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| 1 | Near-infrared reflectance spectroscopy reveals wide variation in major components of sesame seeds from Africa and Asia显示文摘Sesame is an important oilseed crop in Africa and Asia, owing to its high nutritional quality seed and market value. Variation in sesame seed components including oil, oleic acid,linoleic acid, and protein was investigated by near-infrared reflectance spectrometry in 139 samples collected from different countries. Oil and protein contents were between 40.8%and 60.3%(mean 53.0%) and 15.5% to 25.5%(mean 20.4%), respectively. Linoleic acid,ranging from 31.8% to 52.4%(mean 46%) was more abundant than oleic acid(31.8%–50.6%,mean 38.1%). Light-seeded samples displayed higher nutritional quality, as they were richer in oil, protein, and linoleic acid than dark seeds. Samples from Africa had higher oil and linoleic acid contents, while Asian samples had higher oleic content. The analysis revealed West African sesame cultivars containing especially high levels of seed components, which may command high market values. Two clusters of sesame samples grouped by seed composition were obtained, including one cluster with high oil and oleic acid content and the other with high protein and linoleic acid content. This study revealed that sesame samples from Africa and Asia harbor high variation for major seed components and also provided background information for breeding high-nutrition varieties according to the demands of sesame seed markets. | Komivi Dossa Xin Wei Marème Niang Pan Liu Yanxin Zhang Linhai Wang Boshou Liao Ndiaga Cissé Xiurong Zhang Diaga Diouf | 2018 | The Crop Journal2018，6，2： | 7 |
| 2 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 3 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 4 | Nonadiabatic acceleration of plasma sheet ions related to ion cyclotron waves显示文摘The nonadiabatic acceleration of plasma sheet ions is important to the understanding of substorm energetic injections and the formation of ring current. Previous studies show that nonadiabatic acceleration of protons by magnetic field dipolarization is hard to occur at X>–10 RE because the time-scale of dipolarization(several minutes) is much larger than the gyroperiod of protons there(several seconds). In this paper, we present a case of nonadiabatic acceleration of plasma sheet ions observed by Cluster on October 30, 2006 at(XGSM, YGSM)=(-7.7, 4.7) RE. The nonadiabatic acceleration of ions is caused not by previously reported magnetospheric dipolarization but by the ultra low frequency(ULF) waves during magnetospheric dipolarization. The nonadiabatic acceleration of ions generates a new energy flux structure of ions, which is characterized by the usual energy flux increase of ions(28–80 ke V) and a concurrent energy flux decrease of ions in a lower energy range(10 e V–20 ke V). These new observations constitute a complete physical picture: The lower energy ions absorb the wave energy, and thus get accelerated to higher energy. We use a nonadiabatic model to interpret the ion energy flux variations. Both analytic and simulation results are in good agreement with the observations. This indicates that the nonadiabatic acceleration associated with ULF waves superposed on dipolarized magnetic field is an effective mechanism for ion energization in the near-Earth plasma sheet. The presented energy flux structures can be used as a proxy to identify the similar dynamic process. | WANG Zhi Qiang CAO Jin Bin RME Henri DANDOURAS Iannis MA Yu Duan | 2014 | Science China(Technological Sciences)2014，57，12： | 3 |
| 5 | Noninvasive exclusion of fetal aneuploidy in an at risk couple with balanced translocation显示文摘 | Zhen ZK Zilberstein ME | 2000 | Mol Hum Reprod2000，6，2： | 1 |
| 6 | Immune reconstitution inflammatory syndrome in human immunodeficien- cy virus-infected children in Peru显示文摘 | WANG ME CASTILLO ME MONTANO SM | 2009 | Pediatr Infect Dis J2009，28，： | 1 |
| 7 | Positional cloning of a navel potassium channel gene: KVLQTI mutations cause cardiac arrhythmias显示文摘 | Wang Q Curran ME Splawskil | 1996 | Nat Genet1996，12，： | 1 |
| 8 | Determ inants of hum- an pap illom avirus Ioad am ong woman with his tological cervrcal intraepithelial neop lasia 3: dom inant impact of surrounding 1ow-grade lesions显示文摘 | Sherman ME Wang SS Wheeler CM et aI | 2003 | Cancer Epidem lob fore arkers P rev2003，12，10： | 1 |
| 9 | Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1 B1 ( OATP-C ) modulators显示文摘 | Wang X Wolkoff AW Morris ME | 2005 | Drug Metab Dispos2005，33，11： | 1 |
| 10 | Broad, hybrid capture-based next-generation sequencing identifies actionable genomic alterations inlung adenocarcinomas otherwise negative for such alterations by othergenomic testing approaches 显示文摘 | Drilon A Wang L Arcila ME | 2015 | Clin Cancer Res2015，21，16： | 1 |
| 11 | Parenchymal abnormalities associated with cerebral venous sinus thrombosis:assessment with diffusion-weighted MR Imaging显示文摘 | Grant PE Wang B | 2004 | AJNR Am J Neuroradiol2004，25，： | 1 |
| 12 | Mating-type-specific and nonspecific PAK kinases play shared and divergent role in cytokinesis,differentiation and virulence of Cryptococcus neoformans显示文摘 | Wang P Nichols CS Lengeler KB Cardenas ME Cox GM Perfect JR Heitman J | 2002 | Eukaryot Cell2002，1，2： | 1 |
| 13 | Parenchymal abnormalities associated with cerebral venous sinus thrombosis:assessment with diffusion-weighted MR imaging显示文摘 | Mullins ME Grant PE Wang B | 2004 | AJNR2004，25，10： | 1 |
| 14 | The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/-mice显示文摘 | Jérme Lapointe Ying Wang Eve Bigras | 2012 | Cell Biol2012，199，2： | 1 |
| 15 | Osteoporosis in China 显示文摘 | Wang Y Tao Y Hyman ME | 2009 | Osteoporos Int2009，20，10： | 1 |
| 16 | Genetic and epigenetic modeling of the origins of Multidrug resistant cells in a Human sarcoma cell line 显示文摘 | CHEN KG WANG YC SCHANER ME | 2005 | Cancer Res2005，65，20： | 1 |
| 17 | Recombinant connective tissue growth factor modulatesporcine skin fibroblast gene expression显示文摘 | Olson ME Ball DK | 2003 | Wound Repair Regen2003，11，3： | 1 |
| 18 | Inhibition of Janus kinase3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts 显示文摘 | Behbod F Erwin-Cohen RA Wang ME | 2001 | J Immunol2001，166，6： | 1 |
| 19 | Role of Community Youth Volunteers in rehabilitation of people affected by lep- rosy:a case study from China显示文摘 | Wang J Pan ME Zhang GC | 2010 | Lepr Rev2010，81，4： | 1 |
| 20 | Eosinophilic esophagitis: pathogenesis, genetics, and therapy 显示文摘 | Blanchard C Wang N Rothenberg ME | 2006 | J Allergy Clin h''nmunol2006，118，5： | 1 |
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