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| 1 | Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing显示文摘Diabetic ischemic wound treatment remains a critical clinical challenge.Neovascularization plays a significant role in wound healing during all stages of the tissue repair process.Strategies that enhance angiogenesis and neovascularization and improve ischemic pathology may promote the healing of poor wounds,particularly diabetic wounds in highly ischemic conditions.We previously identified a cyclic peptide LXW7 that specifically binds to integrinαvβ3 on endothelial progenitor cells(EPCs)and endothelial cells(ECs),activates vascular endothelial growth factor(VEGF)receptors,and promotes EC growth and maturation.In this study,we designed and synthesized a multi-functional pro-angiogenic molecule by grafting LXW7 and collagen-binding peptides(SILY)to a dermatan sulfate(DS)glycosaminoglycan backbone,named LXW7-DS-SILY,and further employed this multi-functional molecule to functionalize collagen-based extracellular matrix(ECM)scaffolds.We confirmed that LXW7-DS-SILY modification significantly promoted EPC attachment and growth on the ECM scaffolds in vitro and supported EPC survival in vivo in the ischemic environment.When applied in an established Zucker Diabetic Fatty(ZDF)rat ischemic skin flap model,LXW7-DS-SILY-functionalized ECM scaffolds loaded with EPCs significantly improved wound healing,enhanced neovascularization and modulated collagen fibrillogenesis in the ischemic environment.Altogether,this study provides a promising novel treatment to accelerate diabetic ischemic wound healing,thereby reducing limb amputation and mortality of diabetic patients. | Siqi He Tanaya Walimbe Hongyuan Chen Kewa Gao Priyadarsini Kumar Yifan Wei Dake Hao Ruiwu Liu Diana L.Farmer Kit S.Lam Jianda Zhou Alyssa Panitch Aijun Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 2 | Fluoride toxicity on rat testis and cauda epididymal tissue components and its reversal显示文摘 | Chinoy NJ Shukla S Walimbe AS | | 0，，1： | 1 |
| 3 | Automated 3-Dimensional Elastic Registration of Whole-Body PET and CT from Separate or Combined Scanners显示文摘 | Shekhar R Walimbe W Raja S | 2005 | J Nucl Med2005，46，： | 1 |
| 4 | Transient and reversible fluoride toxicity in some soft tissue of female mice 显示文摘 | Chinoy N J Walimbe A S Vyas H A | 1994 | Fluoride1994，27，4： | 1 |
| 5 | Evolutionary rates and timescale comparison of Chikungunya viruses inferred from the whole genome/E1 gene with special reference to the 2005–07 outbreak in the Indian subcontinent显示文摘 | Sarah S. Cherian Atul M. Walimbe Santosh M. Jadhav Swati S. Gandhe Supriya L. Hundekar Akhilesh C. Mishra Vidya A. Arankalle | 2008 | Infection Genetics and Evolution2008，，1： | 1 |
| 6 | Global Stability and Control Analysis of Axial Compressor Stall and Surge Phenomena Using Bifurcation Methods显示文摘 | ] Ananthkrishnan N Vaidya U G Walimbe V W | 2003 | Journal of Power and Energy2003，217，3： | 1 |
| 7 | Swine HEV infection in south India and phylogenetic analysis (1985-1999)显示文摘 | Chobe L P Walimbe A M | 2003 | J Med Virol2003，69，3： | 1 |
| 8 | Evolutionary rates and timescale comparison of chikungunya viruses in- ferred from the whole genome/E1 gene with special reference to the 2005--2007 outbreak in the Indian subcontinent 显示文摘 | CHERIAN S S WALIMBE A M JADHAV S M | 2009 | Infect Genet Evol2009，9，1： | 1 |
| 9 | Transient and reversible fluoride toxicity in some soft tissues of female mice显示文摘 | Chinoy NJ Walimbe AS Vyas HA | | 0，，04： | 1 |
| 10 | Mutual information-based multimodality registration of cardiac ultrasound and SPECT images:a preliminary investigation显示文摘 | Walimbe V Zagrodsky V Raja S | 2003 | Int J Cardiovasc Imaging2003，19，6： | 1 |
| 11 | Automated 3 - dimensional elastic registration of whole-body PET and CT from separate or combined scanners 显示文摘 | Shekhar R Walimbe V Raja S | 2005 | Journal of Nuclear Medicine2005，46，9： | 1 |
| 12 | Development of internal breakdown in alphonso mango by post-harvest exposure of fruits to sun- light 显示文摘 | GUNJATE R T WALIMBE B P LAD B L | 1982 | Science and Culture1982，48，： | 1 |
| 13 | Full length genomes of genotype HI A Hepatitis A virus strains( 1995-2008 )from India and estimates of the evolutionary rates and ages 显示文摘 | Kulkami MA Walimbe AM Cherian S | 2009 | Infect Genet Evol2009，9，6： | 1 |
| 14 | Quantitative real-time 3-dimensional stress echocardiography : a preliminary investigation of feasibility and effective- ness 显示文摘 | Walimbe V Garcia M Lalude O | 2007 | J Am Soc Eehocardiogr2007，20，： | 1 |
| 15 | Image registration accuracy with low-dose CT: how low can we go?显示文摘 | Dandekar O Siddiqui K Walimbe V | 2006 | Biota Imag2006，6，： | 1 |
| 16 | Transient and reversible fluoride toxicity in some soft tissue of female mice显示文摘 | Chinoy NJ Walimbe AS Vyas HA | 1994 | Fluoride1994，27，4： | 1 |
| 17 | Image registrationaccuracy with low-dose CT:how low can we go?显示文摘 | Dandekar O Siddiqui K Walimbe V | 2006 | Biom Imag2006，6，： | 1 |
| 18 | Hepatitis B virus: prevalence of precore/core promoter mutants in different clinical categories of Indian patients显示文摘 | Gandhe SS Chadha MS Walimbe AM | | 0，，： | 1 |
| 19 | Exeperi- mential investigation on mixed refrigerant J -T cryocooler with flammable and non-flammable refrigerant mixture 显示文摘 | N S Walimbe K G Narayankhedkar M D Atrey | 2010 | Cryogenics2010，，50： | 1 |
| 20 | Swine HEV infection in south India and phylogenetic analysis (1985-1999)显示文摘 | Arankalle VA Chobe LP Walimbe AM | | 0，，： | 1 |
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