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| 1 | Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review显示文摘Since Isaacson and Wright first reported on the extranodal marginal zone B-cell lymphoma of the stomach in 1983,following studies have clarified many aspects of this disease.We now know that the stomach is the most affected organ by this disease,and approximately90% of gastric mucosa-associated lymphoid tissue(MALT) lymphomas are related to Helicobacter pylori(H.pylori) infection.This implies that approximately 10% of gastric MALT lymphomas occur independent of H.pylori infection.The pathogenesis of these H.pylori-negative gastric MALT lymphomas remains unclear.To date,there have been several speculations.One possibility is that genetic alterations result in nuclear factor-kappa B(NF-κB) activation.Among these alterations,t(11;18)(q21;q21) is more frequently observed in H.pylori-negative gastric MALT lymphomas,and such translocation results in the synthesis of fusion protein API2-MALT1,which causes canonical and noncanonical NF-κB activation.Another possibility is infection with bacteria other than H.pylori.This could explain why H.pylori eradication therapy can cure some proportions of H.pylori-negative gastric MALT lymphoma patients,although the bacteria responsible for MALT lymphomagenesis are yet to be defined.Recent advances in endoscopy suggest magnifying endoscopy with narrow band imaging as a useful tool for both detecting gastric MALT lymphoma lesions and judging the response to treatment.A certain proportion of H.pylori-negative gastric MALT lymphoma patients respond to eradication therapy; hence,H.pylori eradication therapy could be considered as a first-line treatment for gastric MALT lymphomas regardless of their H.pylori infection status. | Naoki Asano Katsunori Iijima Tomoyuki Koike Akira Imatani Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，26： | 7 |
| 2 | Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients显示文摘AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease(NERD) patients.METHODS: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance- p H on rabeprazole. The symptom index(SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.RESULTS: In 14(40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes(46.7%) than in distal ones(5.7%)(P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(38.5%) and distal ones(20.5%)(NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent(31.0%) than in distal reflux ones(3.3%)(P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(29.4%) and distal ones(14.3%)(NS).CONCLUSION: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy. | Kenichiro Nakagawa Tomoyuki Koike Katsunori Iijima Masahiro Saito Hiroki Kikuchi Waku Hatta Nobuyuki Ara Kaname Uno Naoki Asano Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，47： | 4 |
| 3 | A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma显示文摘 | Waku Hatta Kaname Uno Tomoyuki Koike Katsunori Iijima Naoki Asano Akira Imatani Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 4 | Variants for the Hough transform for line detection显示文摘 | Tetsuo Asano Naoki Katoh | 1996 | Computational Geometry1996，6，： | 1 |
| 5 | Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review显示文摘Nucleotide-binding oligomerization domain 1(NOD1) is an intracellular innate immune sensor for small molecules derived from bacterial cell components. NOD1 activation by its ligands leads to robust production of pro-inflammatory cytokines and chemokines by innate immune cells, thereby mediating mucosal host defense systems against microbes. Chronic gastric infection due to Helicobacter pylori(H. pylori) causes various upper gastrointestinal diseases, including atrophic gastritis, peptic ulcers, and gastric cancer. It is now generally accepted that detection of H. pylori by NOD1 expressed in gastric epithelial cells plays an indispensable role in mucosal host defense systems against this organism. Recent studies have revealed the molecular mechanism by which NOD1 activation caused by H. pylori infection is involved in the development of chronic gastritis and gastric cancer. In this review, we have discussed and summarized how sensing of H. pylori by NOD1 mediates the prevention of chronic gastritis and gastric cancer. | Kosuke Minaga Tomohiro Watanabe Ken Kamata Naoki Asano Masatoshi Kudo | 2018 | World Journal of Gastroenterology2018，24，16： | 1 |
| 6 | Sugars with nitrogen in the ring isolated from the leaves of morus bombycis显示文摘 | Naoki Asano Emiko Tomioka Haruhisa Kizu | 1994 | Carbohydrate Research1994，253，： | 1 |
| 7 | Polyhydroxylated alkaloids-natural occurrence and therapeutic applications显示文摘 | Watson A A George W J Fleet Naoki Asano | | 0，，： | 1 |
| 8 | Sugar-mimic glycosidase inhibitors:natural occurrence,biological activity and prospects for therapeutic application显示文摘 | Naoki Asano Robert J Nash Russell J | 2000 | Tetrahedron:Asymmetry2000，，11： | 1 |
| 9 | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency 显示文摘 | Naoki K Asano K Satoh N | 2004 | Biochem Biophys Res Commun2004，317，： | 1 |
| 10 | Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters显示文摘 | Yuji Iimuro Toru Kashiwagi Junichi Yamanaka Tadamichi Hirano Shinichi Saito Takaaki Sugimoto Shinichiro Watanabe Nobukazu Kuroda Toshihiro Okada Yasukane Asano Naoki Uyama Jiro Fujimoto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 11 | 显示文摘 | Satoh N Asano K Naoki K | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 12 | The Comparative Pathology of the Glycosidase Inhibitors Swainsonine, Castanospermine, and Calystegines A3, B2, and C1 in Mice显示文摘 | Stegelmeier Bryan L Molyneux Russell J Asano Naoki | 2008 | Toxicologic Pathology2008，36，： | 1 |
| 13 | A mutated superantigen SEA D227A fusion diabody specific to MUC1 and CD3 in targeted cancer immunotherapy for bile duct carcinoma显示文摘 | Shin-ichi Takemura Toshio Kudo Ryutaro Asano Masanori Suzuki Kouhei Tsumoto Naoki Sakurai Yu Katayose Hideaki Kodama Hiroshi Yoshida Shinji Ebara Hisaaki Saeki Kohzoh Imai Seiki Matsuno Izumi Kumagai | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 14 | Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level显示文摘 | Katsunori Iijima Nobuyuki Ara Yasuhiko Abe Tomoyuki Koike Toshimitsu Iwabuchi Hirohiko Shinkai Kaname Uno Hiroyuki Endo Naoki Asano Tooru Shimosegawa | 2012 | Journal of Gastroenterology2012，，12： | 1 |
| 15 | Plasma platelet- activating factor acetylhydrolase deficiency in Japanese patients with asthma 显示文摘 | Satoh N Asano K Naoki K | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 16 | Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis显示文摘 | Naoki Asano Emiko Tomioka Haruhisa Kizu | | 0，，： | 1 |
| 17 | calystegine alkaloids from duboisia leichhardtii显示文摘 | Atsushi Kato Naoki Asano Haruhisa Kizu | | 0，，2： | 1 |
| 18 | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency显示文摘 | Naoki K Asano K Satoh N | | 0，，01： | 1 |
| 19 | Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase alpha显示文摘 | Isoko Kuriyama Naoki Asano Ikuo Kato | 2005 | Bioorg Med Chem2005，13，6： | 1 |
| 20 | Cellular and molecular mechanisms underlying NOD 2 risk‐associated polymorphisms in C rohn’s disease显示文摘 | Warren Strober Naoki Asano Ivan Fuss Atsushi Kitani Tomohiro Watanabe | 2014 | Immunol Rev2014，，1： | 1 |
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