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| 1 | Comparison of Modified Mohr-Coulomb Model and Bai-Wierzbicki Model for Constructing 3D Ductile Fracture Envelope of AA6063显示文摘Ductile fracture of metal often occurs in the plastic forming process of parts.The establishment of ductile fracture criterion can effectively guide the selection of process parameters and avoid ductile fracture of parts during machining.The 3D ductile fracture envelope of AA6063-T6 was developed to predict and prevent its fracture.Smooth round bar tension tests were performed to characterize the flow stress,and a series of experiments were conducted to characterize the ductile fracture firstly,such as notched round bar tension tests,compression tests and torsion tests.These tests cover a wide range of stress triaxiality(ST)and Lode parameter(LP)to calibrate the ductile fracture criterion.Plasticity modeling was performed,and the predicted results were compared with corresponding experimental data to verify the plasticity model after these experiments.Then the relationship between ductile fracture strain and ST with LP was constructed using the modified Mohr-Coulomb(MMC)model and Bai-Wierzbicki(BW)model to develop the 3D ductile fracture envelope.Finally,two ductile damage models were proposed based on the 3D fracture envelope of AA6063.Through the comparison of the two models,it was found that BW model had better fitting effect,and the sum of squares of residual error of BW model was 0.9901.The two models had relatively large errors in predicting the fracture strain of SRB tensile test and torsion test,but both of the predicting error of both two models were within the acceptable range of 15%.In the process of finite element simulation,the evolution process of ductile fracture can be well simulated by the two models.However,BW model can predict the location of fracture more accurately than MMC model. | Jianye Gao Tao He Yuanming Huo Miao Song Tingting Yao Wanbo Yang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 6 |
| 2 | Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs显示文摘The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study, we characterized the spatiotemporal landscape of putative enhancers and promoters and their target genes by combining H3K27ac-targeted Ch IP-Seq and RNA-Seq in fetal(prenatal days 74–75) and adult(postnatal days 132–150) tissues(brain, liver, heart, muscle and small intestine) sampled from Asian aboriginal Bama Xiang and European highly selected Large White pigs of both sexes. We identified 101,290 H3K27ac peaks, marking 18,521promoters and 82,769 enhancers, including peaks that were active across all tissues and developmental stages(which could indicate safe harbor locus for exogenous gene insertion) and tissue-and developmental stage-specific peaks(which regulate gene pathways matching tissue-and developmental stage-specific physiological functions). We found that H3K27ac and DNA methylation in the promoter region of the XIST gene may be involved in X chromosome inactivation and demonstrated the utility of the present resource for revealing the regulatory patterns of known causal genes and prioritizing candidate causal variants for complex traits in pigs. In addition, we identified an average of 1,124 super-enhancers per sample and found that they were more likely to show tissue-specific activity than ordinary peaks. We have developed a web browser to improve the accessibility of the results(http://segtp.jxau.edu.cn/pencode/?genome=sus Scr11). | Yaling Zhu Zhimin Zhou Tao Huang Zhen Zhang Wanbo Li Ziqi Ling Tao Jiang Jiawen Yang Siyu Yang Yanyuan Xiao Carole Charlier Michel Georges Bin Yang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，8： | 5 |
| 3 | Design,Manufacture and Maintenance of Pressure Equipment Based on Accidents Survey显示文摘Most of the important units of pressure equipment have been manufactured successfully in China related to the national key construction projects,such as 10 million tons/year oil refinery,million tons/year ethylene,large coal chemical,etc.However,some of them failed to operate shortly after their putting into service.Some suffered severe damage even during the previous period of manufacture and installation.In this paper,cases of accident survey and failure analysis are given for some typical pressure vessels.It is found that many accidents are related to insufficient consideration of the design and manufacture of the equipment.These accidents occur fundamentally because of the Chinese design standards & codes for pressure equipment without risk or life