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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro显示文摘Human embryos of in vitro fertilization(IVF)are often susceptible to developmental arrest,which greatly reduces the efficiency of IVF treatment.In recent years,it has been found that protein arginine methyltransferase 7(PRMT7)plays an important role in the process of early embryonic development.However,not much is known about the relationship between PRMT7 and developmentally arrested embryos.The role of PRMT7 in developmentally arrested embryos was thus investigated in this study.Discarded human embryos from IVF were collected for experimental materials.Quantitative real-time polymerase chain reaction(qRT-PCR)and confocal analyses were used to identify PRMT7 mRNA and protein levels in early embryos at different developmental stages,as well as changes in the methylation levels of H4R3me2s.Additionally,PRMT7 was knocked down in the developmentally arrested embryos to observe the further development of these embryos.Our results demonstrated that PRMT7 mRNA and protein levels in arrested embryos were significantly increased compared with those in control embryos;meanwhile,the methylation levels of H4R3me2s in arrested embryos were also increased significantly.Knockdown of PRMT7 could rescue partially developmentally arrested embryos,and even individual developmentally arrested embryos could develop into blastocysts.In conclusion,over-expression of PRMT7 disrupts the early embryo development process,leading to early embryos developmental arrest,but these developmentally arrested defects could be partially rescued by knockdown of the PRMT7 protein. | Wuwen Zhang Shifeng Li Kai Li Li Li Ping Yin Guoqing Tong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 3 | Interactions between gut microbiota and berberine,a necessary procedure to understand the mechanisms of berberine显示文摘Berberine(BBR),an isoquinoline alkaloid,has been found in many plants,such as Coptis chinensis Franch and Phellodendron chinense Schneid.Although BBR has a wide spectrum of pharmacological effects,its oral bioavailability is extremely low.In recent years,gut microbiota has emerged as a cynosure to understand the mechanisms of action of herbal compounds.Numerous studies have demonstrated that due to its low bioavailability,BBR can interact with the gut microbiota,thereby exhibiting altered pharmacological effects.However,no systematic and comprehensive review has summarized these interactions and their corresponding influences on pharmacological effects.Here,we describe the direct interactive relationships between BBR and gut microbiota,including regulation of gut microbiota composition and metabolism by BBR and metabolization of BBR by gut microbiota.In addition,the complex interactions between gut microbiota and BBR as well as the side effects and personalized use of BBR are discussed.Furthermore,we provide our viewpoint on future research directions regarding BBR and gut microbiota.This review not only helps to explain the mechanisms underlying BBR activity but also provides support for the rational use of BBR in clinical practice. | Hao Cheng Juan Liu Yuzhu Tan Wuwen Feng Cheng Peng | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 1 |
| 4 | Placenta previa: Its relationship with race and the country of origin among Asian women显示文摘 | QIUYINGYANG SHI WUWEN SHARONCAUGHEY DANIELKREWSKI LUMINGSUN MARK C.WALKER | 2010 | Acta Obstetricia et Gynecologica Scandinavica2010，，6： | 1 |
| 5 | An Inverse Eigenvalue Problem for Nonnegative Matrices显示文摘 | Guo Wuwen | 1996 | Linear Algebra Appl1996，，249： | 1 |
| 6 | Eigenvalues of Nonnegative Matrices显示文摘 | Guo Wuwen | 1997 | Linear Algebra Appl1997，，266： | 1 |
| 7 | 显示文摘 | WUWen(武文) ZHANGXin-Lei(张新磊) XUANYa-Wen(宣亚文) | | HuagongXinxingCailiao0，，： | 1 |
| 8 | Green Microstructure Effects on Densification and Distortion in Liquid phase Sintering显示文摘 | Yi Wuwen Xu Xiaoping Lu Peizhen | 2001 | International Journal of Refractory Metals and Hard Materials2001，19，3： | 1 |
| 9 | Alteration of peripheral CD4^+ CD25 ^+ regulatory T lymphocytes in pregnancy and pre - eclampsia 显示文摘 | Dongxiao HU Yan Chen Wuwen Zhang | 2008 | Acta Obstericia et Gynecologica2008，87，： | 1 |
| 10 | Fiber Optic in-Line Distributed Sensor for Detection and Localization of the Pipeline Leaks 显示文摘 | Huang Shihchu Lin Wuwen Tsai Mengtsan | 2007 | Sensors and Actuators A : Physical2007，135，2： | 1 |
| 11 | 档案执法监督与业务指导应当孰先孰后?显示文摘泊客:从档案管理部门来讲.档案执法监督与业务指导都是我们的工作与职责,都必须尽职尽责地做好。但如果从我们档案管理的行政管理相对人(这里指法人)的角度看,它们是可以用两种态度来对待的。对于档案执法监督,必须接受:对于档案业务指导,则可以接受,也可以不接受。在一定条件下,只要档案执法监督到位,不论你对其是否进行档案业务指导,档案行政管理相对人迟早自己会设法去学、去做好这项工作的。 | 泊客 沧海一粟 汝阳老党 maoyue nikkidd 味道 thgw 成长中的小树 wuwen 临溪羡鱼 春风秋水 | 2008 | 档案管理2008，，3： | 1 |
