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| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 3 | VSG-based Adaptive Droop Control for Frequency and Active Power Regulation in the MTDC System显示文摘In this paper,a VSG(virtual synchronous generator)-based method with adaptive active power and DC voltage droop is proposed for the control of VSC stations in the multi-terminal DC(MTDC)system.This control strategy can improve the inertial level of the AC networks and attenuate the rate of change of frequency when a disturbance occurs.In addition,the droop control of the active power and DC voltage is implemented to make the AC networks share the unbalanced power in the MTDC.The droop coefficients are adaptively adjusted depending on the frequency margin of every AC network,which makes the allocation of unbalanced power among AC networks more reasonable from the frequency variation perspective.The control strategy is evaluated in the scenarios of sudden load change and wind turbine tripping,and the results are presented to demonstrate its effectiveness. | Ren Wang Laijun Chen Tianwen Zheng Shengwei Mei | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 13 |
| 4 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 5 | Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure显示文摘AIM:To determine the prognostic value of circulating indicators of cell death in acute-on-chronic liver failure(ACLF)patients with chronic hepatitis B virus(HBV)infection as the single etiology.METHODS:Full length and caspase cleaved cytokeratin 18(detected as M65 and M30 antigens)represent circulating indicators of necrosis and apoptosis.M65and M30 were identified by enzyme-linked immunosorbent assay in 169 subjects including healthy controls(n=33),patients with chronic hepatitis B(CHB,n=55)and patients with ACLF(n=81).According to the 3-mo survival period,ACLF patients were defined as having spontaneous recovery(n=33)and non-spontaneous recovery which included deceased patients and those who required liver transplantation(n=48).RESULTS:Both biomarker levels significantly increased gradually as liver disease progressed(for M65:P<0.001 for all;for M30:control vs CHB,P=0.072;others:P<0.001 for all).In contrast,the M30/M65 ratio was significantly higher in controls compared with CHB patients(P=0.010)or ACLF patients(P<0.001).In addition,the area under receiver operating characteristic curve(AUC)analysis demonstrated that both biomarkers had diagnostic value(AUC≥0.80)in identifying ACLF from CHB patients.Interestingly,it is worth noting that the M30/M65 ratio was significantly different between spontaneous and non-spontaneous recovery in ACLF patients(P=0.032).The prognostic value of the M30/M65 ratio was compared with the Model for End-Stage Liver Disease(MELD)and Child-Pugh scores at the 3-mo survival period,the AUC of the M30/M65ratio was 0.66 with a sensitivity of 52.9%and the highest specificity of 92.6%(MELD:AUC=0.71;sensitivity,79.4%;specificity,63.0%;Child-Pugh:AUC=0.77;sensitivity,61.8%;specificity,88.9%).CONCLUSION:M65 and M30 are strongly associated with liver disease severity.The M30/M65 ratio may be a potential prognostic marker for spontaneous recovery in patients with HBV-related ACLF. | Su-Jun Zheng Shuang Liu Mei Liu Malcolm A McCrae Jun-Feng Li Yuan-Ping Han Chun-Hui Xu Feng Ren Yu Chen Zhong-Ping Duan | 2014 | World Journal of Gastroenterology2014，20，9： | 13 |
| 6 | Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells显示文摘Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2+ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2+ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2+ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells. | Yu Zhang Ling Ren Mei Li Xiao Lin Huafu Zhao Ke Yang | 2012 | Journal of Materials Science & Technology2012，28，9： | 11 |
