|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A numerical study of cavitating flows in high-pressure diesel injection nozzle holes using a two-fluid model显示文摘Cavitating flows inside a diesel injection nozzle hole were simulated using a two-fluid model. Attention was focused on the complex cavitation processes and flow characteristics under constant inlet pressure and fluctuant inlet pressure modes. To validate the two-fluid model, model predictions were compared with the experimental data available in the literatures, and good agreement was achieved. The numerical results show that the appearance of supercavitation in the diesel nozzle hole induces obvious changes of flow field structures and exit flow conditions. The distributions of liquid phase turbulent kinetic energy and exit velocity profiles corresponding to the supercavitation regime indicate the potential for promoting the primary breakup of a diesel jet. Furthermore, the upstream pressure fluctuations significantly influence the cavitation processes. Both partial cavitation and supercavitation show unsteady behaviors as the rapid rise or fall of upstream pressure. | WANG Xiang SU WanHua | 2009 | Chinese Science Bulletin2009，54，10： | 16 |
| 2 | Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection显示文摘 | Yunfang Zhang Ying Zhang Junchao Shi He Zhang Zhonghong Cao Xuan Gao Wanhua Ren Yunna Ning Lina Ning Yujing Cao Yongchang Chen Weizhi Ji Zi-jiang Chen Qi Chen Enkui Duan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 10 |
| 3 | Receptance Coupling for Tool Point Dynamics Prediction on Machine Tools显示文摘Chatter has been a primary obstacle to the successful implementation of high speed machining.The frequency response function(FRF) of the tool point is crucial for identification of chatter free cutting conditions.In order to quickly acquire the FRF of the different components combinations of machine tool,the assembly of machine tool was always decomposed into several parts,where the fluted portion of tool,however,was always treated as a uniform beam,and the associated discrepancy was ignored.This paper presents a new method to predict the dynamic response of the machine-spindle-holder-tool assembly using the receptance coupling substructure analysis technique,where the assembly is divided into three parts:machine-spindle,holder and tool shank,and tool's fluted portion.Impact testing is used to measure the receptance of machine-spindle,the Timoshenko beam model is employed to analyze the dynamics of holder and tool shank,and the finite element method(FEM) is used to calculate the receptance of the tool's fluted portion.The approximation of the fluted portion cross section using an equivalent diameter is also addressed.All the individual receptances are coupled by using substructure method.The predicted assembly receptance is experimentally verified for three different tool overhang lengths.The results also show that the equivalent diameter beam model reaches an acceptable accuracy.The proposed approach is helpful to predict the tool point dynamics rapidly in industry. | ZHANG Jun SCHMITZ Tony ZHAO Wanhua LU Bingheng | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 9 |
| 4 | An Intelligent Non-Collocated Control Strategy for Ball-Screw Feed Drives with Dynamic Variations显示文摘 | Hui Liu Jun Zhang Wanhua Zhao | 2017 | Engineering2017，3，5： | 7 |
| 5 | Preliminary analysis of species sensitivity distribution based on gene expression effect显示文摘Species sensitivity analysis is one of the major techniques applied to derive water quality criteria. Presently, the toxicity data used for development of water quality criteria are mainly in the biological individual level. With the increase of ecotoxicogenomics toxicity data, it is worth studying whether the gene expression effect data can be used to derive water quality criteria. Taking cadmium, copper and zinc as examples, we analyzed the toxic effects of the three heavy metals by constructing the species sensitivity distribution curves on the basis of extensive toxicity data. The results showed that the rank of species sensitivity for the acute, chronic and gene expression effect toxicity data of cadmium is 'chronic>gene>acute'. Although the gene expression effect data of copper and zinc are insufficient, the trend of data sensitivity of zinc is similar to cadmium. However, the trend of species sensitivity of copper is different from that of cadmium and zinc with higher sensitivity of gene expression data. It suggested that though the existing data of gene expression effects are not sufficient enough, they have the potential to be used in the development of chronic water quality criteria. For application in the derivation of water quality criteria, illogical test concentration design and insufficient target genes are two main weaknesses in the study of gene expression effects. | YAN ZhenGuang YANG NiYun WANG XiaoNan WANG WanHua MENG ShuangShuang LIU ZhengTao | 2012 | Science China Earth Sciences2012，55，6： | 7 |
