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您的检索式：作者名="Wanbing Qin"
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| 1 | Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy显示文摘Nanomedicine with high specificity has been a promising tool for cancer diagnosis and therapy.However,the successful application of nanoparticle-based superficial cancer therapy is severely hindered by restricted deep tumor tissue accumulation and penetration.Herein,a self-assembly nanomicelle dissolving microneedle(DMN)patch according to the“nano in micro”strategy was conducted to co-deliver a first-line chemotherapeutic agent paclitaxel(PTX),and a photosensitizer IR780(PTX/IR780-NMs@DMNs)for chemo-photothermal synergetic melanoma therapy.Upon direct insertion into the tumor site,DMNs created a regular and multipoint three-dimensional drug depot to maximize the tumor accumulation.Accompanied by the DMN dissolution,the composition of the needle matrixes self-assembled into nanomicelles,which could efficiently penetrate deep tumor tissue.Upon laser irradiation,the nanomicelles could not only ablate tumor cells directly by photothermal conversion but also trigger PTX release to induce tumor cell apoptosis.In vivo results showed that compared with intravenous injection,IR780 delivered by PTX/IR780-NMs@DMNs was almost completely accumulated at the tumor site.The antitumor results revealed that the PTX/IR780-NMs@DMNs could effectively eliminate tumors with an 88%curable rate without any damage to normal tissues.This work provides a versatile and generalizable framework for designing self-assembly DMN-mediated combination therapy to fight against superficial cancer. | Ying Sun Minglong Chen Dan Yang Wanbing Qin Guilan Quan Chuanbin Wu Xin Pan | 2022 | Nano Research2022，15，3： | 2 |
| 2 | Present Situation of Dictyophora Industry in China and Cultivation Technique of Dictyophora rubrovolvata显示文摘China is the earliest country to eat Dictyophora and to realize its artificial domestication.At present,12 species of Dictyophora have been reported worldwide,7 species of which are found in China.D.rubrovolvata,D.echinovolvata and D.indusiata have been cultivated on a large scale,and the main producing areas are Zhijin in Guizhou Province,Shunchang and Jiangle in Fujian Province,and Qingchuan and Changning in Sichuan Province.The cultivation of D.rubrovolvata had experienced 4 stages:wild tending,casserole cultivation,outdoor simple greenhouse cultivation and rapid development of new cultivation techniques.The present integrated cultivation technique of bag removing and soil covering of D.rubrovolvata were introduced in detail from the aspects of production and selection of high-quality fungi bags,bag removing and soil covering,spawn running,as well as fruiting management and harvesting.As one of the'ten main promoting technologies'of Guizhou Province in 2022,it had realized rapid propagation of liquid strains and supporting cultivation of improved varieties and methods.The suitable strains were selected to support understory cultivation,layer cultivation,basket cultivation,factory cultivation and other modes,which had short cultivation period and can realize annual production and supply.With the development of the industry,it is expected that low-cost secondary fermentation or tertiary fermentation cultivation technology will be more widely used. | Guanglu GONG Tongjing YANG Qin WANG Yang GUI Wanbing HUANG Yingying LU Hongyu LIU Xiaorun HUANG Guosheng ZHU | 2022 | Asian Agricultural Research2022，14，11： | 1 |
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