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| 1 | Involvement of Histone Modifcations in Plant Abiotic Stress Responses显示文摘As sessile organisms,plants encounter various environmental stimuli including abiotic stresses during their lifecycle.To survive under adverse conditions,plants have evolved intricate mechanisms to perceive external signals and respond accordingly.Responses to various stresses largely depend on the plant capacity to modulate the transcriptome rapidly and specifcally.A number of studies have shown that the molecular mechanisms driving the responses of plants to environmental stresses often depend on nucleosome histone post‐translational modifcations including histone acetylation,methylation,ubiquitination,and phosphorylation.The combined effects of these modifcations play an essential role in the regulation of stress responsive gene expression.In this review,we highlight our current understanding of the epigenetic mechanisms of histone modifcations and their roles in plant abiotic stress response. | Lianyu Yuan Xuncheng Liu Ming Luo Songguang Yang Keqiang Wu | 2013 | Journal of Integrative Plant Biology2013，55，10： | 21 |
| 2 | Surface Active Sites on Co_(3)O_(4) Nanobelt and Nanocube Model Catalysts for CO Oxidation显示文摘CO oxidation has been performed on Co_(3)O_(4) nanobelts and nanocubes as model catalysts.The Co_(3)O_(4) nanobelts which have a predominance of exposed{011}planes are more active than Co_(3)O_(4) nanocubes with exposed{001}planes.Temperature programmed reduction of CO shows that Co_(3)O_(4) nanobelts have stronger reducing properties than Co_(3)O_(4) nanocubes.The essence of shape and crystal plane effect is revealed by the fact that turnover frequency of Co3+sites of{011}planes on Co_(3)O_(4) nanobelts is far higher than that of{001}planes on Co_(3)O_(4) nanocubes. | Linhua Hu Keqiang Sun Qing Peng Boqing Xu Yadong Li | 2010 | Nano Research2010，3，5： | 21 |
| 3 | Transcriptional Repression by Histone Deacetylases in Plants显示文摘在 histone 尾巴的 N 终点的可逆 histone acetylation 和 deacetylation 在 eukaryoticgene 活动的规定起关键作用。核心 histones 的 Acetylation 通常导致开的染色质结构并且与基因激活被联系,而 histone 的 deacetylation 经常与关上的染色质和基因压抑被相关。由 histone deacetylases (HDAC ) 的 Histone deacetylation iscatalyzed。越来越多的研究在植物表明了 histone deacetylation/acetylationon 染色体稳定性, transcriptional 规定,和开发的重要性。而且, HDAC 被显示交往在多重 developmentalprocesses 涉及 transcriptional 压抑的 withvarious 染色质 remolding 因素和抄写因素。在这评论,我们在 transcriptional 压抑上总结了最近的调查结果在 plants.Key 词由 HDAC 调停了: | Xuncheng Liua Songguang Yang Minglei Zhaoa Ming Luo Chun-Wei Yu Chia-Yang Chen Ready Tai Keqiang Wu | 2014 | Molecular Plant2014，7，5： | 16 |
| 4 | Arabidopsis NF-YCs Mediate the Light-Controlled Hypocotyl Elongation via Modulating Histone Acetylation显示文摘光是支持 photomorphogenesis 的一个关键环境信号,有为植物到的一系列轻依赖者的改变的发展过程改编各种各样的外部挑战。染色质修正被建议了涉及如此的调停光的生长,但是内在的机制仍然是逃犯的。在这研究,我们识别了四 Arabidopsis thaliana 原子 Factor-YC 相当或相同的事物, NF-YC1, NF-YC3, NF-YC4,和 NF-YC9 (NF-YCs ) ,它经由 histone deacetylation 作为控制光的胚轴延伸的抑压者冗余地工作。明显的青白化显型在在轻条件下面种的 NF-YCs loss-of-function 异种幼苗被观察,包括重要伸长的胚轴和更少打开的子叶。我们发现 NF-YCs 在光与 histone deacetylase HDA15 交往,合作目标一套胚轴的倡导者延伸相关的基因,并且在联系染色质上调制 histone H4 acetylation 的层次,因此镇压基因表示。相反, NF-YC-HDA15 建筑群在黑暗中从目标基因被解除,导致 H4 acetylation 和作为结果的变白的生长的增加的水平。进一步的分析表明控制光的胚轴延伸上的 NF-YCs 的那项 transcriptional 压抑活动部分取决于 NF-YCs overexpression 的短胚轴的显型种的功能能救的 HDA15 的 HDA15,和损失的 deacetylation 活动。一起拿,我们的结果显示 NF-YC1, NF-YC3, NF-YC4,和 NF-YC9 由与 HDA15 交往在早幼苗舞台期间在 photomorphogenesis 禁止胚轴延伸作为 transcriptional 合作抑压者工作。我们 NF-YCs 能调制的调查结果热点响应经由 epigenetic 的环境暗示的植物开发规定。 | Yang Tang Xuncheng Liu Xu Liu Yuge Li Keqiang Wu Xingliang Hou | 2017 | Molecular Plant2017，10，2： | 12 |
| 5 | Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility显示文摘Hydroxyapatite(HA)bioceramic scaffolds were fabricated by using digital light processing(DLP)based additive manufacturing.Key issues on the HA bioceramic scaffolds,including dispersion,DLP fabrication,sintering,mechanical properties,and biocompatibility were discussed in detail.Firstly,the ffects of dispersant dosage,solid loading,and sintering temperature were studied.The optimal dispersant dosage,solid loading,and sintering temperature were 2wt%,50vol%,and 1250℃,respectively.Then,the mechanical properties and biocompatibility of the HA bioceramic scaffolds were investigated.The DLP-prepared porous HA bioceramic scaffold was found to exhibit excellent mechanical properties and degradation behavior.From this study,DLP technique shows good potential for manufacturing HA bioceramic scaffolds. | Chengwei FENG Keqiang ZHANG Rujie HE Guojiao DING Min XIA Xinxin JIN Chen XIE | 2020 | Journal of Advanced Ceramics2020，9，3： | 12 |
