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| 1 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 2 | The Bedload Movement in the Changjiang Estuary显示文摘- Sandwaves in the Changjiang estuary were measured with a shallow sediment profiler and an echosounder from 1978 to 1988. The data, together with grain size and bedform of sediment indicates that the bedload movement by rolling and saltation is of great significance to sediment transport and is the principal factor responsible for sandwave and sandbody development in the estuary. The sandwaves were found well-developed, which is related to the tidal range and the velocity of ebb current. However, the further growth is restricted by strong flood current prevailing in the estuary. Because of the significant bedload, the sandbodies shift obviously and frequently, and sometimes the exchange of position occurs between the sandbodies and tidal channels. As a result, ships are regularly forced to change their navigation course. | Li Jiufa, Shi Weirong, Shen Huanting Xu Haigen and Doeke Eisma Associate Professor, Institute of Estuarine & Coastal Research (1ECR), East China Normal University, Shanghai200062 Professor, IECR, East China Normal University, Shanghai 200062 Professor, Netherlands Institute for Sea Research, P. O. Box 59 1790 AB, Den Burg, Texel, The Netherlands | 1993 | China Ocean Engineering1993，8，4： | 15 |
| 3 | Seeker optimization algorithm:a novel stochastic search algorithm for global numerical optimization显示文摘A novel heuristic search algorithm called seeker optimization algorithm(SOA) is proposed for the real-parameter optimization.The proposed SOA is based on simulating the act of human searching.In the SOA,search direction is based on empirical gradients by evaluating the response to the position changes,while step length is based on uncertainty reasoning by using a simple fuzzy rule.The effectiveness of the SOA is evaluated by using a challenging set of typically complex functions in comparison to differential evolution(DE) and three modified particle swarm optimization(PSO) algorithms.The simulation results show that the performance of the SOA is superior or comparable to that of the other algorithms. | Chaohua Dai Weirong Chen Yonghua Song Yunfang Zhu | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 13 |
| 4 | Degradation and biological properties of Ca-P contained micro-arc oxidation self-sealing coating on pure magnesium for bone fixation显示文摘Poor corrosion resistance is one of the main disadvantages for biodegradable magnesium-based metals,especially applied for bone fixation,where there is a high demand of bio-mechanical strength and stability.Surface coating has been proved as an effective method to control the in vivo degradation.In this study a Ca-P self-sealing micro-arc oxidation(MAO)coating was studied to verify its efficacy and biological properties by in vitro and in vivo tests.It was found that the MAO coating could effectively retard the degradation according to immersion and electrochemical tests as well as 3D reconstruction by X-ray tomography after implantation.The MAO coating exhibited no toxicity and could stimulate the new bone formation.Therefore,the Ca-P self-sealing MAO coating could be a potential candidate for application of biodegradable Mg-based implant in bone fixations. | Weidan Wang Peng Wan Chen Liu Lili Tan Weirong Li Lugee Li Ke Yang | 2015 | Regenerative Biomaterials2015，2，2： | 11 |
| 5 | Significance of Axial Length Monitoring in Children with Congenital Cataract and Update of Measurement Methods显示文摘Congenital cataract is the main cause of blindness in children, with significantly varying treatment effects. The development of axial length is an important factor that affects the prognosis of these children.However,when compared with the eyes of normal children,the mechanism of growth of the axial length is so complicated that the reported findings differ significantly in terms of the measuring apparatus,assessment methods,and statistical outcome,making the rule of axial length development still unclear. In this paper, we first review the process of axial length development in normal healthy children and compare different hypotheses about certain factors that could affect the development of axial length. The results of some current research about the characteristics of axial length development in congenital cataract children are then reviewed. Lastly, the advantages and disadvantages of current axial length measurements methods are compared and analyzed.The purpose of this review is to improve our understanding of the complexity and importance of axial length development and to suggest better use of axial length monitoring measurements in congenital cataract children for pediatric ophthalmologists,with the hope of offering assistance that will enhance long-term therapeutic effects for these children. | Jiao Zhan Haotian Lin Xinyu Zhang Weirong Chen Yizhi Liu | 2013 | Eye Science2013，28，2： | 11 |
