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| 1 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 2 | MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1显示文摘MicroRNAs (miRNAs ) 是由指向多重 mRNAs 的定序明确地在基因表示的 post-transcriptional 规定有一个枢轴的角色的小 noncoding RNA。尽管 miR-33a 最近被报导在类脂化合物动态平衡,动脉粥样硬化,和肝的纤维变性起一个重要作用,在肿瘤前进和转移的 miR-33a 的功能大部分是未知的。这里,我们发现在乳癌纸巾的 downregulated miR-33a 与淋巴节点转移相关。MiR-33a 表示比 noncancerous 胸在高度变形的乳癌房间线是显著地更低的上皮的房间和非变形的乳癌房间。而且,在变形乳癌细胞的 miR-33a 的 overexpression 显著地减少在 vitro 并且显著地的细胞增长和侵略在 vivo 禁止肿瘤生长和肺转移,而它的在非变形的乳癌细胞击倒显著地在 vitro 提高细胞增长和侵略并且在 vivo 支持肿瘤生长和肺转移。联合生物信息学预言和生物化学的分析,我们证明 ADAM9 和 ROS1 是 miR-33a 的直接下游的目标。这些调查结果作为乳癌房间增长和转移的一个否定管理者识别了 miR-33a。 | Chuankai Zhang Yunda Zhang Weiji Ding Yancheng Lin Zhengjie Huang Qi Luo | 2015 | Protein & Cell2015，6，12： | 10 |
| 3 | Enhanced Strength and Ductility Due to Microstructure Refinement and Texture Weakening of the GW102K Alloy by Cyclic Extrusion Compression显示文摘The cyclic extrusion compression(CEC) was applied to severely deform the as-extruded GW102K(Mg–10.0Gd–2.0Y–0.5Zr, wt%) alloy at 350, 400, and 450 °C, respectively. The microstructure, texture, and grain boundary character distribution of the CECed alloy were investigated in the present work. The mechanical properties were measured by uniaxial tension at room temperature. The crack initiation on the longitudinal section near the tensile fracture-surface was investigated by high-resolution scanning electron microscopy(SEM). The result shows that the microstructure was dramatically refined by dynamic recrystallization(DRX). The initial fiber texture was disintegrated and obviously weakened. The 8-passes/350 °C CECed alloy exhibited yield strength of 318 MPa with an elongation-to-fracture of 16.8%, increased by 41.3% and 162.5%, respectively. Moreover, the elongation-to-fracture of the 8-passes/450 °C CECed alloy significantly increased more than 3 times than that of the received alloy. The cracks were mainly initiated at twin boundaries and second phase/matrix interfaces during tensile deformation. The microstructure refinement was considered to result in the dramatically enhanced of the strength and ductility. In addition, the texture randomization during CEC is beneficial for enhancing ductility. The standard positive Hall–Petch relationships have been obtained for the CECed GW102 K alloy. | Jinbao Lin Xinyi Wang Weijie Ren Xuexia Yang Qudong Wang | 2016 | Journal of Materials Science & Technology2016，32，8： | 9 |
| 4 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 5 | Surface effects on in-shoe plantar pressure and tibial impact during running显示文摘目的:探讨在不同表面上跑步对足底压力和胫骨加速度的影响。方法:13位男性跑步者被要求分别在水泥地、塑胶跑道、天然草地、跑步机以及配备EVA缓冲衬垫物的跑步机上以12 km/h的速度进行慢跑。用足底压力测试系统和安放在胫骨粗隆的加速度计,记录和分析足底压力与胫骨冲击的特点。结果:第一和第二足底压力峰值(发生时间)、压力时间积分、峰值压力分布在混凝土、塑胶、草地和正常的跑步机的表面间没有明显差异。在5种不同测试表面下,峰值加速度正值也无显著差异。但相比于混凝土表面,在配备EVA缓冲衬垫物的跑步机上跑步能明显减小在冲击阶段的足底压力第一峰值和压力积分(p<0.05)。上述结果可进一步归因为足后跟区域峰值压力下降(P<0.05)。结论:运动表面和下肢冲击之间也许并无必然关系。然而值得注意的是,在解释足底压力的表现及将其运用到陆地表面的跑步运动中时应考虑不同跑步机表面的影响。 | Weijie Fu Ying Fang David Ming Shuo Liu Lin Wang Sicong Ren Yu Liu | 2015 | Journal of Sport and Health Science2015，4，4： | 4 |
| 6 | Biomolecular network-based synergistic drug combination discovery:a combination of paeoniflorin and liquiritin alleviates neuropathic pain by inhibiting neuroinflammation via suppressing the chemokine signaling pathway显示文摘Dear Editor,Neuropathic pain(NP)resulting from injuries or diseases affecting the somatosensory nervous system is highly prevalent in various pathological conditions.1 Since NP is debilitating and impacts health and the quality of life,there is an urgent need for effective non-addictive new therapies.Traditional Chinese medicine(TCM)has been increasingly used for its benefits in relieving pain in clinics.Wu-Tou Decoction(WTD),which was first described by the famous TCM classic“Jin Gui Yao Lue”,is one of the most effective TCM herbal prescriptions for pain management.A growing body of clinical evidence shows that WTD markedly