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| 1 | Three-dimensional chiral microstructures fabricated by structured optical vortices in isotropic material显示文摘Optical vortices,a type of structured beam with helical phase wavefronts and‘doughnut’-shaped intensity distributions,have been used to fabricate chiral structures in metals and spiral patterns in anisotropic polarization-dependent azobenzene polymers.However,in isotropic polymers,the fabricated microstructures are typically confined to non-chiral cylindrical geometry due to the two-dimensional‘doughnut’-shaped intensity profile of the optical vortices.Here we develop a powerful strategy to realize chiral microstructures in isotropic material by coaxial interference of a vortex beam and a plane wave,which produces threedimensional(3D)spiral optical fields.These coaxial interference beams are generated by designing contrivable holograms consisting of an azimuthal phase and an equiphase loaded on a liquid-crystal spatial light modulator.In isotropic polymers,3D chiral microstructures are achieved under illumination using coaxial interference femtosecond laser beams with their chirality controlled by the topological charge.Our further investigation reveals that the spiral lobes and chirality are caused by interfering patterns and helical phase wavefronts,respectively.This technique is simple,stable and easy to perform,and it offers broad applications in optical tweezers,optical communications and fast metamaterial fabrication. | Jincheng Ni Chaowei Wang Chenchu Zhang Yanlei Hu Liang Yang Zhaoxin Lao Bing Xu Jiawen Li Dong Wu Jiaru Chu | 2017 | Light(Science & Applications)2017，6，1： | 28 |
| 2 | Optimization Transmission Theory and Technical Pathways that Describe Multiscale Urban Agglomeration Spaces显示文摘Urban agglomerations are spatial entities that promote the development of ‘new urbanization' processes within China. In this context, the concept of ‘multiscale urban agglomeration spaces' encompasses three linked levels: macroscale urban agglomerations, mesoscale cities, and microscale urban centers. Applying a series of multidisciplinary integrated research methods drawn from geography, urban planning, and architecture, this paper reveals two intensive utilization laws that can be generalized to apply to multiscale urban agglomeration spaces, top-to-bottom ‘positive transmission' linkage and inside-to-outside ‘negative transmission' movement. This paper also proposes optimization transmission theory and policy decision technical pathways that can be applied to these three urban agglomeration spatial scales. Specific technical pathways of transmission include intensive expansion and simulated decision-making in macroscale urban agglomerations, ecology, production, and living space intensive layout and dynamic decision-making in mesoscale cities, and four cores(i.e., ‘single, ring, axis, and pole core') progressive linkage and intensive optimization decision-making in microscale urban centers. The theory and technical pathways proposed in this paper solve the technical problem of optimization and provide intensive methods that can be applied not only at the individual level but also at multiple scales in urban agglomeration spaces. This study also advances a series of comprehensive technical solutions that can be applied to both compact and smart growth cities as well as to urban agglomerations. Solid theoretical support is provided for the optimization of Chinese land development, urbanization, agricultural development, and ecological security. | FANG Chuanglin YANG Junyan FANG Jiawen HUANG Xiejun ZHOU Yi | 2018 | Chinese Geographical Science2018，28，4： | 14 |
| 3 | Measuring the spatiotemporal variation and evolution of transport network of China's megaregions显示文摘 | SONG Ge YANG Jiawen | 2016 | Journal of Geographical Sciences2016，26，10： | 12 |