| 6 | Molecular dynamics simulation of cylindrical Richtmyer-Meshkov instability显示文摘The microscopic-scale Richtmyer-Meshkov(RM) instability of a single-mode Cu-He interface subjected to a cylindrically converging shock is studied through the classical molecular dynamics simulation. An unperturbed interface is first considered to examine the flow features in the convergent geometry, and notable distortions at the circular inhomogeneity are observed due to the atomic fluctuation. Detailed processes of the shock propagation and interface deformation for the single-mode interface impacted by a converging shock are clearly captured. Different from the macroscopic-scale situation, the intense molecular thermal motions in the present microscale flow introduce massive small wavelength perturbations at the single-mode interface, which later significantly impede the formation of the roll-up structure. Influences of the initial conditions including the initial amplitude,wave number and density ratio on the instability growth are carefully analyzed. It is found that the late-stage instability development for interfaces with a large perturbation does not depend on its initial amplitude any more. Surprisingly, as the wave number increases from 8 to 12, the growth rate after the reshock drops gradually. The distinct behaviors induced by the amplitude and wave number increments indicate that the present microscopic RM instability cannot be simply characterized by the amplitude over wavelength ratio(η). The pressure history at the convergence center shows that the first pressure peak caused by the shock focusing is insensitive to η, while the second one depends heavily on it. | Zhenhong Wu Shenghong Huang Juchun Ding Weirong Wang Xisheng Luo | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 10 |
| 7 | Fabrication of Fuze Micro-electro-mechanical System Safety Device显示文摘Fuze micro-electro-mechanical system(MEMS) has become a popular subject in recent years.Studies have been done for the application of MEMS-based fuze safety and arm devices.The existing researches mainly focused on reducing the cost and volume of the fuze safety device.The reduction in volume allows more payload and,thus,makes small-caliber rounds more effective and the weapon system more affordable.At present,MEMS-based fuze safety devices are fabricated mainly by using deep reactive ion ething or LIGA technology,and the fabrication process research on the fuze MEMS safety device is in the exploring stage.In this paper,a new micro fabrication method of metal-based fuze MEMS safety device is presented based on ultra violet(UV)-LIGA technology.The method consists of SU-8 thick photoresist lithography process,micro electroforming process,no back plate growing process,and SU-8 photoresist sacrificial layer process.Three kinds of double-layer moveable metal devices have been fabricated on metal substrates directly with the method.Because UV-LIGA technology and no back plate growing technology are introduced,the production cycle is shortened and the cost is reduced.The smallest dimension of the devices is 40 μm,which meets the requirement of size.To evaluate the adhesion property between electroforming deposit layer and substrate qualitatively,the impact experiments have been done on the device samples.The experimental result shows that the samples are still in good condition and workable after undergoing impact pulses with 20 kg peak and 150 μs duration and completely met the requirement of strength.The presented fabrication method provides a new option for the development of MEMS fuze and is helpful for the fabrication of similar kinds of micro devices. | DU Liqun JIA Shengfang NIE Weirong WANG Qijia | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 8 |
| 8 | System integration of China's first PEMFC locomotive显示文摘In the face of growing environmental pollution,developing a fuel-cell-driven shunting locomotive is a great challenge in China for environmental protection and energy saving,which combines the environmental advantages of an electric locomotive with the lower infrastructure costs of a diesel-electric locomotive.In this paper,the investigation status and the development trend of the fuel-cell-driven shunting locomotive were introduced.Through innovation of the power system using fuel cells,an experiment prototype of a fuel-cell shunting locomotive was developed,which would reduce the effects on the environment of the existing locomotives.This was the first locomotive to use a proton exchange membrane fuel-cell(PEMFC) power plant in China.From October 2012,we started to test the fuel-cell power plant and further test runs on the test rail-line in Chengdu,Sichuan.The achieved encouraging results can provide fundamental data for the modification of the current individual fuel cell locomotives or further development of the fuel-cell hybrid ones in China. | WeiRong Chen Fei Peng Zhixiang Liu Qi Li Chaohua Dai | 2013 | Journal of Modern Transportation2013，21，3： | 7 |
