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| 1 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 2 | High Serum Resistin Level may be an Indicator of the Severity of Coronary Disease in Acute Coronary Syndrome显示文摘Objective To investigate the correlation between serum resistin level, cardiovascular risk factors and severity of coronary disease in acute coronary syndrome (ACS). Methods After evaluated by clinical history, electrocardiography, exercise tolerance tests, laboratory tests, and coronary angiography, 220 consecutive patients with suspected chest pain were divided into normal control group, stable angina pectoris (SAP) group, and ACS group, respectively. Baseline clinical characteristics, including height, weight, waist circumference, hip circumference, white blood cell count, high-sensitive C-reactive protein (hsCRP), total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were compared among three groups. ELISA was used to detect serum resistin levels. Pearson's correlation coefficient analysis was used to assess association between resistin and other traditional cardiovascular risk factors. Multinomial logistic regression analyses were used to define the relationship between serum resistin level and SAP or ACS. Results Serum resistin level in ACS group (1.18±0.48 μg/L) was significantly higher than that in normal control and SAP groups (0.49±0.40 and 0.66±0.40 μg/L; P<0.01). Only in ACS group, increased serum resistin level was significantly correlated with hsCRP (r=0.262, P=0.004) and white blood cell count (r=0.347, P=0.001). Furthermore, serum resistin levels showed a stepwise increase with the number increase of > 50% stenosed coronary vessels. Multinomial logistic regression test demonstrated that serum resistin was a strong risk factor for ACS (OR=29.132, 95%CI: 10.939-77.581, P<0.001). Conclusion These findings suggested the potential role of resistin in atherosclerosis and especially its involvement in ACS. | Hao Wang De-you Chen Jian Cao Zuo-yun He Bing-po Zhu Min Long | 2009 | Chinese Medical Sciences Journal2009，24，3： | 16 |
| 3 | The interaction among gut microbes,the intestinal barrier and short chain fatty acids显示文摘The mammalian gut is inhabited by a massive and complicated microbial community, in which the hostachieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraintsand participation in an immune response. The interaction between the host gut and themicrobiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, guthomeostasis is pivotal in safeguarding the growth and development and potential productive performanceof the host. As metabolites of microorganisms, short chain fatty acids are not only the preferredenergy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidantsand the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinalmicroorganisms on the host gut and the mechanisms of action of short chain fatty acids on the fourintestinal barriers of the organism, which will shed light on the manipulation of the intestinal communityto achieve precise nutrition for specific individuals and provide a novel perspective for theprevention and treatment of diseases. | Jiayu Ma Xiangshu Piao Shad Mahfuz Shenfei Long Jian Wang | 2022 | Animal Nutrition2022，，2： | 15 |
| 4 | Current advances in orthodontic pain显示文摘Orthodontic pain is an inflammatory pain that is initiated by orthodontic force-induced vascular occlusion followed by a cascade of inflammatory responses, including vascular changes, the recruitment of inflammatory and immune cells, and the release of neurogenic and pro-inflammatory mediators. Ultimately, endogenous analgesic mechanisms check the inflammatory response and the sensation of pain subsides. The orthodontic pain signal, once received by periodontal sensory endings, reaches the sensory cortex for pain perception through three-order neurons: the trigeminal neuron at the trigeminal ganglia, the trigeminal nucleus caudalis at the medulla oblongata and the ventroposterior nucleus at the thalamus. Many brain areas participate in the emotion,cognition and memory of orthodontic pain, including the insular cortex, amygdala, hippocampus, locus coeruleus and hypothalamus. A built-in analgesic neural pathway—periaqueductal grey and dorsal raphe—has an important role in alleviating orthodontic pain. Currently, several treatment modalities have been applied for the relief of orthodontic pain, including pharmacological, mechanical and behavioural approaches and low-level laser therapy. The effectiveness of nonsteroidal antiinflammatory drugs for pain relief has been validated, but its effects on tooth movement are controversial. However, more studies are needed to verify the effectiveness of other modalities. Furthermore, gene therapy is a novel, viable and promising modality for alleviating orthodontic pain in the future. | Hu Long Yan Wang Fan Jian Li-Na Liao Xin Yang Wen-Li Lai | 2016 | International Journal of Oral Science2016，8，2： | 11 |