| 6 | Experimental study on the effects of HP and LP EGR on thermal efficiency and emissions of a two-stage turbocharged diesel engine显示文摘An experimental study was performed to compare the effects of high-and low-pressure exhaust gas recirculation loops(HP and LP EGR loops)on thermal efficiency and emissions of a diesel engine.Tests were conducted on a 12-L six-cylinder turbocharged diesel engine under various operating conditions.We found that at a low speed of 1100 r/min,1 MPa BMEP,the LP EGR loop could achieve higher brake thermal efficiency and lower emissions than the HP EGR.This is because the lower enthalpy available at the turbine inlet of the HP EGR loop increased the fuel/oxygen equivalence ratio.For the HP EGR,the gross indicated thermal efficiency was reduced by 1%,but pumping losses were only reduced by 0.5%,compared to the LP EGR loop.At a higher speed of 1600 r/min,1 MPa BMEP,the HP EGR loop attained a higher brake thermal efficiency and lower emissions because of the relatively sufficient flow through the turbocharger.For the HP EGR loop,the gross indicated thermal efficiency was only reduced by 0.5%and pumping losses were reduced by 1.5%,compared to the LP EGR loop.Lower fuel consumption and a longer ignition delay made the distribution of fuel/oxygen equivalence ratio more homogeneous,leading to lower emissions.Our data also showed that at the high speed of 1600 r/min,0.55 MPa BMEP,the brake thermal efficiency of the HP EGR loop first increased,then decreased as the EGR rate increased.Therefore,under all conditions,a reasonable match of both EGR loops could achieve a good balance between fuel consumption and emissions of NOx and soot. | WU BinYang PU YouZhe YU XiaoYang SU WanHua | 2014 | Science China(Technological Sciences)2014，57，2： | 6 |
| 7 | Structure change of 430 stainless steel in the heating process显示文摘The microstructure analysis was employed for the ferritic stainless steel(SUS430)with the carbon content from 0.029wt% to 0.100wt% under the simulated heating process condition.The higher carbon sample(430H)contains the duplex phase micro- structure at the temperature of 1150℃;on the other hand,the lower carbon content sample(430L)does not touch two phase area even at the temperature of 1450℃and has the single phase ferritic microstructure.The carbon content need be well controlled for the 430 ferritic stainless steel since it can significantly affect the heating process curve,and the heating process may not be done in the two phase area due to the uncontrolled carbon content.With the low carbon content and the proper soaking time,the grain size is not sensitive to the heating process temperature and the soaking time.In the present heat treatment experiments,the soaking time is about 10 min,and the processing parameters can be chosen according to the requirement of the gross energy,the efficiency and the continual forming. | Xinzhong Liu Jingtao Han Wanhua Yu Shifeng Dai | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 6 |
| 8 | Three-dimensional (3D) hydrogel serves as a platform to identify potential markers of chondrocyte dedifferentiation by combining RNA sequencing显示文摘Dedifferentiation of chondrocyte greatly restricts its function and application,however,it is poorly understood except a small number of canonical markers.The non-cell-adhesive property endows polysaccharide hydrogel with the ability to maintain chondrocyte phenotype,which can serve as a platform to identify new molecular markers and therapeutic targets of chondrocyte dedifferentiation.In this study,the high-throughput RNA sequencing(RNA-seq)was first performed on articular chondrocytes at primary(P0)and passage 1(P1)stages to explore the global alteration of gene expression along with chondrocyte dedifferentiation.Significantly,several potential marker genes,such as PFKFB3,KDM6B,had been identified via comparatively analyzing their expression in P0 and P1 chondrocytes as well as in 3D constructs(i.e.chondrocyte-laden alginate hydrogel and HA-MA hydrogel)at both mRNA and protein level.Besides,the changes in cellular morphology and enriched pathway of differentially expressed genes during chondrocyte dedifferentiation was studied in detail.This study developed the use of hydrogel as a platform to investigate chondrocyte dedifferentiation;the results provided new molecular markers and potential therapeutic targets of chondrocyte dedifferentiation. | Yang Ling Weiyuan Zhang Peiyan Wang Wanhua Xie Wei Yang Dong-An Wang Changjiang Fan | 2021 | Bioactive Materials2021，6，9： | 3 |