| 12 | Study on Technology of Electromagnetic Ra- diation of Sensitive Index to Forecast the Coal and Gas Hazards 显示文摘 | Yuliang Li Wuwen | 2010 | Procedia Engineering2010，7，： | 1 |
| 13 | Human umbilical cord mesenchymal stromal cells promote the regeneration of severe endometrial damage in a rat model显示文摘Due to the influence of various social and environmental factors,the incidence of infertility is increasing,and the application of assisted reproductive technology(ART)is becoming more and more widespread.At present,the clinical pregnancy rate of in vitro fertilization(IVF)is 40%~60%,and decreased endometrial receptivity is one of the reasons for implantation failure.Endometrial receptivity refers to the capacity of the endometrium to accept embryos.Intrauterine adhesions(IUA),also known as Asherman syndrome(AS). | Mei Zhuang Wuwen Zhang Nuo Cheng Ling Zhou Dan Liu Hua Yan Ge Fang Boon Chin Heng Yan Sun Guoqing Tong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 14 | CDX2 is essential for human IVF early embryonic development显示文摘Human in vitro fertilization (IVF)embryos usually have developmental block at 4-8 cell stages,in which only 30%-50% percent of IVF embryos develop to blastocyst stage.This is the main cause for low efficiency and repeated treatment failure in human fertility therapy.Transcription factor CDX2 is one of the key genes in human early embryonic development,which decides the differentiation from blastomere to trophoblastic lineage.However,the relationship between the developmental block of human IVF embryos and CDX2 is poorly understood.In this study,we showed that CDX2 is crucial for human IVF embryonic development,q-PCR analysis confirmed that the level of CDX2 in developmental block embryos was dramatically decreased.Immunofluorescence analysis further demonstrated that CDX2 protein level in developmental block embryos was significantly decreased compared with that in control embryos.We also addressed whether reexpression of CDX2 could rescue developmental block defects in human IVF developmental block embryos,As expected,these developmental block defects could be partially rescued by overexpression of CDX2 protein.In conclusion,these findings suggest that CDX2 plays an important role in the process of human early embryonic development. | Wuwen Zhang Kai Li Xiufang Zhong Hua Yan Guoqing Tong | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 1 |
| 15 | “业务指导”是专业还是“万金油”?显示文摘一束草根:“业务指导”的重要性不必再说了。大家都耳熟能详。既然“业务指导”那么重要,那么“业务指导”是不是专业呢?我认为回答应该是肯定的。但是.就是这样重要的工作,在档案专业上并没有名分。《档案学词典》中没有这个术语,《档案管理学》论著中没有对它的论述研究。工作难做使业务指导人员沦为“雇佣工”。这让人怀疑“业务指导”的专业性。事实上,一些地方做业务指导工作的人员,专业上并不是档案专业的骨干,他们在工作中基本上是“雇佣工”。对于新领域的档案工作指导,如农村建档、社区建档等,要么是“雇佣工”,要么是“蜻蜓点水”.就像是“万金油”。当然.我说的这些现象可能只是个别现象。 | 一束草根 沧海一粟 泊客 Wuwen,Zhz 兰台新兵 Nikkidd 汝阳老党 | 2008 | 档案管理2008，，2： | 0 |
| 16 | Differential cytokines expression in cervical exfoliated cells of women with implantation after in vitro fertilization显示文摘In assisted reproductive technology,the quality of embryo and the receptivity of endometrium are the key components for successful pregnancy.Good endometrial receptivity is an important condition to the attachment of embryo[1].In clinical practice,the endometrial thickness,serum hormone level,and some gene expressions are always used to evaluate the functional status of endometrium.However,the hormone levels of serum estrogen and progesterone are out of synchronization of the development of endometrium.The thickness and status of endometrium cannot precisely demonstrate its morphological changes.Meanwhile,the mechanism of embryo implantation is very complicated,and immune cells,immune molecules,cytokines,adhesion molecules,etc. | Li Li Wuwen Zhang Christina(Ling)Tong Hua Yan Ping Yin Kai Li Boon Chin Heng Guoqing Tong | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 0 |
| 17 | An Investigation into the Compressive Strength,Permeability and Microstructure of Quartzite-Rock-Sand Mortar显示文摘River sand is an essential component used as a fine aggregate in mortar and concrete.Due to unrestrained exploitation,river sand resources are gradually being exhausted.This requires alternative solutions.This study deals with the properties of cement mortar containing different levels of manufactured sand(MS)based on quartzite,used to replace river sand.The river sand was replaced at 20%,40%,60%and 80%with MS(by weight or volume).The mechanical properties,transfer properties,and microstructure were examined and compared to a control group to study the impact of the replacement level.The results indicate that the compressive strength can be improved by increasing such a level.The strength was improved by 35.1%and 45.5%over that of the control mortar at replacement levels of 60%and 80%,respectively.Although there was a weak link between porosity and gas permeability in the mortars with manufactured sand,the gas permeability decreased with growing the replacement level.The microstructure of the MS mortar was denser,and the cement paste had fewer microcracks with increasing the replacement level. | Wei Chen Wuwen Liu Yue Liang | 2024 | Fluid Dynamics & Materials Processing2024，20，4： | 0 |