| 6 | Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus显示文摘Increasing the self-resistance levels of Streptomyces is an effective strategy to improve the production of antibiotics.To increase the oxytetracycline(OTC) production in Streptomyces rimosus,we investigated the cooperative effect of three co-overexpressing OTC resistance genes:one gene encodes a ribosomal protection protein(otrA) and the other two express efflux proteins(otrB and otrC).Results indicated that combinational overexpression of otrA,otrB,and otrC(MKABC) exerted a synergetic effect.OTC production increased by 179%in the recombinant strain compared with that of the wild-type strain M4018.The resistance level to OTC was increased by approximately two-fold relative to the parental strain,thereby indicating that applying the cooperative effect of self-resistance genes is useful to improve OTC production.Furthermore,the previously identified cluster-situated activator OtcR was overexpressed in MKABC in constructing the recombinant strain MKRABC;such strain can produce OTC of approximately7.49 g L^((-1)),which represents an increase of 19%in comparison with that of the OtcR-overexpressing strain alone.Our work showed that the cooperative overexpression of self-resistance genes is a promising strategy to enhance the antibiotics production in Streptomyces. | Shouliang Yin Xuefeng Wang Mingxin Shi Fang Yuan Huizhuan Wang Xiaole Jia Fang Yuan Jinliang Sun Tiejun Liu Keqian Yang Yuxiu Zhang Keqiang Fan Zilong Li | 2017 | Science China(Life Sciences)2017，60，9： | 10 |
| 7 | Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes显示文摘公牛,有条件地必要的氨基酸,在心血管的功能起一个关键作用。这里,我们检验了效果在在老鼠 cardiomyocytes 的线粒体和 endoplasmic 蜂窝胃上公牛在葡萄糖剥夺(GD ) 期间。数据证明房间生存能力,细胞内部的公牛的内容,和公牛的 transporter 表示在 GD 期间被减少。相反,反应的氧种类的增加和细胞内部的 Ca2+ 内容被观察。也引起的 GD 破坏了展开的蛋白质反应(UPR ) 的 mitochondrial 膜潜力, apoptotic 房间死亡,和分离在 cardiomyocytes 的相对蛋白质。信号 transduction 分析证明那 Bcl-2 家庭蛋白质平衡被扰乱, caspase-12 被激活, UPR 亲戚蛋白质层次是起来调整的。而且,有 80 公里的预告的处理在 cardiomyocytes 的外长的公牛的稀释 GD 效果。我们的结果建议那公牛在禁止线粒体依赖者房间 apoptosis 和联系 UPR 的房间 apoptosis 上有有益的效果并且可能在未来在尖锐心肌的梗塞上有临床的含意。 | Yujie Yang Yue Zhang Xiaoyu Liu Ji Zuo Keqiang Wang Junbo Ge | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 10 |
| 8 | Kinetics of iron removal from metallurgical grade silicon with pressure leaching显示文摘In this paper, the kinetics of pressure leaching for purification of metallurgical grade silicon with hydrochloric acid was investigated. The effects of particle size, temperature, total pressure, and concentration of hydrochloric acid on the kinetics and mechanism of iron removal were studied. It was found that the reaction kinetic model followed the shrinking core model, and the apparent activation energy of the leaching reaction was 46.908 kJ/mol. And the apparent reaction order of iron removal with pressure leaching was 0.899. The kinetic equation was ob-tained and the mathematical model of iron removal from metallurgical grade silicon (MG-Si) was given as follows: 1-2/3x-(1-x)2/3=exp(5.1654-4811.4591/T+1.287lnp+1.046ln[C])·t/r02· The values calculated from the equation were consistent with the experimental results. | YU Zhanliang XIE Keqiang MA Wenhui ZHOU Yang XIE Gang DAI Yongnian | 2011 | Rare Metals2011，30，6： | 9 |
