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| 1 | Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease显示文摘Forest bathing trip is a short,leisurely visit to forest.In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease(COPD).The patients were randomly divided into two groups.One group was sent to forest,and the other was sent to an urban area as control. | JIA Bing Bing YANG Zhou Xin MAO Gen Xiang LYU Yuan Dong WEN Xiao Lin XU Wei Hong LYU XIAO Ling CAO Yong Bao WANG Guo Fu | 2016 | Biomedical and Environmental Sciences2016，29，3： | 15 |
| 2 | A New Alkaloid from the Root of Isatis indigotica Fort显示文摘A E-2-[(3’-indole)cyanomethylene]-3-indolinone was isolated from the root of Isatis indigotica Fort. The structure elucidation and 1H, 13C NMR assignments were achieved by spectroscopic method. | Wan Sheng CHEN*, Bin LI, Wei Dong ZHANG, Gen Jing YANG, Chuan Zhuo QIAO Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433 | 2001 | Chinese Chemical Letters2001，12，6： | 11 |
| 3 | Alkaloids from Isatis indigotica显示文摘Isaindigotone 1 and 3-(2’-hydroxyphenyl)-4(3H)-quinazolinone 2 were isolated from the roots of Isatis indigotica. Compound 1 was elucidated as a new alkaloid.Compound 2 was discovered for the first time from a natural | Ke Min DENG Xiao Yun WU Gen Jin YANG and Guo Wei QIN (Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031) (School of Pharmacy, Second Military Medical University, Shanghai 200433) ( Visiting scholar from Dept. of Chemistr | 1997 | Chinese Chemical Letters1997，8，3： | 9 |
| 4 | Soluble Nogo receptor 1 fusion protein protects neural progenitor cells in rats with ischemic stroke显示文摘Soluble Nogo66 receptor-Fc protein(sNgR-Fc)enhances axonal regeneration following central nervous system injury.However,the underlying mechanisms remain unclear.In this study,we investigated the effects of sNgR-Fc on the proliferation and differentiation of neural progenitor cells.The photothrombotic cortical injury model of ischemic stroke was produced in the parietal cortex of Sprague-Dawley rats.The rats with photothrombotic cortical injury were randomized to receive infusion of 400μg/kg sNgR-Fc(sNgR-Fc group)or an equal volume of phosphate-buffered saline(photothrombotic cortical injury group)into the lateral ventricle for 3 days.The effects of sNgR-Fc on the proliferation and differentiation of endogenous neural progenitor cells were examined using BrdU staining.Neurological function was evaluated with the Morris water maze test.To further examine the effects of sNgR-Fc treatment on neural progenitor cells,photothrombotic cortical injury was produced in another group of rats that received transplantation of neural progenitor cells from the hippocampus of embryonic Sprague-Dawley rats.The animals were then given an infusion of phosphate-buffered saline(neural progenitor cells group)or sNgR-Fc(sNgR-Fc+neural progenitor cells group)into the lateral ventricle for 3 days.sNgR-Fc enhanced the proliferation of cultured neural progenitor cells in vitro as well as that of endogenous neural progenitor cells in vivo,compared with phosphate-buffered saline,and it also induced the differentiation of neural progenitor cells into neurons.Compared with the photothrombotic cortical injury group,escape latency in the Morris water maze and neurological severity score were greatly reduced,and distance traveled in the target quadrant was considerably increased in the sNgR-Fc group,indicating a substantial improvement in neurological function.Furthermore,compared with phosphate-buffered saline infusion,sNgR-Fc infusion strikingly improved the survival and differentiation of grafted neural progenitor cells.Our findings show that sNgR-Fc regulates neural progenitor cell proliferation,migration and differentiation.Therefore,sNgR-Fc is a potential novel therapy for stroke and neurodegenerative diseases,The protocols were approved by the Committee on the Use of Live Animals in Teaching and Research of the University of Hong Kong(approval No.4560-17)in November,2015. | Hai-Wei He Yue-Lin Zhang Bao-Qi Yu Gen Ye Wei You Kwok-fai So Xin Li | 2019 | Neural Regeneration Research2019，14，10： | 6 |