| 5 | Design and demonstration of a next-generation air quality attainment assessment system for PM_(2.5)and O_3显示文摘Due to the increasingly stringent standards, it is important to assess whether the proposed emission reduction will result in ambient concentrations that meet the standards. The Software for Model Attainment Test—Community Edition(SMAT-CE) is developed for demonstrating attainment of air quality standards of O3 and PM2.5. SMAT-CE improves computational efficiency and provides a number of advanced visualization and analytical functionalities on an integrated GIS platform. SMAT-CE incorporates historical measurements of air quality parameters and simulated air pollutant concentrations under a number of emission inventory scenarios to project the level of compliance to air quality standards in a targeted future year. An application case study of the software based on the U.S. National Ambient Air Quality Standards(NAAQS) shows that SMAT-CE is capable of demonstrating the air quality attainment of annual PM2.5and 8-hour O3 for a proposed emission control policy. | Hua Wang Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua S.Fu Jian Gao Shuang Deng Junping Xie Dian Ding Xuezhen Qiu Shicheng Long | 2015 | Journal of Environmental Sciences2015，27，3： | 11 |
| 6 | Guided chemotherapy based on patient-derived mini-xenograft models improves survival of gallbladder carcinoma patients显示文摘Background:Gallbladder carcinoma is highly aggressive and resistant to chemotherapy,with no consistent strategy to guide first line chemotherapy.However,patient-derived xenograft(PDX)model has been increasingly used as an effective model for in preclinical study of chemosensitivity.Methods:Mini-PDX model was established using freshly resected primary lesions from 12 patients with gallblad-der to examine the sensitivity with five of the most commonly used chemotherapeutic agents,namely gemcitabine,oxaliplatin,5-fluorouracil,nanoparticle albumin-bound(nab)-paclitaxel,and irinotecan.The results were used to guide the selection of chemotherapeutic agents for adjunctive treatment after the surgery.Kaplan-Meier method was used to compare overall survival(OS)and disease free survival(DFS)with 45 patients who received conventional chemo-therapy with gemcitabine and oxaliplatin.Results:Cell viability assays based on mini-PDX model revealed significant heterogeneities in drug responsiveness.Kaplan-Meier analysis showed that patients in the PDX-guided chemotherapy group had significantly longer median OS(18.6 months;95%CI 15.9-21.3 months)than patients in the conventional chemotherapy group(13.9 months;95%CI 11.7-16.2 months)(P=0.030;HR 3.18;95%CI 1.47-6.91).Patients in the PDX-guided chemotherapy group also had significantly longer median DFS(17.6 months;95%CI 14.5-20.6 months)than patients in the conventional chemotherapy group(12.0 months;95%CI 9.7-14.4 months)(P=0.014;HR 3.37;95%CI 1.67-6.79).Conclusion:The use of mini-PDX model to guide selection of chemotherapeutic regimens could improve the out-come in patients with gallbladder carcinoma. | Ming Zhan Rui-meng Yang Hui Wang Min He Wei Chen Sun-wang Xu Lin-hua Yang Qiang Liu Man-mei Long Jian Wang | 2018 | Cancer Communications2018，38，1： | 11 |
| 7 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 8 | Expression of transferrin in hematoma brain tissue at different stages after intra cerebral hemorrhage in rats显示文摘Objective: To explore the expression of transferrin(Tf) and transferrin receptor(Tf R) in hematoma brain tissue at different stage after intracerebral hemorrhage(ICH) in rats. Methods: ICH rats model were established by collagenase method, and rats were sacrificed at 24 h, 72 h, 7 d and 14 d after operation. The levels of Tf and Tf R in different periods of rats were detected by immunohistochemical method, and correlation between two groups was analyzed. Results: Tf, Tf R-positive cells at each time after operation in observation group were significantly higher than that in control group(P<0.05). Tf, Tf R-positive cells began to increase from 24 h after the operation and reached the peak 72 h-7 d after surgery, but then gradually decreased. Tf was mainly expressed in nucleus and cytoplasm of neurons and glial cells around the hematoma, but Tf R was mainly expressed in nucleus and cytoplasm of neurons and choroid plexus endothelial cells. Correlation analysis showed that the Tf-positive cell was significantly positively correlated with Tf R-positive cell expression(r=0.447, P=0.022). Conclusions: Tf and Tf R were important transporters in brain tissue excessive load iron transport after ICH, and detecting the expression levels of the two indicators can provide a reference for prognosis treatmentin ICH. | Long Chen Xue-Gang Jin Jian-Fang Zhu Hui-Juan Li Yan-Ping Wang You-Xin Zhou Jian Wang Wen-Hua Wang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 9 |
