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| 1 | 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia显示文摘3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits. | Wanhong Zhao Chao Luo Jue Wang Jian Gong Bin Li Yingxia Gong Jun Wang Hanqin Wang | 2014 | Neural Regeneration Research2014，9，7： | 43 |
| 2 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 3 | Fractal classification and natural classification of coal pore structure based on migration of coal bed methane显示文摘According to the data of 146 coal samples measured by mercury penetration, coal pores are classified into two levels of <65 nm diffusion pore and >65 nm seeping pore by fractal method based on the characteristics of diffusion, seepage of coal bed methane(CBM) and on the research results of specific pore volume and pore structure. The diffusion pores are further divided into three categories: <8 nm micropore, 8-20 nm transitional pore, and 20-65 nm mini-pore based on the relationship between increment of specific surface area and diameter of pores, while seepage pores are further divided into three categories: 65-325 nm mesopore, 325-1000 nm transitional pore, and >1000 nm macropore based on the abrupt change in the increment of specific pore volume. | Xuehai Fu Yong Qin Wanhong Zhang Chongtao Wei Rongfu Zhou | 2005 | Chinese Science Bulletin2005，50，S1： | 16 |
| 4 | Multi-type ant system algorithm for the time dependent vehicle routing problem with time windows显示文摘The time dependent vehicle routing problem with time windows(TDVRPTW) is considered. A multi-type ant system(MTAS) algorithm hybridized with the ant colony system(ACS)and the max-min ant system(MMAS) algorithms is proposed. This combination absorbs the merits of the two algorithms in solutions construction and optimization separately. In order to improve the efficiency of the insertion procedure, a nearest neighbor selection(NNS) mechanism, an insertion local search procedure and a local optimization procedure are specified in detail. And in order to find a balance between good scouting performance and fast convergence rate, an adaptive pheromone updating strategy is proposed in the MTAS. Computational results confirm the MTAS algorithm's good performance with all these strategies on classic vehicle routing problem with time windows(VRPTW) benchmark instances and the TDVRPTW instances, and some better results especially for the number of vehicles and travel times of the best solutions are obtained in comparison with the previous research. | DENG Ye ZHU Wanhong LI Hongwei ZHENG Yonghui | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 13 |
| 5 | Comparison of the Efficacy of Pterygium Resection Combined with Conjunctival Autograft versus Pterygium Resection Combined with Amniotic Membrane Transplantation显示文摘Purpose:To compare the efficacy of pterygium resection combined with conjunctival autograft versus pterygium resection combined with amniotic membrane transplantation in the treatment of pterygium. Methods: A total of 118 cases (133 eyes) were randomly assigned to receive pterygium resection combined with conjunctival autograft (n=81) or pterygium resection combined with amniotic membrane transplantation(n=52)..Corneal wound healing and neovascularization and the presence or absence of conjunctival proliferation and hyperemia were analyzed at 12 months post-operatively. Results: In the conjunctival autograft group, 6 eyes (7.4%) had recurrent pterygium,.while in the amniotic membrane transplantation group, 10 eyes showed recurrence (19.2%,P<0.05,.chi-square)..Patients in the conjunctival autograft group recovered significantly faster compared with those in the amniotic membrane transplantation group. Conclusion:.Patients receiving pterygium surgery combined with conjunctival autograft had lower recurrence rates and experience faster recovery compared with those undergoing pterygium resection combined with amniotic membrane transplantation. | Wanhong Liang Rongxu Li Xingyun Deng | 2012 | Eye Science2012，27，2： | 12 |
