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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 3 | Primary scientific results of Chang'E-1 lunar mission显示文摘The strategic plan for the development of the unmanned Chinese Lunar Exploration Program is characterized by three distinct stages: 'orbiting around', 'landing on' and 'returning from' the Moon. The first Chinese lunar probe, Chang'E-1, which was successfully launched on October 24th, 2007 at Xichang Satellite Launch Center, and guided to crash on the Moon on March 1st, 2009, at 52.36°E, 1.50°S, in the north of Mare Fecunditatis, is the first step towards the 'orbiting around' stage. The Chang'E-1 mission lasted 495 days, exceeding the expected life-span by about four months. A total of 1.37 TB raw data was received from Chang'E-1. It was then processed into 4 TB scientific data products at various levels. Many scientific results have been obtained by analyzing these data, including especially the 'global lunar image from the first Chinese lunar explora- tion mission'. All scientific goals of Chang'E-1 have been achieved. It provides much useful materials for further advances of lunar sciences and planetary chemistry. Meanwhile, these results will serve as a firm basis for future Chinese lunar missions. | OUYANG ZiYuan1,2, LI ChunLai1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, LIU JianJun1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang3, WANG JianYu4, YANG JianFeng3, CHANG Jin5, WANG HuanYu6, ZHANG XiaoHui7, WANG ShiJin7, WANG Min1, REN Xin1, MU LingLi1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, ZHENG YongChun1, LI JunDuo1, ZOU XiaoDuan1, XU Chun1, SHI ShuoBiao1, GAO YiFei1 & GAO GuanNan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 3 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 4 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China 5 Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008, China 6 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 7 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Earth Sciences2010，53，11： | 11 |
| 4 | Origin of the Red Earth sequence on the northeastern Tibetan Plateau and its implications for regional aridity since the middle Miocene显示文摘The Red Earth deposit around Xining, northeastern Tibetan Plateau, has been studied in terms of soil micro-structure, grain-size distribution, major- and trace-element chemistry and magne- tostratigraphy. Field investigations indicate that the Red Earth sequence consists of 25 visually de- finable yellow-brown and weakly-developed soils interbedded with reddish strongly-developed soils, and has a similar structure to the aeolian Red Clay deposit on the Chinese Loess Plateau. Grain-size analysis shows that the Red Earth deposit is very fine-grained with a negligible sand fraction (>63 μm). Thin-section observations under light microscopy show that the deposit has a clayey texture and the coarse fraction (>10 μm) mainly consists of quartz, feldspar and micas. Pyroxene and hornblende were also observed. This mineralogical composition of the coarse fraction is similar to that of the Quaternary loess. In addition, all of the mineral grains are semi angular semi-angular and are gener- ally finer than 63 μm. There is a good agreement between the major and minor trace element chem- istry of loess-soil units and the Red Earth deposit. The REE distributions of the loess-soil and the Red Earth deposit are similar in shape, with enriched LREE and fairly flat HREE profiles and a clear nega- tive Eu anomaly. The geochemical characteristics of the Red Earth deposit are also identical to those of upper continental crust, thus indicating a wind-blown origin. Magnetostratigraphic investigation shows that onset of the Red Earth deposition predates 11.4 Ma BP (13.6 Ma at a nearby site). The distribution of the reported Miocene aeolian loess at Qin’an of the Loess Plateau is still unknown. Our results indicate that this aeolian deposit had extended to the northeastern Tibetan Plateau by at least the middle Miocene. The similarity of the element geochem- istry between the Red Earth deposit and the overlying loess shows that they may have similar sources and dynamic transport system, and may indicate that the aridification of the interior of the Tibetan Plateau and central Asia began by at least the middle Miocene. Compared with the last intergla-cial-glacial loess, the grain-size of the Red Earth deposit is finer. This may indicate a lower energy transport agent and/or aridity in the dust source region. However, changes in grain-size and other proxies indicate many climatic