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| 1 | Design of a new dynamical core for global atmospheric models based on some efficient numerical methods显示文摘A careful study on the integral properties of the primitive hydrostatic balance equations for baroclinic atmosphere is carried out, and a new scheme todesign the global adiabatic model of atmospheric dynamics ispresented. This scheme includes a method of weighted equal-areamesh and a fully discrete finite difference method with quadraticand linear conservations for solving the primitive equationsystem. Using this scheme, we established a new dynamical corewith adjustable high resolution acceptable to the availablecomputer capability, which can be very stable without anyfiltering and smoothing. Especially, some important integralproperties are kept unchanged, such as the anti-symmetries of thehorizontal advection operators and the vertical convectionoperator, the mass conservation, the effective energy conservationunder the standard stratification approximation, and so on. Somenumerical tests on the new dynamical core, respectively regardingits global conservations and its integrated performances inclimatic modeling, incorporated with the physical packagesfrom the Community Atmospheric Model Version 2 (CAM2) of NationalCenter for Atmospheric Research (NCAR), are included. | WANG Bin, WAN Hui, Jl Zhongzhen, ZHANG Xin, YU Rucong, YU Yongqiang & LIU HongtaoState Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Computational Mathematics, Academy of Mathematics and System Sciences, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，z1： | 92 |
| 2 | Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy显示文摘AIM:To explore the morbidity and risk factors of postoperative pancreatic fistula(POPF)following pancreaticoduodenectomy.METHODS:The data from 196 consecutive patients who underwent pancreaticoduodenectomy,performed by different surgeons,in the General Hospital of the People’s Liberation Army between January 1st,2013and December 31st,2013 were retrospectively collected for analysis.The diagnoses of POPF and clinically relevant(CR)-POPF following pancreaticoduodenectomy were judged strictly by the International Study Group on Pancreatic Fistula Definition.Univariate analysis was performed to analyze the following factors:patient age,sex,body mass index(BMI),hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pancreatic duct diameter,pylorus preserving pancreaticoduodenectomy,pancreatic drainage and pancreaticojejunostomy.Multivariate logistic regression analysis was used to determine the main independent risk factors for POPF.RESULTS:POPF occurred in 126(64.3%)of the patients,and the incidence of CR-POPF was 32.7%(64/196).Patient characteristics of age,sex,BMI,hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pylorus preserving pancreaticoduodenectomy and pancreaticojejunostomy showed no statistical difference related to the morbidity of POPF or CR-POPF.Pancreatic duct diameter was found to be significantly correlated with POPF rates by univariate analysis and multivariate regression analysis,with a pancreatic duct diameter≤3 mm being an independent risk factor for POPF(OR=0.291;P=0.000)and CR-POPF(OR=0.399;P=0.004).The CR-POPF rate was higher in patients without external pancreatic stenting,which was found to be an independent risk factor for CR-POPF(OR=0.394;P=0.012).Among the entire patient series,there were three postoperative deaths,giving a total mortality rate of 1.5%(3/196),and the mortality associated with pancreatic fistula was 2.4%(3/126).CONCLUSION:A pancreatic duct diameter≤3 mm is an independent risk factor for POPF.External stent drainage of pancreatic secretion may reduce CR-POPF mortality and POPF severity. | Qi-Yu Liu Wen-Zhi Zhang Hong-Tian Xia Jian-Jun Leng Tao Wan Bin Liang Tao Yang Jia-Hong Dong | 2014 | World Journal of Gastroenterology2014，20，46： | 32 |