| 9 | Valve Dynamic and Thermal Cycle Model in Stepless Capacity Regulation for Reciprocating Compressor显示文摘The existing researches of stepless capacity regulation system by depressing the suction valve for reciprocation compressor always adopt hypothesis that the compressor valves are open or close instantaneously, the valve dynamic has not been taken account into thermal cycle computation, the influence of capacity regulation system on suction valves dynamic performance and cylinder thermal cycle operation has not been considered. This paper focuses on theoretical and experimental analysis of the valve dynamic and thermal cycle for reciprocating compressor in the situation of stepless capacity regulation. The valve dynamics equation, gas forces for normal and back flow, and the cylinder pressure varying with suction valve unloader moment during compression thermal cycle are discussed. A new valve dynamic model based on L-K real gas state equation for reciprocating compressor is first deduced to reduce the calculation errors induced by the ideal gas state equation. The variations of valve dynamic and cylinder pressure during part of compression stroke are calculated numerically. The calculation results reveal the non-normal thermal cycle and operation condition of compressor in stepless capacity regulation situation. The numerical simulation results of the valve dynamic and thermal cycle parameters are also verified by the stepless capacity regulation experiments in the type of 3L-10/8 reciprocating compressor. The experimental results agree with the numerical simulation results, which show that the theoretical models proposed are effective and high-precision. The proposed theoretical models build the theoretical foundation to design the real stepless capacity regulation system. | JIN Jiangming HONG Weirong | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 7 |
| 10 | Investigation of high-speed abrasion behavior of an abradable seal rubber in aero-engine fan application显示文摘Abradable seal rubber has been widely used in aero-engine fans to improve their efficiency by reducing the clearance between rotating and stationary components. To investigate the high-speed scraping behavior between a vulcanized silicone rubber and a Ti-6Al-4V fan blade and evaluate the abradable performance of seal rubber, abrasion tests were conducted at a blade tip velocity of 50–300 m/s with an incursion rate of 100 lm/s. The influences of the blade tip velocity on the wear mechanism and interaction forces were specially analyzed. It is shown that abrasive wear and pattern wear are the predominant wear mechanisms, and pattern wear can be seen as the emergence and propagation of cracks. With an increase of the blade tip velocity, both of the final incursion depth and wear mass loss of seal rubber exhibit growth trends. The gradual changes of rubbing forces with an increase of rubbing time are the characteristic of abrasive wear, and force curves with unstable mutations are a reflection of pattern wear. At a constant incursion rate of 100 lm/s, the maximum values of interaction forces decrease first and then grow with an increase of the blade tip velocity, and the blade tip velocity of 150 m/s becomes the cut-off point between abrasive wear and pattern wear. | Haijun XUAN Na ZHANG Bin LU Lijun CHENG Weirong HONG | 2017 | Chinese Journal of Aeronautics2017，30，4： | 5 |
| 11 | Containment ability and groove depth design of U type protection ring显示文摘High-energy rotor uncontained failure can cause catastrophic damage effects to aircraft systems if not addressed in design. In this paper, numerical simulations of three high-energy rotor disk fragments impacting on U type protection rings are carried out using LS-DYNA. Protection rings with the same mass and different groove depths are designed to study the influence of the groove depth. Simulation results including kinetic energy and impact force variation of single fragment are presented. It shows that the groove depth infects both the axial containment ability of the protection ring and the transfer process of energy. The depth of groove ought to be controlled to an appropriate value to meet both the requirement of axial containment and higher safety factor. Verification test on high-speed spin tester has been conducted and shows that protection ring with appropriate U structure can resist the impact of the disk burst fragments. The ring is inflated from a circular to an oval-triangle shape. The corresponding simulation shows good agreement with the test. | Bai Conger Xuan Haijun Huang Xiannian He Zekan Hong weirong | 2016 | Chinese Journal of Aeronautics2016，29，2： | 5 |
| 12 | The deubiquitinase UCHLS/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened显示文摘 | Zizhang Zhou Xia Yao Shu Pang Ping Chen Weirong Jiang Zhaoliang Shan Qing Zhang | 2018 | Journal of Molecular Cell Biology2018，10，3： | 4 |