| 6 | Photocatalytic debromination of decabromodiphenyl ether by graphitic carbon nitride显示文摘The graphitic carbon nitride(g-C3N4) is found to be an efficient photocatalyst for the reductive degradation of decabromodiphenyl ether(BDE209) under UV irradiation(>360 nm).g-C3N4 was prepared by heating dicyandiamide.X-ray diffraction,X-ray photoelectron spectroscopy,and UV-vis spectra were used to characterize the properties of as-prepared catalysts.The photoreductive degradation kinetics of BDE209 was further investigated under different reaction conditions.The degradation of BDE209 is a stepwise process,and the bromines at meta positions are much more susceptible to remove than those at the ortho and para positions.A possible photoreductive mechanism was also proposed. | SUN ChunYan CHEN ChunCheng MA WanHong ZHAO JinCai | 2012 | Science China Chemistry2012，55，12： | 8 |
| 7 | SAD2 in Arabidopsis Functions in Trichome Initiation through Mediating GL3 Function and Regulating GL1,TTG1 and GL2 Expression显示文摘Most genes identified that control Arabidopsis trichome initiation and formation are transcription factors or regulatory com- ponents in transcriptional networks and include GLABROUS1 (GL1), GLABRA2 (GL2), GLABRA3 (GL3) and TRANSPARENT TESTA GLABRA1 (TTG1). Herein, we report that an importin β-like protein, SENSITIVE TO ABA AND DROUGHT2 (SAD2), is required for trichome initiation. Mutations in SAD2 disrupted trichome initiation resulting in reduced trichome number, but had no effect on trichome development or root hair number and development. Expression levels of GL1, MYB23, GL2 and TTG1 were reduced in shoots of sad2 mutants while expression levels of GL3 and ENHANCER OF GLABRA3 (EGL3) were enhanced. Overexpression of GL3 increased trichome numbers in wild type but not in sad2 mutants, indicating that the function of the GL3 protein is altered in the sad2 mutants. In contrast, overexpression of GFP-GL1 decreased trichome number in both wild type and sad2. Double mutant analysis of gl1 sad2 and gl3 sad2 indicated that SAD2 functions genetically, at least in part, in the same pathway with these two genes. Co-immunoprecipitation indicated that the sad2 mutation does not disrupt formation of the TTG1-GL3-GL1 complex. Analysis of GFP fusions of GL1, GL2, GL3 and TTG1 suggested that these proteins are most likely not direct cargo of SAD2. Our data suggest that SAD2 is involved in trichome initiation by regulating these nuclear genes. | Ying Gao Ximing Gong Wanhong Cao Jinfeng Zhao Liqin Fu XuechenWang Karen S. Schumaker Yan Guo | 2008 | Journal of Integrative Plant Biology2008，50，7： | 7 |
| 8 | Mechanical properties and enhancement mechanisms of titanium-graphene nanocomposites显示文摘Molecular dynamics(MD)simulations of the titanium-graphene nanocomposites(TiGNCs)under uniaxial tension are carried out to investigate the mechanical properties and reinforcement mechanism of graphene in composites.It is found that introduction of mechanically robust graphene limits the strain-induced dislocation and araorphization and thereby highly improves the mechanical properties of metallic titanium that are greatly affected by the crystal stacking orientation of graphene and titanium layers.The thickness of titanium layers,interface interaction and working temperature play an important role in the mechanical strength and elastic moduli of composites.The results show the mechanical properties of TiGNCs are monotonically enhanced with reduction of the titanium layer thickness and working temperature,and the Young5s modulus obtained by MD simulation are higher than that predicted by the rule of mixture(ROM)due to consideration of interfacial interaction in computational calculation.In addition,once the critical thickness of titanium layer is reached,graphene wrinkles are induced in composites because of Poisson's effect induced large lateral compression stress in the interface region.This study provides helpful insights into fundamental understanding reinforcing mechanism of graphene and ultimately contribute to the optimal design and performance of mechanically robust graphene-based metallic composites. | Wanhong Tang Jie Zhang Jianyang Wu Jinyou Shao Peng Ding Guozhen Hou Xiaoming Chen | 2020 | Acta Mechanica Sinica2020，36，4： | 7 |