| 9 | Adaptive fuzzy sliding mode control for coordinated longitudinal and lateral motions of multiple autonomous vehicles in a platoon显示文摘In this paper, the platoon control problem of autonomous vehicles in highway is studied. Since the autonomous vehicles have the characteristics of nonlinearities, external disturbances and strong coupling, a novel adaptive fuzzy sliding coordinated control system is constructed to supervise the longitudinal and lateral motions of autonomous vehicles, in which the fuzzy system is employed to approximate the unknown nonlinear functions. Due to the low sensitivity to disturbances and plant parameter variations, the proposed control approach is an efficient way to handle with the complex dynamic plants operating under un-certainty conditions. The asymptotic stability of adaptive coordinated platoon close-loop control system is verified based on the Lyapunov stability theory. The results indicate that the presented adaptive coordinated platoon control approach can accurately achieve the tracking performance and ensures the stability and riding comfort of autonomous vehicles in a platoon. Finally,simulation test is exploited to demonstrate the effectiveness of the proposed control approach. | GUO JingHua LUO YuGong LI KeQiang | 2017 | Science China(Technological Sciences)2017，60，4： | 9 |
| 10 | Initiation of Parkinson’s disease from gut to brain byδ-secretase显示文摘Lewy pathology,composed ofα-Synuclein(α-Syn)inclusions,a hallmark of Parkinson’s disease(PD),progressively spreads from the enteric nervous system(ENS)to the central nervous system(CNS).However,it remains unclear how this process is regulated at a molecular level.Here we show thatδ-secretase(asparagine endopeptidase,AEP)cleaves bothα-Syn at N103 and Tau at N368,and mediates their fibrillization and retrograde propagation from the gut to the brain,triggering nigra dopaminergic neuronal loss associated with Lewy bodies and motor dysfunction.α-Syn N103 and Tau N368 robustly interact with each other and are highly elevated in PD patients’gut and brain.Chronic oral administration of the neurotoxin rotenone induces AEP activation andα-Syn N103/Tau N368 complex formation in the gut,eliciting constipation and dopaminergic neuronal death in an AEP-dependent manner.Preformed fibrils(PFFs)ofα-Syn N103/Tau N368 are more neurotoxic and compact,and aggregate more quickly along the vagus nerve than their FL/FL counterparts or the individual fragments’fibrils.Colonic injection of PFFs induces PD pathologies,motor dysfunctions,and cognitive impairments.Thus,δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS. | Eun Hee Ahn Seong Su Kang Xia Liu Guiqin Chen Zhentao Zhang Bindu Chandrasekharan Ashfaqul M.Alam Andrew S.Neish Xuebing Cao Keqiang Ye | 2020 | Cell Research2020，30，1： | 9 |
| 11 | Progress and challenges towards additive manufacturing of SiC ceramic显示文摘Silicon carbide(SiC)ceramic and related materials are widely used in various military and engineering fields.The emergence of additive manufacturing(AM)technologies provides a new approach for the fabrication of SiC ceramic products.This article systematically reviews the additive manufacturing technologies of SiC ceramic developed in recent years,including Indirect Additive Manufacturing(Indirect AM)and Direct Additive Manufacturing(Direct AM)technologies.This review also summarizes the key scientific and technological challenges for the additive manufacturing of SiC ceramic,and also forecasts its possible future opportunities.This paper aims to provide a helpful guidance for the additive manufacturing of SiC ceramic and other structural ceramics. | Rujie HE Niping ZHOU Keqiang ZHANG Xueqin ZHANG Lu ZHANG Wenqing WANG Daining FANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 9 |
| 12 | Vertical diversity of sediment bacterial communities in two different trophic states of the eutrophic Lake Taihu, China显示文摘Vertical diversity of sediment bacterial communities in 2 different trophic states(macrophyte-dominated and algae-dominated) of the large shallow eutrophic Lake Taihu,China,were investigated using denaturing gradient gel electrophoresis(DGGE) and 16S rRNA sequence analysis.Clustering analysis of DGGE profiles showed that different clusters were recognized in different depths of sediment cores in the 2 lake trophic states.Analyses of the bacterial diversity,as estimated by the Shannon index(H '),showed that different sediment layers of the macrophyte-dominated state had higher diversity than the algae-dominated state.In addition,bacterial diversity of the sediment in the macrophyte-dominated state changed abruptly throughout the layers,but