| 5 | Hollow spherical rare-earth-doped yttrium oxysulfate: A novel structure for upconversion显示文摘锻烧跟随的一条灵巧的 帮助biomolecule 的热水的线路为空范围与另外的稀土元素的离子做了的单斜晶的钇 oxysulfate 的准备被采用了( Yb <啜class=“ a-plus-plus ”>3+和 Eu <啜class=“ a-plus-plus ”>3+或嗯<啜class=“ a-plus-plus ”>3+)。空范围的形成可以包含 Ostwald 成熟。产生混合材料被用于 upconversion 应用。主人水晶结构允许容易没有显著地改变主人格子,二个不同稀土元素的金属离子共同做。光性质被稀土元素的金属离子由于精力转移和水晶的对称回答的掺杂物的比率和集中影响。光中心的类型和样品的 crystallinity 也被显示在同样准备的产品的光性质上有重要影响。 | Gen Chen Fashen Chen Xiaohe Liu Wei Ma Hongmei Luo Junhui Li Renzhi Ma Guanzhou Qiu | 2014 | Nano Research2014，7，8： | 6 |
| 6 | Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells显示文摘Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced brain injury.Although mesenchymal stem cell therapy has emerged as a novel treatment for this pathology,the mechanisms are not fully understood.To address this issue,we first co-cultured 1.5×10^5 PC12 cells with mesenchymal stem cells that were derived from induced pluripotent stem cells at a ratio of 1:1,and then intervened with cobalt chloride(CoCl2)for 24 hours.Reactive oxygen species in PC12 cells was measured by Mito-sox.Mitochondrial membrane potential(ΔΨm)in PC12 cells was determined by JC-1 staining.Apoptosis of PC12 cells was detected by terminal deoxynucleotidal transferase-mediated dUTP nick end-labeling staining.Mitochondrial morphology in PC12 cells was examined by transmission electron microscopy.Transfer of mitochondria from the mesenchymal stem cells derived from induced pluripotent stem cells to damaged PC12 cells was measured by flow cytometry.Mesenchymal stem cells were induced from pluripotent stem cells by lentivirus infection containing green fluorescent protein in mitochondria.Then they were co-cultured with PC12 cells in Transwell chambers and treated with CoCl2 for 24 hours to detect adenosine triphosphate level in PC12 cells.CoCl2-induced PC12 cell damage was dose-dependent.Co-culture with mesenchymal stem cells significantly reduced apoptosis and restoredΔΨm in the injured PC12 cells under CoCl2 challenge.Co-culture with mesenchymal stem cells ameliorated mitochondrial swelling,the disappearance of cristae,and chromatin margination in the injured PC12 cells.After direct co-culture,mitochondrial transfer from the mesenchymal stem cells stem cells to PC12 cells was detected via formed tunneling nanotubes between these two types of cells.The transfer efficiency was greatly enhanced in the presence of CoCl2.More importantly,inhibition of tunneling nanotubes partially abrogated the beneficial effects of mesenchymal stem cells on CoCl2-induced PC12 cell injury.Mesenchymal stem cells reduced CoCl2-induced PC12 cell injury and these effects were in part due to efficacious mitochondrial transfer. | Yan Yang Gen Ye Yue-Lin Zhang Hai-Wei He Bao-Qi Yu Yi-Mei Hong Wei You Xin Li | 2020 | Neural Regeneration Research2020，15，3： | 6 |
| 7 | A New Alkaloid from Patrinia scabra显示文摘A new alkaloid has been isolated from the root of Patrinia scabra. Its structure was elucidated as 2-acetamido-3-phenyl propyl 2-benzamido-3-phenyl propionate by extensive spectr- oscopic analysis. | Zheng Bing GU*, Gen Jin YANG, Wen Yong LIU, Ting Zhao LI, Yan QIU, Wei Dong ZHANG College of Pharmacy, Second Military Medical University, Shanghai 200433 | 2002 | Chinese Chemical Letters2002，13，10： | 5 |
| 8 | A New Glycoside from Erigeron Breviscapus显示文摘Erigeside I was isolated from Erigeron breviscapus. The structure elucidation and 1H.13C NMR assignments were achieved by spectroscopic method. | Wei Dong ZHANG De Yun KONG Hui Ting LI Gen Jin YANG(Department of Traditional Chinese Medicine. Shanghai Institute ofPharmaceutical Industry. 1320 Beijing Road (w.), Shanghai 200040) | 1999 | Chinese Chemical Letters1999，10，2： | 5 |