| 9 | Heterogeneous degradation of toxic organic pollutants by hydrophobic copper Schiff-base complex under visible irradiation显示文摘A hydrophobic complex of Cu2+[bis-salicylic aldehyde-o-phenylenediamine],Cu-SPA,was prepared and used as a heterogeneous photocatalyst to degrade organic pollutants in water under visible irradiation(420 nm)at neutral pH.The structure of complex was characterized by using nuclear magnetic resonance(NMR),elemental analysis,IR and UV-vis spectrometries.Degradation of Rhodamine B(RhB),Sulforhodamine B(SRB)and Benzoic acid(BA)in water were used as model reactions to evaluate the photocatalytic activities of Cu-SPA.The results indicated that RhB and SRB were easily adsorbed on the hydrophobic surface of Cu-SPA from aqueous solution(the maximum adsorption amount:Qmax=11.09 and 8.05μmol/g,respectively).Under visible irradiation,RhB and SRB were decolorized completely after 210 and 240 min,respectively,and BA was removed completely after 5 h.The efficiency of H2O2was>95%,in contrast to that of the reaction without catalyst or light(<20%).In water soluble medium,the hydrophobic Cu-SPA can be used more than 6 cycles.ESR results and the behavior of cyclic voltammetry showed that,in the reaction process,Cu2+-SPA was reduced to intermediate state Cu+-SPA firstly,which was extremely unstable and reacted rapidly with H2O2,leading to high reactive oxygen species(·OH radical)to degrade the substrate. | SONG Quan JIA ManKe MA WanHong FANG YanFen HUANG YingPing | 2013 | Science China Chemistry2013，56，12： | 5 |
| 10 | Spherical Headed Silicone Intubation in the Treatment of 26 Cases (31 eyes) of Chronic Dacryocystitis under Nasal Endoscopy显示文摘Purpose:To observe the clinical efficacy of spherical headed silicone implantation in the treatment of chronic dacryocystitis under nasal endoscopy.Methods:Twenty-six patients (31 eyes) with chronic dacryocystitis were subjected to spherical headed silicone implantation under topical anesthesia (lacrimal passage and nasal mucosal surface).Lacrimal passage irrigation was performed daily throughout the first postoperative week,and once each month thereafter.Results:All spherical headed silicone tube placements were successfully performed.The operative time ranged from 6 to 11 minutes.Symptoms of epiphora were immediately ameliorated post-operatively,and irrigation demonstrated patency of the lacrimal system in all patients.All patients were followed from 7 to 24 months,during which symptoms of tearing were improved.The lacrimal ducts of 27 eyes (87.7%) were normal.The lacrimal ducts of 4 others.(12.3%).were still blocked.Lacrimal passage irrigation was open and secretion disappeared in 28 eyes(90.3%).Tearing was observed in 3 eyes (9.68%).Conclusion:Spherical headed silicone tube implantation under nasal endoscopy is successful in relieving symptoms of tearing. | Wanhong Liang Yongqiang Liang Xingyun Deng Hongzhi Yuan | 2011 | Eye Science2011，26，4： | 5 |
| 11 | Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α(TNF-α) conjugate for therapeutic application显示文摘To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-TNF- ), facilitating its clinical use for anti-tumor therapy. Comparative pharmaco- kinetic and pharmacodynamic studies showed that the half-lives of both PEGylated forms of TNF-α were ~60-fold greater than that of unmodified TNF-α . In addition, the in vitro bioactivity of rPEG-TNF-α was greater than that of PEG-TNF-α with the same degree of PEG modification. Release of TNF-α from rPEG-TNF-α in vitro was dependent on the presence of cathepsin B and was inhibited by a