| 7 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 8 | Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway显示文摘We investigated the liver protective activity of dandelion polyphenols(DP)against acetaminophen(APAP;Paracetamol)-induced hepatotoxicity.Mice were acclimated for 1 week and randomly divided into the following groups(n=9 per group):Control,APAP,APAP+DP(100 mg·kg^–1),APAP+DP(200 mg·kg^–1),and APAP+DP(400 mg·kg^–1)groups.Mice were pretreated with DP(100,200,and 400 mg·kg^–1)by oral gavage for 7 d before being treated with 350 mg·kg^–1 APAP for 24 h to induced hepatotoxicity.Severe liver injury was observed,and hepatotoxicity was analyzed after 24 h by evaluation of biochemical markers,protein expressions levels,and liver histopathology.Pretreatment with DP was able to restore serum liver characteristics(aspartate transaminase,AST;alanine aminotransferase,ALT;alkaline phosphatase,AKP),improve redox imbalance(superoxide dismutase,SOD;glutathione,GSH;malondialdehyde,MDA),and decrease inflammatory factors(tumor necrosis factor-α,TNF-α;interleukin-1β,IL-1β).Pretreatment with DP also significantly inhibited the expression levels of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).Furthermore,DP pretreatment could inhibit the apoptosis of liver cells caused by APAP through up-regulation of Bcl-2 and down-regulation of Bax and caspase-9 protein.DP also down-regulated p-JNK protein expression levels to inhibit APAP-induced mitochondrial oxidative stress and up-regulated the expression of Nrf-2 and its target gene HO-1.The histopathological staining demonstrated that DP pretreatment could inhibit APAP-induced hepatocyte infiltration,congestion,and necrosis.Our results demonstrate that DP pretreatment could protect against APAP-induced hepatic injury by activating the Nrf-2/HO-1 pathway and inhibition of the intrinsic apoptosis pathway. | REN Yong-Shen ZHENG Yao DUAN Huan LEI Lei DENG Xin LIU Xin-Qiao MEI Zhi-Nan DENG Xu-Kun | 2020 | Chinese Journal of Natural Medicines2020，18，2： | 11 |
| 9 | Efficient revocation in ciphertext-policy attribute-based encryption based cryptographic cloud storage显示文摘It is secure for customers to store and share their sensitive data in the cryptographic cloud storage.However,the revocation operation is a sure performance killer in the cryptographic access control system.To optimize the revocation procedure,we present a new efficient revocation scheme which is efficient,secure,and unassisted.In this scheme,the original data are first divided into a number of slices,and then published to the cloud storage.When a revocation occurs,the data owner needs only to retrieve one slice,and re-encrypt and re-publish it.Thus,the revocation process is accelerated by affecting only one slice instead of the whole data.We have applied the efficient revocation scheme to the ciphertext-policy attribute-based encryption(CP-ABE) based cryptographic cloud storage.The security analysis shows that our scheme is computationally secure.The theoretically evaluated and experimentally measured performance results show that the efficient revocation scheme can reduce the data owner's workload if the revocation occurs frequently. | Yong CHENG Zhi-ying WANG Jun MA Jiang-jiang WU Song-zhu MEI Jiang-chun REN | 2013 | Journal of Zhejiang University-Science C(Computers and Electronics)2013，14，2： | 11 |
| 10 | Synthesis of 2, 6-(substituded)pyridine Derivatives Using Amide and Imine Groups显示文摘A new wo-armed?acyclic diamide Ia 2, 6-bis(1-ethanecarbozamido-2-amino)pyridine, and a new series of aromatic aldehyde schiff bases containing pyridine ring and amide bridge, IIa-f, were prepared. The compounds were characterized by elemental analysis, IR, 1HNMR and MS. The bioactivity half inhibitory concentration C1/2 is given. | Mei Ying LI, Pei Zhi HU*, Wan Ren ZHU, Kuo Xi XU College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072 | 2003 | Chinese Chemical Letters2003，14，6： | 9 |
| 11 | Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice显示文摘目的: 在在焦点的服的局部缺血以后的半影,朊酶 Omi 的增加被连接到联系 Hs1 的蛋白质 X-1 (Hax-1 ) 的减少,属于 Bcl-2 家庭的蛋白质。在这研究,我们调查了在服的 ischemia/reperfusion (I/R ) 由朊酶 Omi 位于 Hax-1 的规定下面的机制损害。 | Jia-yuan WU Mei LI Li-juan CAO Mei-ling SUN Dong CHEN Hai-gang REN Qin XIA Zhou-teng TAO Zheng-hong QIN Qing-song HU Guang-hui WANG | 2015 | Acta Pharmacologica Sinica2015，36，9： | 8 |
