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| 1 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 2 | Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells显示文摘 | Kylie Su Mei Yong Choong Tat Keng Shu Qi Tan Eva Loh Kenneth TE Chang Thiam Chye Tan Wanjin Hong Qingfeng Chen | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 3 | Effects of leaning and curving of blades with high turning angles on the aerodynamic characteristics of turbine rectangular cascades显示文摘 | HAN Wanjin TAN Chunqing SHI Hong | 1994 | Journal of Turbomachinery1994，116，3： | 1 |
| 4 | ECT2 regulates the Rho/ERK signalling axis to promote early recurrence in human hepatocellular carcinoma显示文摘 | Jianxiang Chen Hongping Xia Xiaoqian Zhang Sekar Karthik Seshachalam Veerabrahma Pratap London Lucien Ooi Wanjin Hong Kam M. Hui | 2015 | Journal of Hepatology2015，，： | 1 |
| 5 | VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis显示文摘 | Cosen-Binker Laura I Binker Marcelo G Wang Cheng-Chun Hong Wanjin Gaisano Herbert Y | 2008 | Journal of Clinical Investigation2008，，： | 1 |
| 6 | Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1 显示文摘 | Zeng Qi Hong Wanjin Tan YH | 1998 | Biochem Biophys Res Commun1998，244，2： | 1 |
| 7 | Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response显示文摘RIPK1 is a master regulator of multiple cell death pathways,including apoptosis and necroptosis,and inflammation.Importantly,activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis,in animal models of amyotrophic lateral sclerosis(ALS)and Alzheimer's disease(AD),and in human ALS and AD.Rare human genetic carriers of non-cleavable RIPK1 variants(D324V and D324H)exhibit distinct symptoms of recurrent fevers and increased transcription of proinflammatory cytokines.Multiple RIPK1 inhibitors have been advanced into human clinical trials as new therapeutics for human inflammatory and neurodegenerative diseases,such as ALS and AD.However,it is unclear whether and how RIPK1 kinase activity directly mediates inflammation independent of cell death as the nuclear function of RIPK1 has not yet been explored.Here we show that nuclear RIPK1 is physically associated with the BAF complex.Upon RIPK1 activation,the RIPK1/BAF complex is recruited by specific transcription factors to active enhancers and promoters marked by H3K4me1 and H3K27ac.Activated nuclear RIPK1 mediates the phosphorylation of SMARCC2,a key component of the BAF complex,to promote chromatin remodeling and the transcription of specific proinflammatory genes.Increased nuclear RIPK1 activation and RIPK1/BAF-mediated chromati n-remodeling activity were found in cells expressi ng non-cleavable RIPK1,and in creased enrichment of activated RIPK1 on active enhancers and promoters was found in an animal model and human pathological samples of ALS.Our results suggest that RIPK1 kinase serves as a transcriptional coregulator in nucleus that can transmit extracellular stimuli to the BAF complex to modulate chromatin accessibility and directly regulate the transcription of specific genes involved in mediating inflammatory resp onses. | Wanjin Li Bing Shan Chengyu Zou Huibing Wang Meng-Meng Zhang Hong Zhu Masanori Gomi Naito Daichao Xu Vica Jean Manuel Lauren Mifflin Zhaodong Hou John Ravits Junying Yuan | 2022 | Cell Research2022，32，7： | 1 |
| 8 | Combating COVID-19 with Chloroquine显示文摘Since December 2019,the world is increasingly facing an unprecedented challenge by coronavirus disease 2019(COVID-19)caused by a virus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is structurally related to the human severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syn-drome CoV(MERS-CoV)(Zhu et al.,2020).The World Health Organization(WHO)has declared COVID-19 a pandemic and is calling for forceful action from all countries,as the number of infected patients and the number of deaths are increasing daily,causing catastrophic consequence to the daily life,economy,and society. | Wanjin Hong | 2020 | Journal of Molecular Cell Biology2020，12，4： | 1 |
| 9 | Rab7: Role of its protein interaction cascades in endo-lysosomal traffic显示文摘 | Tuanlao Wang Zhang Ming Wu Xiaochun Wanjin Hong | 2010 | Cellular Signalling2010，，3： | 1 |
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