| 9 | Catalysis Conversion Methane into C2 Hydrocarbons via Electric Field Enhanced Plasma显示文摘In this paper the effect of catalyst and carrier in electric field enhanced plasma on methane conversion into C2 hydrocarbons was investigated. Methane coupling reaction was studied in the system of continuous flow reactor on Ni, MoO3, MnO2 catalysts and different ZSM-5 carriers. The per pass conversion of methane can be as high as 22%, the selectivity of ethylene can be as high as 23.8%, of acetylene 60.8%, of ethane 5.4% and of total C2 hydrocarbons was more than 90%. ZSM-5-25 was the better carrier and MnO2 was the better active component. The efficiency of energy was as high as 7.81%. | Bao Wei WANG, Gen Hui XU* State Key Laboratory of C1 Chemistry and Technology, Tianjin University, Tianjin 300072 | 2003 | Chinese Chemical Letters2003，14，12： | 5 |
| 10 | Improving the electrochemical performance of Fe3O4 nanoparticles via a double protection strategy through carbon nanotube decoration and graphene networks显示文摘氧化铁是为锂离子电池的有希望的阳极材料,但是因为它的差的传导性和大体积变化,它通常在锂举起和版本过程期间展出差的电气化学的性质。在这个工作,为改进 Fe 的电气化学的性能的双保护策略 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 通过有多围的碳 nanotubes 和减少的 graphene 氧化物网络的装饰的使用的 4 nanoparticles 被开发了。产生 MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 -rGO nanocomposites 与 MWCNTs-Fe 比较展出了优秀骑车的性能和率能力<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 , MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”>身体上与 rGO 混合的 4 ,和 Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class= a-plus-plus > 4 -rGO 。680 | Shuliang Yang Changyan Cao Gen Li Yongbin Sun Peipei Huang Fangfang Wei Weiguo Song | 2015 | Nano Research2015，8，4： | 4 |
| 11 | Expression Pattern of Peptide and Amino Acid Genes in Digestive Tract of Transporter Juvenile Turbot(Scophthalmus maximus L.)显示文摘Turbot(Scophthalmus maximus L.),a carnivorous fish species with high dietary protein requirement,was chosen to examine the expression pattern of peptide and amino acid transporter genes along its digestive tract which was divided into six segments including stomach,pyloric caeca,rectum,and three equal parts of the remainder of the intestine.The results showed that the expression of two peptide and eleven amino acid transporters genes exhibited distinct patterns.Peptide transporter 1(Pep T1) was rich in proximal intestine while peptide transporter 2(PepT2) was abundant in distal intestine.A number of neutral and cationic amino acid transporters expressed richly in whole intestine including B^0-type amino acid transporter 1(B^0AT1),L-type amino acid transporter 2(LAT2),T-type amino acid transporter 1(TAT1),proton-coupled amino acid transporter 1(PAT1),y^+L-type amino acid transporter 1(y^+LAT1),and cationic amino acid transporter 2(CAT2) while ASC amino acid transporter 2(ASCT2),sodium-coupled neutral amino acid transporter 2(SNAT2),and y^+L-type amino acid transporter 2(y^+LAT2) abundantly expressed in stomach.In addition,system b^(0,+) transporters(rBAT and b^(0,+)AT) existed richly in distal intestine.These findings comprehensively characterized the distribution of solute carrier family proteins,which revealed the relative importance of peptide and amino acid absorption through luminal membrane.Our findings are helpful to understand the mechanism of the utilization of dietary protein in fish with a short digestive tract. | XU Dandan HE Gen MAI Kangsen ZHOU Huihui XU Wei SONG Fei | 2016 | Journal of Ocean University of China2016，15，2： | 3 |
| 12 | Phenolic Components from Rhododendron latoucheae Part 5 in the series 'Chemical Studies on Ericaceae Plants显示文摘From the leaves of Rhododendron latoucheae (Ericaceae). two new natural phenolic compounds named (+)-rhodolatouchol 1 and isoepirhododendrin 4 were identified. Six other known compounds. (+)-rhododendrol, epirhododendrin, 4-[3’-O-β-D-gIucopyranosyl-4’ hydroxypheny]-2-butanone, 4-(4’-O-β-D-glucopyranosylphenyl benzyl-O-β-Dglucopyranoside and arbutin were also obtained. | Cheng Qi FAN Gen Jin YANG Wei Min ZHAO Bing Yang DING Guo Wei QIN(Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031)(College of Pharmacy. Second Military Medical University. Shanghai 200433)(College of Life Science. Ha | 1999 | Chinese Chemical Letters1999，10，7： | 3 |
