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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 3 | A New Approach to Isothermal Precipitation Kinetics of Carbides显示文摘A new approach to isothermal precipitation kinetics of carbides in undercooled austenite has been proposed firstly, which is based on measuring the changes of Ms point vs holding time at a certain temperature. The isothermal precipitation kinetics (PTT) Curve of carbides was obtained by the use of the method for 13Cr-8Mn-0.07N stainless steel, and compared with the results of chemical phase analysis and TEM method. The results show that the new method is more sensitive and convenient than the other methods. | Fu, WT Wang, Z Jing, TF Zheng, YZ Ma, JG | 1998 | Journal of Materials Science & Technology1998，14，5： | 2 |
| 4 | Morroniside prevents peroxideinduced apoptosis by induction of endogenous glutathione in human neuroblastoma cells显示文摘 | Wang W Huang WT Li L | 2008 | Cell Mol Neurobiol2008，28，： | 1 |
| 5 | Prediction of outcome of patients with metastatic breast cancer:evaluation with prognostic factors and Nottingham prognostic index显示文摘 | Liu MT Huang WT Wang AY | 2010 | Support Care Cancer2010，18，12： | 1 |
| 6 | Ischemic preconditioning attenuates pulmonary dysfunction after unilateral thigh tourniquet-induced ischemia-reperfusion显示文摘 | Lin LN Wang LR Wang WT | 2010 | Anesth Analg2010，111，2： | 1 |
| 7 | Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice显示文摘 | Cefalu WT Wang ZQ Schneider DJ | 2004 | Acta Diabetol2004，41，1： | 1 |
| 8 | Cultivation of Bacillus Thuringiensis in an Airlift Reactor with Wire Mesh Draft Tubes显示文摘 | HUANG T K WANG P M WU WT | 2001 | Biochem Eng J2001，，7： | 1 |
| 9 | Design and synthesis of novel chemokine analogs derived from vMIP-Ⅱ显示文摘 | WANG J KUMAR S CHOI WT | 2006 | Protein Pept Lett2006，13，5： | 1 |
| 10 | Morroniside prevents perox- ide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells 显示文摘 | Wang W Huang WT Li L | 2008 | Cell Mol Neurobiol2008，28，2： | 1 |
| 11 | Functional analysis of connexin-32 mutants associated with X-linked dominant Charcot- Marie-Tooth disease显示文摘 | Wang HL Chang WT Yeh TH | 2004 | Neurobiol Dis2004，15，： | 1 |
| 12 | Efficacy of a cell phone- based exercise programme for COPD显示文摘 | Liu WT Wang C I-I Lin HC | 2008 | European Respiratory Journal2008，32，3： | 1 |
| 13 | High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer显示文摘 | Liao WT Liu JL Wang ZG | 2013 | BMC Gastroenterol2013，13，： | 1 |
| 14 | microRNA-224 promotes cell prolif- eration and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2 显示文摘 | Liao WT Li TT Wang ZG | 2013 | Clin Cancer Res2013，19，17： | 1 |
| 15 | Differentially expressed microRNAs in the serum of cervical squamous cell carcino- ma patients before and after surgery 显示文摘 | Wang WT Zhao YN Yan IX | 2014 | J Hematol On- col2014，7，： | 1 |
| 16 | Stress or drug priming induces reinstatement of extinguished conditioned place preference显示文摘 | Wang B Luo F Zhang WT | 2000 | Neuroreport2000，11，12： | 1 |
| 17 | Bacteriology and antimicrobial susceptibility in biliary tract disease:an audit of 10-year's experience显示文摘 | Chang WT Lee KT Wang SR | 2002 | Kaohsiung J Med Sci2002，18，5： | 1 |
| 18 | A mobile telephone-based interactive self-care system improves asthma control 显示文摘 | Liu WT Huang CD Wang CH | 2011 | Eur Respir J2011，37，： | 1 |
| 19 | Morroniside prevents peroxideinduced apoptos is by induction of endogenous glutathione in human neuroblastoma cells显示文摘 | Wang W Huang WT Li L | 2008 | Cell Mol Neurobiol2008，28，2： | 1 |
| 20 | Activation of eL2 adrenoceptors inhibi- ted NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain 显示文摘 | Fan QQ Li L Wang WT | 2014 | Neuropharmacology2014，77，： | 1 |
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