| 3 | Tectonic Evolution of the Meso-Tethys in the Western Segment of Bangonghu-Nujiang Suture Zone: Insights from Geochemistry and Geochronology of the Lagkor Tso Ophiolite显示文摘The subduction of the Bangonghu-Nujiang Meso-Tethys and the collision between the Lhasa and Qiangtang blocks were important events in the growth of the Tibetan crust. However,the timing of collision initiation and closure timing,as well as nature and structure of the Bangonghu ocean basin,are still poorly constrained. The Lagkor Tso ophiolite,located in the south of Gerze County,Tibet,is one of the most completed ophiolites preserved in the southern side of the BangonghuNujiang suture zone. This study discussed the tectonic evolution of the Bangonghu-Nujiang suture zone as revealed by the Lagkor Tso ophiolite investigated by field investigations,petrology,geochemistry,geochronology and tectonic analysis methods. We present new LA-ICP-MS zircon U-Pb and 39Ar/40 Ar ages for the Lagkor Tso ophiolite,in addition to geochemical and platinum-group element(PGE) data presented for the Lagkor Tso ophiolite in Tibet. It is suggested that the ancient Lagkor Tso oceanic basin split in Middle Jurassic(161.2 ± 2.7 Ma – 165.4 ± 3.5 Ma),and experienced a second tectonic emplacement during the Early Cretaceous(137.90 ± 6.39 Ma). The Lagkor Tso ophiolite likely developed in an independent suture zone. The Bangonghu-Nujiang ocean subducted southwards,and the dehydration of the subducting oceanic crust materials caused partial melting of the continental mantle wedge,which formed the second-order expanding center of the obduction dish. This led to inter-arc expansion,followed by the formation of inter-arc and back-arc basins with island arc features,which are represented by ophiolites around the Shiquanhe-Lagkor Tso-Yongzhu region. The tectonic environment presently can be considered to be similar to that of the current Western Pacific,in which a large number of island arc-ocean basin systems are developed. | YUAN Yajuan YIN Zhengxin LIU Weiliang HUANG Qiangtai LI Jianfeng LIU Hongfei WAN Zhifeng CAI Zhourong XIA Bin | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 17 |
| 4 | Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice显示文摘AIM To reveal the inhibitory effects ofCurcuma aromatica oil(CAO)on cellproliferation of hepatoma in mice.METHODS Two tumor inhibitory experimentsof CAO on hepatoma in mice were conducted.The inhibitory effects of CAO on proliferation ofhepatoma in mice were evaluated by DNA imagecytometry and immunohistochemical staining ofproliferating cell nuclear antigen(PCNA).RESULTS The tumor inhibitory rates of CAOwere 52% and 51% in two experiments,respectively.Compared with those of the saline-treated control groups,both differences werestatistically significant(P<0.01).In the groupof mice treated with CAO,the cellular nuclearDNA OD value(249±70),areas(623 μm^2±228 μm^2)and DNA(2.38±0.67)index of hepaticcarcinomas were significantly lower than thoseof the control group(430±160,1073 μm^2±101 μm^2 and 4.48±0.71).CAO also couldincrease diploidy cell rates(29.00%±9.34% vs2.97%±5.69%,P<0.01)and decreasepentaploidy cell exceeding rate(30.04%±15.10% vs 70.89%±14.94%,P<0.01).In thegroup of mice treated with CAO,the labelingindexes of proliferating cell nuclear antigen (PCNA-LI)were 30%±4%,which weresignificantly lower than 40%±6% of the controlgroup(P<0.01).CONCLUSION The inhibition of CAO on thegrowth of hepatoma in mice might be associatedwith its depression on cellular proliferativeactivity. | Wan Yin Wu Qin Xu Ling Chun Shi Wei Bin Zhang | 2000 | World Journal of Gastroenterology2000，6，2： | 16 |
| 5 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 6 | High-resolution 3D crustal S-wave velocity structure of the MiddleLower Yangtze River Metallogenic Belt and implications for its deep geodynamic setting显示文摘The Middle-Lower Yangtze River Metallogenic Belt(MLYMB) is an important mineral resource region in China.High-resolution crustal models can provide crucial constraints to understand the ore-forming processes and geodynamic setting in this region. Using ambient seismic noise from 107 permanent and 82 portable stations in the MLYMB and the adjacent area,we present a new high-resolution 3D S-wave velocity model of this region. We first extract 5–50 s Rayleigh wave phase velocity dispersion data by calculating ambient noise cross-correlation functions(CFs) and then use the surface wave direct inversion method to invert the mixed path travel times for the 3D S-wave velocity structure. Checkerboard tests show that the horizontal resolution of