| 9 | A case study of development and application of a streamlined control and response modeling system for PM_(2.5)attainment assessment in China显示文摘This article describes the development and application of a streamlined air control and response modeling system with a novel response surface modeling-linear coupled fitting method and a new module to provide streamlined model data for PM_(2.5) attainment assessment in China.This method is capable of significantly reducing the dimensions required to establish a response surface model,as well as capturing more realistic response of PM_(2.5) to emission changes with a limited number of model simulations.The newly developed module establishes a data link between the system and the Software for Model Attainment Test—Community Edition(SMAT-CE),and has the ability to rapidly provide model responses to emission control scenarios for SMAT-CE using a simple interface.The performance of this streamlined system is demonstrated through a case study of the Yangtze River Delta(YRD) in China.Our results show that this system is capable of reproducing the Community Multi-Scale Air Quality(CMAQ) model simulation results with maximum mean normalized error < 3.5%.It is also demonstrated that primary emissions make a major contribution to ambient levels of PM_(2.5) in January and August(e.g.,more than50%contributed by primary emissions in Shanghai),and Shanghai needs to have regional emission control both locally and in its neighboring provinces to meet China's annual PM_(2.5)National Ambient Air Quality Standard.The streamlined system provides a real-time control/response assessment to identify the contributions of major emission sources to ambient PM_(2.5)(and potentially O_3 as well) and streamline air quality data for SMAT-CE to perform attainment assessments. | Shicheng Long Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Bin Zhao Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，3： | 9 |
| 10 | On-chip silicon photonic signaling and processing: a review显示文摘The arrival of the big data era has driven the rapid development of high-speed optical signaling and processing, ranging from long-haul optical communication links to short-reach data centers and highperformance computing, and even micro-/nano-scale inter-chip and intra-chip optical interconnects.On-chip photonic signaling is essential for optical data transmission, especially for chip-scale optical interconnects, while on-chip photonic processing is a critical technology for optical data manipulation or processing, especially at the network nodes to facilitate ultracompact data management with low power consumption. In this paper, we review recent research progress in on-chip photonic signaling and processing on silicon photonics platforms. Firstly, basic key devices (lasers, modulators, detectors)are introduced. Secondly, for on-chip photonic signaling, we present recent works on on-chip data transmission of advanced multi-level modulation signals using various silicon photonic integrated devices(microring, slot waveguide, hybrid plasmonic waveguide, subwavelength grating slot waveguide).Thirdly, for on-chip photonic processing, we summarize recent works on on-chip data processing of advanced multi-level modulation signals exploiting linear and nonlinear effects in different kinds of silicon photonic integrated devices (strip waveguide, directional coupler, 2D grating coupler, microring,silicon-organic hybrid slot waveguide). Various photonic processing functions are demonstrated, such as photonic switch, filtering, polarization/wavelength/mode (de)multiplexing, wavelength conversion,signal regeneration, optical logic and computing. Additionally, we also introduce extended silicon+photonics and show recent works on on-chip graphene-silicon photonic signal processing. The advances in on-chip silicon photonic signaling and processing with favorable performance pave the way to integrate complete optical communication systems on a monolithic chip and integrate silicon photonics and silicon nanoelectronics on a chip. It is believed that silicon photonics will enable more and more emerging advanced applications even beyond silicon photonic signaling and processing. | Jian Wang Yun Long | 2018 | Science Bulletin2018，63，19： | 9 |
