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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 3 | Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress显示文摘Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H 2 O 2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H 2 O 2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. | Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao | 2014 | Neural Regeneration Research2014，9，3： | 17 |
| 4 | Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells显示文摘Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt's lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a microsphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young's modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young's modulus than that of indolent cancer cells, which may improve our understanding of metastasis. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2012 | Science China(Life Sciences)2012，55，11： | 16 |
| 5 | The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998. | Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING | 2017 | Journal of Meteorological Research2017，31，2： | 11 |
| 6 | Effects of riparian land use on water quality and fish communities in the headwater stream of the Taizi River in China显示文摘 | Sen DING Yuan ZHANG Bin LIU Weijing KONG Wei MENG | 2013 | Frontiers of Environmental Science & Engineering2013，7，5： | 8 |
| 7 | Tropospheric biennial oscillation of the western Pacific subtropical high and its relationships with the tropical SST and atmospheric circulation anomalies显示文摘There is the significant period of tropospheric biennial Oscillation(TBO)over East Asian monsoon region at the interannual timescales,which has the important influences on East China climate.Based on a set of reconstructed indices which describes the western Pacific subtropical high(WPSH)objectively,this paper focuses on the TBO component of WPSH,one of the key members of the East Asian Monsoon system,and its relationships with the tropical SST and atmospheric circulation anomalies.It is found that(1)As an important interannual component of WPSH,the time series of TBO has the obvious transition in the late1970s,and the variability of the WPSH’s TBO component is more significant after the late 1970s.(2)The time-lag correlations between the WPSH’s TBO and the tropical sea surface temperature(SST)anomalies in several key ocean regions are more significant and have longer correlation duration than the raw data.The response of the western boundary index to ENSO is earlier than the intensity index,and the time-lag correlations of them are up to maximum when lagging ENSO by 3–5 months and 5–6months,respectively.(3)In the course of the WPSH’s TBO cycle,the occurrence of the El Ni o-like anomaly in the tropical central-eastern Pacific in winter is always coupled with the weak East Asian winter monsoon,with the most significant enhancing phase of the WPSH’TBO.In contrast,the La Ni a-like anomaly in the central-eastern Pacific in winter is coupled with the strong East Asian winter monsoon,with the most weakening phase of the WPSH’s TBO.(4)The distribution of the tropical SST and atmospheric circulations anomalies are asymmetric in the TBO cycle.The WPSH’s TBO is more significant in the period of the developing El Ni o-like anomaly in central-eastern Pacific than in the period of the developing La Ni a-like anomaly.Therefore,during the period of developing El Ni o-like anomaly,more attention should be paid to the interannual component of TBO signal in the short-term climate prediction. | LIU YunYun DING YiHui GAO Hui LI WeiJing | 2013 | Chinese Science Bulletin2013，58，30： | 8 |
| 8 | Mapping CD20 molecules on the lymphoma cell surface using atomic force microscopy显示文摘Atomic force microscopy (AFM) was used to locate CD20 molecules on the surface of lymphoma Raji cells. Rituximab (a monoclonal antibody against CD20) molecules were linked onto the AFM tip via a polyethylene glycol (PEG) linker. Raji cells were adsorbed onto glass slides coated with poly-L-lysine. First, the CD20 distribution in a local area of the cell surface was visualized using the AFM lift scan mode. Second, 16 × 16 force curves were obtained from the same cell area to construct the CD20-rituximab binding force map. Finally, free rituximab was added to block the CD20 molecules on the cell surface and the lift phase image and CD20-rituximab force map were obtained again. The experimental results indicated that when the lift height was greater than the length of the PEG linker, no recognition sites were observed in the lift phase image. However, as the lift height decreased to the length of the PEG linker, some recognition sites were observed in the lift phase image and these sites were generally consistent with the pixels in the force map. After blocking, both the recognition sites in the lift phase image and the gray pixels in the binding force map decreased markedly. These results can improve our understanding of the distribution of protein molecules on the cell surface and facilitate further investigations into cellular functions. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2013 | Chinese Science Bulletin2013，58，13： | 6 |