the 3D S-wave velocity model is approximately 0.5°–1.0° and that the vertical resolution decreases with increasing noise and depth. Our high-resolution 3D S-wave velocity model reveals:(1) AV-shaped high-velocity zone(HVZ) is located in the lower crust and the uppermost mantle in the study region. The western branch of the HVZ passes through the Jianghan Basin,the Qinling-Dabie orogenic belt and the Nanxiang Basin. The eastern branch, which almost completely covers the main body of the MLYMB, is located near the Tanlu Fault. The low-velocity anomalies between the western and eastern branches are located in the area of the Qinling-Dabie orogenic belt.(2) High-velocity uplifts(HVUs) are common in the crust of the MLYMB,especially in the areas near the Tanlu Fault, the Changjiang Fault and the Yangxin-Changzhou Fault. The intensities of the HVUs gradually weaken from west to east. The V-shaped HVZ in the lower crust and uppermost mantle and the HVUs in the middle and lower crust likely represent cooled mantle intrusive rocks. During the Yanshanian period, fault systems formed in the MLYMB due to the convergence between the South China Plate and the North China Plate, the multiple-direction drifting of the PaleoPacific Plate and its subduction beneath the Eurasian Plate. The dehydration of the cold oceanic crust led to partial melting in the upper mantle. Temperature differences caused strong convection of the upper mantle material that underplated the lower crust and rose to near the surface along the deep fault systems. After mixing with the crustal materials, mineralization processes, such as assimilation and fractional crystallization, occurred in the MLYMB. | Song LUO Huajian YAO Qiusheng LI Weitao WANG Kesong WAN Yafeng MENG Bin LIU | 2019 | Science China Earth Sciences2019，62，9： | 13 |
| 7 | 3-D shear wave velocity structure in the shallow crust of the Tan-Lu fault zone in Lujiang,Anhui,and adjacent areas,and its tectonic implications显示文摘The Tan-Lu fault zone is a large NNE-trending fault zone in eastern China.Investigations of the structures of the fault zone and its surrounding areas have attracted much attention.In this study,we used dense-array ambient noise tomography to construct a threedimensional shear wave velocity model of shallow crust in an area about 80km×70km in Lujiang,Anhui Province,eastern China.For approximately one month we collected continuous ambient noise signals recorded by 90 short-period seismographs in the region,and obtained the short-period Rayleigh wave empirical Green's functions between stations by the cross-correlation method;we also extracted 0.5–8 s fundamental mode Rayleigh wave group velocity and phase velocity dispersion curves.Based on the direct surface wave tomography method,we jointly inverted the group velocity and phase velocity dispersion data of all paths and obtained the 3-D shear wave velocity structure in the depth range of 0–5 km.The results revealed important geological structural features of the study area.In the north region,the sedimentary center of the Hefei Basin—the southwestern part of the Chaohu Lake—shows a significant low-velocity anomaly to a depth of at least 5 km.The southwestern and southeastern regions of the array are the eastern margin of the Dabie orogenic belt and the intrusion area of Luzong volcanic rocks,respectively,and both show obvious high-speed anomalies;the sedimentary area within the Tan-Lu fault zone(about 10 km wide)shows low-velocity anomalies.However,the volcanic rock intrusion area in the fault zone is shown as high velocity.Our shallow crustal imaging results reflect the characteristics of different structures in the study area,especially the high-speed intrusive rocks in the Tan-Lu fault zone,which were probably partially derived from the magmatic activity of Luzong volcanic basin.From the Late Cretaceous to Early Tertiary,the Tan-Lu fault zone was in a period of extensional activity;the special stress environment and the fractured fault zone morphology provided conditions for magma in the Luzong volcanic basin to intrude into the Tan-Lu fault zone in the west.Our 3-D model can also provide important information for deep resource exploration and earthquake strong ground motion simulation. | Cheng Li HuaJian Yao Yuan Yang Song Luo KangDong Wang KeSong Wan Jian Wen Bin Liu | 2020 | Earth and Planetary Physics2020，4，3： | 12 |
