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| 1 | Humification degrees of peat in Qinghai-Xizang Plateau and palaeoclimate change显示文摘In this article we report a new and sensitive palaeoclimate proxy indieator-humification degrees of peat. Based on the comparison of humification degrees with other climate proxy records, such as δ^13C time series of the C. mulieensis remains cellulose in the same peat profile, we suggest that humifieation degrees of peat in Qinghai-Xizang Plateau can served as a palaeoclimate proxy indicator. The higher the hnmification degrees of peat, the warmer-wetter the climate; on the contrary, the lower the humification degrees, the colder-drier the climate. Due to the simple method of deter-mination, humifieation degree of peat is worthy studying and applying further. | WANGHua HONGYetang ZHUYongxuan HONGBing LINQinghua XUHai LENGXuetian MAOXumei | 2004 | Chinese Science Bulletin2004，49，5： | 16 |
| 2 | Effects of transforming growth factor beta 1 on the growth of rhabdomyosarcoma cell line RD显示文摘Backgroud Transforming growth factor-β (TGF-β) can inhibit the growth of most epithelial and endothelial cells. The growth regulative role of TGF-β on soft tissue sarcoma was seldom reported. Here we examined TGF-β1 effects on the growth of human rhabdomyosarcoma cell RD and searched the relative molecular mechanism. Methods The viability of RD was examined by [ 3H]-thymidine incorporation and [3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetraz olium bromide] (MTT) assay. RD cell cycle was analysed by flow cytometry. The protein and mRNA of cell cycle regulative factors in RD were detected by Western blot and reverse transcription-polymerase chain reation (RT-PCR), respectively. The kinase activity of cdk2 or cdk4 was examined by immunoprecipitation and kinase assay. Immunofluorescent staining was used to detect the location of cell cycle regulative factors in RD by laser scanning confocal microscope.Results TGF-β1 inhibits RD proliferation by G1-arrest in cell cycle progression. TGF-β1 can prominently up-regulate P27 of RD, then augment P27 to bind cyclinE-cdk2 complexes, which effectively suppress cdk2 kinase activity. P21 increased and c-myc decreased in RD due to TGF-β1. Both P15 and cdk4 have not been involved in the growth inhibitory event. TGF-β1 treatment induced P27 to congregate around nucleus. P21 pervaded from nucleus to both nucleus and cytoplasm by TGF-β1 treatment.Conclusion TGF-β1 inhibits the proliferation of human rhabdomyosarcoma cell line RD and induces RD G1-arrest. This course is accomplished by TGF-β1 up-regulating P27 to suppress cdk2 kinase activity. The induction of P21 and down-regulation of C-myc might participate in the growth-arrest event. | YELü ZHANGHong-ying WANGHua YANGGuang-hua BUHong ZHANGLi WANGShou-li | 2005 | Chinese Medical Journal2005，，8： | 7 |
| 3 | Chemokines in homeostasis and diseases显示文摘For the past twenty years,chemokines have emerged as a family of critical mediators of cell migration during immune surveillance,development,inflammation and cancer progression.Chemokines bind to seven transmembrane G protein-coupled receptors(GPCRs)that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation.Although chemokines have evolved to benefit the host,inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases.Therefore,understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic targets.This review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis,inflammation,immune responses and cancer. | Keqiang Chen Zhiyao Bao Peng Tang Wanghua Gong Teizo Yoshimura Ji Ming Wang | 2018 | Cellular & Molecular Immunology2018，15，4： | 7 |
| 4 | Grout diffusion characteristics during chemical grouting in a deep water-bearing sand layer显示文摘 | Wang Dangliang Sui Wanghua | 2012 | International Journal of Mining Science and Technology2012，22，4： | 6 |
| 5 | The Essential Role of Phosphoinositide 3-Kinases(PI3Ks)in Regulating Pro-Inflammatory Responses and the Progression of Cancer显示文摘Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors. | Keqiang Chen Pablo Iribarren Wanghua Gong Ji-Ming Wang | 2005 | Cellular & Molecular Immunology2005，2，4： | 6 |
