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| 1 | Expression and significance of proapoptotic gene Bax in gastric carcinoma显示文摘INTRODUCTIONRecentinvestigationshavedemonstratedthatapoptosisplaysasignificantroleinthepathogenesisoftumors[1,2].Emphasishas... | LIU Hai Feng, LIU Wei Wen, FANG Dian Chun and MEN Rong Pu | 1999 | World Journal of Gastroenterology1999，5，1： | 32 |
| 2 | Expression of bcl-2 protein in gastric carcinoma and its significance显示文摘Expressionofbcl2proteiningastriccarcinomaanditssignificanceLIUHaiFeng,LIUWeiWen,FANGDianChunandMENRongPuSubjectheadings... | LIU Hai Feng, LIU Wei Wen, FANG Dian Chun and MEN Rong Pu | 1998 | World Journal of Gastroenterology1998，4，3： | 23 |
| 3 | Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)-associated protein 9(CRISPR-Cas9) system provides a novel genome editing technology that can precisely target a genomic site to disrupt or repair a specific gene. Some CRISPR-Cas9 systems from different bacteria or artificial variants have been discovered or constructed by biologists, and Cas9 nucleases and single guide RNAs(sgRNA) are the major components of the CRISPR-Cas9 system. These Cas9 systems have been extensively applied for identifying therapeutic targets, identifying gene functions, generating animal models, and developing gene therapies.Moreover, CRISPR-Cas9 systems have been used to partially or completely alleviate disease symptoms by mutating or correcting related genes. However, the efficient transfer of CRISPR-Cas9 system into cells and target organs remains a challenge that affects the robust and precise genome editing activity. The current review focuses on delivery systems for Cas9 mRNA, Cas9 protein, or vectors encoding the Cas9 gene and corresponding sgRNA. Non-viral delivery of Cas9 appears to help Cas9 maintain its on-target effect and reduce off-target effects, and viral vectors for sgRNA and donor template can improve the efficacy of genome editing and homology-directed repair. Safe, efficient, and producible delivery systems will promote the application of CRISPR-Cas9 technology in human gene therapy. | Zhi-Yao He Ke Men Zhou Qin Yang Yang Ting Xu Yu-Quan Wei | 2017 | Science China(Life Sciences)2017，60，5： | 10 |
| 4 | Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects显示文摘 | ZHANG Bing-jun MEN Xue-jiao LU Zheng-qi LI Hai-yan QIU Wei HU Xue-qiang | 2013 | Chinese Medical Journal2013，，12： | 9 |
| 5 | Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease显示文摘 | GAO Fei WANG Zan-xin MEN Jian-long REN Jing WEI Min-xin | 2011 | Chinese Medical Journal2011，，11： | 8 |
| 6 | Geochemical characteristics of soil selenium and evaluation of Serich land resources in the central area of Guiyang City,China显示文摘Based on the results of multipurpose regional geochemical surveys of the Guizhou Province, geochemical characteristics of soil Se and Se-rich land resources in the central area of Guiyang City were studied and evaluated.Major conclusions are as follows:(1) the Se content in surface soil of the central area of Guiyang City was 0.17–2.89 mg kg^(-1), and the average was 0.78 mg kg^(-1), which were respectively 2.6 and 3.9 times of the national background value of soil and the world background value of soil.The Se content in deep soil was 0.11–1.48 mg kg^(-1), and the average was 0.44 mg kg^(-1), which were respectively 1.5 and2.2 times of the national background value of soil and the world background value of soil. The soil Se content decreased with the increase in the soil depth on the vertical profile, and the surface soil had a higher Se content.(2)Distribution of Se content was mainly affected by parent material, physicochemical properties of soil and other components, soil type, and land use type. Parent material played a key role, as the soil Se content was mainly originated from parent rock and increased with the background value of Se in parent rock, physicochemical properties of soil and other components had certain influences upon the Se content. Se was shown to have a significant linear positive correlation with S and organic carbon but no significant correlation with p H value. Se content varied with different types of soil as follows: skeleton soil > yellow soil > paddy soil > limestone soil > purple soil. Land use type also hadcertain influences upon the soil Se content as follows: dry land > construction land > garden plot > grassland =garden plot > forest land.