cathepsin B inhibitor. Despite the potent cytotoxicity of unmodified TNF-α against normal cells, its PEGylated forms at higher TNF-α concentrations showed low cytotoxic activity against these cells. In contrast, both forms of PEGylated TNF-α showed potent cytotoxic activity against the B16 and L929 cell lines, with rPEG-TNF-α being 5- and 9- fold more potent, respectively, than PEG-TNF-α . Moreover, rPEG-TNF-α was a more potent in vivo antitumor agent than PEG-TNF-α . | DAI ChuanYun FU Ya CHEN ShaoCheng LI Biao YAO Bo LIU WanHong ZHU LiQing CHEN Nan CHEN Ji ZHANG Qiang | 2013 | Science China(Life Sciences)2013，56，1： | 4 |
| 12 | The long non-coding RNA expression profile of Coxsackievirus A16 infected RD cells identified by RNA-seq显示文摘Coxsackievirus A16(CVA16) is one of major pathogens of hand, foot and mouth disease(HFMD) in children. Long non-coding RNAs(Inc RNAs) have been implicated in various biological processes,but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the landscape of Inc RNAs of normal and CVA16 infected rhabdomyosarcoma(RD)cells using RNA-Seq to investigate the functional relevance of Inc RNAs. We showed that a total of 760 Inc RNAs were upregulated and 1210 Inc RNAs were downregulated. Out of these dysregulated Inc RNAs, 43.64% were intergenic, 22.31% were sense, 15.89% were intronic, 8.67% were bidirectional, 5.59% were antisense, 3.85% were s RNA host Inc RNAs and 0.05% were enhancer. Six dysregulated Inc RNAs were validated by quantitative PCR assays and the secondary structures of these Inc RNAs were projected. Moreover, we conducted a bioinformatics analysis of an Inc RNAs(ENST00000602478) to elucidate the diversity of modification and functions of Inc RNAs. In summary, the current study compared the dysregulated Inc RNAs profile upon CVA16 challenge and illustrated the intricate relationship between coding and Inc RNAs transcripts. These results may not only provide a complete picture of transcription in CVA16 infected cells but also provide novel molecular targets for treatments of HFMD. | Yingying Shi Huilin Tu Xiong Chen Yingying Zhang Liujun Chen Zhongchun Liu Jiqun Sheng Song Han Jun Yin Biwen Peng Xiaohua He Wanhong Liu | 2016 | Virologica Sinica2016，31，2： | 4 |
| 13 | miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice显示文摘骨胳的肌肉质量和动态平衡大部分在出生后的肌肉开发和新生期间取决于成年肌肉干细胞(卫星房间) 。我们最近证明 miR-378 的全球 overexpression 显著地在老鼠减少了骨胳的肌肉质量。在当前的学习,我们使用了 miR-378 转基因(Tg ) 估计的老鼠在里面 vivo 骨胳的肌肉生长和新生上的 miR-378 的功能的效果。骨胳的肌肉纸巾的代表性的分析证明 myofibers 的数字和尺寸比在野类型的老鼠在 miR-378 Tg 老鼠是显著地更低的。在 miR-378 Tg 老鼠的稀释导致 cardiotoxin 的肌肉新生被发现与推迟的卫星房间激活和区别被联系。机械学地, miR-378 被发现直接在 vitro 并且在 vivo 在肌肉房间指向 Igf1r。这些 miR-378 Tg 老鼠可以为在人在联系肌肉的疾病调查骨胳的肌肉的生理、病理学的角色提供一个模型,特别地在 sarcopenia。 | Ping Zeng Wanhong Han Changyin Li Hu Li Dahai Zhu Yong Zhang Xiaohong Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 14 | Large manipulative experiments reveal complex effects of food supplementation on population dynamics of Brandt's voles显示文摘Although food supplementation is well known to increase population density,there is still debate on the causative effects of food supplementation on reproduction,survival,and immigration.Large manipulative experiments,which exclude any confounding effects of dispersal and predation,are essential for clarifying the debate.In this study,we investigated the effects of food supplementation on Brandt's vole population dynamics and plant community in eight large enclosures(0.48 ha each) from2010 to 2014.Food supplementation showed significant positive effects on population density due to increases in recruitment;however,it showed a complex effect on survival of voles:positive in non-breeding seasons,but negative in breeding seasons.In addition,food supplementation increased the quality of plants(as reflected by increased crude protein content),but decreased the quantity of less preferred plants in experimental enclosures.Thus,food seems to have direct positive effects on small rodents through improvement of food supply and indirect negative effects through food-induced density-dependent effects,and may have long-term effects on rodents through altering plant community composition and abundance. | Baofa Yin Guoliang Li Xinrong Wan Guozhen Shang Wanhong Wei Zhibin Zhang | 2017 | Science China(Life Sciences)2017，60，8： | 4 |