alleviates different types of NP,such as trigeminal neuralgia,inflammatory pain,and cancer-induced pain,with a total effectiveness of~80%.2 Our previous data demonstrated the analgesic effects of WTD via suppression of glial cell activation and neuroinflammation and further revealed that WTD attenuated NP partially by inhibiting spinal astrocytic IL-1R1/TRAF6/JNK signaling and regulating the glutamatergic system in CA3 in spinal nerve ligation(SNL)-induced NP in vivo.3,4 However,the bioactive compounds(BACs)of WTD that have an effect on NP and the underlying mechanisms remain unclear. | Qiuyan Guo Weijie Li Chao Wang Xia Mao Xiaoyue Wang Wenjia Chen Haiyu Xu Qian Wang Yanqiong Zhang Na Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 7 | Combinational biosynthesis and characterization of a fluorescent 82β-phycocyanin of Spirulina platensis显示文摘To biosynthesize fluorescent Spirulina platensis (Sp)β -phycocyanin (PC) in Escherichia coli, a BLASTP search for homologs of the cpeS gene, a chromophore lyase, was performed against the Synechocystis sp. PCC 6803 (S6) proteome. A highly homologous gene, slr2049, was obtained from the S6 genome. Sites 82 and 153 in -phycocyanin of Sp were modified by site-directed muta- genesis. Two recombinant expression vectors were constructed and transformed into E. coli BL21: (i) pCDF-cpcB (C153A)- slr2049-sll0583-ho1-pcyA; and (ii) pCDF-cpcB (C82I)-slr2049-sll0583-ho1-pcyA. Lyases encoded by the genes slr2049 and sll0583 catalyzed the linking of Sp 82β -PC to phycocyanobilin (PCB), and fluorescent CpcB (C153A)-PCB was generated. We present a strategy for the co-expression of multiple genes in a single expression vector to identify the function of an unknown gene. Recombinant phycobiliproteins produced on a large scale are promising fluorescent tags for diagnostics and pharmacology. | GUAN XiangYu ZHANG WeiJie CHI XiaoYuan LIN HanZhi WANG JinFeng QIN Song | 2012 | Chinese Science Bulletin2012，57，25： | 3 |
| 8 | Molecular Cloning,Bioinformatics Analysis and Transcriptional Expression of Virulence-related Gene(exsA)of Vibrio alginolyticus显示文摘[Objectives]The purpose was to investigate the function and mechanism of exsA gene in type III secretion system of Vibrio alginolyticus.[Methods]The full length of exsA was cloned using molecular biology techniques to analyze its biological information.Fluorescence quantitative PCR technology was used to analyze the expression of exsA after different media stress.[Results]The exsA gene contains an open reading frame(ORF)of 861 bp,encoding 286 amino acids.The physico-chemical analysis shows that the molecular structural formula is C1442H2267N393O441S12,the theoretical molecular weight is 32.549 kD,the theoretical pI value is 6.0,and the protein is non-hydrophilic and unstable.The gene does not contain a transmembrane region,and there is no obvious signal peptide.The prediction result of protein subcellular localization shows that the protein is inside the cell.The deduced amino acid sequence and constructed phylogenetic tree show that V.alginolyticus has a close relationship with Vibrio antiquarius.The qPCR results show that the expression level of exsA in different media is different,highest in TSB medium containing bile salts,followed by DMEM medium,and lowest in ordinary TSB medium.[Conclusions]The gene sequence,molecular structure and isoelectric point of exsA,as well as its expression in three different media were obtained. | Weijie ZHANG Liangchuan CHEN Lin LIN Shihui ZHOU Zihao HE Yanqiu LIANG Huanying PANG | 2021 | Asian Agricultural Research2021，13，1： | 2 |