| 9 | Atomic force microscopy imaging of live mammalian cells显示文摘Atomic force microscopy (AFM) was used to examine the morphology of live mammalian adherent and suspended cells. Time-lapse AFM was used to record the locomotion dynamics of MCF-7 and Neuro-2a cells. When a MCF-7 cell retracted, many small sawtooth-like filopodia formed and reorganized, and the thickness of cellular lamellipodium increased as the retraction progressed. In elongated Neuro-2a cells, the cytoskeleton reorganized from an irregular to a parallel, linear morphology. Suspended mammalian cells were immobilized by method combining polydimethylsiloxane-fabricated wells with poly-L-lysine electrostatic adsorption. In this way, the morphology of a single live lymphoma cell was imaged by AFM. The experimental results can improve our understanding of cell locomotion and may lead to improved immobilization strategies. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2013 | Science China(Life Sciences)2013，56，9： | 6 |
| 10 | Progress of AFM single-cell and single-molecule morphology imaging显示文摘Atomic force microscopy (AFM) can probe single living cells and single native membrane proteins in natural fluid environments with label-free high spatial resolution. It has thus become an important tool for cellular and molecular biology that significantly complements traditional biochemical and biophysical techniques such as optical and electron microscopy and X-ray crystallog-raphy. Imaging surface topography is the primary application of AFM in the life sciences. Since the early 1990s, researchers have used AFM to investigate morphological features of living cells and native membrane proteins with impressive results. Steady improvements in AFM techniques for imaging soft biological samples have greatly expanded its applications. Based on the authors' own research in AFM imaging of living cell morphologies, a review of sample preparation procedures for single-cell and single-molecule imaging experiments is presented, along with a summary of recent progress in AFM imaging of living cells and native membrane proteins. Finally, the challenges of AFM high-resolution imaging at the single-cell and single-molecule levels are discussed. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2013 | Chinese Science Bulletin2013，58，26： | 5 |
| 11 | Effects of temperature and cellular interactions on the mechanics and morphology of human cancer cells investigated by atomic force microscopy显示文摘Cell mechanics plays an important role in cellular physiological activities. Recent studies have shown that cellular mechanical properties are novel biomarkers for indicating the cell states. In this article, temperature-controllable atomic force microscopy(AFM) was applied to quantitatively investigate the effects of temperature and cellular interactions on the mechanics and morphology of human cancer cells. First, AFM indenting experiments were performed on six types of human cells to investigate the changes of cellular Young's modulus at different temperatures and the results showed that the mechanical responses to the changes of temperature were variable for different types of cancer cells. Second, AFM imaging experiments were performed to observe the morphological changes in living cells at different temperatures and the results showed the significant changes of cell morphology caused by the alterations of temperature. Finally, by co-culturing human cancer cells with human immune cells, the mechanical and morphological changes in cancer cells were investigated. The results showed that the co-culture of cancer cells and immune cells could cause the distinct mechanical changes in cancer cells, but no significant morphological differences were observed. The experimental results improved our understanding of the effects of temperature and cellular interactions on the mechanics and morphology of cancer cells. | LI Mi LIU LianQing XI Ning WANG YueChao XIAO XiuBin ZHANG WeiJing | 2015 | Science China(Life Sciences)2015，58，9： | 5 |