bacterial diversity of the algae-dominated state decreased gradually with sediment depth.Phylogenetic analysis showed that Proteobacteria was the most abundant phylum in the middle sediment of the 2 lake trophic states.In the macrophyte-dominated state,clone sequences related to Betaproteobacteria(50.0%) were the most abundant,followed by Epsilonproteobacteria(21.1%),Acidobacteria(7.9%),Deltaproteobacteria(7.9%),Chloroflexi(7.9%),and Bacteroidetes(5.3%);whereas in the algae-dominated state,sequences affiliated with Betaproteobacteria(84.4%) were predominant,followed by Deltaproteobacteria(12.5%) and Acidobacteria(3.1%).Canonical correspondence analysis showed that organic matter and pH play key roles in driving the vertical changes of bacterial community composition. | Keqiang Shao Guang Gao Yongping Wang Xiangming Tang Boqiang Qin | 2013 | Journal of Environmental Sciences2013，25，6： | 9 |
| 13 | Trend and Development of Semi-Solid Metal Processing显示文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed. | Xianfeng PAN, Haifeng ZHANG, Aimin WANG, Bingzhe DING, Keqiang QIU and Zhuangqi HU (State Key Laboratory of Rapidly Solidified Nonequilibrium Alloys, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 7 |
| 14 | 7,8-dihydroxyflavone,a small molecular TrkB agonist,is useful for treating various BDNF-implicated human disorders显示文摘Brain-derived neurotrophic factor(BDNF)regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB.It is a potential therapeutic target in numerous neurological,mental and metabolic disorders.However,the lack of efficient means to deliver BDNF into the body imposes an insurmountable hurdle to its clinical application.To address this challenge,we initiated a cell-based drug screening to search for small molecules that act as the TrkB agonist.7,8-Dihydroxyflavone(7,8-DHF)is our first reported small molecular TrkB agonist,which has now been extensively validated in various biochemical and cellular systems.Though binding to the extracellular domain of TrkB,7,8-DHF triggers TrkB dimerization to induce the downstream signaling.Notably,7,8-DHF is orally bioactive that can penetrate the brain blood barrier(BBB)to exert its neurotrophic activities in the central nervous system.Numerous reports suggest 7,8-DHF processes promising therapeutic efficacy in various animal disease models that are related to deficient BDNF signaling.In this review,we summarize our current knowledge on the binding activity and specificity,structure-activity relationship,pharmacokinetic and metabolism,and the pre-clinical efficacy of 7,8-DHF against some human diseases. | Chaoyang Liu Chi Bun Chan Keqiang Ye | 2016 | Translational Neurodegeneration2016，5，1： | 7 |
| 15 | Chemokines in homeostasis and diseases显示文摘For the past twenty years,chemokines have emerged as a family of critical mediators of cell migration during immune surveillance,development,inflammation and cancer progression.Chemokines bind to seven transmembrane G protein-coupled receptors(GPCRs)that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation.Although chemokines have evolved to benefit the host,inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases.Therefore,understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic targets.This review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis,inflammation,immune responses and cancer. | Keqiang Chen Zhiyao Bao Peng Tang Wanghua Gong Teizo Yoshimura Ji Ming Wang | 2018 | Cellular & Molecular Immunology2018，15，4： | 7 |
| 16 | How freezing and thawing processes affect black-soil aggregate stability in northeastern China显示文摘Laboratory experiments were carried out to investigate the effect of freezing and thawing processes on wet aggregate stability (WAS) of black soil. Wet aggregate stability was determined by different aggregate size groups, different water contents, various freeze-thaw cycles, and various freezing temperatures. The results showed that, when at suitable water content, aggregate stability was enhanced, aggregate sta-bility will be disrupted when moisture content is too high or too low, especially higher water content. Temperature also had a significant ef-fect, but moisture content determined the suitable freezing temperatures for a given soil. Water-stable aggregate (WSA>0.5), the total aggre-gate content, and mean weight diameter decreasing with the freeze-thaw cycles increase, reached to 5 percent significance level. The reason for crumbing aggregates is the water and air conflict, thus raising the hypothesis that water content affects the aggregate stability in the process of freezing and thawing. | FengWang XiaoZeng Han LiangHao Li KeQiang Zhang | 2010 | Research in Cold and Arid Regions2010，2，1： | 7 |