| 9 | Effects of inherent alkali and alkaline earth metals on nitrogen transformation during steam gasification of Shengli lignite显示文摘This work evaluated the effects of inherent alkali and alkaline earth metals on nitrogen transformation during steam gasification of Shengli lignite at the temperature of 873-1173 K in a fluidized-bed/fixed-bed quartz reactor. The results indicated that the alkali metal Na and alkaline earth metals Ca, Mg in coal have different effects on inherent nitrogen transformation to NH3, HCN and char-N during the lignite steam gasification. Specifically during the steam gasification of Shengli lignite, Na and Ca, Mg not only catalyze the inherent nitrogen conversions to NH3, but also promote the secondary reactions of the nascent char-N as well as the generation of NH3 from the generated HCN, meanwhile they also inhibited the inherent nitrogen conversion to HCN and char-N. The presence of Na, Ca and Mg hindered the formation of oxidized nitrogen (N-X) functional groups, but enhanced pyridinic nitrogen (N-6) and quaternary nitrogen's (N-Q) formation in char. | Panpan Zheng Yonggang Wang Chen Liu Weijie Guo Lei Bai Xiao Hu Xiongchao Lin | 2019 | International Journal of Coal Science & Technology2019，6，2： | 2 |
| 10 | Relationships between body weight and other morphological traits in young sea cucumbers Apostichopus japonicas显示文摘Correlation, multiple regression, and path analyses were used to investigate the relationships between body weight and three other morphological traits in juvenile Japanese sea cucumbers Apostichopus japonicus . We measured live body weight (BW), body length (BL), numbers of papillae (NP), and numbers of tube feet (NF) at 60, 80, 100, and 130 days post-hatching (dph). We calculated path correlation coefficients, correlation indices ( R 2 ), and coefficients of determination with BW as the dependent variable and the other morphological traits as independent variables. The coefficient of variation for BW was high across all age groups, and all measured morphological traits were significantly correlated ( P < 0.01). BL had the greatest direct eff ect on BW across all age groups (60 dph, 0.526;80 dph, 0.404;100 dph, 0.620;and 130 dph, 0.681), while NF had the greatest indirect eff ect on BW across all age groups (60 dph, 0.528;80 dph, 0.452;100 dph, 0.666;and 130 dph, 0.603). Regression analyses between morphological traits and BW indicated that R 2 was greater than 0.85 only in the 100-dph specimens. The indirect eff ects of the other measured morphological traits on BW were age-dependent. The optimal regression equations, as determined with stepwise regression, were, for 60-dph specimens: BW 60 =10 (-3.04+0.092BL+0.014NP+0.014NF)( R 2 =0.632);for 80-dph specimens: BW 80 =10 (- 3.035+0.056BL+0.017NP+0.02NF)( R 2 =0.686);for 100-dph specimens: BW 100 =10 (- 3.742+0.069BL+0. 633 · lg (NP)+0. 464 · lg (NF))( R 2 =0.893);and for 130-dph specimens: BW 130 =10 (- 2.472+0.065BL+0.012NP)( R 2 =0.774). Our work clarified the correlation between various morphological traits and body weight of a commercially-important sea cucumber species ( A . japonicus ). Our predictive models for body weight might be useful for the aquaculture and selective breeding of A . japonicus . These models might also provide theoretical support for the indirect selection of traits that are difficult to select directly. | ZHAN Yaoyao ZHANG Weijie GE Chen LIN Kai LI Guang SONG Jian CHANG Yaqing | 2019 | Journal of Oceanology and Limnology2019，37，2： | 2 |
| 11 | Co encapsulated N-doped carbon nanotubes as robust catalyst for valorization of levulinic acid in aqueous media显示文摘The construction of an acid resistant catalyst for synthesis of γ-valerolactone from levulinic acid in aqueous media is an important but highly challenging goal.Herein,an efficient Co@NCNT-800(after 800℃ pyrolysis) catalyst was constructed by confining Co in N-doped carbon nano-tubes(NCNT) from low cost materials by a facile strategy.Combined with the characterization results and control experiments,the in situ formed Co and Co-Ox, but not Co-Nx, proved to be the main synergistic active sites of the catalyst.It was also found that Co species are completely isolated within the bamboo-like NCNT,which could protect the metal nanoparticles from agglomeration and leaching in the strong acid reaction system.The γ-valerolactone yield of no less than 99.9% can be obtained under a relatively mild condition,and the catalytic performance has not been significantly reduced within five cycles.Therefore,this work may pave a way for the design of robust non-noble catalyst,and has potential for the production of γ-valerolactone from biomass in large-scale industries. | Xiangjin Kong Weijie Geng Wenxiu Li Lin Liu Xiaoqi Yan Longchen Gong Junhai Liu | 2021 | Journal of Energy Chemistry2021，30，1： | 1 |