| 12 | Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma显示文摘Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a humanmouse chimeric anti-CD20 monoclonal antibody(SCT400) in Chinese patients with CD20-positive B-cell nonHodgkin's lymphoma(CD20+ B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is common in Asians.Methods: Fifteen patients with CD20+ B-cell NHL received dose-escalating SCT400 infusions(250 mg/m^2: n=3; 375 mg/m^2: n=9; 500 mg/m^2: n=3) once weekly for 4 consecutive weeks with a 24-week follow-up period. The data of all patients were collected for pharmacokinetics and pharmacodynamics analyses.Results: No dose-limiting toxicities were observed. Most drug-related adverse events were grade 1 or 2. Two patients had grade 3 or 4 neutropenia. Under premedication, the drug-related infusion reaction was mild. A rapid, profound and durable depletion of circulating B cells was observed in all dose groups without significant effects on T cell count, natural killer(NK) cell count or immunoglobulin levels. No patient developed antiSCT400 antibodies during the course of the study. SCT400 serum half-life(T1/2), maximum concentration(Cmax) and area under the curve(AUC) generally increased between the first and fourth infusions(P<0.05). At the 375 mg/m^2 dose, the T1/2 was 122.5±46.7 h vs. 197.0±75.0 h, respectively, and the Cmax was 200.6±20.2 μg/m L vs. 339.1±71.0 μg/m L, respectively. From 250 mg/m^2 to 500 mg/m^2, the Cmax and AUC increased significantly in a dose-dependent manner(P<0.05). Patients with a high tumor burden had markedly lower serum SCT400 concentrations compared with those without or with a low tumor burden. Of the 9 assessable patients, 1 achieved complete response and 2 achieved partial responses.Conclusions: SCT400 is well-tolerated and has encouraging preliminary efficacy in Chinese patients with CD20+ B-cell NHL. | Lin Gui Xiaohong Han Xiaohui He Yuanyuan Song Jiarui Yao Jianliang Yang Peng Liu Yan Qin Shuxiang Zhang Weijing Zhang Wenlin Gai Liangzhi Xie Yuankai Shi | 2016 | Chinese Journal of Cancer Research2016，28，2： | 5 |
| 13 | Role of MR-DWI and MR-PWI in the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbits显示文摘Objective: To detect the activity of tumor cells and tumor blood flow before and after the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbit models by using magnetic resonance diffusion-weighted imaging(MR-DWI) and magnetic resonance perfusion weighted imaging(MR-PWI), and to evaluate the effectiveness and safety of the radiotherapy based on the changes in the MR-DWI and MR-PWI parameters at different treatment stages.Methods: A total of 56 rabbit models with implanted pulmonary VX-2 carcinoma were established, and then equally divided into treatment group and control group. MR-DWI and MR-PWI were separately performed using a Philips Acheiva 1.5T MRI machine(Philips, Netherland). MRI image processing was performed using special perfusion software and the WORKSPACE advanced workstation for MRI. MRDWI was applied for the observation of tumor signals and the measurement of apparent diffusion coefficient(ADC) values; whereas MR-PWI was used for the measurement of wash in rate(WIR), wash out rate(WOR), and maximum enhancement rate(MER). The radiation treatment was performed using Siemens PRIMUS linear accelerator. In the treatment group, the radiotherapy was performed 21 days later on a once weekly dosage of 1,000 c Gy to yield a total dosage of 5,000 c Gy.Results: The ADC parameters in the region of interest on DWI were as follows: on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values at the center and the edge of the lesions were 1.352 and 1.461 in the treatment group and control group(P>0.05). During weeks 0-1 after treatment, the t values at the center and the edge of the lesions were 1.336 and 1.137(P>0.05). During weeks 1-2, the t values were 1.731 and 1.736(P<0.05). During weeks 2-3, the t values were 1.742 and 1.749(P<0.05). During weeks 3-4, the t values were 2.050 and 2.127(P<0.05). During weeks 4-5, the t values were 2.764 and 2.985(P<0.05). The ADC values in the treatment group were significantly higher than in the control group. After the radiotherapy(5,000 c Gy), the tumors remarkably shrank, along with low signal on DWI, decreased signal on ADC map, and remarkably increased ADC values. As shown on PWI, on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values of the WIR, WOR, and MER at the center of the lesions were 1.05, 1.31, and 1.33 in the treatment group and control group(P>0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.35, 1.07, and 1.51(P>0.05). During weeks 0-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 1.821, 1.856, and 1.931(P<0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.799, 2.016, and 2.137(P<0.05). During weeks 