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| 1 | Novel fluorescent probes of 10-hydroxyevodiamine:autophagy and apoptosis-inducing anticancer mechanisms显示文摘Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. | Shuqiang Chen Guoqiang Dong Shanchao Wu Na Liu Wannian Zhang Chunquan Shengn | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
| 2 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 3 | Radiosensitization of human pancreatic cancer by piperlongumine analogues显示文摘Radiotherapy is commonly used to treat advanced pancreatic cancers and can improve survival by2 months in combination with gemcitabine.However,prognosis and survival improvement remain unsatisfactory,and effective therapies are urgently needed.Piperlongumine has been demonstrated to have therapeutic potentials against various cancers.In this study,we synthesized a series of piperlongumine derivatives and provided evidence that piperlongumine derivatives could be used as effective radiosensitizers in pancreatic cancer.Two compounds enhanced the radiosensitivity of Panc-1 and SW1990 cells.In a pancreatic bi-flank xenograft tumor model,they significantly inhibited tumor growth.Piperlongumine derivatives could induce reactive oxygen species(ROS)expression and regulate the Keapl-Nrf2 protective pathway with enhancement of radiation-induced DNA damage,G2/M-phase cell cycle arrest,and apoptosis.Collectively,our data offer a proof of concept for the use of piperlongumine derivatives as a novel class of radiosensitizers for the treatment of pancreatic cancer. | Hao Ma Yuelin Wu Wannian Zhang Huojun Zhang Zhenyuan Miao Chunlin Zhuang | 2021 | Chinese Chemical Letters2021，32，3： | 4 |
| 4 | Immunohistochemical localization of Ca^(2+)/calmodulin-dependent kinase in tobacco显示文摘The existence of Ca2+/calmodulin-dependent kinase (CaM kinase, CaMK) in tobacco is verified immuno-logically and its distribution in different tissues of tobacco is studied. It has been demonstrated that CaMK is mainly distributed in early developing anthers, developing ovules and embryos, lateral root primordium, apical meristem and leaf primordium of buds and mesophyll cells and developing vascular bundles of leaves. There is enormous CaM kinase distributed in leaf epidermis fair cells and guard cells of stomas too. Little kinase is found in mature stem or root cells. The distribution properties of CaM kinase in tobacco are consistent with those of CaM, suggesting that there exists the Ca2+ signal transduction pathway mediated by CaM kinase in tobacco and it plays an important role in the plant growth and development. | YANG Wannian, LIANG Shuping & LU YingtangCenter of Developmental Biology, College of Life Science, Wuhan University, Wuhan 430072, China | 2001 | Chinese Science Bulletin2001，46，3： | 4 |
| 5 | Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer显示文摘Eight new water-soluble amino acid conjugates 6 a-h of chlorin p6 ethers(5 a-d) were synthesized and preliminarily investigated for their in vitro PDT antitumor activity and structure-activity relationship(SAR). The results showed that all compounds exhibited much higher phototoxicity against tumor cells than talaporfin. SAR analysis indicated that PDT antitumor effect enhanced with the increase of carbon chain length of alkoxyl ether bonds at 3~1-position, and L-aspartic acid was superior to L-glutamic acid. In particular, the IC_50 values of most phototoxic compound 6 d were 0.20 mmol/L against A549 cell and0.41υmmol/L against B16-F10 cell, which individually represented 31-and 24-fold increase of antitumor potency compared to talaporfin, suggesting that it was a promising candidate photosensitizer(PS) for PDT applications due to its strong absorption at long wavelength, high phototoxicity, low dark cytotoxicity and good water-solubility. | Xingjie Zhang Zhi Meng Zhiqiang Ma Junhong Liu Guiyan Han Fujia Ma Ningyang Jia Zhenyuan Miao Wannian Zhang Chunquan Sheng Jianzhong Yao | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 6 | Persevere in the Dynamic COVID-Zero Strategy in China to Gain a Precious Time Window for the Future显示文摘According to the report of the World Health Organization(WHO),as of April 20,2022,the cumulative number of confirmed cases of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in the world had exceeded 500 million,with 6.20 million deaths and over 580,000 new confirmed cases on that day(1).As many countries have announced to relax quarantine policies,China is facing increasing pressure from overseas imports.All 31 provincial-level administrative divisions(PLADs)of China have reported a total of 191,112 local confirmed cases,with 2,761 new confirmed cases,17,166 new asymptomatic infections,and 7 new deaths(all in Shanghai Municipality)on April 19(2).Recently,several local outbreaks in clusters have appeared in China,presenting a grim and complex situation with multiple spots,wide coverage,and frequent occurrence(3). | Jue Liu Min Liu Wannian Liang | 2022 | China CDC weekly2022，4，18： | 3 |