| 11 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 12 | Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma显示文摘AIM: To study the expression of β-catenin in esophageal squamous cell carcinoma (ESCC) at stage T2-3N0M0 and its relation with the prognosis of ESCC patients. METHODS: Expression of β-catenin in 227 ESCC speci-mens was detected by immunohistochemistry (IHC). A reproducible semi-quantitative method which takes both staining percentage and intensity into account was applied in IHC scoring, and receiver operating char-acteristic curve analysis was used to select the cut-off score for high or low IHC reactivity. Then, correlation of β-catenin expression with clinicopathological features and prognosis of ESCC patients was determined. RESULTS: No significant correlation was observed between β-catenin expression and clinicopathological parameters in terms of gender, age, tumor size, tumor grade, tumor location, depth of invasion and pathologi-cal stage. The Kaplan-Meier survival curve showed that the up-regulated expression of β-catenin indicated a poorer post-operative survival rate of ESCC patients at stage T2-3N0M0 (P = 0.004), especially of those with T3 lesions (P = 0.014) or with stage ⅡB diseases (P = 0.007). Multivariate analysis also confirmed that β-catenin was an independent prognostic factor for the overall survival rate of ESCC patients at stage T2-3N0M0 (relative risk = 1.642, 95% CI: 1.159-2.327, P = 0.005). CONCLUSION: Elevated β-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage ⅡB diseases. | Dong-Rong Situ Yi Hu Zhi-Hua Zhu Jian Wang Hao Long Tie-Hua Rong | 2010 | World Journal of Gastroenterology2010，16，41： | 7 |
| 13 | A Mobile Localization Strategy for Wireless Sensor Network in NLOS Conditions显示文摘The problem of mobile localization for wireless sensor network has attracted considerable attention in recent years. The localization accuracy will drastically grade in non-line of sight(NLOS) conditions. In this paper, we propose a mobile localization strategy based on Kalman filter. The key technologies for the proposed method are the NLOS identification and mitigation. The proposed method does not need the prior knowledge of the NLOS error and it is independent of the physical measurement ways. Simulation results show that the proposed method owns the higher localization accuracy when compared with other methods. | Long Cheng Yan Wang Xingming Sun Nan Hu Jian Zhang | 2016 | China Communications2016，13，10： | 7 |
| 14 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 15 | Altered Resting-State Signals in Patients with Acute Stroke In or Under the Thalamus显示文摘Previous studies have suggested that cortical functional reorganization is associated with motor recovery after stroke and that normal afferent sensory information is very important in that process.In this study,we selected patients who had a stroke in or under the thalamus,with potentially impaired afferent sensory information and analyzed the differences between these patients and healthy controls at three levels:brain regions,the functional connectivity between brain areas,and the whole-brain functional network.Compared with healthy controls,regional homogeneities in the left middle temporal gyrus decreased and functional connectivity between the left middle temporal gyrus and the stroke area increased in the patients.However,there was no significant change in the wholebrain functional network.By focusing on stroke located in or under the thalamus,our study contributes to wider inquiries into understanding and treating stroke. | Lijun Chen Chuanfu Li Jian Zhai Anqin Wang Qin Song Ying Liu Ru Ma Long Han Yamikani Ndasaukas Xiaoming Li Hai Li Xiaochu Zhang | 2016 | Neuroscience Bulletin2016，32，6： | 6 |
| 16 | Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light显示文摘AIM: To investigate the apoptotic effect of photoexcited titanium dioxide (TiO2) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS: Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human hepatoma cells were cultured in RPMI 1640 medium in a humidified incubator with 50 mL/L CO2 at 37℃. A 15 W fluorescent lamp with continuous wavelength light was used as light source in the photocatalytic test. Fluorescence morphology and agarose gel eletrophoresis pattern were performed to analyze apoptotic cells. RESULTS: The Ce (Ⅳ)-doped TiO2 nanoparticles displayed their superiority. The adsorption edge shifted to the 400-450 nm region. With visible light illuminated for 10 min, 10 μg/cm3 Ce (Ⅳ)-doped TiO2 induced micronuclei and significant apoptosis in 4 and 24 h, respectively. Hochest 33 258 staining of the fixed cells revealed typical apoptotic structures (apoptotic bodies), agarose gel electrophoresis showed typical DNA ladder pattern in treated cells but not in untreated ones. CONCLUSION: Ce (Ⅳ) doped TiO2 nanoparticles can induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light. | Long Wang Jian Mao Gao-Hua Zhang Ming-Jing Tu | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 17 | Validity assessment and determination of the cutoff value for the Index of Complexity, Outcome and Need among 12-13 year-olds in Southern Chinese显示文摘To validate the use of the Index of Complexity,Outcome and Need (ICON) in assessing orthodontic treatment need among 12-13 year-olds in southern China,we determined the threshold value of ICON based on Chinese orthodontists' judgments. The samples consisted of 335 students in grade 7 from 16 randomly selected middle schools in Chengdu,China. Three associate professors provided ICON scores