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| 1 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 2 | Fine mapping of cisc(t),a gene for cold-induced seedling chlorosis,and identification of its candidate in rice显示文摘The seedlings of indica rice cultivar Dular are susceptible to chlorosis under low temperature conditions.Our previous studies indicated that low temperature-induced seedling chlorosis is controlled by a recessive gene,located between SSR markers RM257 and RM242,on the long arm of chromosome 9.We temporarily named the gene cisc(t).Using a large F2 population derived from a cross between Dular and the japonica cultivar Lemont,which displays a normal green color at low temperatures,cisc(t)was fine mapped to within a 12-kb interval.There is only one annotated gene in this interval,which encodes a pentatricopeptide repeat(PPR)protein.Sequence analysis indicated that 8 bases were deleted at the 60th base in the Dular allele,resulting in a frame-shift mutation and loss of function of the gene.This is consistent with the chlorosis mutant phenotype of Dular.In addition,previous studies have shown that many chlorosis mutants of seedlings are related to PPR proteins.Hence,we presume that the PPR gene is the candidate for cisc(t). | LAN Tao WANG Bin LING QiuPing XU ChunHua TONG ZhiJun LIANG KangJing DUAN YuanLin JIN Jing WU WeiRen | 2010 | Chinese Science Bulletin2010，55，27： | 5 |
| 3 | 3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes显示文摘 | ZHANG Shuo WANG Yuli LIU Wei XIE Yafei LIU Yuqiang XU Weiren TANG Lida WANG Jianwua ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 4 | gem-Dimethyl-bearing C-Glucosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors显示文摘三新奇 gem-dimethyl C 配糖物作为钠葡萄糖 co 搬运被设计 2 (SGLT2 ) 禁止者,和他们的综合体从 D 葡萄糖开始了,三 2-substituted-5-bromobenzoic 酸经由一个灵巧的 8 步协议被完成,与是无水的关键步铝第三级的白酒和苯乙醚的催化氯化物的 Friedel 手艺完化。这三个 SGLT2 禁止者在 vivo 被评估与一鼠标口头的葡萄糖忍耐测试(OGTT ) ,和所有这三混合物的 anti-hyperglycemic 活动与积极控制 Dapagliflozin 的是可比较的。 | Shi, Yongheng Zhao, Guilong Lou, Yuanyuan Wang, Yuli Shao, Hua Liu, Wei Xu, Weiren Tang, Lida | 2011 | Chinese Journal of Chemistry2011，29，6： | 2 |
| 5 | Scalable video object coding & QoS control for next generation space internet显示文摘The next generation space internet (NGSI) is based on all-IP-based mobile network that merges land-based network, sea-based network, sky-based network, spacebased network, deep space-based network together using existing assess network technologies. There are high signal propagation delays, high error rate, bandwidth variation and time-variety in NGSI. In order to adapt to various space communication environment constraints and bandwidth variation, we propose a reduced dimension scalable video coding scheme based on CCSDS IDCS algorithm and quality of service (QoS) control method by cross layer design (CLD). The experimental result shows that this new method has better performance than that of existing algorithms, and can be adaptive to the bandwidth variation dynamically. | TU GuoFang ZHANG Can HEINRICH Nimann XU Jie WU WeiRen | 2008 | Science in China(Series F)2008，51，5： | 2 |
| 6 | Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors显示文摘 | CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 7 | The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations显示文摘The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics.In addition,we compared the fluvastatin pharmacokinetics differences between extended-release(ER)80 mg tablet and immediate-release(IR)40 mg capsule in terms of drug metabolism enzyme and transporter genetic polymorphisms.In this open-label,randomized,two-period,two-treatment,crossover study(n=24),effects of ABCG2,SLCO1B1,ABCB1,CYP2C9 and CYP3A5 polymorphisms on the pharmacokinetics of fluvastatin were analyzed.The administration dosage for IR 40 mg and ER 80 mg were twice and once daily,respectively,for total 7 d.Blood samples for pharmacokinetic evaluation were taken on the 1st and 7th d.The lower exposure following ER was observed.For ER tablets,SLCO1B1 T521C genotype correlated with AUC 0-24 of repeat doses(P=0.010).SLCO1B1 T521C genotype had no statistically significant effect on AUC 0-24 of IR capsule of fluvastatin after single or repeated doses.In vitro study demonstrated that when the concentration of fluvastatin was low(<1μmol/l),the uptake of fluvastatin in the HEK293-OATP1B1 with SLCO1B1521TT(K m=0.18μmol/l)was faster than that with SLCO1B1521CC(K m=0.49μmol/l),On the other hand,when concentration reached to higher level(>1μmol/l),transport velocity of fluvastatin by HEK293-OATP1B1 with SLCO1B1521TT(K m=11.4μmol/l)and with SLCO1B1521TCC(K m=15.1μmol/l)tend to be the same.It suggests that the increased effect of SLCO1B1 T521C genotype on ER formulation of fluvastatin was mainly caused by lower blood concentrations.We recommend that formulation should be incorporated into future pharmacogenomics studies. | Qian Xiang Weidang Wu Nan Zhao Chuan Li Junyu Xu Lingyue Ma Xiaodan Zhang Qiufen Xie Zhuo Zhang Jiancheng Wang Weiren Xu Xia Zhao Yimin Cui | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 1 |
| 8 | Progress in pharmacological studies of berberine显示文摘 | Zhen Hongyan Xu Weiren | 2004 | Chinese Traditional and Herbal Drug2004，35，6： | 1 |
| 9 | Facile Synthesis of Enantiomerically Pure 1-(5-Bromo-2-chlorophenyl)-1-(4-ethoxyphenyl)ethane显示文摘 | ZHANG Shuo WANG Wenjin LI Chuan LIU Peng XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，2： | 0 |
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