| 6 | CD40/CD40L Dyad in the Inflammatory and Immune Responses in the Central Nervous System显示文摘CD40 和它的血缘的 ligand (CD40L ) 是支持 inflammatory 和有免疫力的回答的一双管理者。在中央神经系统(CNS ) , CD40 在许多房间上被表示,包括脉管的 endothelial 房间,光滑的肌肉房间,星形细胞和 microglia (大脑巨噬细胞,是最敏感的房间打字对 CD40 ligand 作出回应) 。在渗入 T 淋巴细胞和另外的居民 CNS 房间介绍的 microglia 和 CD40L 上的 CD40 之间的相互作用触发支持 cytokines, chemokines 和神经毒素的一个宽数组的生产的一系列细胞内部的发信号事件。因此,两个分子在 CNS 用作支持 inflammatory 和有免疫力的回答的放大器并且为疾病的治疗学的干预组成重要分子的目标。 | Keqiang Chen Jian Huang Wanghua Gong Lingzhi Zhang Peichu Yu Ji Ming Wang | 2006 | Cellular & Molecular Immunology2006，3，3： | 5 |
| 7 | Development and Validation of a Novel Reverse Phase HPLC for Determination of Aloperine in Aloperine Tablets显示文摘Aim To develop a reverse phase HPLC method for the determination of aloperine, an alkaloid that is newly extracted from Sophora alopecuraides and has shown wide pharmacological effects including antibacterial and antimflammatory actions. Methods The samples were analyzed on a ODS column with methanol-water-triethylamine (3:97:0.1 V/V) as a mobile phase, The flow rate was 1.0 mL·min^-1, and UV detection wavelength 205 nm. Results Linear regression equation was A = 1.6920C + 1.7455 (r^2 = 0.9999, n = 5) in concentratim ranging from 20 to 120μg·mL^-1. The recoveries were 101.2±1.46 % at 80 μg·mL^-1, 100.5±0.75% at 100μg·mL^-1, and 100.7±1.10% at 120 μg·mL^-1, respectively, and the precisions of aloperine within or between run were from 0.80% to 1.98% ( n = 5). The relative contents of aloperine in three lots of tablets were 101.59 ± 1.38%, 98.46 ± 0.23%, and 99.41 ± 1.09% ( n = 3).Conclusion The newly developed reverse phase HPLC method is simple and useful for daily assay of aloperine tablets and can overcome the interference from excipient and other alkaloids in titration and UV detection. | WANGHua ZHENGLi WANGZhan ZHANGYong-qiang] WUFeng-lan | 2003 | Journal of Chinese Pharmaceutical Sciences2003，12，4： | 4 |
| 8 | Notch signaling stimulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells显示文摘Notch signaling is one of the most important pathways mediating cell determination and differentiation. In this study, the roles of Notch signal in the regulation of osteogenic differentiation of human bone marrow mesen-chymal stem cells (hMSCs) were investigated. The expression of Notch1, Jagged1 and DTX1 detected by reverse transcrip-tion polymerase chain reaction (RT-PCR) suggested that Notch signal might exhibit a physiological regulatory role in the differentiation of MSCs. Constitutive expression of the intracellular domain of Notch1 (ICN), the active form of Notch1 protein, can activate Notch signal in cells without ligands binding. hMSCs were isolated, expanded, and in-fected with retrovirus carrying green fluorescent protein (GFP) gene or ICN. Overexpression of ICN in hMSCs re-sulted in enhanced osteogenic differentiation induced by dexamethasone (Dex), which was characterized by an in-crease of cellular alkaline phosphatase (ALP) activity and calcium deposition. These results indicate that Notch stimu-lates differentiation of MSCs into osteoblasts. | LUZhuozhuang WUZuze ZHANGQunwei WANGHua JIAXiangxu DUANHaifeng WANGLisheng | 2004 | Chinese Science Bulletin2004，49，8： | 4 |
| 9 | Thermodynamic Analysis and Experimental Investigation into Nonflame Combustion Technology(NFCT) with Thermal Cyclic Carrier显示文摘The utilization of fossil fuels causes serious negative impacts on the environment and human life. To mitigate greenhouse gases and other pollutants, a novel combustion process-the nonflame combustion technology with a thermal cyclic carrier of molten salt is introduced. In this technology, a whole combustion is divided into two steps, i.e., the section of producing oxide and the section of combustion. In the first step, oxygen is separated from air, and pure N2 is simultaneously formed which is easily recovered. In the other step, the