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| 1 | The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998. | Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING | 2017 | Journal of Meteorological Research2017，31，2： | 11 |
| 2 | Effects of riparian land use on water quality and fish communities in the headwater stream of the Taizi River in China显示文摘 | Sen DING Yuan ZHANG Bin LIU Weijing KONG Wei MENG | 2013 | Frontiers of Environmental Science & Engineering2013，7，5： | 8 |
| 3 | Validation of a HRGC–ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma显示文摘Short-chain chlorinated paraffins(SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/serum, mainly due to the difficulty of sample preparation and quantitative analysis. A method using high resolution gas chromatography coupled with electron capture negative ionization low resolution mass spectrometry(HRGC–ECNI/LRMS) was developed and validated to measure SCCPs in human plasma. The pretreatment process included protein denaturation and lipid elimination, liquid–liquid extraction with a mixture of n-hexane/dichloromethane(1:1, V/V), and cleanup on a multilayer silica column. The blank controls, including procedural blank, vacuum blood collection tube blank, and instrumental blank, were the most pivotal points for the reliable analysis of SCCPs. The average value of procedural blanks was 9.0 ng/g; and the method detection limit(MDL), calculated as the sum of the average procedural blank value and 3 times of the standard deviation of the procedural blanks, was 12.6 ng/g plasma. The validated method was applied to measure the concentrations of the total SCCPs(∑ SCCPs) in50 plasma samples from a general population. The measured plasma concentrations of ∑SCCPs ranged from | Jiazhi Xu Weijing Guo Linhuan Wei Yuan Gao Haijun Zhang Yichi Zhang Ming Sun Jiping Chen | 2019 | Journal of Environmental Sciences2019，31，1： | 5 |
| 4 | Role of MR-DWI and MR-PWI in the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbits显示文摘Objective: To detect the activity of tumor cells and tumor blood flow before and after the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbit models by using magnetic resonance diffusion-weighted imaging(MR-DWI) and magnetic resonance perfusion weighted imaging(MR-PWI), and to evaluate the effectiveness and safety of the radiotherapy based on the changes in the MR-DWI and MR-PWI parameters at different treatment stages.Methods: A total of 56 rabbit models with implanted pulmonary VX-2 carcinoma were established, and then equally divided into treatment group and control group. MR-DWI and MR-PWI were separately performed using a Philips Acheiva 1.5T MRI machine(Philips, Netherland). MRI image processing was performed using special perfusion software and the WORKSPACE advanced workstation for MRI. MRDWI was applied for the observation of tumor signals and the measurement of apparent diffusion coefficient(ADC) values; whereas MR-PWI was used for the measurement of wash in rate(WIR), wash out rate(WOR), and maximum enhancement rate(MER). The radiation treatment was performed using Siemens PRIMUS linear accelerator. In the treatment group, the radiotherapy was performed 21 days later on a once weekly dosage of 1,000 c Gy to yield a total dosage of 5,000 c Gy.Results: The ADC parameters in the region of interest on DWI were as follows: on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values at the center and the edge of the lesions were 1.352 and 1.461 in the treatment group and control group(P>0.05). During weeks 0-1 after treatment, the t values at the center and the edge of the lesions were 1.336 and 1.137(P>0.05). During weeks 1-2, the t values were 1.731 and 1.736(P<0.05). During weeks 2-3, the t values were 1.742 and 1.749(P<0.05). During weeks 3-4, the t values were 2.050 and 2.127(P<0.05). During weeks 4-5, the t values were 2.764 and 2.985(P<0.05). The ADC values in the treatment group were significantly higher than in the control group. After the radiotherapy(5,000 c Gy), the tumors remarkably shrank, along with low signal on DWI, decreased signal on ADC map, and remarkably increased ADC values. As shown on PWI, on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values of the WIR, WOR, and MER at the center of the lesions were 1.05, 1.31, and 1.33 in the treatment group and control group(P>0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.35, 1.07, and 1.51(P>0.05). During weeks 0-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 1.821, 1.856, and 1.931(P<0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.799, 2.016, and 2.137(P<0.05). During weeks 1-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.574, 2.156, and 2.059(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 1.869, 2.058, and 2.057(P<0.05). During weeks 2-3 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.461, 2.098, and 2.739(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.951, 2.625, and 2.154(P<0.05). During weeks 3-4 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.584, 2.107, and 2.869(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.057, 2.637, and 2.951(P<0.05). During weeks 4-5 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.894, 2.827, and 3.285(P<0.05) and the t values of the WIR, WOR, andMER at the edge of the lesions were 3.45, 3.246, and 3.614(P<0.05). After the radiotherapy(500 c Gy), the tumors shrank on the T1 WI, WIR, WOR, and MER; meanwhile, the PWI parameter gradually decreased and reached its minimum value.Conclusions: MR-DWI and MR-PWI can accurately and directly reflect the inactivation of tumor cells and the tumor hemodynamics in rabbit models with implanted pulmonary VX-2 carcinoma, and thus provide theoretical evidences for judging the clinical effectiveness of radiotherapy for the squamous cell carcinoma of the lung. | Qiang Zhang Mingmin Zhang Zhaoxin Liu Baoqi Shi Fuliang Qi Haijiang Wang Yuan Lv Haijiao Jin Weijing Zhang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 5 |
