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25篇 您的检索式：作者名="Ward KE"

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	题名	作者	年代	出处	被引量
1	Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly显示文摘Error-free cell division depends on the accurate assembly of the spindle midzone from dynamic spindle microtubules to ensure chromatid segregation during metaphase-anaphase transition.However,the mechanism underlying the key transition from the mitotic spindle to central spindle before anaphase onset remains elusive.Given the prevalence of chromosome instability phenotype in gastric tumorigenesis,we developed a strategy to model context-dependent cell division using a combination of light sheet microscope and 3D gastric organoids.Light sheet microscopic image analyses of 3D organoids showed that CENP-E inhibited cells undergoing aberrant metaphase-anaphase transition and exhibiting chromosome segregation errors during mitosis.Highresolution real-time imaging analyses of 2D cell culture revealed that CENP-E inhibited cells undergoing central spindle splitting and chromosome instability phenotype.Using biotinylated syntelin as an affinity matrix,we found that CENP-E forms a complex with PRC1 in mitotic cells.Chemical inhibition of CENP-E in metaphase by syntelin prevented accurate central spindle assembly by perturbing temporal assembly of PRC1 to the midzone.Thus,CENP-E-mediated PRC1 assembly to the central spindle constitutes a temporal switch to organize dynamic kinetochore microtubules into stable midzone arrays.These findings reveal a previously uncharacterized role of CENP-E in temporal control of central spindle assembly.Since CENP-E is absent from yeast,we reasoned that metazoans evolved an elaborate central spindle organization machinery to ensure accurate sister chromatid segregation during anaphase and cytokinesis.	Xu Liu Leilei Xu Junying Li Phil Y.Yao Wanjuan Wang Hazrat Ismail Haowei Wang Bryce Liao Zhihong Yang Tarsha Ward Ke Ruan Jianchun Zhang Quan Wu Ping He Xia Ding Dongmei Wang Chuanhai Fu Zhen Dou Feng Yan Wenwen Wang Xing Liu Xuebiao Yao	2020	Journal of Molecular Cell Biology2020，12，8：	3
2	Pulmonary autograft in children: realized growth potential显示文摘	Elkins RC Knott- Craig CJ Ward KE	1994	Ann Thorac Surg1994，57，6：	1
3	C2 domain membrane penetration by group IV A cytosolic phospholipase A2 induces membrane curvature changes显示文摘	Ward KE Ropa JP Adu-Gyamfi E	2012	J Lipid Res2012，53，12：	1
4	Neonatal repair of Ebstein's anomaly : indications, surgical technique, and medium- term follow-up显示文摘	Knott-Craig CJ Overholt El) Ward KE	2000	Ann Thorac Surg2000，69，：	1
5	Eosinophilic bronchitis is animportant cause of chronic cough显示文摘	Brightling CE Ward R Goh KE et at	1999	Am J Respir Crit Care Med1999，160，：	1
6	Repair of Ebstein anomaly in the symptomatic neonate : an evolution of technique with 7-year follow-up 显示文摘	Knott-Craig CJ Overholt ED Ward KE	2002	Ann Thorac Surg2002，73，：	1
7	Complete repair of Eb- stein anomaly in neonates and young infants: a 16-year follow-up 显示文摘	Boston US Goldberg SP Ward KE	2011	J Thorac Cardiovasc Surg2011，141，：	1
8	C2 domain membrane penetration by group IVA cytosolic phos- pholipase A2 induces membrane curvature change显示文摘	Ward KE Ropa JP Adu-Gyamfi E	2012	J Lipid Res2012，53，12：	1
9	The rhythm of the heart in active elderly subjects 显示文摘	Carom AJ Evans KE Ward DE	1980	American heart journal1980，99，5：	1
10	An evaluation of sex diffe- rences in psychological and physiological responses to ex- perimentally-induced pain: a path analytic description显示文摘	Dixon KE Thorn BE Ward LC	2004	Pain2004，112，12：	1
11	Clinical implications of vancomycin heteroresistant and intermediately susceptible Staphylococcus aureus显示文摘	Gomes DM Ward KE LaPlante KL	2015	Pharmacotherapy2015，35，4：	1
12	Pulmonary autograft in children:realized growth potential显示文摘	Elkins RC Knott-Craig CT Ward KE	1994	Ann Thorac Surg1994，57，：	1
13	Severe adverse skin reactions to nonsteroidal antiinflammatory drugs:A review of the literature显示文摘	Ward KE Archambault R Mersfelder TL	2010	Am J Health Syst Pharm2010，67，3：	1
14	Depsone-induced methemoglobinemia显示文摘	KE Ward Me Carthy	1998	The annals of pharmacotherapy1998，32，5：	1
15	Pulmonary autograft in children:realized growth potential显示文摘	Elkins RC Knott-craig CJ Ward KE	1994	Ann Thorac Surg1994，57，6：	1
16	The rhythm of the heart in active elderly subjects显示文摘	Evans KE Ward DE	1980	Am Heart J1980，99，：	1
17	Transseptal decompression of the left heart during ECMO for severe myocarditis显示文摘	Ward KE Tuggle DW Gessouroun MR	1995	Ann Thorac Surg1995，59，3：	1
18	Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism显示文摘	Feng JQ Ward LM Liu S Lu Y Xie Y Yuan B Yu X Rauch F Davis SI Zhang S Rios H Drezner MK Quarles LD Bonewald LF White KE		0，，：	1
19	The rhythm of the heartin active elderly subjects 显示文摘	Carom AJ Evans KE Ward DE	1980	Am Heart J1980，99，5：	1
20	Repair of Ebstein's anomaly in the symptomatic neonate:an evolution of technique with 7 -year follow-up显示文摘	Knott-Craig CJ Overholt ED Ward KE	2002	Ann Thorac Surg2002，73，17：	1

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