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| 1 | Technical issues and new devices of ESD of early gastric cancer显示文摘Endoscopic submucosal dissection(ESD) is a highly refined technique compared to conventional endoscopic mucosal resection.It enables complete resection of early gastric cancer(EGC) which has no possibility of lymph node metastasis.Indication for ESD of EGC generally entails early gastric cancer confined to the mucosa with well differentiated histology,though there are clinically suitable expanded criteria.As ESD requires specific skill and expertise,endoscopists need to be familiarized with basic methods and the use of special devices.The essence of the technique is to dissect the submucosal layer with direct vision and maintain thecutting plane above the underlying proper muscle layer.Although there are some differences in the detailed technical aspect,the cardinal method of ESD is now well established and standardized.Furthermore,research and development of new ESD devices that render more efficient,safe ESD are still in progress to improve the overall result of ESD on early gastric cancer. | Wan Sik Lee Jin Woong Cho Young Dae Kim Kyu Jong Kim Byung Ik Jang | 2011 | World Journal of Gastroenterology2011，17，31： | 8 |
| 2 | Epidermal growth factor upregulates Skp2/Cks1 and p27^(kip1) in human extrahepatic cholangiocarcinoma cells显示文摘AIM:To evaluate the expression status of S-phase kinase-associated protein 2(Skp2)/cyclin-dependent kinases regulatory subunit 1(Cks1)and p27kip1,and assess the prognostic significance of Skp2/Cks1 expression with p27kip1in patients with extrahepatic cholangiocarcinoma.METHODS:Seventy-six patients who underwent curative resection for histologically confirmed extrahepatic cholangiocarcinoma at our institution from December1994 to March 2008 were enrolled.Immunohistochemical staining for Skp2,Cks1,p27kip1,and Ki67,along with other relevant molecular biologic experiments,were performed.RESULTS:By Cox regression analyses,advanced age(>65 years),advanced AJCC tumor stage,poorly differentiated histology,and higher immunostaining intensity of Skp2 were identified as independent prognostic factors in patients with extrahepatic cholangiocarcinoma.Exogenous epidermal growth factor(EGF,especially 0.1-10 ng/mL)significantly increased the proliferation indices by MTT assay and the mRNA levels of Skp2/Cks1 and p27kip1in SNU-1196,SNU-1079,and SNU-245 cells.The protein levels of Skp2/Cks1(from nuclear lysates)and p27kip1(from cytosolic lysate)were also significantly increased in these cells.There were significant reductions in the protein levels of Skp2/Cks1and p27kip1(from nuclear lysate)after the treatment of LY294002.By chromatin immunoprecipitation assay,we found that E2F1 transcription factor directly binds to the promoter site of Skp2.CONCLUSION:Higher immunostaining intensity of Skp2/Cks1 was an independent prognostic factor for patients with extrahepatic cholangiocarcinoma.EGF upregulates the mRNA and protein levels of Skp2/Cks1and p27kip1via the PI3K/Akt pathway and direct binding of E2F1 transcription factor with the Skp2 promoter. | Ja-yeon Kim Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Dong Hoon Kim Seoung Wan Chae Jin Hee Sohn | 2014 | World Journal of Gastroenterology2014，20，3： | 4 |
| 3 | UV radiation curing of epoxidized palmoil-cycloaliphatic diepoxide system induced by cationic photoinitiators for surface coatings显示文摘 | WAN IKOSLI W D KUMAIK IK N MEK ZAH S | 2003 | European Polymer Journal2003，39，3： | 1 |
| 4 | HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
| 5 | Tympanometric norms for Chinese young adults显示文摘 | Wan IK Wong LL | 2002 | Ear Hear2002，23，5： | 1 |
| 6 | HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
| 7 | Stercoral perfora- tion of the colon in sigmoid colostomy patients: Two case reports 显示文摘 | Young Wan Kim Hyun Jun Kwon Ik Yong Kim | 2013 | International Journal of Surgery Case Reports2013，4，11： | 1 |
| 8 | HER-2 / neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
| 9 | HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
| 10 | Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain显示文摘The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. Male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise + light groups (n = 9 per group). The rats in the exercise group were subjected to treadmill exercise (5 days per week, 30 minutes per day, over a 4-week period), the light group rats were irradiated (5 days per week, 30 minutes per day, 10 000 lx, over a 4-week period), the exercise + light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise + light groups. Moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise + light group. These results indicate that low-intensity treadmill exercise (first 5 minutes at a speed of 2 m/min, second 5 minutes at a speed of 5 m/min, and the last 20 minutes at a speed of 8 m/min) or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural development. | Sung Jin Kwon Jeongsook Park So Yun Park Kwang Seop Song Sun Tae Jung So Bong Jung Ik Ryeul Park Wan Sung Choi Sun Ok Kwon | 2013 | Neural Regeneration Research2013，8，10： | 0 |
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