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| 1 | Cancer Transmission From Organ Donors—Unavoidable But Low Risk显示文摘 | Rajeev Desai Dave Collett Christopher J. Watson Philip Johnson Tim Evans James Neuberger | 2012 | Transplantation Journal2012，，12： | 2 |
| 2 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 3 | Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex显示文摘 | Watson FL Heerssen tiM Moheban DB | 1999 | J Neurosci1999，19，18： | 1 |
| 4 | Argon plasma coagulation ablation versus endoscopic surveillance of Barrett’s esophagus: late outcomes from two randomized trials显示文摘 | Corina Sie Tim Bright Mark Schoeman Philip Game William Tam Peter Devitt David Watson | 2013 | Endoscopy2013，，： | 1 |
| 5 | Associations between meeting 24-hour movement guidelines and academic achievement in Australian primary school-aged children显示文摘Background:Few studies have investigated associations between academic achievement and meeting recommendations from the 24-hour(24-h)movement guidelines.The specific guidelines associated with the most benefit academic achievement are unknown.Utilizing both self-report and objective movement data,this study examined associations between academic achievement and meeting individual recommendations and combinations of recommendations from the 24-h movement guidelines(sleep,physical activity,and screen time).Methods:Data from CheckPoint,a cross-sectional study nested between Waves 6 and 7 of the Longitudinal Study of Australian Children,were used.Movement behaviors were measured using 24-h wrist-worn accelerometry(GENEActiv(Activinsights,Kimbolton,UK))and were selfreported by children using the Multimedia Activity Recall for Children and Adolescents.Academic achievement was measured using a nationally administered standardized test in literacy and numeracy.Analysis of covariance,with t tests with sequential Bonferroni adjustments,was used to compare academic achievement with all possible combinations of meeting recommendations,adjusting for demographic confounders.Two models were considered:guideline compliance assessed by self-report(n=1270,mean age=11.99 years,52%males)and by accelerometry(for moderate-to-vigorous intensity physical activity(MVPA)and sleep))and self-report(screen time)in combination(n=927,mean age=11.97 years,52%males).Results:Literacy achievement significantly differed based on self-report(F_((7,1258))=3.08,p=0.003)and accelerometer derived(F_((7,915))=2.40,p=0.02)guideline compliance.Numeracy achievement significantly differed based on self-report(F_((7,1258))=2.92,p=0.005)but not accelerometer derived guideline compliance(F_((7,915))=0.80,p=0.58).When assessed by self-report,children who met all guidelines(t_((334))=-4.05,p=0.0001)or met the screen time and sleep guidelines in combination(t_((125))=-5.02,p<0.001)had superior literacy achievement.Meeting the self-report MVPA guideline in any combination was associated with higher numeracy scores(p<0.05).Post-hoc analyses showed no differences in academic achievement for any category of accelerometer derived guideline compliance.Conclusion:The findings suggest that limiting recreational screen time is important for literacy achievement and that encouraging compliance with the MVPA guideline is important for numeracy achievement. | Amanda Watson Dorothea Dumuid Carol Maher Tim Olds | 2022 | Journal of Sport and Health Science2022，11，4： | 1 |
| 6 | Structural Monitoring of Cable-stayed Bridge:Analysis of GPS versus Modeled Deflections显示文摘 | Watson Christopher Watson Tim Coleman Richard | 2007 | Journal of Survering Engineering2007，，133： | 1 |
| 7 | Monitoring systemic donor lymphocyte macrochimerism to aid the diagnosis of graftversus-host disease after liver transplantation显示文摘 | Anna L. Taylor Paul Gibbs Surendran Sudhindran Tim Key Reyna S. Goodman C. Helen Morgan Christopher J. E. Watson Luc Delriviere Graeme J. Alexander Neville V. Jamieson J. Andrew Bradley Craig J. Taylor | 2004 | Transplantation2004，，3： | 1 |
| 8 | Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke: Real-World Experience and a Call for Action显示文摘 | Rohit Bhatia Michael D. Hill Nandavar Shobha Bijoy Menon Simerpreet Bal Puneet Kochar Tim Watson Mayank Goyal Andrew M. Demchuk | 2010 | Stroke2010，，10： | 1 |
| 9 | Fuel-cycle greenhouse gas emissions from alternative fuels in Australian heavy vehicles显示文摘 | Tom Beer Tim Grant David Williams Harry Watson | 2002 | Atmospheric Environment2002，，4： | 1 |
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