| 8 | A New Alkaloid from the Root of Isatis indigotica Fort显示文摘A E-2-[(3’-indole)cyanomethylene]-3-indolinone was isolated from the root of Isatis indigotica Fort. The structure elucidation and 1H, 13C NMR assignments were achieved by spectroscopic method. | Wan Sheng CHEN*, Bin LI, Wei Dong ZHANG, Gen Jing YANG, Chuan Zhuo QIAO Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433 | 2001 | Chinese Chemical Letters2001，12，6： | 11 |
| 9 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 10 | A cross-sectional study on HGV infection in a rural population显示文摘AbstractAIMTodeterminetheepidemiologicalcharacteristicsandclinicalsignificanceofHGVinfection,andtocomparewithHBVandHCVinfecti... | LING Bin Hua 1, ZHUANG Hui 1, CUI Yi Hui 1, AN Wen Feng 1, LI Zhi Jie 1, WANG Shu Ping 2 and ZHU Wan Fu 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 10 |
| 11 | Fluid–solid coupling analysis of rock pillar stability for concealed karst cave ahead of a roadway based on catastrophic theory显示文摘In order to study the mechanism of water inrush from a concealed, confined karst cave, we established a fluid–solid coupling model of water inrush from a concealed karst cave ahead of a roadway and a strength reduction method in a rock pillar for preventing water inrush based on catastrophic theory. Fluid–solid coupling effects and safety margins in a rock pillar were studied. Analysis shows that rock pillar instability, exerted by disturbance stress and seepage stress, is the process of rock pillar catastrophic destabilization induced by nonlinear extension of plastic zones in the rock pillar. Seepage flow emerges in the rock pillar for preventing water inrush, accompanied by mechanical instability of the rock pillar. Taking the accident of a confined karst cave water-inrush of Qiyi Mine as an example, by studying the safety factor of the rock pillar and the relationship between karst cave water pressure and thickness of the rock pillar,it is proposed that rock pillar thickness with a safety factor equal to 1.5 is regarded as the calculated safety thickness of the rock pillar, which should be equal to the sum of the blasthole depth, blasting disturbance depth and the calculated safety thickness of the rock pillar. The cause of the karst water inrush at Qiyi Mine is that the rock pillar was so small that it did not possess a safety margin. Combining fluid–solid coupling theory, catastrophic theory and strength reduction method to study the nonlinear mechanical response of complicated rock engineering, new avenues for quantitative analysis of rock engineering stability evaluation should be forthcoming. | Zhao Yanlin Peng Qingyang Wan Wen Wang Weijun Chen Bin | 2014 | International Journal of Mining Science and Technology2014，24，6： | 9 |
| 12 | First total synthesis of two nematicidal prenylated flavanones显示文摘全部的合成(±)-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one 并且(±)-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 首先通过 C-prenylation,酉分的氢氧根组的保护,丁间醇醛冷凝作用,环合和从便宜 benzaldehyde, 4-hydroxybenzaldehyde 和 2-hydroxyacetophenone 开始的 deprotection 被完成,与 20 和 16.3% 的全部的产量。新混合物的所有结构被红外证实, 1 H NMR 和 MS。 | Jin Hui Yang Shi Zhi Jiang Yan Min Zhao Yun Feng Li Cong Bin Ji Wan Yi Liu | 2009 | Chinese Chemical Letters2009，20，9： | 9 |
| 13 | Effect of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi Compatibility on Uric Acid Metabolism and Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Rats with Hyperuricemia显示文摘Objective:To explore the effects of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomicompatibility(PR) on uric acid metabolism and the expression of urinary neutrophil gelatinase-associated lipocalin(NGAL) and kidney injury molecule-1(KIM-1) in rats with hyperuricemia. Methods:Seventy male Sprague Dawley(SD) rats were randomly divided into 7 groups with 10 rats per group, including the normal group, model group, allopurinol group, benzbromarone group and PR groups at 3 doses(3.5, 7, 14 g/kg). Except the normal group, rats of the other groups were intragastrically administered 100 mg/kg hypoxanthine and 250 mg/kg ethambutol, and subcutaneously injected