fluctuations, with two important shifts at 9.61-9.91 Ma and 7-8 Ma. In addition, the grain-size record shows a shift from a high-frequency and high-amplitude pattern to a low-frequency and low-amplitude pattern at around 10.4 Ma and may indicate a significant environ- mental event at this time. Previous research has shown that the intensity of the southwest Asian monsoon increased at this time, coincident with heavier foraminiferal oxygen isotope values and a sharp fall in sea-level. Thus the environmental event in the Northeast Tibetan Plateau at 10.4 Ma may have global implications. | WANG Xianyan1,7, LU Huayu1,2, JI Junfeg3, WANG Xiaoyong1,7, ZHAO Jingbo4, HUANG Baochun5 & LI Zhen6 1. SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 2. Department of Urban and Resources Sciences, Nanjing University, Nanjing 210093, China 3. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 4. Department of Geography, Shaanxi Normal University, Xi’an 710062, China 5. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 6 Department of Geography, Qinghai Normal University, Xining 810008, China 7. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2006 | Science China Earth Sciences2006，49，5： | 9 |
| 5 | “地壳异常压力”学术研讨会显示文摘延用至今的地质作用深度测算方法 ,即重力 /密度法 ,是基于“地下岩石处于静水压力状态” (Heim,1978)和“地下某一深处的垂直压力等于上覆岩石柱的总重量” (ДИННИК,1937)两个理论假设。下面刊登的是“地壳异常压力学术研讨会”专家们的发言 (北京 ,2 0 0 0 . 2 )。到会专家对上述假设和测算方法提出了不同见解 ,指出 ,浅部地壳直至地幔深处的岩石都是固体状态 ,地下的压力是极不均匀的 ,所以对地壳中的地质作用深度的测算必须把所处岩石看作固体 ,并依据固体物理理论 ,也就是说 ,除重力之外 ,构造力、瞬时压力、结晶力、变质作用、岩石相变等都会产生局部巨大的异常压力。因此 ,应该对地壳异常压力进行深入研究以建立更具普适性的深度测算公式。专家们还认为 ,对在全球具有重要地位的大别超高压变质带的形成深度 ,我国科学家认为是 32 km左右 ,属壳内成因 ,并提供了测算数据 ,但该项研究还应深化。 | CHEN Qing-xuan,REN Xi-fei,LU Gu-xian: ( Institute of Geomechanics,CAGS,Beijing 1 0 0 0 81 ,China) ( 2 ) DONG Shen-bao,LIU Rui-xun,CHEN Jing: ( Departmentof Geology,Peking University,Beijing 1 0 0 871 ,China) ( 3 ) WANG Fang-zheng:( Chinese University of Geosciences,Wuhan 4 3 0 0 74 ,China) ( 4) REN Ji-shun,LITing-dong,LIU Dun-yi: ( Institute of Geology,CAGS,Beijing 1 0 0 0 3 7,China) ( 5) ZHAIYu-sheng:( Chinese University of Geosciences,Beijing1 0 0 0 83 ,China) ( 6) ZHANG Bing-xi:( Ministry of Land and Resources,Beijing1 0 0 0 3 5,China) ( 7) SHAO Li-qin:( Ministry of Science and Technology,Beijing 1 0 0 0 3 8,China) | 2000 | 地质力学学报2000，6，3： | 6 |
| 6 | Three dimensional diagnostic,semidiagnostic and prognostic calculations of current in the East China Sea in April of 1994显示文摘Three dimensional diagnostic,semidiagnostic and prognostic models in the σ coordinate are used to compute the current in the East China Sea with wind and hydrographic data obtained from the investigation of ocean fluxes in the East China Sea during the cruise of April 1994.The computed results show that:the density and velocity fields and so on have been adjusted when time t ≈ 23 d, i.e.,the solution of semidiagnostic calculation has been obtained.The quasi steady state solution also has been reached after about 60 d.Comparing the results of diagnostic calculation with those of semidiagnostic and prognostic calculations,it is found that they agree qualitatively.For example,they all show that:(1)The Kuroshio flows along the shelf break of 200~1 000 m isobaths;(2)In the southeastern part of the computational region there is a stronger counter current with an anticyclonic eddy;(3)The volume transport through Section PN is about 30×10 6m 3/s and so on.However there are some quantitative differences between them.For example,(1)For the semidiagnostic results the Kuroshio current is stronger and clearer than that for diagnostic results and the Kuroshio width is more narrow than that for diagnostic results.This shows that the semidiagnostic calculation can better reflect the topography effect;(2)In most computed region the vertical component of velocity intensifies for semidiagnostic result,especially on the shelf break.Comparing the results of semidiagnostic calculation with those of prognostic calculation,they agree qualitatively,and also agree quantitatively in the middle of computed region. | Wang Huiqun 1,2 ,Yuan Yaochu 1,21 .KeyLaboratoryofOceanDynamicProcessesandSatelliteOceanography ,StateOceanicAdministration ,China 2 .SecondInstituteofOceanography ,StateOceanicAdministration ,POBox .12 0 7,Hangzhou 310 0 12 ,China | 2001 | Acta Oceanologica Sinica2001，20，1： | 3 |