1-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.574, 2.156, and 2.059(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 1.869, 2.058, and 2.057(P<0.05). During weeks 2-3 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.461, 2.098, and 2.739(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.951, 2.625, and 2.154(P<0.05). During weeks 3-4 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.584, 2.107, and 2.869(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.057, 2.637, and 2.951(P<0.05). During weeks 4-5 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.894, 2.827, and 3.285(P<0.05) and the t values of the WIR, WOR, andMER at the edge of the lesions were 3.45, 3.246, and 3.614(P<0.05). After the radiotherapy(500 c Gy), the tumors shrank on the T1 WI, WIR, WOR, and MER; meanwhile, the PWI parameter gradually decreased and reached its minimum value.Conclusions: MR-DWI and MR-PWI can accurately and directly reflect the inactivation of tumor cells and the tumor hemodynamics in rabbit models with implanted pulmonary VX-2 carcinoma, and thus provide theoretical evidences for judging the clinical effectiveness of radiotherapy for the squamous cell carcinoma of the lung. | Qiang Zhang Mingmin Zhang Zhaoxin Liu Baoqi Shi Fuliang Qi Haijiang Wang Yuan Lv Haijiao Jin Weijing Zhang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 5 |
| 14 | An observational study of snow aging and the seasonal variation of snow albedo by using data from Col de Porte, France显示文摘An 18-year long(1993–2011) comprehensive dataset of snow and meteorological variables from Col de Porte, France is used to analyze the variation of shortwave broadband albedo with elapsed time after snowfalls(snow aging) during each snow season. The effects of air temperature, snow surface temperature and snow depth on snow albedo are investigated. An index based on the accumulation of air temperature over several consecutive days with daily mean higher than 2.5 °C is proposed to divide each snow-covered period into a dry and the following wet snow season when this index reaches 18 °C.The results indicate that snow surface albedo decreases exponentially with time in both dry and wet snow seasons.Snow albedo reduction with snow aging is small at low surface temperature and the reduction rate increases with the rise of surface temperature. However, the reduction rate is widely scattered within the observed range of temperature, implying a loose relationship between snow albedo and snow surface temperature. Snow albedo in wet snowseason is generally smaller and decreases faster than in dry snow season. For Col de Porte site, snow depths to effectively mask the underlying surface are 21 and 33 cm in dry and wet snow season respectively. | Ajiao Chen Weiping Li Weijing Li Xin Liu | 2014 | Chinese Science Bulletin2014，59，34： | 5 |
| 15 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 16 | Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence显示文摘 | Hui Ye Xiaobo Wang Zongcheng Li Fan Zhou Xianlong Li Yanli Ni Weijing Zhang Fuchou Tang Bing Liu Yu Lan | 2017 | Cell Research2017，27，8： | 4 |
| 17 | Improvement of 6–15 Day Precipitation Forecasts Using a Time-Lagged Ensemble Method显示文摘A time-lagged ensemble method is used to improve 6–15 day precipitation forecasts from the Beijing Climate Center Atmospheric General Circulation Model, version 2.0.1. The approach averages the deterministic predictions of precipitation from the most recent model run and from earlier runs, all at the same forecast valid time. This lagged average forecast(LAF) method assigns equal weight to each ensemble member and produces a forecast by taking the ensemble mean. Our analyses of the Equitable Threat Score, the Hanssen and Kuipers Score, and the frequency bias indicate that the LAF using five members at time-lagged intervals of 6 h improves 6–15 day forecasts of precipitation frequency above 1 mm d-1and 5 mm d-1in many regions of China, and is more effective than the LAF method with selection of the time-lagged interval of 12 or 24 h between ensemble members. In particular, significant improvements are seen over regions where the frequencies of rainfall days are higher than about 40%–50% in the summer season; these regions include northeastern and central to southern China, and the southeastern Tibetan Plateau. | JIE Weihua WU Tongwen WANG Jun LI Weijing LIU Xiangwen | 2014 | Advances in Atmospheric Sciences2014，31，2： | 4 |