| 18 | TEM and TEM-EDX Analysis of Cross-section of TiO_2Thin Film and Glass Substrate显示文摘TiO2 thin film was deposited on Na-Ca-Si glass substrate by sol-gel process. TEM observation showed that the film is compactly joined to the substrate. TEM-EDX analyses of the film, film-substrate interface, and substrate revealed that the diffusion of Na+ from the substrate to the film is negative diffusion. | YU Xingang MA Hongwen LUO Wuwen ZHOU Ao KOU Qinghua ZHAO Huifeng (Department of Materials Science, CUG, Beijing, 100083, China) (Research Institute of Glass, CBMA) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，2： | 0 |
| 19 | Prmt7 regulates epiboly and gastrulation ce movements by facilitating syntenin显示文摘Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation.Despite of its fundamental function,little is known about the molecular mechanisms that control this coordinated cell movement.In this study,we investigated protein arginine methyltransferase 7 (PrmtT)morphants with an epibolic delay defect in zebrafish.The ratio of morphants with epiboly delay phenotypes increased as the dose of the injected morpholino (MO)increased.Here,syntenin transcripts are maternally deposited and ubiquitously expressed from the oocyte period to the early larva stage.Furthermore,we demonstrated that Prmt7 modulates epibolic movements of the enveloping layer by regulating F-actin organization.These defects can be partially rescued by re-expression of Prmt7 or syntenin protein. Analysis of the earliest cellular defects suggested a role of Prmt7 in the autonomous vegetal expansion of the yolk syncytial layer and the rearrangement of the actin cytoskeleton in extra-embryonic tissues. By a combination of knockdown studies and rescue experiments in zebrafish,we showed that epiboly relies on the molecular networking of Prmt7 by facilitating syntenin,which acts as a regulator for cytoskeleton.This study identifies the important function of the Prmt7 for the progression of zebrafish epiboly and establishes its key role in directional cell movements during early development. | Wuwen Zhang Yunbin Zhang Shifeng Li Zhili Wu Yuanchang Yan Yiping Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 0 |
| 20 | Measurement of serum granulocyte colonystimulating factor levels in patients with different phase of infection显示文摘Objective: To detect the serum granulocyte colony-stimulating factor (G-CSF) levels between the patients with frequently repeated infection (repeaters) and others (non-repeaters) in different phase of infection. Methods: An enzyme-linked immunosorbent assay (ELISA) method was used to detect serum G-CSF levels in 50 cases (32 non-repeaters and 18 repeaters) with acute phase of infection. Serum G-CSF levels were detected in recovery phase in 10 cases. Results: Serum G-CSF levels were significantly higher (1429.97±506.43ng/L) in 32 non-repeaters with acute infection. There was a positive correlation between white blood cell count (WBC) and serum G-CSF level (r =0. 396, P <0.05). There was also a positive correlation between absolute neutrophil count (ANC) and serum G-CSF level (r=0.346,P<0,05). Serum G-CSF levels were higher (98.62 -+56.40ng/L) in 18 repeaters with acute infection, It was showed that serum G-CSF levels were significantly higher in non-repeaters than in repeaters with acute phase of infection ( P <0. 001 ). In the meanwhile, the body temperature was significantly higher in non-repeaters than in repeaters with acute infection (37.95±0.14℃ rs 36.91±0.13℃ ,P <0.001), There were no significant differences in age, WBC, ANC, type of bacterial, liver function and renal function (P > 0.05). Serum G-CSF levels in recovery phase of the two groups were below the sensitivity of the assay ( < 60 ng/L), Conlusion: It is suggested that application of recombinant G-CSF may be useful for the patients with repeated infection, | WUWen HUJiong ZHAOWei-li YANHua TANGWei XULan SHIGuang-ning SHENZhi-xiang SUNGuan-lin WANGZhen-yi | 2005 | 上海第二医科大学学报2005，25，7： | 0 |
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