for each participant and the results were compared with the gold standard judgments from 25 experts on treatment needs. Based on the gold standard,195 casts belonged to the treatment category,while the rest 140 belonged to the no-treatment category. With the international cutoff point of 43,the sensitivity and specificity of the ICON score were 0.29 and 0.98. The best compromise between sensitivity and specificity in Chengdu,compared with the gold standard,was found at a cutoff point of 29,and the sensitivity and specificity were 0.88 and 0.83. When used to evaluate the treatment need of 12-13 year-olds in southern China,the international ICON cutoff value did not correspond well with Chinese orthodontists' judgments; a lower cutoff value of 29 offered a greater sensitivity and specificity with respect to expert orthodontists' perception of treatment need. | Zheng-Yu Liao Fan Jian Hu Long Yun Lu Yan Wang Zhi Yang Yu-Wei He Peter Wamalwa Jing Wang Nian-Song Ye Sheng Wang Wen-Li Lai | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 18 | The Synthesis and Electronic Characteristics of Poly(p-Phenylene Vinylene) Derivatives显示文摘A series of soluble poly(p-phenylene vinylene) (PPV) derivatives were synthesized through dehydrochlorination with the p-methoxy phenol as starting materials. The electronic characteristics of PPV derivatives were studied. | Jian Ying WANG Yin Kui LI Wen Xiang HU Sheng Jian TAN Yong Fu LONG (The Centre of Research and Development of Medicine Pharmaceuticals Commission of Science & Technology and Industry for National Defence. Beijing 100101 Materials Engineering and Appl | 1998 | Chinese Chemical Letters1998，9，1： | 5 |
| 19 | Microencapsulated essential oils combined with organic acids improves immune antioxidant capacity and intestinal barrier function as well as modulates the hindgut microbial community in piglets显示文摘Background:The objective of this experiment was to evaluate the effect of a combination of microencapsulated essential oils and organic acids(MOA)on growth performance,immuno-antioxidant status,intestinal barrier function and microbial structure of the hindgut in piglets.A total of 120 piglets(Duroc×[Landrace×Yorkshire];weighted 7.66±1.79 kg,weaned at d 28)were randomly selected and allocated to 3 treatments with 4 replicates per group and 10 piglets per replicate according to the initial body weight and gender.The dietary treatments were as follows:1)basal diet(Ctrl);2)Ctrl+chlortetracycline(75 mg/kg)(AGP);3)Ctrl+MOA(1500 mg/kg).The experiment period was lasted for 21 d.Results:Compared to the Ctrl group,dietary supplemented MOA alleviated(P<0.05)the diarrhea rate from d 12 to 21,enhanced(P<0.05)the concentration of serum interlukin-10 and glutathione peroxidase in piglets on d 11 after weaning and serum superoxide dismutase in 21-day piglets.The MOA group also improved(P<0.05)the apparent digestibility of dry matter(DM),organic matter(OM)and gross energy(GE),up-regulated(P<0.05)the mRNA expression level of occludin,claudin-1 and mucin-2 in ileum and increased(P<0.05)the contents of propionic and butyric acids in the cecum of piglets.The MOA group modulated the cecal and colonic microbial community structure and increased(P<0.05)the abundance of Faecalibacterium and Muribaculaceae in cecum and Streptococcus and Weissella in colon.Additionally,AGP group decreased(P<0.05)apparent digestibility of DM,OM and GE as well as down-regulated(P<0.05)relative gene expression level of claudin-1 in duodenum and jejunum,ZO-1 and mucin-1 in jejunum of piglets.Conclusion:In summary,dietary supplemented MOA alleviated diarrhea and improved nutrient apparent digestibility in piglets via enhancing immuno-antioxidant properties,increasing digestive enzyme activity,upregulating the expression of intestinal barrier-related genes,and modifying the microbial community structure of the cecum and colon.Therefore,dietary supplementation with MOA as an alternative to antibiotics was feasible to improve intestinal health of piglets in practical production. | Jiayu Ma Shenfei Long Jian Wang Jie Gao Xiangshu Piao | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 5 |
| 20 | The Synthesis of Soluble Copolymer of Poly(p-Phenylene Vinylene)显示文摘Appling the dehydrochlorination reaction, the copolymerization of 1,4-bis(chioromethyl)-2, 5-dimethyl benzene and 1, 4-bis(chloromethyl)-2-methoxy-5-hexyloxylbenzene was studied. The solubility of the copolymer was determined by the siructure and molar ratio of two monomers. The structure of the copolymer was identified by UV, IR. and 1H NMRanalyses. | Jian Ying WANG Yin Kui LI Wen Xiang HU Sheng Jian TAN Yong Fu LONG(The Centre of Research and Development of Medicine Pharmaceuticals, Commission of Science & Technology and industry for National Defence, Beijing 100101 Materials Science and Applied | 1998 | Chinese Chemical Letters1998，9，1： | 5 |
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