| 13 | Acupuncture/electroacupuncture enhances antidepressant effect of Seroxat:the Symptom Checklist-90 scores显示文摘One hundred and five patients with primary unipolar depression were randomly divided into three groups: drug group(Seroxat administration), acupuncture group(Seroxat plus acupuncture), and electroacupuncture group(Seroxat plus acupuncture plus electroacupuncture). Patients' symptoms were evaluated using a psychometric questionnaire, the Symptom Checklist-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checklist-90 reduced in all three groups as treatment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, depressive and anxiety symptoms. | Junqi Chen Weirong Lin Shengxu Wang Chongqi Wang Ganlong Li Shanshan Qu Yong Huang Zhangjin Zhang Wei Xiao | 2014 | Neural Regeneration Research2014，9，2： | 4 |
| 14 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 15 | Characteristics and mechanisms of turboshaft engine axial compressor casing containment显示文摘To investigate the containment characteristics and mechanisms of axial compressor blade and casing in turboshaft engine,experimental and simulation research is conducted on Titanium alloy axial compressor blades and stainless steel simulator casings in this paper.Experiments for four thicknesses(from 0.8 mm to 1.4 mm)of casings are presented on high-speed spin tester.Perforation,ricochet with and without failure of the casings are obtained in test results.Three obvious bulges or dishing region are observed,petaling failure occurs in the first bulge or the third deformation region.Parabolic and elongated dimples are observed at the fracture surface.Finite Element(FE)models with calibrated Johnson-Cook material behavior law are built and analyzed by using explicit dynamic software for a better understanding on the containment behavior.Good agreement is obtained between the experimental observations and numerical predictions.The evolution of the impact force,energy absorption,temperature increase and the cracks’propagation are analyzed.Three force peaks occur in the impact process.Energy analysis reveals that penetration condition of ricochet with failure leads to most internal energy of the casing. | Zekan HE Xiaojun GUO Haijun XUAN Xiaoming SHAN Xiaojing FAN Chuanyong CHEN Weirong HONG | 2021 | Chinese Journal of Aeronautics2021，34，1： | 4 |
| 16 | SEDIMENT RESUSPENSION IN THE CHANGJIANG ESTUARY显示文摘SEDIMENTRESUSPENSIONINTHECHANGJIANGESTUARYSHIWeirong1andLIJiufa2Abstract:Aspecificvariationpatternofthenearbottomsuspendedsed... | SHI Weirong 1 and LI Jiufa2( , Institute of’ Estuarine and Coastal Research, East China Normal University Shanghai,200062, China)( Institute of Estuarine and Coastal Research, East China Normal University Shanghai.200062. China) | 1995 | International Journal of Sediment Research1995，10，1： | 3 |
| 17 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 18 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 19 | Fe-B-Y-Nb bulk metallic glasses in relation to clusters显示文摘Bulk metallic glass formations in the Fe-B-Y-Nb quaternary alloy system were in-vestigated by using the cluster line rule in combination with the minor alloying principle. The Fe-B-Y ternary system was selected as the basic system and the intersections of cluster lines were taken as the basic ternary compositions. The basic compositions were further alloyed with minor amounts of Nb. After 3-5 at.% Nb was added,the basic composition Fe68.6B25.7Y5.7,which was developed from the most densely packed cluster Fe8B3,formed 3 mm bulk metallic glasses. These quaternary bulk metallic glasses (Fe68.6B25.7Y5.7)100-xNbx (x=3-5 at.%) are expressed approximately with a unified simple composition formula: (Fe8B3)1(Y,Nb)1. The (Fe68.6B25.7Y5.7)97Nb3 bulk metallic glass has the largest glass forming ability with the following characteristic parameters Tg=907 K,Tx=1006 K,Tg/Tl=0.644,γ=0.434,and longness t=22 mm. The combination of the cluster line rule and the minor-alloying principle is a promising new route towards the quantitative composition design of multi-component metallic glasses. | CHENG Xu WANG Qing CHEN WeiRong DONG Chuang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 3 |
| 20 | A modified highly precise direct integration method for a class of linear time-varying systems显示文摘It is always a bottleneck to design an effective algorithm for linear time-varying systems in engineering applications.For a class of systems,whose coefficients matrix is based on time-varying polynomial,a modified highly precise direct integration(VHPD-T method)was presented.Through introducing new variables and expanding dimensions,the system can be transformed into a timeinvariant system,in which the transfer matrix can be computed for once and used forever with a highly precise direct integration method.The method attains higher precision than the common methods(e.g.RK4 and power series)and high efficiency in computation.Some numerical examples demonstrate the validity and efficiency of the method proposed. | LIU XiaoMei ZHOU Gang ZHU Shuai WANG YongHong SUN WeiRong WENG ShiLie | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 3 |
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