(3) Taking 0.4 mg kg^(-1)B x(Se) <3.0 mg kg^(-1) as the standard for Se-rich soil, Se-rich soil of the study area covered an area of 2224 km^2 and 92.5% of the total area; the remaining is general soil. The study area had no Se-excess soil. Therefore, the central area of Guiyang City has a high proportion of Se-rich land, a large area of Serich land resources, and a moderate selenium enrichment strength, which have been rarely seen anywhere and provide advantageous resources for the development of Se-rich featured agriculture. | Ziping Pan Shaolin He Chaojin Li Wei Men Chengzhi Yan Fang Wang | 2017 | Acta Geochimica2017，36，2： | 8 |
| 7 | Relationship with spatial memory in diabetic rats and protein kinase Cγ,caveolin-1 in the hippocampus and neuroprotective effect of catalpol显示文摘 | Zhou Haicheng Liu Jing Ren Liyuan Liu Wei Xing Qian Men Lili Song Guirong Du Jianling | 2014 | Chinese Medical Journal2014，，5： | 7 |
| 8 | CRISPR/Cas9-mediated correction of human genetic disease显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) protein 9 system(CRISPR/Cas9) provides a powerful tool for targeted genetic editing. Directed by programmable sequence-specific RNAs,this system introduces cleavage and double-stranded breaks at target sites precisely. Compared to previously developed targeted nucleases, the CRISPR/Cas9 system demonstrates several promising advantages, including simplicity, high specificity,and efficiency. Several broad genome-editing studies with the CRISPR/Cas9 system in different species in vivo and ex vivo have indicated its strong potential, raising hopes for therapeutic genome editing in clinical settings. Taking advantage of non-homologous end-joining(NHEJ) and homology directed repair(HDR)-mediated DNA repair, several studies have recently reported the use of CRISPR/Cas9 to successfully correct disease-causing alleles ranging from single base mutations to large insertions. In this review, we summarize and discuss recent preclinical studies involving the CRISPR/Cas9-mediated correction of human genetic diseases. | Ke Men Xingmei Duan Zhiyao He Yang Yang Shaohua Yao Yuquan Wei | 2017 | Science China(Life Sciences)2017，60，5： | 7 |
| 9 | ^(226)Ra and ^(228)Ra in the Seawater of the Western Yellow Sea显示文摘Radium isotopes 226Ra and 228Ra in seawater of the western Yellow Sea were measured by using the Mn-fiber adsorption-HPGe γ spectrum method. The distribution features of the two isotopes have been studied. The activities of 226Ra and 228Ra are 2.72-5.57 Bq m -3 and 7.51-34.3 Bq m -3, respectively. The activities of 226Ra and 228Ra from surface to bottom for each depth profile station are comparable within the experimental error, but the mean activities decrease with distance from the shore. From the distribution data of 228Ra, the horizontal eddy diffusion coefficient was estimated at 29×106 cm2 s -1. | MEN Wu WEI Hao LIU Guangshan | 2006 | Journal of Ocean University of China2006，5，3： | 5 |
| 10 | Effect of the end cap on the fragment velocity distribution of a cylindrical cased charge显示文摘The prediction of the fragment velocity distribution of a cylindrical cased charge with end caps is one of the key issues to assess the damage efficiency of the warhead. However, limited work has been conducted to predict the fragment velocity distributions along the axis of cylindrical cased charges with end caps. This paper presents a study of the velocity distribution of fragments caused by the explosion of a cylindrical cased charge with end caps. The fragment velocity distribution and the end cap velocity were determined by an X-ray radiography method, and the axial fragment distribution was determined by witness plates. It was found that the velocities of fragments, especially near the edge, were increased when the end caps were added, and the position of maximum