| 13 | Power Reversal Strategies for Hybrid LCC/MMC HVDC Systems显示文摘Power reversal control strategies for different types of hybrid line-commutated-converter(LCC)/modular multi-level converter(MMC)based high-voltage direct-current(HVDC)systems have been proposed with the consideration of system configurations and MMC’s topologies.The studies show that the full-bridge(FB)MMC gives better performance than half-bridge(HB)MMCs in terms of power reversal in hybrid LCC/MMC systems.The modulation method employed in this paper can achieve a smooth online polarity reversal for hybrid LCC/FB-MMC HVDC systems.Additional DC switches and/or discharging resistors may be needed to reverse the DC polarity of LCC/HB-MMC HVDC systems.Based on the proposed strate-gies,the power reversal processes of the studied systems can be accomplished within several seconds.The speed can be changed according to system operation requirements.The effectiveness of the proposed control strategies has been verified through simulations conducted in PSCAD/EMTDC. | Gen Li Ting An Jun Liang Wei Liu Tibin Joseph Jingjing Lu Marcio Szechtman Bjarne R.Andersen Yuanliang Lan | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 14 | Two New Glucosides from Radix Polygoni multiflori Preparata显示文摘2,3,5,4’-tetrahydroxystilbene-2-O-(2’’-O-feruloyl)-(-D-glucopyranoside, 2,3,5,4’-tetra hydroxystilbene-2-O-(2’’-O-p-coumaroyl)-(-D-glucopyranoside were isolated from Radix Polygoni multiflori Preparata. Structures were elucidated by chemical and spectral evidences. | Wan Sheng CHEN*, Wei Dong ZHANG, Gen Jing YANG, Hai Sheng CHEN, Chuan Zhuo QIAO Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433 | 2001 | Chinese Chemical Letters2001，12，6： | 3 |
| 15 | Effects of the momentum dependence of nuclear symmetry potential on pion observables in Sn+Sn collisions at 270 MeV/nucleon显示文摘Within a transport model,we investigated the effects of the momentum dependence of the nuclear symmetry potential on the pion observables in central Sn+Sn collisions at 270 MeV/nucleon.To this end,the quantity U^(∞)_(sym)(ρ_(0))(i.e.,the value of the nuclear symmetry potential at the saturation densityρ_(0) and infinitely large nucleon momentum)was used to characterize the momentum dependence of the nuclear symmetry potential.With a certain L(i.e.,the slope of the nuclear symmetry energy at(ρ_(0))),the characteristic parameter U^(∞)_(sym)(ρ_(0))of the symmetry potential significantly affects the production of−and+and their pion ratios.Moreover,by comparing the charged pion yields,pion ratios,and spectral pion ratios of the theoretical simulations for the reactions ^(108) Sn+^(112) Sn and ^(132)Sn+^(124)Sn with the corresponding data in the SRIT experiments,we found that our results favor a constraint on U^(∞)_(sym)(ρ_(0))(i.e.,−160_(−9)^(+18) MeV),and L is also suggested within a range of 62.7 MeV | Gao‑Feng Wei Xin Huang Qi‑Jun Zhi Ai‑Jun Dong Chang‑Gen Peng Zheng‑Wen Long | 2022 | Nuclear Science and Techniques2022，33，12： | 3 |
| 16 | Assessment of dairy cow feed intake based on BP neural network with polynomial decay learning rate显示文摘To overcome the shortcomings of traditional dairy cow feed intake assessment model andBP neural network, this paper proposes a method of optimizing BP neural network usingpolynomial decay learning rate, taking the cow’s body weight, lying duration, lying times,walking steps, foraging duration and concentrate-roughage ratio as input variables andtaking the actual feed intake is the output variable to establish a dairy cow feed intakeassessment model, and the model is trained and verified by experimental data collectedon site. For the sake of comparative study, feed intake is simultaneously assessed by SVRmodel, KNN logistic regression model, traditional BP neural network model, and multilayerBP neural network model. The results show that the established BP model using the polynomial decay learning rate has the highest assessment accuracy, the MSPE, RMSE, MAE,MAPE and R2 are 0.043 kg2/d and 0.208 kg/d, 0.173 kg/d, 1.37% and 0.94 respectively. Compared with SVR model