| 12 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 13 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 14 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 15 | Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium显示文摘Biocompatible and biodegradable magnesium(Mg)based metals have attracted great interest for use in orthopedic implants and devices.Based on our previous study that Mg with and without micro-arc oxidation(MAO)coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg,this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma(MG-63)cells by analyzing the cell adhesion,morphology and number through observation of scanning electron microscope,as well as live/dead staining,lactate dehydrogenase(LDH)activity and 4,6-diamidino-2-phenylindole(DAPI)assay.The results indicated that,compared to titanium,Mg could strongly inhibit the cell adherence,morphology and number of MG-63 on the surface of the naked Mg,whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells,expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice. | Mei Li Ling Ren LiHua Li Peng He GuoBo Lan Yu Zhang Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，9： | 7 |
| 16 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 17 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 18 | Determination of Partial Molar Volumes of EPA and DHA Ethyl Esters in Supercritical Carbon Dioxide显示文摘The use of supercritical-fluid chromatography for determining partial molar volumes of ethyl esters of cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and cis -4,7,10,13,16,19- docosa-hexaenoic acid (DHA) in supercritical carbon dioxide is presented and discussed. Partial molar volumes of EPA and DHA esters are obtained from the variation of the retention properties with the density of mobile phase at 313.15 K, 323.15 K, 333.15 K and in the pressure range from 9 MPa to 21 MPa. | Mei HUANG, Xian Da WANG, Ren Tian XIONG, Ping Dong WU, Qi Long REN* National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027 | 2002 | Chinese Chemical Letters2002，13，1： | 6 |
| 19 | Sediment discharge of the Yellow River, China: past, present and future——A synthesis显示文摘The Yellow River cut through Sanmenxia Gorge and discharged into the sea via the North China Plain in 150 ka BP; since then, around 86 000 × 108 t sediment has been transported passing Sanmenxia Gorge. Based on land use and land cover changes in Loess Plateau and other available evidence, an estimate of the Yellow River sediment budget is presented here: about 72% of the sedimentary material was trapped in the North China Plain and the remainder(i.e., 26%) escaped to the sea. At the present stage, < 0.2×108 t/a suspended sediment of the Yellow River enter the northern Yellow Sea. The transport pattern is determined mainly by the shelf current system. Annually 0.2×108–0.3×108 t of suspended particles are carried to the East China Sea; the materials are derived mainly from coastal and subaqueous delta erosion associated with the abandoned Yellow River on the Jiangsu coast. Since 1972, the lower Yellow River started to have a situation of continuous no-flow. During 1996–2000, the annual water flow and sediment discharge are only 19%, as compared with normal years(i.e., average for 1950–1979). In response to global warming and increase of water diversion from the Yellow River for industrial and urban use, the sediment flux of the Yellow River to the sea will most likely remain small in the next two to three decades. | REN Mei'e | 2015 | Acta Oceanologica Sinica2015，34，2： | 6 |
| 20 | Antibacterial Properties of Ti-6Al-4V-xCu Alloys显示文摘Surgical implant-associated bacterial infection is becoming a serious clinical problem.A series of copper-bearing titanium alloy,Ti—6AI—4V—xCu(x = 1,3,5 wt%),were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element.The metallography,X-ray diffraction,antibacterial ability,corrosion resistance and cytotoxicity of Ti—6AI—4V—xCu alloys were preliminarily studied with comparison to the commercial medical Ti—6AI—4V alloy.The Ti—6AI—4V—xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility,and the antibacterial role was enhanced with increasing Cu content,which has significant potential for clinical applications as surgical implant materials. | Ling Ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，7： | 5 |
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