| 12 | Microstructure and Mechanical Property of In Situ Synthesized Multiple-Reinforced (TiB + TiC + La2 O3 )/Ti Composites 显示文摘 | Yang Zhifeng Lu Weijie Zhao Lin | 2008 | Journal of AUoys and Compounds2008，455，12： | 1 |
| 13 | Electron spin resonance studies of CuO supported on tetragonal ZrO2显示文摘 | Zheng Liu Weijie Ji Lin Dong | 1997 | J Catal1997，172，： | 1 |
| 14 | Modeling and optimization of a seeded suspension polymerization process显示文摘 | Weijie Lin Lorenz T. Biegler Annette M. Jacobson | 2010 | Chemical Engineering Science2010，，15： | 1 |
| 15 | Synthesis of multifarious hierarchical flower-like Ni O and their gas-sensing properties显示文摘 | Lin Liyang Liu Tianmo Yu Weijie | 2013 | Materials Research Bulletin2013，48，： | 1 |
| 16 | Purifying chylous plasma by precluding triglyceride via carboxylated polyethersulfone microfiltration membrane显示文摘Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is high-cost and time-consuming.Herein,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were conducted.Attenuated total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified membrane.To test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification effectiveness.Furthermore,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting materials.The carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma. | Yang Liu Qiu Han Guiliang Li Haibo Lin Fu Liu Gang Deng Dingfeng Lv Weijie Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，9： | 1 |
| 17 | Correlates of Sexual Lifestyles Among Older Adults Living With HIV in China: Findings From the Sexual Well-being (SWELL) Study显示文摘Sexual lifestyles are closely related to overall human health and well-being.Few studies have focused on sexual lifestyles among older adults living with HIV(OALHIV),especially in low-and middle-income countries.This study is a part of the sexual well-being among older adults in China(SWELL)study,which is a multicenter cross-sectional study focused on sexual health among older adults aged 50 years and older.Participants were 680 OALHIV(≥50 years old)from the SWELL study conducted from June 2020 to December 2022.Data were collected through one-on-one interviews.We used logistic regression to assess the correlates of sexual activity and sexual satis-faction.Among all participants,37.1%were sexually active.Being older,male,in a steady relationship and employed were associated with being sexually active.The prevalence of sexual satisfaction was 69.8%among sexually active OALHIV.Being homosexual and reporting a better general health status were associated with sexual satisfaction.The OALHIV who have depressive symptoms were less likely to report sexual satisfaction.To support holistic healthy aging among OALHIV,it is important for healthcare providers to be educated about the importance of enquiring about sexual activity,satisfaction and problems and addressing concerns while conveying sex-positive attitudes during clinical reviews,as these are still critical aspects of their health and well-being. | Bingyi Wang Xin Peng Leiwen Fu Xinyi Li Tongxin Shi Bowen Liang Tian Tian Thomas Fitzpatrick Zhen Lu Weijie Zhang JunyeBian Xin Xiao YingWang Yunlong Ao Lin Ouyang YongCai Maohe Yu Guohui Wu Linghua Li Xiaojun Meng Huachun Zou | 2023 | Infectious Microbes & Diseases2023，5，3： | 1 |