| 4 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 5 | Restraining effect of nitrogen on coal oxidation in different stages:Non-isothermal TG-DSC and EPR research显示文摘Nitrogen is widely used to prevent the spontaneous combustion of coal in underground coal mines. A spontaneous combustion-prone coal seam was studied to investigate the restraining effect of nitrogen on coal oxidation in different oxidation stages, based on non-isothermal thermogravimetry-differential scanning calorimetry(TG-DSC) and electron paramagnetic resonance(EPR) experiments. We found that the key feature temperatures grow steadily with increasing nitrogen in the oxidation environment,resulting in longer oxidation stages. The most significant finding is that there is a stagnation of the inhibitory effect of nitrogen on coal oxidation in the range of 85.0–95.0% nitrogen in the slow and the rapid oxidation stages, owing to the competitive adsorption of coal by nitrogen and oxygen. However, the restraining effect cannot be reflected by the kinetic parameters of the coal before it reaches the thermal decomposition and combustion stage. Nitrogen can also affect free radical types and free radical concentrations during coal oxidation: the higher the concentration of nitrogen in the oxidation environment, the greater the number of free radical types and the lower the free radical concentration. This experimental study improves the understanding of the restraining effect of nitrogen on coal oxidation in different oxidation stages and provides an important reference for coal fire prevention in spontaneous combustionprone coal seams. | Tongyu Zhao Shengqiang Yang Xincheng Hu Wanxin Song Jiawen Cai Qin Xu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 9 |
| 6 | Effects of Material Composition and Water Content on the Mechanical Properties of Landslide Deposits Triggered by the Wenchuan Earthquake显示文摘Abundant landslide deposits were triggered by the Wenchuan earthquake,providing a rich source of material for subsequent debris flows or slope failures under rainfall conditions.A good understanding of the physical and mechanical properties of the landslide deposits is very important to the research on slope failure mechanisms and the initiation of debris flow.Laboratory biaxial compression tests are used to study the material compositions and water content impacts on the mechanical properties of landslide deposits,and a discrete element method(a bond-contact model)is used to study the particle stiffness,bond force,friction coefficient and confining stress impact on the mechanical behaviors and the relationships between the numerical and experimental parameters.The experimental results show that the failure stress of landslide deposits is decreased with increasing content of fine particles and also with increased water content,especially at the initial increasing stage.Cohesion of the saturated landslide deposits is increased,but the friction angle is decreased with the increase in the fine particle content.Shear strength parameters(the cohesion and friction angle)are decreased with the increasing water content at the initial increasing stage,and then,they slowly decrease.There is a critical value of the water content at 5%-7%(in weight)for the failure stress and shear strength parameters of the landslide deposits.Quadratic equations are presented to describe the relation between the bond force and cohesion,and the numerical friction coefficient and the experimental friction angle. | ZHOU Jiawen CUI Peng YANG Xingguo | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 9 |
| 7 | Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs显示文摘The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study, we characterized the spatiotemporal landscape of putative enhancers and promoters and their target genes by combining H3K27ac-targeted Ch IP-Seq and RNA-Seq in fetal(prenatal days 74–75) and adult(postnatal days 132–150) tissues(brain, liver, heart, muscle and small intestine) sampled from Asian aboriginal Bama Xiang and European highly selected Large White pigs of both sexes. We identified 101,290 H3K27ac peaks, marking 18,521promoters and 82,769 enhancers, including peaks that were active across all tissues and developmental stages(which could indicate safe harbor locus for exogenous gene insertion) and tissue-and developmental stage-specific peaks(which regulate gene pathways matching tissue-and developmental stage-specific physiological functions). We found that H3K27ac and DNA methylation in the promoter region of the XIST gene may be involved in X chromosome inactivation and demonstrated the utility of the present resource for revealing the regulatory patterns of known causal genes and prioritizing candidate causal variants for complex traits in pigs. In addition, we identified an average of 1,124 super-enhancers per sample and found that they were more likely to show tissue-specific activity than ordinary peaks. We have developed a web browser to improve the accessibility of the results(http://segtp.jxau.edu.cn/pencode/?genome=sus Scr11). | Yaling Zhu Zhimin Zhou Tao Huang Zhen Zhang Wanbo Li Ziqi Ling Tao Jiang Jiawen Yang Siyu Yang Yanyuan Xiao Carole Charlier Michel Georges Bin Yang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，8： | 5 |