| 9 | FEATURE EXTRACTION OF BONES AND SKIN BASED ON ULTRASONIC SCANNING显示文摘In the prosthetic socket design, aimed at the high cost and radiation deficiency caused by CT scanning which is a routine technique to obtain the cross-sectional image of the residual limb, a new ultrasonic scanning method is developed to acquire the bones and skin contours of the residual limb. Using a pig fore-leg as the scanning object, an overlapping algorithm is designed to reconstruct the 2D cross-sectional image, the contours of the bone and skin are extracted using edge detection algorithm and the 3D model of the pig fore-leg is reconstructed by using reverse engineering technology. The results of checking the accuracy of the image by scanning a cylinder work pieces show that the extracted contours of the cylinder are quite close to the standard circumference. So it is feasible to get the contours of bones and skin by ultrasonic scanning. The ultrasonic scanning system featuring no radiation and low cost is a kind of new means of cross section scanning for medical images. | Zheng Shuxian Zhao Wanhua Lu Bingheng Zhao Zhao | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 3 |
| 10 | Multi-factors decision-making entropy method and its application in engineering management显示文摘以便在设计管理为信息满足严格的要求,积极间隔(0, 1 ] 在香农信息,熵被扩大到实数间隔[-1, 1 ] 。信息理论和决定理论有效地被联合,并且传统的 Bayes 决策方法仅仅考虑一个单个因素的缺乏被补救。多因素工程决策方法被建议,并且一些批评问题在实际工程管理决策过程被解决。 | Qiu Wanhua | 2010 | Engineering Sciences2010，8，4： | 2 |
| 11 | THE EFFECTS OF MARKET DEPTH ON THE ARRIVAL RATE OF ORDERS显示文摘This paper presents a model to describe the dynamic trading process in limit order book.By studying the dynamic pattern of execution probabilities of limit orders with both time and the depth of limit order book,the authors conclude with the following properties:Arrival rates of market buy orders increase as the depth of buy queue in the book increases and decrease as the depth of sell queue increases,and vice versa;similar regularities for the arrival rate of market sell orders;both the arrival rate of market buy order and market sell orders increase as the depth of both sides in the book increases by the same amount.Furthermore,the authors describe more detailed temporary and permanent effects of the market depth on the arrival rates of orders. | ZHANG Qiang LIU Shancun QIU Wanhua | 2014 | Journal of Systems Science & Complexity2014，27，6： | 2 |
| 12 | Influence of Strut Cross-section of Stents on Local Hemodynamics in Stented Arteries显示文摘Stenting is a very effective treatment for stenotic vascular diseases, but vascular geometries altered by stent implantation may lead to flow disturbances which play an important role in the initiation and progression of restenosis, especially in the near wall in stented arterial regions. So stent designs have become one of the indispensable factors needed to be considered for reducing the flow disturbances. In this paper, the structural designs of strut cross-section are considered as an aspect of stent designs to be studied in details. Six virtual stents with different strut cross-section are designed for deployments in the same ideal arterial model. Computational fluid dynamics(CFD) methods are performed to study how the shape and the aspect ratio(AR) of strut cross-section modified the local hemodynamics in the stented segments. The results indicate that stents with different strut cross-sections have different influence on the hemodynamics. Stents with streamlined cross-sectional struts for circular arc or elliptical arc can significantly enhance wall shear stress(WSS) in the stented segments, and reduce the flow disturbances around stent struts. The performances of stents with streamlined cross-sectional struts are better than that of stents with non-streamlined cross-sectional struts for rectangle. The results also show that stents with a larger AR cross-section are more conductive to improve the blood flow. The present study provides an understanding of the flow physics in the vicinity of stent struts and indicates that the shape and AR of strut cross-section ought to be considered as important factors to minimize flow disturbance in stent designs. | JIANG Yongfei ZHANG Jun ZHAO Wanhua | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 2 |
| 13 | The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis显示文摘Circular RNAs(circRNAs)regulate gene expression and participate in various biological and pathological processes.However,little is known about the effects of specific circRNAs on T helper cell 17(Th17)differentiation and related autoimmune diseases,such as multiple sclerosis(MS).Here,using transcriptome microarray analysis at different stages of experimental autoimmune encephalomyelitis(EAE),we identified the EAE progression-related circINPP4B,which showed upregulated expression in Th17 cells from mice with EAE and during Th17 differentiation in vitro.Silencing of circINPP4B inhibited Th17 differentiation and alleviated EAE,characterized by less demyelination and Th17 infiltration in the spinal cord.Mechanistically,circINPP4B served as a sponge that directly