with 200 mg/kg potassium oxonate. All rats were continuously modeled for 17 days, and gavaged with corresponding drugs. The rats of the normal and model groups were gavaged with saline, once a day, for 2 weeks. The levels of serum uric acid(SUA), blood urea nitrogen(BUN) and creatinine(Cr) were determined. In addition, the contents of NGAL and KIM-1 in urine and the m RNA and protein expressions of xanthine oxidase(XOD) in liver of hyperuricemia rats were measured by reverse transcription polymerase chain reaction(RT-PCR) and Western blot, respectively. Moreover, the pathological changes of kidney were analyzed by hematoxylin and eosin(HE) stain method. Results:Compared with the normal group, the levels of SUA, BUN, NGAL and KIM-1 and the expressions of hepatic XOD m RNA and protein in the hyperuricemia rats were increased significantly(P<0.01). PR significantly decreased the levels of SUA, BUN, NGAL and KIM-1 and down-regulated the m RNA and protein expressions of hepatic XOD(P<0.05 or P<0.01). In addition, the pathological changes of kidney were significantly suppressed by oral administration of PR. Conclusions:PR ameliorated uric acid metabolism and protected renal function, the underlying mechanism was mediated by decreasing the levels of SUA, BUN, NGAL and KIM-1, inhibiting the expression of hepatic XOD and ameliorating the pathological change of kidney. | HAN Bin ZHU Chun-xia SHI Wan HUANG Hui-zhu HU Xu-guang ZHOU Xiao-ming LEI Ming LI Zhong | 2017 | Chinese Journal of Integrative Medicine2017，23，7： | 9 |
| 14 | A chlorinated low-bandgap small-molecule acceptor for organic solar cells with 14.1% efficiency and low energy loss显示文摘A new acceptor-donor-acceptor(A-D-A) type small-molecule acceptor NCBDT-4 Cl using chlorinated end groups is reported.This new-designed molecule demonstrates wide and efficient absorption ability in the range of 600–900 nm with a narrow optical bandgap of 1.40 eV. The device based on PBDB-T-SF:NCBDT-4 Cl shows a power conversion efficiency(PCE) of 13.1%without any post-treatment, which represents the best result for all as-cast organic solar cells(OSCs) to date. After device optimizations, the PCE was further enhanced to over 14% with a high short-circuit current density(Jsc) of 22.35 m A cm-2 and a fill-factor(FF) of 74.3%. The improved performance was attributed to the more efficient photo-electron conversion process in the optimal device. To our knowledge, this outstanding efficiency of 14.1% with an energy loss as low as 0.55 eV is among the best results for all single-junction OSCs. | Bin Kan Huanran Feng Huifeng Yao Meijia Chang Xiangjian Wan Chenxi Li Jianhui Hou Yongsheng Chen | 2018 | Science China Chemistry2018，61，10： | 9 |
| 15 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 16 | In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A显示文摘Bisphenol A (BPA) is a chemical with high production volume and wide applications in many industries.Although BPA is known as an endocrine disruptor,its toxic mechanisms have not been fully characterized.Due to its structural similarity to thyroid hormones thyroxine (T4) and triiodothyronine (T3),one possible mechanism of BPA toxicity is disruption of hormone transport by competitive binding with the transport proteins.In this study,the binding interactions of BPA,T4,and T3 with three thyroid hormone transport proteins,human serum albumin (HSA),transthyretin (TTR),and thyroxine-binding globulin (TBG) were investigated by fluorescence measurement.Using two site-specific fluorescence probes dansylamide and dansyl-L-proline,the binding constants of BPA with HSA at drug site I and site II were determined as 2.90 × 10 4 and 3.14 × 10 4 L/mol,respectively.By monitoring the intrinsic fluorescence of tryptophan,a binding constant of 4.70 × 10 3 L/mol was obtained.Similarly,by employing 8-anilino-1-naphthalenesulfonic acid as fluorescence probe,the binding affinity of BPA with TTR and TBG was measured to be 3.10 × 10 5 and 5.90 × 10 5 L/mol,respectively.In general,BPA showed lower binding affinity with the proteins than T3 did,and even lower affinity than T4.Using these binding constants,the amount of BPA which would bind to the transport proteins in human plasma was estimated.These results suggest that the concentrations of BPA commonly found in human plasma are probably not high enough to interfere with T4 transport. | Jie Cao Liang-Hong Guo Bin Wan Yin Wei | 2011 | Journal of Environmental Sciences2011，23，2： | 8 |