| 18 | Enhanced photon communication through Bayesian estimation with an SNSPD array显示文摘Laser communication using photons should consider not only the transmission environment’s effects,but also the performance of the single-photon detector used and the photon number distribution.Photon communication based on the superconducting nanowire single-photon detector(SNSPD)is a new technology that addresses the current sensitivity limitations at the level of single photons in deep space communication.The communication’s bit error rate(BER)is limited by dark noise in the space environment and the photon number distribution with a traditional single-pixel SNSPD,which is unable to resolve the photon number distribution.In this work,an enhanced photon communication method was proposed based on the photon number resolving function of four-pixel array SNSPDs.A simulated picture transmission was carried out,and the error rate in this counting mode can be reduced by 2 orders of magnitude when compared with classical optical communication.However,in the communication mode using photon-enhanced counting,the four-pixel response amplitude for counting was found to restrain the communication rate,and this counting mode is extremely dependent on the incident light intensity through experiments,which limits the sensitivity and speed of the SNSPD array’s performance advantage.Therefore,a BER theoretical calculation model for laser communication was presented using the Bayesian estimation algorithm in order to analyze the selection of counting methods for information acquisition under different light intensities and to make better use of the SNSPD array’s high sensitivity and speed and thus to obtain a lower BER.The counting method and theoretical model proposed in this work refer to array SNSPDs in the deep space field. | XIANG LI JINGROU TAN KAIMIN ZHENG LABAO ZHANG LIJIAN ZHANG WEIJI HE PENGWEI HUANG HAOCHEN LI BIAO ZHANG QI CHEN RUI GE SHUYA GUO TAO HUANG XIAOQING JIA QINGYUAN ZHAO XUECOU TU LIN KANG JIAN CHEN PEIHENG WU | 2020 | Photonics Research2020，8，5： | 1 |
| 19 | Pyrrole derivatives as interlayer modifier of Li-S batteries:Modulation of electrochemical performance by molecular perturbation显示文摘The electrochemical performance of lithium-sulfur(Li-S)batteries is strongly hampered by the shuttle effect and slow redox kinetics of lithium polysulfides(Li PSs).Surface modified interlayer of a separator of Li-S batteries is demonstrated to be an effective strategy to overcome this problem.Herein,cobalt nanoparticles confined in nitrogen co-doped porous carbon framework(Co-CN)were developed from pyrolysis of ZIF-67 and used as interlayer of PP separator for Li-S batteries,and were functionalized by four pyrrole derivatives,1-phenylpyrrole,1-methyl pyrrole,1-(p-toluenesulfonyl)pyrrole,and 1-pyrrole,respectively,which were screened in terms of the electron-withdrawing/donating ability of the substituent groups on the pyrrolic nitrogen.The impact of the molecular structure of pyrrole derivatives on the interaction with Li PSs and the electrochemical performance of Li-S batteries were explored by nuclear magnetic resonance and theoretical calculation.It is uncovered that 1-phenylpyrrole shows the highest enhancement of redox kinetics of Li PSs,attributing to the optimal interaction with Co nanoparticles and Li PSs.Therefore,1-phenylpyrrole modified Co-CN interlayer enables the best electrochemical performance for the Li-S batteries,delivering a specific capacity of 562 m Ah g^(-1)at 5 C and a capacity of 538,526,and 449 m Ah g^(-1)after 500 cycles at 1,2,and 3 C,respectively.At a high sulfur loading of 5.5 mg cm^(-2),it achieves a capacity of 440 m Ah g^(-1)after 500 cycles at 1 C.This work reveals the interaction mechanism among Li PSs,Co nanoparticles and the molecular modifiers in improving the electrochemical performance of Li-S batteries. | Jiajv Lin Yuan Zhou Jingbo Wen Weijie Si Hongcheng Gao Gongming Wang Xiongwu Kang | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 20 | Soluble dendron-functionalized carbon nanotubes: Preparation, characterization, and properties 显示文摘 | Sun Yaping Huang Weijie Lin Yi | 2001 | Chemistry Materials2001，13，9： | 1 |
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