| 15 | Supported noble metal nanoparticles as photo/sono-catalysts for synthesis of chemicals and degradation of pollutants显示文摘This review summarizes the utilization of supported noble metal nanoparticles (such as Au/TiO2, Au/ZrO2, Ag/AgCl) as efficient photo/sono-catalysts for the selective synthesis of chemicals and degradation of environmental pollutants. Supported noble metal nanoparticles could efficiently catalyze the conversion of solar energy into chemical energy. Under UV/visible light irradiation, important chemical transformations such as the oxidation of alcohols to carbonyl compounds, the oxidation of thiol to disulfide, the oxidation of benzene to phenol, and the reduction of nitroaromatic compounds to form aromatic azo compounds, are effectively achieved by supported noble metal nanoparticles. Under ultrasound irradiation, supported noble metal nanoparticles could efficiently catalyze the production of hydrogen from water. Moreover, various pollutants, including aldehydes, alcohols, acids, phenolic compounds, and dyes, can be effectively decomposed over supported noble metal nanoparticles under UV/visible light irradiation. Under ultrasound irradiation, pollutant molecules can also be completely degraded with supported noble metal nanoparticles as catalysts. | WEN Bo MA JiaHai CHEN ChunCheng MA WanHong ZHU HuaiYong ZHAO JinCai | 2011 | Science China Chemistry2011，54，6： | 3 |
| 16 | Outlier deletion based improvement on the StOMP algorithm for sparse solution of large-scale underdetermined problems显示文摘StOMP algorithm is well suited to large-scale underdetermined applications in sparse vector estimations.It can reduce computation complexity and has some attractive asymptotical statistical properties.However,the estimation speed is at the cost of accuracy violation.This paper suggests an improvement on the StOMP algorithm that is more efficient in finding a sparse solution to the large-scale underdetermined problems.Also,compared with StOMP,this modified algorithm can not only more accurately estimate parameters for the distribution of matched filter coefficients,but also improve estimation accuracy for the sparse vector itself.Theoretical success boundary is provided based on a large-system limit for approximate recovery of sparse vector by modified algorithm,which validates that the modified algorithm is more efficient than StOMP.Actual computations with simulated data show that without significant increment in computation time,the proposed algorithm can greatly improve the estimation accuracy. | ZHANG WanHong ZHOU Tong HUANG BoXue | 2014 | Science China(Information Sciences)2014，57，9： | 2 |
| 17 | Cooling precipitation and strengthening study in powder metallurgy superalloy Rene88DT显示文摘 | MAO Jian CHANG Keh-Minn YANG Wanhong | 2002 | Materials Science and Engineering2002，332，： | 1 |
| 18 | Formation of disinfection byproducts upon chlorine dioxide peroxidation followed by chlorination or chloramination of natural organic matter 显示文摘 | Xin Yang Wanhong Guo Wontae Lee | 2013 | Chemosphere2013，91，11： | 1 |
| 19 | A novel approach for the oxidative degradation of organic pollutants in aqueous solutions mediated by iron tetrasulfophthalocyanine under visible light radiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2002 | Chem Eur J2002，8，6： | 1 |
| 20 | Efficient photooxidative degradation of organic compounds in the presence of iron tetrasulfophthalocyanine under visible light irradiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2001 | Angewandte Chemie International Edition2001，40，16： | 1 |
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