| 18 | Detecting CD20-Rituximab interaction forces using AFM single-molecule force spectroscopy显示文摘The invention of atomic force microscopy(AFM) has provided new technology for measuring specific molecular interaction forces.Using AFM single-molecule force spectroscopy(SMFS) techniques,CD20-Rimximab rupture forces were measured on purified CD20 proteins,Raji cells,and lymphoma patient B cells.Rimximab molecules were linked onto AFM tips using AFM probe functionalization technology,and purified CD20 proteins were attached to mica using substrate functionalization technology.Raji cells(a lymphoma cell line) or lymphoma patient cells were immobilized on a glass substrate via electrostatic adsorption and chemical fixation.The topography of the purified CD20 proteins,Raji cells,and patient lymphoma cells was visualized using AFM imaging and the differences in the rupture forces were analyzed and measured.The results showed that the rupture forces between the CD20 proteins on Raji cells and Rituximab were markedly smaller than those for purified CD20 proteins and CD20 proteins on lymphoma patient B cells.These findings provide an effective experimental method for investigating the mechanisms underlying the variable efficacy of Rituximab. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi LI GuangYong XIAO XiuBin ZHANG WeiJing | 2011 | Chinese Science Bulletin2011，56，35： | 3 |
| 19 | Decomposition and decoupling analysis of carbon dioxide emissions in African countries during 1984–2014显示文摘The potential for mitigating climate change is growing worldwide,with an increasing emphasis on reducing CO_(2)emissions and minimising the impact on the environment.African continent is faced with the unique challenge of climate change whilst coping with extreme poverty,explosive population growth and economic difficulties.CO_(2)emission patterns in Africa are analysed in this study to understand primary CO_(2)sources and underlying driving forces further.Data are examined using gravity model,logarithmic mean divisia index and Tapio's decoupling indicator of CO_(2)emissions from economic development in 20 selected African countries during 1984-2014.Results reveal that CO_(2)emissions increased by 2.11%(453.73 million ton)over the research period.Gravity centre for African CO_(2)emissions had shifted towards the northeast direction.Population and economic growth were primary driving forces of CO_(2)emissions.Industrial structure and emission efficiency effects partially offset the growth of CO_(2)emissions.The economic growth effect was an offset factor in central African countries and Zimbabwe due to political instability and economic mismanagement.Industrial structure and emission efficiency were insufficient to decouple economic development from CO_(2)emissions and relieve the pressure of population explosion on CO_(2)emissions in Africa.Thus,future efforts in reducing CO_(2)emissions should focus on scaleup energy-efficient technologies,renewable energy update,emission pricing and long-term green development towards sustainable development goals by 2030. | Claudien Habimana Simbi Jianyi Lin Dewei Yang Jean Claude Ndayishimiye Yang Liu Huimei Li Lingxing Xu Weijing Ma | 2021 | Journal of Environmental Sciences2021，33，4： | 3 |
| 20 | Precursory influence of the Antarctic Oscillation on the onset of Asian summer monsoon显示文摘The Asian summer monsoon(ASM) begins firstly over the Indo-China Peninsula in early May and over the South China Sea(SCS) in mid-May.The different monsoon onset dates can exert distinct effects on the summer rainfall in Asia.Statistical results indicate that the Antarctic Oscillation(AAO) in the boreal winter has a significant precursory influence on the ASM onset dates.In stronger AAO years,both the Mascarene high and the Australia high in March are stronger owing to the 'see-saw' structure of atmospheric circulation over the subtropics and higher latitudes in the Southern Hemisphere,and the tropical intertropical convergence zone(ITCZ) is deeper.Thus,the pressure gradient between the subtropical and tropical regions increases in spring.As a result,the Somalia cross-equatorial flow(SCEF) occurs earlier,strengthens,and enhances the westerlies over the tropical Indian Ocean.The enhanced westerlies impel an eastward withdrawal of the western Pacific subtropical high and intensify the convergence and rising motion at the lower troposphere,accelerating the burst of ASM.Differently,weaker AAO weakens the pressure gradient between the tropical and subtropical regions and delays the establishment of SCEF,resulting in a delayed onset of ASM.This study extends the leading time of seasonal forecast of ASM onset from the previous spring to winter and provides useful information about precursory signals in climate prediction operation. | GAO Hui LIU YunYun WANG YongGuang LI WeiJing | 2013 | Chinese Science Bulletin2013，58，6： | 2 |
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