| 7 | Application of YLD Calculation in Assessing Disease Data──An Analysis of 4 Diseases in 2 Regions显示文摘The objective of the curtent study is to discuss the problems related to how data is used to calculate Yeare Lost with Disability (YLD) with the method recommended by the World Bank. The study includes collecting useful data, estimating disease duration and average age of disease onset,adjusting incidence and prevalence data by means of a software programme, DISMOD (Harvard University Incidence & Prevalence Model), and assessing the importance of YLD calculation for different diseases.Remission and fatality rates of 3 diseases were estimated by experts at 2 round consultations.Incidence rates, disease duration and average age of disease onset were calculated and adjusted by DISMOD. YLD due to schizothrenia is the highest among 4 diseases in two regions. YLD is 18. 88 % in disability adjusted life year for 4 diseases in Xiacheng District, and 19 .97 % in Fuyang County.Available data can be used for the calculation of YLD after being adjusted. DISMOD is a useful instrument to test the internal consistency of incidence, prevalence, rendssion and fatality rate. The adjusted data are acceptable to experts and DISMOD. To get rational remission and fatality rates, we can use a cohort method through expert consultations. To renect overall burden of disease, YLD calculation should be used. | MA EN-BO WANG RUO-TAO YANG GONG-HUAN AND MICHAEL R. PHILIPS(Union School of Public Health, Peking Union Medical college, 7 Pan Jia YuanNan Li, Beijing 100027, China)(Institute of Epidemiology and Microbiology,Chinese Academy of Preventive Medicine, 27 | 1999 | Biomedical and Environmental Sciences1999，12，4： | 2 |
| 8 | Methane emissions from an alpine wetland on the Tibetan Plateau : Neglected but vital contribution of the non- growingseason显示文摘 | Song 7/ Wang H Wang G | 2015 | Journal of Geophysical Research2015，120，： | 1 |
| 9 | New Public Key Cryp- tosystems Using Polynomials over Non-com- mutative Rings显示文摘 | Cao 7' Dong X Wang L | 2007 | IACR Cryptology ePrint Archi- ve2007，2007，： | 1 |
| 10 | Image categorization by learning and reasoningwith regions 显示文摘 | Chen Y X Wang J 7 | 2004 | Journal of Machine learning Research2004，5，8： | 1 |
| 11 | 查看详情显示文摘 | 7 Liao Y Cao B Wang W C Zhang L Q | | 0，，： | 1 |
| 12 | Isolation and markers in Dendrobium endemic to China 显示文摘 | GU S DING X Y WANG characterization of microsatellite officinale an endangered herb Molecular Ecology Notes 2007 7 Y | 2007 | (6) : 1166-11682007，，6： | 1 |
| 13 | Cardiac valve calcifica- tion as an important predictor for all-cause mortality and cardiovascular mortality in long- term peritoneal dialysis patients: a prospective study显示文摘 | Wang AY Wang M Woo 7 | 2003 | J Am Soc Nephrol2003，，： | 1 |
| 14 | REMOVAL OF ORGANIC POLLUTANTS USING TITANIUM DIOXIDE MEDIATED PHOTOCATALYTIC OXIDATION显示文摘A simple and effective method of removing polluted organics in water isreported here.Titanium dioxide is a catalyst in photo-oxidation of monocrotophos.Themechanism of photocatalytic oxidation and the kinetics of the reaction were studied.This same principle also leads to the construction of instrument of PTR-FIA analysisfor monitoring organic phosphorus and phosphate in water. | Manping ZHANG Zongfeng XIA Shinan XIE Peipei LI Junbo BAO Juying WANG Daiwen KANG (Department of Marine Chemistry,Ocean University of Qingdao,Qingdao.266003) Yujun WANG Nianhong CHEN Lidong YU (Institute of Oceanography,Academia Sinica,Oingdao,266003) G.K-C LOW (CSIRO Division of Feul Technology,Lucas Heights Research laboratories,PMB 7,M nai,2234 NSW,Australia) | 1990 | Chinese Chemical Letters1990，1，3： | 1 |
| 15 | A novel filamentous phage from the deep-sea bacterium Shewanella piezotoIerans WP3 is induced at low temperature显示文摘 | WANG F WANG F LI Q et 7/ | 2007 | Journal of Bacteriology2007，189，19： | 1 |
| 16 | Free-space optical communi- cations using orbital-angular-momentum multiplexing com- bined with MIMO-based spatial multiplexing 显示文摘 | Ren Y Wang 7 Xie G | 2015 | Optics Letters2015，40，18： | 1 |
| 17 | Image quality as- sessment: from error visibility to structural similarity显示文摘 | Wang 7 Bovik A C Sheikh H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 18 | Effectiveness of 3T PRO- PELLER DUO diffusion-weighted MRI in differentiating sinonasal lymphomas and carcinomas显示文摘 | Wang X Zhang ZQ Chen 7? | 2014 | Clin Radiol2014，69，11： | 1 |
| 19 | 2 GHz/Mw显示文摘 | Wang J Zhu X Pavlidis D Low-Power InP/GaAsSb/InP DHBT Cascade Transimpedance Amplifier with GBP/Pdc of 7 | 2006 | Electronics Letters2006，42，1： | 1 |
| 20 | Early percutaneous transhepatic gallbladder drainage compared with endoscopic retrograde eholangiopancreatog- raphy and papillotomy treatment for severe gallstone associated acute pancreatitis 显示文摘 | Yu W Li W Wang 7 | 2007 | Postgrad Med J2007，83，977： | 1 |
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