and KNN mode, the RMSE value reduced by 43.9% and 26.5%, it isalso found that the model designed in this paper has many advantages in comparison withthe BP model and multilayer BP model in terms of precision and generalization. Therefore,this method is ready to be applied for accurately evaluating the dairy cow feed intake, andit can provide theoretical guidance and technical support for the precise-feeding and canalso be of high significance in the improvement of dairy precise-breeding. | Weizheng Shen Gen Li Xiaoli Wei Qiang Fu Yonggen Zhang Tengyu Qu Congcong Chen Runtao Wang | 2022 | Information Processing in Agriculture2022，9，2： | 2 |
| 17 | Synthesis and NHE1 inhibitory activity of ligustrazine derivatives显示文摘A series of novel derivatives of ligustrazine linked with substituted benzoyl guanidine were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, 1H NMR and MS. The results of NHE1 inhibitory activity test showed that compounds I2, I3, I4, I6, and I7 possess more potent NHE1 inhibitory activity than cariporide. | Mei Ren Yun Gen Xu Na Wen Da Yong Zhang Wei Yi Hua | 2007 | Chinese Chemical Letters2007，18，5： | 2 |
| 18 | An Empirical Likelihood Method in a Partially Linear Single-index Model with Right Censored Data显示文摘Empirical-likelihood-based inference for the parameters in a partially linear single-index model with randomly censored data is investigated. We introduce an estimated empirical likelihood for the parameters using a synthetic data approach and show that its limiting distribution is a mixture of central chi-squared distribution. To attack this difficulty we propose an adjusted empirical likelihood to achieve the standard χ2-limit. Furthermore, since the index is of norm 1, we use this constraint to reduce the dimension of parameters, which increases the accuracy of the confidence regions. A simulation study is carried out to compare its finite-sample properties with the existing method. An application to a real data set is illustrated. | Yi Ping YANG Liu Gen XUE Wei Hu CHENG | 2012 | Acta Mathematica Sinica,English Series2012，28，5： | 2 |
| 19 | A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019显示文摘Human respiratory syncytial virus(RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we performed a molecular epidemiological study during 2015–2019. A total of 964 RSV-positive specimens were identified from 5529 enrolled patients during a multi-center study. RSV subgroup A(RSV-A) was the predominant subgroup during this research period except in2016. Totally, 535 sequences of the second hypervariable region(HVR-2) of the G gene were obtained. Combined with182 Chinese sequences from GenBank, phylogenetic trees showed that 521 RSV-A sequences fell in genotypes ON1(512),NA1(6) and GA5(3), respectively;while 196 RSV-B sequences fell in BA9(193) and SAB4(3). ON1 and BA9 were the only genotypes after December 2015. Genotypes ON1 and BA9 can be separated into 10 and 7 lineages, respectively. The HVR-2 of genotype ON1 had six amino acid changes with a frequency more than 10%, while two substitutions H258 Q and H266 L were co-occurrences. The HVR-2 of genotype BA9 had nine amino acid substitutions with a frequency more than10%, while the sequences with T290 I and T312 I were all from 2018 to 2019. One N-glycosylation site at 237 was identified among ON1 sequences, while two N-glycosylation sites(296 and 310) were identified in the 60-nucleotide duplication region of BA9. To conclusion, ON1 and BA9 were the predominant genotypes in China during 2015–2019. For the genotypes ON1 and BA9, the G gene exhibited relatively high diversity and evolved continuously. | Xiangpeng Chen Yun Zhu Wei Wang Changchong Li Shuhua An Gen Lu Rong Jin Baoping Xu Yunlian Zhou Aihuan Chen Lei Li Meng Zhang Zhengde Xie | 2021 | Virologica Sinica2021，36，6： | 2 |
| 20 | Chemical constituents of Erigeron breviscapus 显示文摘 | Zhang Wei - Dong Kong De - Yun Li Hui - Ting Yang Gen - Jin Qin La- Ping | 1998 | Zhongguo Yiyao Gongye Zazhi1998，29，12： | 1 |
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