velocity is closer to the non-detonation end. The fragment velocities were increased, and the fragment projection range was decreased with the increase of the thickness of the end cap. A formula for fragment velocity distributions of a cylindrical cased charge with end caps, which is based on Huang’s formula, was proposed by the theoretical analysis and data fitting and validated experimentally. The results indicate that the proposed formula is accurate in predicting the fragment velocity distribution along the axis of a cylindrical cased charge with end caps detonated at one end. | Wei Liao Jian-wei Jiang Jian-bing Men Shu-you Wang Mei Li Han Liu | 2021 | Defence Technology(防务技术)2021，17，3： | 4 |
| 11 | Sliding wear behaviors of Nomex fabric/phenolic composite under dry and water-bathed sliding conditions显示文摘A Nomex fabric/phenolic composite was prepared,and its tribological properties were evaluated under dry and water‐bathed sliding conditions by a pin‐on‐disk tribometer.The resulting size of the friction coefficient for the Nomex fabric/phenolic composite in the study occurred in the following order:dry sliding condition>distilled water‐bathed sliding condition>sea water‐bathed sliding condition.The fabric composite’s wear rate from high to low was as follows:distilled water‐bathed sliding condition>sea water‐bathed sliding condition>dry sliding condition.Under water‐bathed sliding conditions,penetration of water into the cracks accelerated the composite’s invalidation process,resulting in a higher wear rate.We also found that the extent of corrosion and transfer film formed on the counterpart pin significantly influenced the wear rate of the Nomex fabric composite.Discussion of the Nomex fabric composite’s wear mechanisms under the sliding conditions investigated is provided on the basis of the characterization results. | Guina REN Zhaozhu ZHANG Xiaotao ZHU Xuehu MEN Wei JIANG Weimin LIU | 2014 | Friction2014，2，3： | 3 |
| 12 | Combined effects of interface modification and micro-filler reinforcements on the thermal and tribological performances of fabric composites显示文摘The high specific‐strength of glass fibers and exceptional self‐lubrication of polytetrafluoroethylene(PTFE)fibers promote the potential application of hybrid PTFE/glass fabric composites in the tribological field,but their weak interfacial adhesion and inferior thermal properties significantly inhibit their tribological performance and reliability.Herein,a hybrid of polydopamine/silicon carbide/polyethyleneimine(PDA/SiC/PEI)functional coating was co‐deposited onto the hybrid PTFE/glass fabric surface through a one‐step impregnation method,leading to increased surface roughness and abundant amine groups.Tensile and peeling tests showed that this functional coating offered 47.8%enhancement in the fabric/matrix interfacial adhesion without compromising the strength of the pristine fabric.Moreover,the additional incorporation of WS_(2),and aluminum nitride(AlN)micro‐fillers contributed to the development of a high‐quality tribofilm and improved the thermal properties of fabric composites.The results of wear tests proved that the hybrid‐fabric composites,after the introduction of functional coating and micro‐fillers,exhibited outstanding tribological performance,which was attributed to the superior interfacial adhesion as well as the synergistic enhancement effects between WS2 and AlN micro‐fillers. | Junya YUAN Zhaozhu ZHANG Mingming YANG Xin ZHAO Liangfei WU Peilong LI Wei JIANG Xuehu MEN Weimin LIU | 2021 | Friction2021，9，5： | 3 |
