Amr | 2016 | World Journal of Hepatology2016，8，30： | 2 |
| 4 | In vitro propagation and evaluation for salt stress tolerance in some grape culfivars显示文摘 | WAFAA H W A E EI-HAMMADY M T E I-SAIDI | 1999 | Arab Universities J Agric Sci1999，，7： | 1 |
| 5 | Soil-vegetation relationships in coastal desert plain of southern Sinai, Egypt显示文摘 | Monier M A Wafaa M A | 2003 | Journal of Arid Environments2003，55，： | 1 |
| 6 | In vitro propagation of mono- and poly-embryonic mango cultivars显示文摘 | SHAHIN M F M WAFAA H W EL-HAMMADY A M HAGGAG L F | 2003 | Arab Univ J Agric Sci2003，11，1： | 1 |
| 7 | Soil–vegetation relationships in a coastal desert plain of southern Sinai, Egypt显示文摘 | Monier M.Abd El-Ghani Wafaa M Amer | 2003 | Journal of Arid Environments2003，，4： | 1 |
| 8 | Purification of raw surface water using electrocoagulation method显示文摘 | Mohamed H Olfatm S Wafaa K M | 2004 | Air and Soil Pollution2004，158，： | 1 |
| 9 | Impact of the socioeconomic status on the severity and outcome of community-acquired pneumonia among Egyptian children: a cohort study显示文摘Background:Community-acquired pneumonia(CAP)is one of the five leading causes of death among children in developing countries,accounting for approximately three million deaths per year.Identification of the modifiable risk factors of CAP may help to reduce the burden of this disease.In this study,the impact of the socioeconomic status(SES)on the severity and outcome of CAP among Egyptian children was studied.Methods:This was a prospective longitudinal cohort study which included 1,470 children diagnosed with CAP,aged two to 15 years(median age 5.4 years).The diagnosis of CAP was based on clinical and radiological findings.A structured questionnaire and the patients’medical records were used for the data collection.The subjects were divided into two groups:mild and severe CAP.Social and demographic variables were compared,and a multivariate logistic regression analysis was performed.Results:The multivariate analysis showed that a low maternal education level(OR:3.8;95%CI:2.12-6.70;P=.0001),unavailability of adequate medical care(OR:3.1;95%CI:1.99-4.88;P=.0001),a low family income(OR:2.2;95%CI:0.99-4.78;P=.047),and parents’smoking habits(OR:2.0;95%CI:1.15-3.55;P=.014)were significant independent predictive risk factors for severe CAP among Egyptian children.Conclusion:Public health measures against these socio-demographic risk factors should be identified as priorities in order to help reduce the disease burden of deaths from severe CAP among Egyptian children. | Seham Fathy Abdel Hameed Azab Laila M Sherief Safaa H Saleh Wafaa F Elsaeed Mona A Elshafie Sanaa M Abdelsalam | 2014 | Infectious Diseases of Poverty2014，3，1： | 1 |
| 10 | Antiretro- viral therapy: A promising HIV prevention strategy? 显示文摘 | Wafaa M E1-Sadr Megan Affrunti Theresa Gamble | 2010 | Acquir Immune Defic Syndr2010，55，2： | 1 |
| 11 | Soil vegetation relationships in a coastal desert plain of southern Sinai,Egypt显示文摘 | MONIER M ABD E G WAFAA M A | 2003 | Journal of Arid Environments2003，55，： | 1 |
| 12 | Epidemiology and the Association of the Fusarium Species with the Mango Malformation Disease in Egypt显示文摘 | WAFAA H M HAZZA M SEHAB A | 2010 | Nature and Science2010，8，4： | 1 |
| 13 | Rhizoshenth of Sinai desert plants is potential repository for associative diazotrophs显示文摘 | Areal A Wafaa M A Fayez M | 2004 | Microbiological Research2004，159，： | 1 |
| 14 | Sustainable Agriculture Management of Plant Diseases显示文摘 | Wafaa M Haggag | 2002 | OnLine Journal of Biological Sciences2002，2，4： | 1 |
| 15 | Modification of polyester fabric by chemical/thermal treatment to improve dyeing ability 显示文摘 | RASLAN WAFAA M BENDAK | 2010 | Colora-tion Technolo- gy2010，126，4： | 1 |
| 16 | Biological ac- tivities of some galactomannans and their suLfated derivatives 显示文摘 | M Magdel-Din Hussein Wafaa A Helmy H M Salem | 1998 | Phytochemistry1998，48，3： | 1 |
| 17 | Determination of natural colors by thin layer chromatography显示文摘 | Wegdan M Lotfi Rasmia A Hassan Wafaa A Tawfik | 2008 | Journal of Applied Science Research2008，4，12： | 1 |
| 18 | Signaling Necessities and Function of Polyamines/Jasmonate-Dependent Induced Resistance in Sugar Beet Against Beet Mosaic Virus (BtMV) Infection显示文摘 | Haggag Wafaa M Younis S Mahmoud E | 2010 | New York Science Journal USA2010，3，8： | 1 |
| 19 | Cancer chemo preventive and anti-inflammatory activities of chemically modified guar gum显示文摘 | Amira M Gamal E Hassan A Wafaa A H | 2006 | Chemico-Biological Interactions2006，161，： | 1 |
| 20 | Soil vegetation relationships in a coastal desert plain of southern Sinai,Egypt显示文摘 | MONIER M ABD E G WAFAA M A | 2003 | Journal of Arid Environments2003，55，： | 1 |
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