fuels react with lattice oxygen in the oxides formed in the first step, and at the same time, thermal energy, CO2 and H2O vapor are produced. It is noted that the CO2 is easily separated from water vapor and ultimately captured. Theoretically, there are no environmental-unfriendly gases such as CO2, NOx and SO2 discharged in the whole combustion process. Some metal oxides scattered into molten salts play the roles of oxygen carriers in the combustion system, and they can constantly charge and discharge oxygen element from air to fuels during the combustion process. A nonflame combustion system with Li2CO3+K2CO3+Na2SO4 as the molten salt system, CH4 as the fuel and CuO as the catalyst was experimentally investigated. The experimental results show that the combustion process proceeded as it was theoretically analyzed, and CO2 with a high volume fraction of 77.0%95.0% and N2 with a high volume fraction of 91.9%99.3% were obtained. The high concentration of CO2 is favorable for capturing and storing subsequently. Therefore, the potential of reducing CO2 emissions of this nonflame combustion technology is huge. | HEFang WANGHua DAIYong-nian | 2004 | Chemical Research in Chinese Universities2004，20，5： | 3 |
| 10 | Hydrogeological analysis and salvage of a deep coalmine after a groundwater inrush显示文摘 | Wanghua Sui Jinyuan Liu Siguang Yang | 2011 | Environment Earth Science2011，62，4： | 1 |
| 11 | 应用辛硫磷拌种防治蛴螬的研究显示文摘 | CANGCHOW DISTRICT INSTITUTE OF AGRICULTURE HOPEI PROVINCEHENAN PRODUCTION BRIGADE WANGHUA COUNTY HOPEI PROVINCEBUREAU OP AGRICULTURE WANGHUA COUNTY HOPEI PROVINCE | 1976 | 昆虫学报1976，，02： | 1 |
| 12 | On-line vision recognition of auto rack girders based on combination of wavelet transform with ART1 neural network显示文摘 | Wanghua Wang Longshan Gao Jingang etc | 2008 | Fourth International Symposium on Precision Mechanical Measurements2008，，71： | 1 |
| 13 | 显示文摘 | ZhangHeng(张恒) WangHua(王华) LinCunguo(蔺存国) WangLi(王利) YuanShiling(苑世领) | | 化学学报0，，： | 1 |
| 14 | Electrochemical behavior of Cu-Zn-Al shape memory alloy after surface modification by electroless plated Ni-P显示文摘The electrochemical behavior of Cu-Zn-Al shape memory alloy (SMA) with and without electroless plated Ni-P was investigated by electrochemical methods in artificial Tyrode's solution. The results showed that Cu-Zn-Al SMA engendered dezincification corrosion in Tyrode's solution. The anodic active current densities as well as electrochemical dissolution sensitivity of the electroless plated Ni-P Cu-Zn-Al SMA increased with NaCl concentration rising, pH of solution decreasing and environmental temperature uprising. X-ray diffraction analysis indicated that after surface modification by electroless plated Ni-P, an amorphous plated film formed on the surface of Cu-Zn-Al SMA. This film can effectively isolate matrix metal from corrosion media and significantly improve the electrochemical property of Cu-Zn-Al SMA in artificial Tyrode's solution. | LIANGChenghao CHENBangyi CHENWan WANGHua | 2004 | Rare Metals2004，23，4： | 1 |
| 15 | 显示文摘 | WEIFang-Fang(卫芳芳) WANGHua(王华) XUYang(徐阳) etal | | RengongJingtiXuebao0，，： | 1 |
| 16 | Visualization of Engineering Geological Model and its Application to the Determi- nation the Upper Limit of Mining显示文摘 | SUI Wanghua ZHENG Lei DONG Qinghong | 2004 | Mining Science and Tech- nology2004，，10： | 1 |
| 17 | 显示文摘 | WANGHua(王华) DINGGang(丁刚) CUIFu-jun(崔福君) | 2002 | 中外葡萄与葡萄酒2002，2，： | 1 |
| 18 | Study of Gires-Toutnois interferometer dispersion 显示文摘 | Wang Qingyue Liu Hang Xiang Wanghua | 1988 | ACTA OPTICASINICA1988，8，： | 1 |
| 19 | Toll-like receptors in inflammation, infection and cancer显示文摘 | Keqiang Chen Jian Huang Wanghua Gong Pablo Iribarren Nancy M. Dunlop Ji Ming Wang | 2007 | International Immunopharmacology2007，，10： | 1 |
| 20 | I-Iydrogeological analysis and salvage of a deep coalmine after an underground wa- ter inrush 显示文摘 | Sui Wanghua Liu Jinyuan Yang Siguang | 2011 | Environmental Earth Sciences2011，62，4： | 1 |
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