| 7 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 8 | 基于混合PN/肖特基结构的新一代600V SiC肖特基二极管显示文摘第二代碳化硅(SiC)肖特基二极管——thinQ!2G是由一个肖特基结构和一个与它平行的独特的低电阻PN结组成,因此具备更加强大的浪涌电流处理能力,同时又继承了第一代碳化硅肖特基二极管所实现的良好的动态性能。 | Peter Wannian Huang Junyang Luo | 2006 | 电子设计技术 EDN CHINA2006，13，11： | 1 |
| 9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives显示文摘 | Yulan Xu Chunquan Sheng Wenya Wang Xiaoying Che Yongbing Cao Guoqiang Dong Shengzheng Wang Haitao Ji Zhenyuan Miao Jianzhong Yao Wannian Zhang | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，9： | 1 |
| 10 | Emergency medical rescue efforts after a major earthquake: lessons from the 2008 Wenchuan earthquake显示文摘 | Lulu Zhang Xu Liu Youping Li Yuan Liu Zhipeng Liu Juncong Lin Ji Shen Xuefeng Tang Yi Zhang Wannian Liang | 2012 | The Lancet2012，，9818： | 1 |
| 11 | Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy显示文摘Receptor-interacting protein(RIP)kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis(UC)by regulating necroptosis and inflammation.Our group previously identified TAK-632(5)as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3.In this study,using ligand-based substituent-anchoring design strategy,we focused on the benzothiazole ring to obtain a series of TAK-632 analogues showing significantly improving on the anti-necroptosis activity and RIP1 selectivity over RIP3.Among them,a conformational constrained fluorine-substituted derivative(25)exhibited 333-fold selectivity for RIP1(K_(d)= 15 nmol/L)than RIP3(K_(d)>5000 nmol/L).This compound showed highly potent activity against cell necroptosis(EC_(50)=8 nmol/L)and systemic inflammatory response syndrome(SIRS)induced by TNF-α in vivo.Especially,it was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of UC.Taken together,the highly potent,selective,orally active anti-necroptosis inhibitor represents promising candidate for clinical treatment of UC. | Jing Zhu Meng Xin Congcong Xu Yuan He Wannian Zhang Zhibin Wang Chunlin Zhuang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 12 | The total chromatic number of regular graphs of high degree显示文摘The total chromatic number χT (G) of a graph G is the minimum number of colors needed to color the edges and the vertices of G so that incident or adjacent elements have distinct colors. We show that if G is a regular graph and d(G) 32 |V (G)| + 263 , where d(G) denotes the degree of a vertex in G, then χT (G) d(G) + 2. | XIE DeZheng YANG WanNian | 2009 | Science China Mathematics2009，52，8： | 1 |
| 13 | Asymmetric Synthesis, Antifungal Activity and Molecular Modeling of Iodiconazole Isomers显示文摘Iodiconazole 是在它的外消旋的形式被开发的一个新奇抗真菌的代理人。为了在 iodiconazole 的抗真菌的活动, R 异构体和 S 异构体调查 chiral 中心的效果,根据不对称的 Sharpless epoxidation 被准备。(S)-Iodiconazole 被证明比(R) 异构体举办更好抗真菌的活动。有 lanosterol 14-demethylase 的二异构体的有约束力的模式被分子的停靠澄清。 | Yongqiang Zhang ShengzhengWang Zhenyuan Miao Jianzhong Yao Wannian Zhang Chunquan Sheng | 2013 | Chinese Journal of Chemistry2013，31，9： | 1 |
| 14 | Trends of SARS-CoV-2 Infection in Rural Area in Sentinel Community-Based Surveillance——China,December 2022 to January 2023显示文摘Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and evaluate trends of SARS-CoV-2 infection in rural China among the community population.Methods:Data on SARS-CoV-2 infection among approximately 90,000 participants in rural China were collected by the National Sentinel Community-Based Surveillance(NSCS)system.Participants were tested for SARS-CoV-2 infection(defined as positive for SARS-CoV-2 nucleic acid or antigen)twice weekly from December 16,2022 to January 12,2023.The daily average of newly positive rate and its estimated daily percentage change were calculated to describe the national and regional trends of SARS-CoV-2 infection in rural China.Results:In rural China,the daily average new positive rate of SARS-CoV-2 infection peaked at 4.79%between December 20–22,2022 and then decreased to 0.57%between January 10–12,2023,with an average decrease of 29.95%per round.The peak of new SARS-CoV-2 infection was slightly earlier and lower in North China(5.28%between December 20–22,2022)than in South China(5.63%between December 23–26,2022),and then converged from December 30,2022 to January 2,2023.The peak of 6.09%occurred between December 20–22,2022 in eastern China,while the peak of 5.99%occurred later,between December 27–29,2022,in central China.Conclusions:Overall,the epidemic wave in rural China peaked between December 20–22,2022,and passed quickly following the optimization of prevention and control measures.Currently,SARSCoV-2 infection in community populations in rural China is sporadic. | Wenzhan Jing Fan Ding Yanping Zhang Guoqing Shi Jue Liu Yu Wu Fangyuan Li Wenxin Yan Chenyuan Qin Min Liu Qun Li Wannian Liang | 2023 | China CDC weekly2023，5，11： | 1 |