targeted miR-30a to regulate Th17 differentiation.Furthermore,circINPP4B levels were associated with the developing phases of clinical relapsing-remitting MS patients.Our results indicate that circINPP4B plays an important role in promoting Th17 differentiation and progression of EAE by targeting miR-30a,which provides a potential diagnostic and therapeutic target for Th17-mediated MS. | Jingjing Han Wei Zhuang Wanhua Feng Fuxing Dong Fang Hua Ruiqin Yao Xuebin Qu | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 14 | Vanadyl ions binding to GroEL (HSP60) and inducing its depolymerization显示文摘Several vanadium compounds have been known for the hypoglycemic and anticancer effects. However, the mechanisms of the pharmacological and toxicological effects were not clear. In this work, we in- vestigated the potential targets of vanadium in mitochondria. Vanadyl ions were found to bind to mi- tochondria from rat liver with a stoichiometry of 244±58 nmol/mg protein and an apparent dissocia- tion constant (Kd) of (2.0±0.8)×10·16 mol/L. Using size exclusion chromatography, a vanadium-binding protein was isolated and identified to be the 60-kDa heat shock protein (HSP60) by mass spectrometry analysis and immunoassays. Additionally, binding of vanadyl ions was found to result in depolymeri- zation of homo-oligomeric HSP60 (GroEL). HSP60 is an indispensable molecular chaperone and in- volved in many kinds of pathogenesis of inflammatory and autoimmune diseases, e.g. type 1 diabetes. Our results suggested that HSP60 could be a novel important target involved in the biological and/or toxicological effects of vanadium compounds. | LEI WanHua LIU HuiXue ZHONG LiJun YANG XiaoDa WANG Kui | 2007 | Chinese Science Bulletin2007，52，20： | 2 |
| 15 | Orthogonal tests of copper-clad aluminum bimetal continuous casting by nitrogen pressure core-illing显示文摘To provide theoretical basis and practical guidance for preparing composite rods by direct continuous casting, copper-clad aluminum composite rods of external copper layer diameter 12 mm and inner aluminum core diameter 8 mm were manufactured. Orthogonal tests consisted of three factors and three levels were carried out to research the effects of melting copper temperature, continuous casting speed and nitrogen pressure on the performance of composite rods. Results showed that nitrogen pressure is the most important factor in influencing the surface quality; continuous casting speed is the most important factor in influencing copper & aluminum inter diffusion amount. Nitrogen pressure can noticeably improve the surface quality and make the rods easily be drawn out, but the surface quality does not show visible improvement when the nitrogen pressure is above 0.05 MPa. Measured by tests, the compound layer can be divided into three types according to its cladding layer degree: deficient cladding, normal cladding and excess cladding. The diameter of normal copper-clad aluminum composite rods can be successfully drawn less than 0.6 mm without annealing. | Xue Zhiyong Liang He Yu Wanhua Wu Chunjing | 2013 | China Foundry2013，10，6： | 2 |
| 16 | Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China显示文摘 | Yang Liu Xinyu Ye Hong Zhang Xiaogang Xu Wanhua Li Demei Zhu Minggui Wang | 2010 | Diagnostic Microbiology & Infectious Disease2010，，4： | 2 |
| 17 | TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c‐Kit<sup>+</sup> cardiac stem cells in ischemic heart disease显示文摘 | Rafia S. Al‐Lamki Wanhua Lu Jun Wang Jun Yang Timothy J. Sargeant Richard Wells Chenqu Suo Penny Wright Martin Goddard Qunhua Huang Amir H. Lebastchi George Tellides Yingqun Huang Wang Min Jordan S. Pober John R. Bradley | 2013 | Stem Cells2013，，9： | 1 |
| 18 | Development and calibration of a reduced chemical kinetic model of n-heptane for HCCI engine combustion 显示文摘 | Su Wanhua Huang Haozhong | 2005 | Fuel2005，，84： | 1 |
| 19 | Effects of Heat Release Mode on Emissions and Efficiency of a Compound Homogeneous Charge Compression Ignition Combustion Engine显示文摘 | Su Wanhua Zhang Xiaoyu Lin Tiejian | 2006 | Journal of Engineering for Gas Turbines and Power2006，128，4： | 1 |
| 20 | Over-expression of miR-125a-5p inhibits proliferation in C2C12 myoblasts by targeting E2F3显示文摘MicroRNAs miRNAs 是在长度的 2025 核苷酸的小非编码的 RNA 的一个班。miRNAs 在房间的许多类型的增长起重要作用,这被显示出,包括 myoblasts。在这研究,我们使用了即时量的聚合酶链反应,西方的弄污,在 C2C12 myoblasts 的增长期间探索 miR-125a-5p 的角色的 EdU,流动 cytometry,和 CCK-8 试金。miR-125a-5p 的表示在 C2C12 myoblast 增长期间被减少,这被发现。miR-125a-5p 的在表示上禁止了由 EdU 染色,流动 cytometry,和 CCK8 试金显示了的 C2C12 myoblast 增长。miR-125a-5p 能否定地在 posttranscriptional 水平调整 E2F3 表示,这也被发现,经由在 3 untranslated 区域的一个特定的目标地点。显示出的 E2F3 击倒 C2C12 myoblast 增长上的类似的禁止的效果。因此,我们的调查结果建议 miR-125a-5p 可以由指向 E2F3 充当 C2C12 myoblast 增长的一个否定管理者。 | Chengchuang Song Guofang Wu Aoqi Xiang Qiangling Zhang Wanhua Li Gongshe Yang Xin'e Shi Shiduo Sun Xiao Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员