| 13 | Three-dimensional nitrogen-doped graphene hydrogel supported Co-CeOx nanoclusters as efficient catalysts for hydrogen generation from hydrolysis of ammonia borane显示文摘The development of highly active noble-metal-free catalysts for catalytic hydrolysis of ammonia borane is mandatory for its application in hydrogen storage.Herein,Co-CeO_xnanoclusters have been successfully anchored on a three-dimensional nitrogen-doped graphene hydrogel(NGH)by a simple coreduction method and further used as efficient catalysts to catalytic hydrolysis of ammonia borane at room temperature.Thanks to the strong synergistic electronic effect between Co and CeO_x,as well as the strong metal-support interaction between Co-CeO_xand 3D NGH,the as-synthesized Co-(CeO_x)_(0.91)/NGH catalyst exhibits superior catalytic activity toward hydrolysis of ammonia borane,with the turnover frequency(TOF)value of 79.5 min^(-1),which is almost 13 times higher than that of Co/NGH,and higher than most of the reported noble-metal-free catalysts. | Yana Men Jun Su Chaozhang Huang Lijing Liang Ping Cai Gongzhen Cheng Wei Luo | 2018 | Chinese Chemical Letters2018，29，11： | 3 |
| 14 | NiPt nanoparticles supported on CeO_2 nanospheres for efficient catalytic hydrogen generation from alkaline solution of hydrazine显示文摘Searching for highly efficient catalysts toward dehydrogenation of hydrazine for chemical hydrogen storage is highly desirable for the development of hydrogen economy. Herein, we report a simple in situ co-reduction synthesis of NiPt nanoparticles supported on CeO_2 nanospheres and their superior catalytic performance for hydrogen generation from alkaline solution of hydrazine at room temperature. Thanks to the strong electronic interaction arising from synergistic effect at atomic lever and support-metal interaction between NiPt and CeO_2.The obtained Ni_5Pt_5-CeO_2 catalyst exhibits 100% hydrogen selectivity and superior catalytic performance for hydrogen generation from alkaline solution of hydrazine at room temperature, with a TOF value of 416 h 1. | Yana Men Jun Su Xiangli Wang Ping Cai Gongzhen Cheng Wei Luo | 2019 | Chinese Chemical Letters2019，30，3： | 3 |
| 15 | Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-βpathway显示文摘The activation of hepatic stellate cells(HSCs)participates in liver fibrosis,and emerging evidences indicate that microRNAs(miRNAs)are abnormally expressed during HSC activation.However,the potential roles of miRNAs in liver fibrosis still remain elusive.Therefore,this study aimed to investigate the role of miR-199a-3p in liver fibrosis and its underlying mechanism.We found that miR-199a-3p expression was dramatically upregulated during HSC activation in vitro,and during liver fibrogenesis in CCl4-treated rats,and its liver expression was increased in the patients with cirrhosis.By the luciferase assay and RT-qPCR,we revealed that the expression of miR-199a-3p in HSCs was driven by the transcription factor Twist1 which could be further induced by TGF-βtreatment.Functional studies showed that inhibition of miR-199a-3p in both human LX2 cells and rat HSCs significantly decreased the expression of fibrotic markers,such as fibronectin and connective tissue growth factor(CTGF),whereas the forced expression of miR-199a-3p exhibited opposite effects,demonstrating the role of miR-199a-3p in promoting HSC activation.Mechanistically,miR-199a-3p plays an important role in TGF-βsignalling pathway activation through targeting CAV2 that negatively regulates the expression of transforming growth factor-beta receptor type I(TGFβRI).Importantly,administration of antagomiR-199a-3p in the CCl4-treated mice significantly ameliorated hepatic fibrosis.In conclusion,Twist1-induced miR-199a-3p mediates the activation of HSCs by suppressing CAV2 expression and subsequently increasing TGFβRI expression to promote TGF-βpathway.Our findings highlight the therapeutic potential of miR-199a-3p for hepatic fibrosis. | Xiaoxue Yang Liping Ma Rong Wei Tinghong Ye JianKang Zhou Maoyao Wen Ruoting Men Rami I.Aqeilan Yong Peng Li Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 16 | Early stopping for the iterative decoding for Q-LDPC显示文摘Q-ary low-density parity-check (Q-LDPC) codes have a better performance than those of the binary low-density parity-check (B-LDPC) codes, at short and medium block lengths, but the decoder of Q-LDPC has more complexity. In this article, a new stop criterion is proposed. By analyzing the changes of the maximum posteriori probability of the variable node, the criterion decides whether the iteration of the decoder must be stopped. The simulation results show that the stop criterion can effectively reduce the computation complexity of the Q-LDPC decoder with negligible performance loss. | ZHOU Wei MEN Ai-dong QUAN Zi-yi | 2008 | The Journal of China Universities of Posts and Telecommunications2008，15，1： | 2 |