| 8 | NIR-II light activated photodynamic therapy with proteincapped gold nanoclusters显示文摘 | Qian Chen Jiawen Chen Zhijuan Yang Lin Zhang Ziliang Dong Zhuang Liu | 2018 | Nano Research2018，11，10： | 3 |
| 9 | EAST-Educational Adaptive-optics Solar Telescope显示文摘For the public having a better understanding of solar activities,the Educational Adaptive-optics Solar Telescope(EAST)was built in July 2021 and is located at the Shanghai Astronomy Museum.The EAST consists of a 65 cm aperture solar telescope with a 177-element adaptive optics system and two-channel high resolution imaging system at the Hαand TiO bands,in addition to three full disk solar telescopes at CaK,Hαand TiO bands equipped on the tube of the main telescope.In this paper,the configuration of the EAST is described.Its performance and on-sky observational results are presented.The EAST,to our knowledge,is the most advanced solar telescope for the popularization of science in the world.Due to its excellent performance,the data acquired by the EAST can also be used for research on solar physics and space weather prediction. | Changhui Rao Xuejun Rao Zhimao Du Hua Bao Cheng Li Jinlong Huang Youming Guo Libo Zhong Qing Lin Xin Ge Jinsheng Yang Xinlong Fan Yangyi Liu Dan Jia Xin Li Mei Li Ming Zhang Yuntao Cheng Jiahui Zhou Jiawen Yao Lanqiang Zhang Naiting Gu | 2022 | Research in Astronomy and Astrophysics2022，22，6： | 3 |
| 10 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 11 | 中国城市的土地使用和交通研究显示文摘本文评估了可达性和机动性对中国城市土地使用和空间结构转换的影响,通过分析当前开发项目给这些因素带来的不确定性,定义了中国背景下交通-土地使用之间关系,包括CBD的形成、卫星城开发、新开发区建设和城市多中心布局趋向等。 | Ralph Gakenheimer(著) Jiawen Yang(著) 董金柱(译) | 2006 | 国外城市规划2006，21，6： | 2 |
| 12 | Insights Into the Interfacial Degradation of High-Voltage All-Solid-State Lithium Batteries显示文摘Poly(ethylene oxide)(PEO)-based solid polymer electrolyte(SPE)is considered as a promising solid-state electrolyte for all-solid-state lithium batteries(ASSLBs).Nevertheless,the poor interfacial stability with high-voltage cathode materials(e.g.,LiCoO_(2))restricts its application in high energy density solid-state batteries.Herein,high-voltage stable Li_(3)AlF_(6) protective layer is coated on the surface of LiCoO_(2) particle to improve the performance and investigate the failure mechanism of PEO-based ASSLBs.The phase transition unveils that chemical redox reaction occurs between the highly reactive LiCoO_(2) surface and PEO-based SPE,resulting in structure collapse of LiCoO_(2),hence the poor cycle performance of PEO-based ASSLBs with LiCoO_(2) at charging voltage of 4.2 V vs Li/Li+.By sharp contrast,no obvious structure change can be found at the surface of Li_(3)AlF_(6)-coated LiCoO_(2),and the original layered phase was well retained.When the charging voltage reaches up to 4.5 V vs Li/Li+,the intensive electrochemical decomposition of PEO-based SPE occurs,leading to the constant increase of cell impedance and directly causing the poor performance.This work not only provides important supplement to the failure mechanism of PEO-based batter-ies with LiCoO_(2),but also presents a universal strategy to retain structure stability of cathode-electrolyte interface in high-voltage ASSLBs. | Jiawen Li Yuchen Ji Haoran Song Shiming Chen Shouxiang Ding Bingkai Zhang Luyi Yang Yongli Song Feng Pan | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 13 | Antihepatofibrotic effect of Guizhifuling pill(桂枝茯苓丸) on carbon tetrachloride-induced liver fibrosis in mice显示文摘OBJECTIVE: To evaluate the protective effects and the underlying mechanism of Guizhifuling pill(桂枝茯苓丸, GZFL) on carbon tetrachloride(CCl4)-induced hepatic fibrosis in mice. METHODS: Male ICR mice by intraperitoneally administered with 20% CCl4(mixed 1∶4 in soybean oil) to induce liver fibrosis. Mice that underwent CCl4 were orally with GZFL. Using hematoxylin and eosin and Masson staining to examine the pathological changes in liver tissue. Serum biochemical parameters, antioxidant enzyme activity and proinflammatory cytokines was assessed. Nuclear factor-kappa B(NF-κB) pathway and nuclear factor-erythroid 2-related factor 2(Nrf2) family members were evaluated by Western blotting. RESULTS: Our findings indicated that GZFL could effectively suppress the progression of liver fibrosis in mice, which was determined based on the