concepts and the support from a database for potential risk existing in their dynamic service.Most designers and manufacturers are unable to make correct design,materials selection and manufacturing process all due to a lack of engineering experience.In order to avoid the repetition of the accidents and improve the safety,reliability and economy of pressure equipment,a platform is suggested for design,manufacture and maintenance of pressure equipment in China based on accidents survey.In other words,some effective precautionary measures are taken at the design and manufacture stage,and the design methodology has to be based on service life requirement and desirable risk level.At the service stage some reasonable inspection/monitoring approaches should be utilized to control risks and ensure the equipment operating safely until its desired lifespan.Finally,the basic scheme and some key technologies are briefly given for the platform construction.The concept of risk and life based design,manufacture and maintenance proposed herein has important significance for improving and perfecting the codes and standards for design,manufacture and maintenance of Chinese pressure-bearing equipment,enhancing the life and reliability of Chinese pressure-bearing equipment and promoting the development of in-service maintenance technology that combines safety and economy. | CHEN Xuedong AI Zhibin FAN Zhichao WANG Bing DOU Wanbo YANG Tiecheng GUAN Weihe | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 3 |
| 4 | OD Matrix Infer- ence for Urban Public Transportation Trip Based on GPS and IC Card Data显示文摘 | Yang Wanbo Wang Hao Ye Xiaofei Xu Ch- uangchuang Jiang Dongxue | 2015 | Journal of Chongqing Jiaotong University(Natural Sci- ence)2015，34，3： | 1 |
| 5 | Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant显示文摘Dear Editor,The COVID-19 pandemic has had a devastating effect on global health,resulting in over 6.2 million deaths worldwide.Continuous emergence of adaptive mutations of SARS-CoV-2 alters its pathogenicity and transmissibility,and renders its resistance to current vaccines and antiviral drugs.1 A new variant named Omicron discovered initially in South Africa has recently been proposed as a variant of concern(VOC)by the World Health Organization,because of its high transmissibility and resistance to current vaccines and therapeutic antibodies.2 Therefore,development of vaccines against prevalent variants including Omicron is urgently needed for COVID-19 prevention. | Wanbo Tai Benjie Chai Shengyong Feng Xinyu Zhuang Jun Ma Mujia Pang Lin Pan Zi Yang Mingyao Tian Gong Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 6 | Diverse O-methyltransferases catalyze the biosynthesis of floral benzenoids that repel aphids from the flowers of waterlily Nymphaea prolifera显示文摘Nymphaea is a key genus of the ANA grade(Amborellales,Nymphaeales,and Austrobaileyales)of basal flowering plants,which serve as a key model to study the early evolution of floral traits.In this study,we comprehensively investigated the emission,biosynthesis,and biological function of the floral scent in a night-blossoming waterlily Nymphaea prolifera.The headspace volatile collection combined with GC-MS analysis showed that the floral scent of N.prolifera is predominately comprised by methylated benzenoids including anisole,veratrole,guaiacol,and methoxyanisole.Moreover,the emission of these floral benzenoids in N.prolifera exhibited temporal and spatial pattern with circadian rhythm and tissue specificity.By creating and mining transcriptomes of N.prolifera flowers,12 oxygen methyltransferases(NpOMTs)were functionally identified.By in vitro enzymatic assay,NpOMT3,6,and 7 could produce anisole and NpOMT5,7,9,produce guaiacol,whereas NpOMT3,6,9,11 catalyzed the formation of veratrole.Methoxyanisole was identified as the universal product of all NpOMTs.Expression patterns of NpOMTs provided implication for their roles in the production of the respective benzenoids.Phylogenetic analysis of OMTs suggested a Nymphaea-specific expansion of the OMT family,indicating the evolution of lineage-specific functions.In bioassays,anisole,veratrole,and guaiacol in the floral benzenoids were revealed to play the critical role in repelling waterlily aphids.Overall,this study indicates that the basal flowering plant N.prolifera has evolved a diversity and complexity of OMT genes for the biosynthesis of methylated benzenoids that can repel insects from feeding the flowers.These findings provide new insights into the evolutional mechanism and ecological significance of the floral scent from early-diverged flowering plants. | Guanhua Liu Jianyu Fu Lingyun Wang Mingya Fang Wanbo Zhang Mei Yang Xuemin Yang Yingchun Xu Lin Shi Xiaoying Ma Qian Wang Hui Chen Cuiwei Yu Dongbei Yu Feng Chen Yifan Jiang | 2023 | Horticulture Research2023，10，12： | 0 |