| 17 | Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine显示文摘Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical trials.However,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully explored.Here,we demonstrate that oxidized mitochondrial DNA(mtDNA)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell vaccine.Elevations in ROS and oxidized mtDNA 8-OHG content could be induced in irradiated tumor cells.Oxidized mtDNA derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDNA,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor immunity.The results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines. | Chunju Fang Fei Mo Li Liu Jing Du Min Luo Ke Men Feifei Na Wei Wang Hanshuo Yang Xiawei Wei | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 18 | Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals显示文摘 | Xue Ying He Wen Wan-Liang Lu Ju Du Jia Guo Wei Tian Ying Men Yan Zhang Ruo-Jing Li Ting-Yuan Yang De-Wei Shang Jin-Ning Lou Liang-Ren Zhang Qiang Zhang | 2009 | Journal of Controlled Release2009，，2： | 2 |
| 19 | Cross-Ice Acoustic Communication:Cascade Acoustic Channel Model and Experimental Results显示文摘Cross-ice acoustic information transmission is an effective means of communication in polar sea areas covered by ice.However,the channel is extremely complicated because of the combined influence of water,ice,and air.Based on the normalmode theory,this paper establishes a cascade acoustic channel(CAC)model for the transmission of underwater acoustic waves across ice layer.The model can calculate the displacement response of the ice layer’s upper surface by separating the upward waves from normal modes in the water and multiplying it by a transmission coefficient matrix.The relationship between the displacement response of the upper surface of ice layer and the acoustic frequency is calculated by the finite-element method,and the calculation result was consistent with that of the CAC model.To verify the applicability of the model,a cross-ice acoustic communication experiment was conducted in Songhua River in January 2019.Experimental results show the energy of the acoustic signals received by geophones is closely related to sound frequency and crossice acoustic communication is feasible.The result of present research is important for understanding crossice acoustic channel characteristics and developing future cross-ice acoustic communication in polar sea areas. | Jingwei Yin Wei Men Guangping Zhu Xiao Han | 2021 | China Communications2021，18，2： | 2 |
| 20 | Dual-atom active sites embedded in two-dimensional C_(2)N for efficient CO_(2) electroreduction: A computational study显示文摘Double-atom catalysts(DACs)have emerged as an enhanced platform of single-atom catalyst for promoting electrocatalytic CO_(2) reduction reaction(CO_(2) RR).Herein,we present a density-functional theory study on CO_(2) RR performance of seven C_(2) N-supported homo-and heteronuclear DACs,denoted as M_(2)@C_(2) N.Our results demonstrate that there exists substantial synergistic effect of dual-metal-atom N_(2) M_(2) N_(2) active site and C_(2) N matrix on O=C=O bond activation.The dual-atom M_(2) sites are able to drive CO_(2) RR beyond C1 products with low limiting potential(UL).Specifically,C_(2) H4 formation is preferred on FeM@C_(2) N(M=Fe,Co,Ni,Cu)versus CH4 formation on CuM@C_(2) N(M=Co,Ni,Cu).Furthermore,^(*)CO+^(*)CO cobinding strength can serve as a descriptor for CO_(2) RR activity for making C_(2) products such that the moderate binding results in the lowest UL.Remarkably,C-affinity matters most to C-C bond coupling and C_(2) H4 formation while both C-and O-affinity control CH4 formation.Our results provide theoretical insight into rational design of DACs for efficient CO_(2) RR. | Haimei Liu Qingliang Huang Wei An Yuanqiang Wang Yong Men Shuang Liu | 2021 | Journal of Energy Chemistry2021，30，10： | 1 |
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