| 17 | Calculation methodology of marine environmental capacity for heavy metal:A case study in Jiaozhou Bay,China显示文摘Results from past pollution control practices show that environmental quality can be ensured by controlling the actual amount of pollutants formed in the environment.Therefore,the marine environmental capacity for heavy metals was introduced.Marine environmental capacity for heavy metals is defined as the maximum amount of heavy metals permitted in the marine environment system to preserve the benign cycle of materials in the oceansphere,and to limit the adverse effects of heavy metals on the biosphere,hydrosphere,atmosphere,and lithosphere.Based on the box or three-dimensional model in the target coastal region,including the self-purification and output of heavy metals,the marine environmental capacity for heavy metals can be calculated within a given criterion and time.In this study,a method was proposed to calculate the marine environmental capacity for heavy metals which includes four steps:(1) gathering the basis information of target coastal ecosystem,(2) selection of water control points and water quality criteria for these points,(3) development of numerical models for the biogeochemical cycling of heavy metals in target coastal region,and(4) calculation of environmental capacity using the developed model.According to the proposed method,the marine environmental capacity for lead is approximately 60 tons per year if Grade I seawater quality is set as the control criterion in Jiaozhou Bay.An effective seawater quality management plan can also be framed based on the environmental capacity for metals. | LI KeQiang WANG XiuLin | 2013 | Chinese Science Bulletin2013，58，2： | 7 |
| 18 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 19 | The Essential Role of Phosphoinositide 3-Kinases(PI3Ks)in Regulating Pro-Inflammatory Responses and the Progression of Cancer显示文摘Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors. | Keqiang Chen Pablo Iribarren Wanghua Gong Ji-Ming Wang | 2005 | Cellular & Molecular Immunology2005，2，4： | 6 |
| 20 | The Expression of Manganese Superoxide Dismutase Gene from Nelumbo nucifera Responds Strongly to Chilling and Oxidative Stresses显示文摘A manganese superoxide dismutase(Mn-SOD) gene,NnMSD1,was identified from embryonic axes of the sacred lotus(Nelumbo nucifera Gaertn.) . The NnMSD1 protein contains all conserved residues of the Mn-SOD protein family,including four consensus metal binding domains and a signal peptide for mitochondrial targeting. Southern blot analysis suggests the existence of two Mn-SOD genes in sacred lotus. NnMSD1 was highly expressed in developing embryonic axes during seed development,but appeared in cotyledons only at the early stage of development and became undetectable in the cotyledons during late embryogenesis. The expression of the NnMSD1 gene in germinating embryonic axes,in response to various stresses such as heat shock,chilling,and exposure to stress-related chemicals,was also studied. Heat shock strongly inhibited the expression of the NnMSD1 gene,whereas the NnMSD1 transcript level increased strongly in chilling stress treatment. An increase in expression was also highly induced by H2O2 in germinating embryonic axes. The results suggest that the expression pattern of the NnMSD1 gene differed between developing axes and cotyledons,and that the NnMSD1 gene expression responds strongly to chilling and oxidative stress. | Wen Li Lin Qi Xiaodong Lin Huhui Chen Zhanqi Ma Keqiang Wu Shangzhi Huang | 2009 | Journal of Integrative Plant Biology2009，51，3： | 6 |
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