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| 1 | 早期胃癌内镜下切除日本指南的历史和未来展望显示文摘日本胃癌治疗指南首次发表于2001年,其目的是为了明确不同治疗方案的适应证,从而减少不同医疗机构间治疗方式的差异。随着病例的积累及内镜黏膜下剥离术(ESD)的发展,早期胃癌(EGC)内镜下切除(ER)的适应证和治愈性范围有所扩大,但是,仍有部分问题亟待解决。使用风险评分系统(eCura system)评估淋巴结转移(LNM)的情况,可能有助于确定不符合内镜切除标准的EGC患者的治疗方案。对于不符合内镜切除标准的EGC患者,即最新指南中的eCura C-2分期的患者,尽管他们的LNM风险较高,但对于很多患者来说,追加胃切除联合淋巴结清扫术仍然是过度的治疗。而保留功能的低侵入性手术,如内镜下非开放式胃壁反转切除术联合腹腔镜前哨淋巴结活检,有可能会解决该问题。此外,对于拒绝追加胃切除术的患者,可采取更多的低侵入性治疗方式,如ER联合化疗。 | Waku Hatta Takuji Gotoda Tomoyuki Koike Atsushi Masamune 丁士刚(译) 张冬雪(译) 乌雅罕(译) | 2020 | 中华胃肠内镜电子杂志2020，7，1： | 22 |
| 2 | Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients显示文摘AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease(NERD) patients.METHODS: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance- p H on rabeprazole. The symptom index(SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.RESULTS: In 14(40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes(46.7%) than in distal ones(5.7%)(P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(38.5%) and distal ones(20.5%)(NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent(31.0%) than in distal reflux ones(3.3%)(P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(29.4%) and distal ones(14.3%)(NS).CONCLUSION: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy. | Kenichiro Nakagawa Tomoyuki Koike Katsunori Iijima Masahiro Saito Hiroki Kikuchi Waku Hatta Nobuyuki Ara Kaname Uno Naoki Asano Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，47： | 4 |
| 3 | A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma显示文摘 | Waku Hatta Kaname Uno Tomoyuki Koike Katsunori Iijima Naoki Asano Akira Imatani Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 4 | Deformation and fracture behavior of an Al 2 O 3 /YAG composite from room temperature to 2023 K显示文摘 | S. Ochiai T. Ueda K. Sato M. Hojo Y. Waku N. Nakagawa S. Sakata A. Mitani T. Takahashi | 2001 | Composites Science and Technology2001，，14： | 2 |
| 5 | Metamorphosis of midgut epithelial cells in the silkworm(Bombyx mori L) with special regard to the calcium salt deposits in the cytoplasm:Ⅰ:Light microscopy显示文摘 | WAKU Y SUMIMOTO K | 1971 | Tissue Cell1971，3，： | 1 |
| 6 | Pattern recognition of a grasped object by univector distribution显示文摘 | Ozaki H Waku S Mohri A | 1982 | IEEE Trans Syst Man Cybern1982，12，3： | 1 |
| 7 | Molecu- lar characterization of wild-type measles viruses circulating in the Indian Ocean Islands during 2005-2006 and in Fran- cein2006 显示文摘 | Waku Kouomou D Landreau D Olivier S | 2007 | J MedVirol2007，79，9： | 1 |
| 8 | Dislocation mechanism of deformation and strength of Al2O3-YAG single crystal composites at high temperatures above 1 500℃显示文摘 | Waku Y Sakuma T | 2000 | Journal of the European Ceramic Society2000，20，10： | 1 |
| 9 | Significance of brain natriuretic peptid measurement as a diagnostic indicator of cardiac function 显示文摘 | Waku S Iida N Ishihara T | 2000 | Methord Inf Med2000，39，： | 1 |
| 10 | Ultrastructure and scretory mechanism of the alluring gland cell in the silkworm, Bombyx mori 显示文摘 | WAKU Y SUMIMOTO K | 1969 | Appl Entomol Zool1969，4，： | 1 |
| 11 | Fracture and Deformation Behavior of Melt Growth Composites at Very high Temperatures显示文摘 | Waku Y Nakagawa N Ohtsubo H | 2001 | JMaterSci2001，36，： | 1 |
| 12 | Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation显示文摘 | Itoshima T Fujiwara T Waku T | | 0，，07： | 1 |
| 13 | Significance of brain natriuretic peptide measurement as a diagnostic indicator of cardiac function显示文摘 | Waku S Iida N Ishihara T | 2000 | Metholds Inf Med2000，39，3： | 1 |
| 14 | A Ductile Ceramic Eutectic Composite with High Strength at 1 873 K 显示文摘 | Waku Y Nakagawa N Wakamoto T | 1997 | Nature1997，389，： | 1 |
| 15 | Surgical laparoscopic therapy of small bowel tumors:review of the literature and report of two cases显示文摘 | Napolitano L Waku M De Nicola P | 2004 | G Chir2004，25，67： | 1 |
| 16 | Significance of brain nat riuretic peptide measurement as a indicator diagnostic of cardiac function显示文摘 | Waku S Lida N Ishihara T | 2000 | Met hods Inf Med2000，39，3： | 1 |
| 17 | Significance of brain natriuretic peptide measurement as a diagnostic indicator of cardiac function显示文摘 | Waku S Iida N Ishihara T | 2000 | Methods Inf Med2000，39，3： | 1 |
| 18 | Cliuincal study on laparoscopic approach to cholelithiasis in the elderly显示文摘 | Napolitano L Waku M Di Bartolomeo N | 2004 | G Chit2004，25，89： | 1 |
| 19 | Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene显示文摘 | Murakami T Tokunaga N Waku T | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 20 | Surgical laparoscopic therapy of amall bowel tundra: review of the literature and report of two cases显示文摘 | Napohano L Waku M De Nicola P | 2004 | G Chir2004，25，： | 1 |
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