| 17 | Spatial Pattern Evolution and Casual Analysis of County Level Economy in Changsha-Zhuzhou-Xiangtan Urban Agglomeration, China显示文摘In order to evaluate whether or not the county units′ economy in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan) Urban Agglomeration was growing as expected, this study analyzed the spatial economy pattern at county-level by using the Exploratory Spatial Data Analysis(ESDA) method. In this process, the global Moran′s I and local Getis-Ord G*i indexes were employed to analyze indicators including per capita GDP and three industrials(i.e. primary, secondary and tertiary industry) from 2000 to 2010. The results show that: 1) the county units′ economy in the Chang-Zhu-Tan Urban Agglomeration has exhibited a strong spatial autocorrelation and an accelerated integration trend since 2008(Moran′ s I increased from 0.26 to 0.56); 2) there is a significant difference in economy development between the northern and southern county units in the Chang-Zhu-Tan Urban Agglomeration: the hotspot zone with high economic level was formed among the northern county units whereas the coldspot zone with low economic level was located in the southern areas. This difference was caused primarily by the increasingly prominent economic radiation effect of Changsha ′upheaval′; 3) town density, secondary industry, and the integration policy are the major contributors driving the evolution of the spatial economy pattern in the Chang-Zhu-Tan Urban Agglomeration. | DONG Minghui ZOU Bin PU Qiang WAN Neng YANG Lingbin LUO Yanqing | 2014 | Chinese Geographical Science2014，24，5： | 8 |
| 18 | Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)显示文摘The fall armyworm(FAW),Spodoptera frugiperda(J.E.Smith),is native to the Americas.It has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in 2016.It is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous characteristics.The inherently superior biological characteristics of FAW contribute to its invasiveness.Integrated pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and botanicals.Knowledge gaps remain to be filled to:(1)understand the invasive mechanisms of S.frugiperda;(2)understand how to prevent its further spread and(3)provide better management strategies.This review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management. | Jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao | 2021 | Journal of Integrative Agriculture2021，20，3： | 7 |
| 19 | The development in aqueous lithium-ion batteries显示文摘To meet the growing energy demands, it is urgent for us to construct grid-scale energy storage system than can connect sustainable energy resources. Aqueous Li-ion batteries(ALIBs) have been widely investigated to become the most promising stationary power sources for sustainable energy such as wind and solar power. It is believed that advantages of ALIBs will overcome the limitations of the traditional organic lithium battery in virtue of the safety and environmentally friendly aqueous electrolyte. In the past decades, plentiful works have been devoted to enhance the performance of different types of ALIBs.In this review, we discuss the development of cathode, anode and electrolyte for acquiring the desired electrochemical performance of ALIBs. Also, the main challenges and outlook in this field are briefly discussed. | Duan Bin Yunping Wen Yonggang Wan Yongyao Xia | 2018 | Journal of Energy Chemistry2018，27，6： | 7 |
| 20 | Record-Setting Ocean Warmth Continued in 2019显示文摘Human-emitted greenhouse gases(GHGs)have resulted in a long-term and unequivocal warming of the planet(IPCC,2019).More than 90%of the excess heat is stored within the world's oceans,where it accumulates and causes increases in ocean temperature(Rhein et al.,2013;Abram et al.,2019). | Lijing CHENG John ABRAHAM Jiang ZHU Kevin ETRENBERTH John FASULLO Tim BOYER Ricardo LOCARNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN | 2020 | Advances in Atmospheric Sciences2020，37，2： | 7 |
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