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| 1 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 2 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 3 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 4 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 5 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 6 | Improving plasticity of the Zr46Cu46Al8 bulk metallic glass via thermal rejuvenation显示文摘In this paper,effects of cryogenic thermal cycling on deformation behavior and thermal stability of the Zr_(46)Cu_(46)Al_8bulk metallic glass(BMG)were studied.The results show that with the increase of the number of cryogenic thermal cycles(CTC),thermal stability remains almost unchanged,while the plasticity is increased,indicating that the cryogenic thermal cyclic treatment is an effective way to improve plasticity of metallic glasses without distinctly deteriorating thermal stability.Our analysis suggests that the increase in the defect density resulted from the cryogenic thermal treatments are responsible for the plasticity increment.Variation of yield strength can be well interpreted from microstructural percolation which affected by both density and characteristic volume of the defect sites. | Wenli Song Xiaohe Meng Yuan Wu Di Cao Hui Wang Xiongjun Liu Xianzhen Wang Zhaoping Lu | 2018 | Science Bulletin2018，63，13： | 9 |
| 7 | Hollow spherical rare-earth-doped yttrium oxysulfate: A novel structure for upconversion显示文摘锻烧跟随的一条灵巧的 帮助biomolecule 的热水的线路为空范围与另外的稀土元素的离子做了的单斜晶的钇 oxysulfate 的准备被采用了( Yb <啜class=“ a-plus-plus ”>3+和 Eu <啜class=“ a-plus-plus ”>3+或嗯<啜class=“ a-plus-plus ”>3+)。空范围的形成可以包含 Ostwald 成熟。产生混合材料被用于 upconversion 应用。主人水晶结构允许容易没有显著地改变主人格子,二个不同稀土元素的金属离子共同做。光性质被稀土元素的金属离子由于精力转移和水晶的对称回答的掺杂物的比率和集中影响。光中心的类型和样品的 crystallinity 也被显示在同样准备的产品的光性质上有重要影响。 | Gen Chen Fashen Chen Xiaohe Liu Wei Ma Hongmei Luo Junhui Li Renzhi Ma Guanzhou Qiu | 2014 | Nano Research2014，7，8： | 6 |
| 8 | Engineering of carbon and other protective coating layers for stabilizing silicon anode materials显示文摘Silicon(Si)has been attracting extensive attention for rechargeable lithium(Li)‐ion batteries due to its high theoretical capacity and low potential vs Li/Li+.However,it remains challenging and problematic to stabilize the Si materials during electrochemical cycling because of the huge volume expansion,which results in losing electric contact and pulverization of Si particles.Consequently,the Si anode materials generally suffer from poor cycling,poor rate performance,and low coulomb efficiency,preventing them from practical applications.Up‐to‐date,there are numerous reports on the engineering of Si anode materials at microscale and nanoscale with significantly improved electrochemical performances.In this review,we will concentrate on various precisely designed protective layers for silicon‐based materials,including carbon layers,inorganic layers,and conductive polymer protective layer.First,we briefly introduced the alloying and failure mechanism of Si as anode materials upon electrochemical reactions.Following that,representative cases have been introduced and summarized to illustrate the purpose and advancement of protective coating layers,for instance,to alleviate pulverization and improve conductivity caused by volume expansion of Si particles during charge/discharge process,and maintain the surface stability of Si particles to form a stable solid‐electrolyte interphase layer.At last,possible strategies on the protective coating layer for stabilizing silicon anode materials that can be applied in the future have been indicated. | Fenglin Wang Gen Chen Ning Zhang Xiaohe Liu Renzhi Ma | 2019 | Carbon Energy2019，1，2： | 3 |
| 9 | Rhubarb-based Chinese herbal formulae for hepatic encephalopa-thy:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the effectiveness and safety of rhubarb-based Chinese herbal formulae(RCHF), which are widely used to treat hepatic encephalopathy(HE) in China.METHODS: Nine online databases were searched from inception to November 22, 2016. Eligible studies were randomized controlled trials of Traditional Chinese Medicine(TCM) treatment for adult patients(≥ 18 years old) with HE. Outcomes such as mortality rate, clinical response rate, blood ammonia level, and alanine aminotransferase were evaluated between TCM group and control group.RESULTS: Thirty studies involving 2661 HE patients were analyzed. Most studies used RCHF treatment.Compared with conventional treatment as usual,lactulose, and vinegar, RCHF were associated with significant improvement in clinical response rate[risk ratio(RR) = 1.33, 95% confidence interval(CI) =1.25, 1.43, I2= 0%; RR = 1.26, 95% CI = 1.14, 1.38, I2=22%; and RR = 1.19, 95% CI = 1.06, 1.33, I2= 0%, respectively] and significant reductions in levels of blood ammonia and alanine aminotransferase. Only minor RCHF-associated adverse events, such as abdominal pain(0.3%), anal tenesmus(0.3%), and