improvement in liver function and reduction of collagen deposition. GZFL treatment also decreased the level of cytokines and increased the activity of antioxidant enzymes in liver tissue. Moreover, GZFL exerted anti-inflammatory and antioxidant effects through regulating the Nrf2-mediated antioxidant system and inhibiting the NF-κB pathway. CONCLUSIONS: GZFL may prevent the progression of liver fibrosis by regulating the Nrf2/heme oxygenase-1 and NF-κB signaling pathways, thereby highlighting its role in the management of liver fibrosis. | XU Baogui ZHENG Jiawen TIAN Xiaoxiao YUAN Falei LIU Zhongliang YANG Zuisu DING Xianjun | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 14 | Meteorological observations on Mount Everest in 2005显示文摘山珠穆琅玛,地球上的最高的点是经常被指地球如此的这个地方相对无法接近、小的第三杆对它的气象学被知道。在 2005 年 4 月,一个自动气象站作为山的诺思关口被安装(6523 m 一。s。l.) 。根据观察 10 分钟的吝啬、每日的记录,气象学的特征被分析。所有气象学的元素显示了明显日报变化在到 2005 年 7 月 22 日的 5 月 1 日期间。山珠穆琅玛上的每日的气象学的元素的每月的变化在 Dingri 上与那与一致,最近平淡的气象学的车站与 0.928 的高关联系数, 0.877 , 0.682 , 0.755 , 0.826 和 0.676 ( n = 83 , p <
0.001 )为吝啬的温度,最小的温度,最大的温度,相对湿度,压力和风分别地加速。而且,温度的垂直吝啬的坡度在 0.6 ° C /100 m 上面,特别为每天最大的温度。山珠穆琅玛上的大多数天气事件显著地在 Dingri 上出现在象那些的一样的天,特别那些与 0.673, 0.485 和 0.487 的跨关联的系数从每天意味着压力,温度和相对湿度(n = 83, p< 0.001 ) 分别地。山珠穆琅玛上的一些另外的天气事件落后 Dingri 上的在那些后面的一天。而且,在 Dingri 上从压力在山珠穆琅玛上天气事件预报是比从另外的气象学的元素的那些更可靠的。结论在这个区域为关于气象学和气候变化的研究是重要的。 | Xie Aihong Qin Dahe Ren Jiawen Qin Xiang Xiao Cunde Hou Shugui Kang Shichang Yang Xingguo Jiang Youyan | 2007 | Progress in Natural Science:Materials International2007，17，7： | 2 |
| 15 | Preparation,morphology,and properties of polyurethane-urea elastomers derived from sulphone-containing aromatic diamine显示文摘 | Qin Xiumin Xiong Jiawen Yang Xiaohui | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 16 | Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway显示文摘 | Jiawen Zhang Yongbin Yang Zhenbo Zhang Yinyan He Zhiqiang Liu Yinhua Yu Sufang Wu Bin Cai Youji Feng | 2012 | Cancer Letters2012，，： | 1 |
| 17 | Nontradables and the Valuation of RMB--An E- valuation of the Big Mac Index显示文摘 | Jiawen YANG | 2004 | China Economic Review2004，，15： | 1 |
| 18 | Securitization and Bank's Equity Risk 显示文摘 | Deming Wu Jiawen Yang Han Hong | 2011 | Journal of Financial Services Research2011，，39： | 1 |
| 19 | Is exchange rate pass-through symmetric? Evidence from US imports显示文摘 | Jiawen Yang | 2007 | Applied Economics2007，，2： | 1 |
| 20 | Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma显示文摘Objective: Solute carrier family 38(SLC38 s) transporters play important roles in amino acid transportation and signaling transduction. However, their genetic alterations and biological roles in tumors are still largely unclear.This study aimed to elucidate the genetic signatures of SLC38 s transporters and their implications in esophageal squamous cell carcinoma(ESCC).Methods: Analyses on somatic mutation and copy number alterations(CNAs) of SLC38 A3 were performed as described. Immunohistochemistry(IHC) assay and Western blot assay were used to detect the protein expression level. MTS assay, colony formation assay, transwell assay and wound healing assay were used to explore the malignant phenotypes of ESCC cells. Immunofluorescence assay was used to verify the colocalization of two indicated proteins and immunopreciptation assay was performed to confirm the interaction of proteins.Results: Our findings revealed that SLC38 s family was significantly disrupted in ESCC, with high frequent CNAs and few somatic mutations. SLC38 A3 was the most frequent loss gene among them and was linked to poor survival and lymph node metastasis. The expression of SLC38 A3 was lower in tumor tissues compared to that in normal tissues, which was also significantly associated with worse clinical outcome. Further experiments revealed that depletion of SLC38 A3 could promote EMT in ESCC cell lines, and the interaction of SLC38 A3 and SETDB1 might lead to the reduced transcription of Snail. Pharmacogenomic analyses demonstrated that fifteen inhibitors were showed significantly correlated with SLC38 A3 expression.Conclusions: Our investigations have provided insights that SLC38 A3 could act as a suppressor in EMT pathway and serve as a prognostic factor and predictor of differential drug sensitivities in ESCC. | Rui Liu Ruoxi Hong Yan Wang Ying Gong Danna Yeerken Di Yang Jinting Li Jiawen Fan Jie Chen Weimin Zhang Qimin Zhan | 2020 | Chinese Journal of Cancer Research2020，32，5： | 1 |
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