| 5 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 6 | A freshwater ecoregion delineation approach based on freshwater maeroinvertebrate community features and spatial environmental data in Taizi River Basin, Northeastern China 显示文摘 | KONG Weijing MENG Wei ZHANG Yuan | 2013 | Ecological Research2013，28，： | 1 |
| 7 | End-user searching behavior in information re- trieval: a longitudinal study 显示文摘 | YUAN Weijing | 1997 | Journal of the American so- ciety for information science1997，48，3： | 1 |
| 8 | A freshwater ecoregion delineation approach based on freshwater macroinvertebrate community features and spatial environmental data in Taizi River Basin, Northeastern China 显示文摘 | KONG Weijing MENG Wei ZHANG Yuan | 2013 | Ecological Research2013，28，4： | 1 |
| 9 | End-user searching behavior in information retrieval: a longitudinal study 显示文摘 | YUAN Weijing | 1997 | Journal of the American Society for Information Science1997，48，3： | 1 |
| 10 | Measuring the impact of information: Defining the concepts 显示文摘 | Meadow C T Yuan Weijing | 1997 | Information Processing & Management1997，33，6： | 1 |
| 11 | Relationshipsbetween macroinvertebrate communities and land use types withindifferent riparian widths in three headwater streams of Taizi River,China显示文摘 | ZHANG Yuan ZHAO Rui KONG Weijing | 2013 | Journal of Freshwater Ecology2013，28，22： | 1 |
| 12 | Relationships betweenmacroinvertebrate communities and land use types within differentriparian width in three headwater streams of Taizi River,China显示文摘 | ZHANG Yuan ZHAO Rui KONG Weijing | 2013 | Journal of Freshwater Ecology2013，28，3： | 1 |
| 13 | A freshwaterecoregion delineation approach based on freshwatermacroinvertebrate community features and spatial environmentaldata in Taizi River Basin, Northeastern China 显示文摘 | KONG Weijing MENG Wei ZHANG Yuan | 2013 | EcologicalResearch2013，28，4： | 1 |
| 14 | CSCO guidelines for metastatic colorectal cancer:personalized medicine in clinical practice显示文摘Colorectal cancer(CRC)is the second most common cancer in China,the morbidity and mortality rates of which are rapidly increasing1,2.Among newly-diagnosed CRC patients,20%have metastatic disease at the time of presentation and an additional 25%present with localized disease and will subsequently develop metastases3.The treatment of metastatic colorectal cancer(mCRC)is gradually moving towards the era of precision therapy,which involves guided treatment based on individual genetic characteristics4.Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guidelines was published in 2017,the guidelines have been updated annually according to the latest clinical trial findings5-9.Herein we summarize how the CSCO guidelines enable tailor-made treatments of mCRC with different molecular characteristics(Figure 1). | Mengyuan Yang Ziheng Xu Mi Mi Yuwei Ding Yuefen Pan Ying Yuan Weijing Sun Shanshan Weng | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 15 | Screening for inhibitors against SARS-CoV-2 and its variants显示文摘Severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)continues to evolve,generating new variants that pose a threat to global health;therefore,it is imperative to obtain safe and broad‐spectrum antivirals against SARS‐CoV‐2 and its variants.To this end,we screened compounds for their ability to inhibit viral entry,which is a critical step in virus infection.Twenty compounds that have been previously reported to inhibit SARS‐CoV‐2 replication were tested by using pseudoviruses containing the spike protein from the original strain(SARS‐CoV‐2‐WH01).The cytotoxicity of these compounds was determined.Furthermore,we identified six compounds with strong antagonistic activity against the WH01 pseudovirus,and low cytotoxicity was identified.These compounds were then evaluated for their efficacy against pseudoviruses expressing the spike protein from B.1.617.2(Delta)and B.1.1.529(Omicron),the two most prevalent circulating strains.These assays demonstrated that two phenothiazine compounds,trifluoperazine 2HCl and thioridazine HCl,inhibit the infection of Delta and Omicron pseudoviruses.Finally,we discovered that these two compounds were highly effective against authentic SARS‐CoV‐2 viruses,including the WH01,Delta,and Omicron strains.Our study identified potential broad‐spectrum SARS‐CoV‐2 inhibitors and provided insights into the development of novel therapeutics. | Weijing Yuan Xiaojing Dong Lan Chen Xiaobo Lei Zhuo Zhou Li Guo Jianwei Wang | 2022 | Biosafety and Health2022，4，3： | 0 |
| 16 | Improved picoliter-sized micro-reactors for high-throughput biological analysis显示文摘High-throughput pyrosequencing,carried out in millions of picoliter-sized reactors on a fiber-optic slide,is known for its longer read length.However,both optical crosstalk(which reduces the signal-to-noise ratio of CCD images)and chemical retention adversely affect the accuracy of chemiluminescence determination,and ultimately decrease the read length and the accuracy of pyrosequencing results.In this study,both titanium and oxidized aluminum films were deposited on the side walls and upper faces of micro-reactor slides to enhance optical isolation;the films reduced the inter-well crosstalk by one order of magnitude.Subsequently,chemical retention was shown to be caused by the lower diffusion coefficient of the side walls of the picolitersized reactors because of surface roughness and random pores.Optically isolated fiber-optic slides over-coated with silicon oxide showed smoother surface morphology,resulting in little chemical retention;this was further confirmed with theoretical calculations.Picoliter-sized micro-reactors coated with titanium-silicon oxide films showed the least inter-well optical crosstalk and chemical retention;these properties are expected to greatly improve the high-throughput pyrosequencing performance. | HAN WeiJing YUAN LiNa WEI QingQuan LI YunTao REN LuFeng ZHOU XiaoGuang YU Jun YU YuDe | 2013 | Science China(Life Sciences)2013，56，12： | 0 |
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