| 7 | Interfacial friction at action: Interactions, regulation, and applications显示文摘Friction is a fundamental force that impacts almost all interface-related applications.Over the past decade,there is a revival in our basic understanding and practical applications of the friction.In this review,we discuss the recent progress on solid–liquid interfacial friction from the perspective of interfaces.We first discuss the fundamentals and theoretical evolution of solid–liquid interfacial friction based on both bulk interactions and molecular interactions.Then,we summarize the interfacial friction regulation strategies manifested in both natural surfaces and artificial systems,focusing on how liquid,solid,gas,and hydrodynamic coupling actions mediate interfacial friction.Next,we discuss some practical applications that are inhibited or reinforced by interfacial friction.At last,we present the challenges to further understand and regulate interfacial friction. | Zhiran YI Xiong WANG Wanbo LI Xuezhi QIN Yang LI Kaiqiang WANG Yunting GUO Xing LI Wenming ZHANG Zuankai WANG | 2023 | Friction2023，11，12： | 0 |
| 8 | Study on the continuous Chinese speech recognition system for speaker-dependent and topic-constrained application显示文摘In this article a speaker-dependent,topic-constrained and continu-ous Chinese speech recognition system based on vector quantization(VQ),hidden Markov model(HMM)and finite states syntax is studied.The differ-ences of zero-cross amplitude and the average amplitude are used to determinethe position of voice start and end.The words data used in HMM's trainingare obtained by segmentation of continuously spoken sentences.And at eachframe several distinct syntactic nodes are considered;through each of them aoptimum model is possible to translate to some other models.As a result therecognition accuracy is improved.The system can be applied in speaker-dependent and topic constrained information request services. | LIN Daofa, YANG Jiayuan, LUO Wanbo WANG Gendong(Sichuan University. Chengdu 610064) | 1992 | Chinese Journal of Acoustics1992，11，4： | 0 |
| 9 | Structural-functional unit ordering for high-performance electron-correlated materials显示文摘Electron-correlated materials have been drawing ever-increasing attention due to their fascinating physical behaviors and extensive application scenarios.In this review,a new method for material research and design(R&D),named structural-functional unit ordering(SFU ordering),which is presented,overcomes the shortcomings—for example,the limitation of finite chemical elements and long R&D circle-of conventional strategy and thus provides guidance for the design of these high-performance functional materials on demand.Meanwhile,with the development of material characterization technologies,SFUs of different scales and types can be directly observed,which,moreover,regulate the corresponding orderings.The review,starts with an introduction of the profile for SFU ordering and the synergistic effect between SFUs.Then,studies on several new high-performance electronic-correlated materials,for example,a ferromagnetic semiconductor with local spin,ferromagnetic metals with spin topologies,ferroelectric thin films with polar topologies,piezoelectric thin films with nanopillars enclosed by charged boundaries,thermoelectric materials with local ferromagnetic nanoparticles and topotactic phase transformation with conducting nanofilaments are stated in detail one by one.The vital aspect is the breaking of local symmetry,the construction,the structure,of SFUs and their orderings existing or theoretically existing,together with the enhanced/new performance.All in all,the main comments of the review tend to the remaining challenges,promising design approaches for the SFUs,and their orderings for high-performance functional materials. | Guyang Peng Lei Hu Wanbo Qu Chenglong Zhang Shurong Li Ziyu Liu Juncheng Liu Shengwu Guo Yu Xiao Zhibin Gao Zhen Zhang Yang Zhang Haijun Wu Stephen J.Pennycook Jun Sun Xiangdong Ding | 2023 | Interdisciplinary Materials2023，2，1： | 0 |
| 10 | Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss显示文摘Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO. | Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni | 2022 | Bone Research2022，10，4： | 0 |
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