| 15 | The Dynamic COVID-Zero Strategy in China显示文摘Since its outbreak in late 2019,coronavirus disease 2019(COVID-19)has remained a global pandemic for nearly two years,which poses a huge test on the resilience of global public health system(1).After experiencing the large-scale epidemic in February 2020,China has entered a normalization stage of prevention and control since May 2020(2).In response to the spread of the highly transmissible Delta variant,China adopted a new strategy called“Dynamic COVID-zero”from August 2021.This strategy is a summary of China’s experience in dealing with the spread of the Delta variant,considering how to control the epidemic at a higher level,at a lower cost,and in a shorter time(3).The most important purpose is to minimize the impact of the epidemic on the economy,society,production,and people’s normal lives,and to balance the prevention and control of this disease with socioeconomic stability.For instance,multiple outbreaks that occurred in Beijing were controlled in 2 maximum incubation periods(within 28 days)by this strategy(Figure 1). | Jue Liu Min Liu Wannian Liang | 2022 | China CDC weekly2022，4，4： | 1 |
| 16 | Prevalence and Factors Associated With CKD: A Population Study From Beijing显示文摘 | LuXia Zhang PuHong Zhang Fang Wang Li Zuo Ying Zhou Ying Shi Gang Li ShuFang Jiao ZeJun Liu WanNian Liang HaiYan Wang | 2008 | American Journal of Kidney Diseases2008，，3： | 1 |
| 17 | Constructing virtual combinatorial fragment libraries based upon MDL Drug Data Report database显示文摘Structural analysis of known drugs or drug-like compounds provides important information for drug design. The 142553 drug molecules in the MDL Drug Data Report database were analyzed, and then the common structural features were extracted. According to the common structural features, drug molecules were segmented into 32017 fragments, including 13642 ring fragments, 10076 linker fragments, and 8299 side chain fragments. These fragments were further used to establish three types of virtual combinatorial fragment libraries: a basic framework library containing 13574 rings; a linker library of 8051 linkers and a pharmacophore library of 34244 fragments combined by rings and side chains. After energy minimization, all fragments in the above three libraries maintain reasonable geometrical features and spatial conformations, and would be useful for building a virtual combinatorial database and de novo drug design. | ZHANG Min SHENG ChunQuan XU Hui SONG YunLong ZHANG WanNian | 2007 | Science China Chemistry2007，50，3： | 1 |
| 18 | A three-Dimensional model of lanosterol 14α-demethylase of Candida albicans and its interaction with azole antifungal显示文摘 | Zhang Wannian Zhou Youjun | 2000 | J Med chem2000，43，13： | 1 |
| 19 | New homocamptothecins:synthesis,antitumor activity,and molecular modeling显示文摘 | Miao ZhenYuan Sheng ChunQuan Zhang WanNian | 2008 | Bioorg Med Chem2008，16，3： | 1 |
| 20 | Nutritional evaluation,fatty acid analysis and anticancer properties investigation of seeds from kan-zaw,a potential diet oil and medicinal plant显示文摘Payenapara lleloneura Kurz.(Kan-zaw),an endemic medicinal plant only found in Tanintharyi Region of Myanmar,is widely used in the treatment of various cancer and different ailments.In the present research,the seeds were phytochemical investigated for their nutritional potential for their use as functional foods or novel diet oil resources.Nutritional evaluation showed that the seeds are rich in fats and carbohydrates(soluble sugars and starch).Fatty acid analyses showed that the seeds accumulate very richα-eleostearic acid(α-ESA,18:3^(Δ9 cis,11-trans),13 trans),an important conjugated fatty acid,up to more than 70% of total fatty acids.The seed oil derived from the Kan-zaw tree contains approximately 3.25% β-eleostearic acid(18:3^(Δ9 trans,11 trans,13 trans)),an unusual conjugated fatty acid that imparts a potent anticancer application and industrially important drying qualities to Kan-zaw oil.Physicochemical properties of the Kan-zaw seeds were examined;petroleum ether(60–90℃)extract of seed oils were also investigated for the saponification value,iodine value and estimation of acid value.Further,the present study investigated cytotoxic potential of ethanol,methanol,acetone,chloroform Kan-zaw seed extracts and commercial Kan-zaw oil against human cervical cancer cell line(HeLa).The Kan-zaw extracts and oil have shown significant anticancer activity on HeLa cells. | Moe Moe Lwin Ye Jin Xianpeng Yang Hao Shen Chao Qi Yizhong Wang Phyo Phyo Zin Oo Za Khai Tuang Shiyou Lü Wannian Yang | 2021 | Oil Crop Science2021，6，3： | 0 |
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