diarrhea(2.3%), were reported, and there were no significant differences in these events between the treatment group and the three types of control group.CONCLUSION: The findings suggest that RCHF may be an alternative treatment option for HE patients. More rigorous multicenter studies with larger samples and longer observational periods are needed to confirm these findings. | Zhang Ning Zhou Shuangnan Xiao Xiaohe Wanq Zhen Bai Yunfeng He Tingting Zhou Chao Wang Yao Kun Zhou Wang Zhongxia Liu Bing Larry J.Prokop Matthew C.Hernandez Li Jun Gong Man | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 10 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 11 | RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer显示文摘Objective:RECQL4(a member of the RECQ helicase family)upregulation has been reported to be associated with tumor progression in several malignancies.However,whether RECQL4 sustains esophageal squamous cell carcinoma(ESCC)has not been elucidated.In this study,we determined the functional role for RECQL4 in ESCC progression.Methods:RECQL4 expression in clinical samples of ESCC was examined by immunohistochemistry.Cell proliferation,cellular senescence,the epithelial-mesenchymal transition(EMT),DNA damage,and reactive oxygen species in ESCC cell lines with RECQL4 depletion or overexpression were analyzed.The levels of proteins involved in the DNA damage response(DDR),cell cycle progression,survival,and the EMT were determined by Western blot analyses.Results:RECQL4 was highly expressed in tumor tissues when compared to adjacent non-tumor tissues in ESCC(P<0.001)and positively correlated with poor differentiation(P=0.011),enhanced invasion(P=0.033),and metastasis(P=0.048).RECQL4 was positively associated with proliferation and migration in ESCC cells.Depletion of RECQL4 also inhibited growth of tumor xenografts in vivo.RECQL4 depletion induced G0/G1 phase arrest and cellular senescence.Importantly,the levels of DNA damage and reactive oxygen species were increased when RECQL4 was depleted.DDR,as measured by the activation of ATM,ATR,CHK1,and CHK2,was impaired.RECQL4 was also shown to promote the activation of AKT,ERK,and NF-k B in ESCC cells.Conclusions:The results indicated that RECQL4 was highly expressed in ESCC and played critical roles in the regulation of DDR,redox homeostasis,and cell survival. | Guosheng Lyu Peng Su Xiaohe Hao Shiming Chen Shuai Ren Zixiao Zhao Yaoqin Gong Qiao Liu Changshun Shao | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 12 | Microcrystallization and lattice contraction of NiFe LDHs for enhancing water electrocatalytic oxidation显示文摘The lattice-oxygen-mediated mechanism is considered as a reasonable mechanism for the electrochemical catalytic oxygen evolution reaction(OER)of NiFe layered double hydroxides(LDHs).A NiFe LDH with distinct lattice contraction and microcrystallization was synthesized via a simple one-step method using sodium gluconate.The lattice contraction is attributed to the interaction of carbon in sodium gluconate and iron in NiFe LDH.The NiFe LDH with optimized microcrystallization and lattice contraction shows a low overpotential of 217 mV at a current density of 10 mA cm^(−2) and excellent durability of 20 h at a high current density of 100 mA cm^(−2).The results revealed that a contractive metal–oxygen bond could boost the intrinsic activity of active sites and the microcrystallization promotes an increase in the number of active sites in terms of unit area.The chemical environment of oxygen elemental characterization and resistance at different chronopotentiometry times confirm that the lattice oxygen element is indeed involved in the process of OER,supporting the lattice-oxygen-mediated mechanism of NiFe LDH.Density functional theory calculations reveal that contractive metal–oxygen bonds induced a reduction of the adsorption energy barrier of intermediate products,thus improving the intrinsic catalytic activity.The special characteristics of microcrystallization and lattice contraction of NiFe LDH provide a strategy to improve both the number and the intrinsic activity of active sites in a versatile manner. | Zhicheng Zheng Dan Wu Gen Chen Ning Zhang Hao Wan Xiaohe Liu Renzhi Ma | 2022 | Carbon Energy2022，4，5： | 2 |
| 13 | Shape-controlled synthesis and properties of manganese sulfide microcrystals via a biomolecule-assisted hydrothermal process 显示文摘 | JIANG Jinghui YU Runnan LIU Xiaohe | 2009 | Mater Chem Phys2009，115，： | 1 |
| 14 | High concentration ethanol production from corncob residues by fed-batch strategy显示文摘 | Kai Liu XiaoH ui Lin Jun Yue | 2009 | Bioresource Technology2009，101，13： | 1 |
| 15 | Anchoring Active Sites by Pt_(2)FeNi Alloy Nanoparticles on NiFe Layered Double Hydroxides for Efficient Electrocatalytic Oxygen Evolution Reaction显示文摘Strategy of anchoring alloy nanoparticles made up of the efficient catalytic element(e.g.,Ni,Fe)on dodecyl sulfate(DS^(-))-intercalated NiFe layered double hydroxides(DS^(-)-NiFe LDH)obtained by a convenient one-step hydrothermal coprecipitation method for essentially enhancing oxygen evolution reaction(OER)performance was proposed.The results of structural characterization indicate Pt_(2)FeNi alloy nanoparticles evenly distribute on the surface of DS^(-)-NiFe LDH.The sizes of the Pt_(2)FeNi nanoparticles,closely related to their OER performance,could be wellcontrolled by adjusting the amount of H;PtCl;addition.The composite structure of as-prepared product was stable during processes of synthesis,exfoliation,self-assembly,and subsequent electrocatalytic OER.Rigorous electrochemical test proving the contributing catalytic active sites was located at the interface between Pt_(2)FeNi and DS^(-)-NiFe LDH,and the Ni and Fe were the major active elements while O atoms are adsorption sites.The formation of Pt_(2)FeNi nanoparticles could greatly prompt the reduction of Tafel slope.The best-performing Pt_(2)FeNi/DS^(-)-NiFe LDH with a Pt content of 0.98 wt%achieved low overpotential of 204 mV at 10 mA cm^(-2)and 262 mV at 50 mA cm^(-2).This work provides a convenient and effective strategy to create additional active sites for enhancing OER performance of NiFe LDH and make contribution to its wide application. | Zhicheng Zheng Yanru Guo Hao Wan Gen Chen Ning Zhang Wei Ma Xiaohe Liu Shuquan Liang Renzhi Ma | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 16 | Enhancement of refresh time in quasi-nonvolatile memory by the density of states engineering显示文摘The recently reported quasi-nonvolatile memory based on semi-floating gate architecture has attracted extensive attention thanks to its potential to bridge the large gap between volatile and nonvolatile memory.However,the further extension of the refresh time in quasi-nonvolatile memory is limited by the charge leakage through the p-n junction.Here,based on the density of states engineered van der Waals heterostructures,the leakage of electrons from the floating gate to the channel is greatly suppressed.As a result,the refresh time is effectively extended to more than 100 s,which is the longest among all previously reported quasi-nonvolatile memories.This work provides a new idea to enhance the refresh time of quasi-nonvolatile memory by the density of states engineering and demonstrates great application potential for high-speed and low-power memory technology. | Zhaowu Tang Chunsen Liu Senfeng Zeng Xiaohe Huang Liwei Liu Jiayi Li Yugang Jiang David Wei Zhang Peng Zhou | 2021 | Journal of Semiconductors2021，42，2： | 1 |
| 17 | Functional evaluation of a novel vitreous substitute using polyethylene glycol sols injected into a foldable capsular vitreous body显示文摘 | Han Chen Songfu Feng Yaqin Liu Zhen Huang Xuyuan Sun Lian Zhou Xiaohe Lu Qianying Gao | 2013 | J Biomed Mater Res2013，，9： | 1 |
| 18 | Laser-induced fluorescence:Progress and prospective for in vivo cancer diagnosis显示文摘Cancer diagnosis and treatment are of great interest due to the high death rate of cancer.To improve the cure rates of cancer,a diagnostic tool which can detect and treat cancer at initial stages is great needed.Laser-induced fluorescence(LIF) is an adequate analytical technique with advantages of high sensitivity,low sample consumption,short testing time,and suitable for in situ testing.Therefore,it has become one of the most widely used spectroscopic methods for cancer in vivo diagnosis in recent years.This review mainly focuses on the applications of in vivo LIF to distinguish premalignant,malignant from normal tissues in a variety of organ systems,such as lung breast,colon,cervix,esophagus,and bronchus.The potential influence factors for cancer diagnostics and the subsequent suitability of the method to different applications are well discussed.Meanwhile,the technical merits and weaknesses of the LIF technology for cancer diagnosis are also evaluated.Furthermore,different exogenous fluorophores,endogenous fluorophores,and fluorophores synthesized in the tissue are compared on their active principle and effect contrast.The technical potentials of LIF for further development and future applications are also presented as well in this review. | LIU Wei ZHANG XiaoHe LIU KunPing ZHANG SiDa DUAN YiXiang | 2013 | Chinese Science Bulletin2013，58，18： | 1 |
| 19 | ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy显示文摘 | Millie Das Jonathan W. Riess Paul Frankel Erich Schwartz Robyn Bennis H. Ben Hsieh Xiaohe Liu Janey C. Ly Lisa Zhou Jorge J. Nieva Heather A. Wakelee Richard H. Bruce | 2012 | Lung Cancer2012，，2： | 1 |
| 20 | Circulating Sfrp5 Is a Signature of Obesity-Related Metabolic Disorders and Is Regulated by Glucose and Liraglutide in Humans显示文摘 | Wenjing Hu Ling Li Mengliu Yang Xiaohe Luo Wenxia Ran Dongfang Liu Zhengai Xiong Hua Liu Gangyi Yang | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，： | 1 |
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