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| 1 | Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study显示文摘A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke.Thus,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients.Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations.However,little is reported on this in post-stroke patients.The purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke individuals.In this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and post-intervention.After intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone group.There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES groups.After intervention,a better cognitive performance was found in both groups compared with before the intervention.After intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone group.In addition,the intervention induced lower levels of lipid peroxidation.After intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the EXE group alone.In each group,both histone deacetylase(HDAC2)and histone acetyltransferase activities were increased after intervention compared with before the intervention.These findings suggest that a single exercise session with WalkAide FES is more effective on balance ability and cognitive performance compared with conventional exercise alone in post-stroke patients.This is likely to be related to the regulation of oxidative stress markers.The present study was approved by the Research Ethics Committee of the Methodist University Center-IPA(approval No.2.423.376)on December 7,2017 and registered in the Brazilian Registry of Clinical Trials—ReBEC(RBR-9phj2q)on February 11,2019. | Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio | 2021 | Neural Regeneration Research2021，16，5： | 3 |
| 2 | Mechanisms mediating renal sympathetic activation to leptin in obesity显示文摘 | Morgan DA Thedens DR Weiss R | 2008 | Am J Physiol Regul Integr CompPhysiol2008，295，6： | 1 |
| 3 | Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymplomatic individuals 显示文摘 | Lieberman DA Prindiville S Weiss DG | 2003 | JAMA2003，290，22： | 1 |
| 4 | Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum Pox Virus显示文摘 | da CAMARA MACHADO M L da CAMARA MACHADO A HANZER V WEISS H REGNER F STEINKELINER H | 1992 | Plant Cell Rep1992，11，： | 1 |
| 5 | Mechanisms mediating renal sympathetic activation to leptin in obesity显示文摘 | Morgan DA Thedens DR Weiss R | 2008 | Am J Physiol Regul Integr Comp Physiol2008，295，6： | 1 |
| 6 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | Am Acad Dermatol1997，37，： | 1 |
| 7 | Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals显示文摘 | Lieberman DA Prindiville S Weiss DG | 2003 | JAMA2003，290，22： | 1 |
| 8 | Mucinous tubular and spindle cell carcinoma of the kidney显示文摘 | Yang G Breyer BN Weiss DA | 2010 | J Urol2010，183，2： | 1 |
| 9 | Five year colon surveil-lance after screening colonoscopy显示文摘 | Lieberman DA Weiss DG Harford WV | 2007 | Gastroenterology2007，133，4： | 1 |
| 10 | Wine as a digestive aid:comparative antimicrobial effects of bismuth salicylate and red and white winc显示文摘 | Weisse ME Eberly B Person DA | 1995 | BMJ1995，311，： | 1 |
| 11 | Obesity and asthma 显示文摘 | Beuther DA Weiss ST Sutherland ER | 2006 | AM J Respir Crit Care Med2006，174，2： | 1 |
| 12 | Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals显示文摘 | LIEBERMAN DA PRINDIVILLE S WEISS DG | | 0，，22： | 1 |
| 13 | Endorectal Advancement Flap显示文摘 | Nelly Mizrahi Steven D. Wexner Oded Zmora Giovanna Da Silva Jonathan Efron Eric G. Weiss Anthony M. Vernava Juan J. Nogueras | 2002 | Diseases of the Colon & Rectum2002，，12： | 1 |
| 14 | Continuous combined hormone replacement therapy and risk of endometrial cancer显示文摘 | Hill DA Weiss NS Beresford SAA | 2000 | Am J Obstet Gynecol2000，183，6： | 1 |
| 15 | Mechanisms mediating renal sympathetic activation to leptin in obesity显示文摘 | Morgan DA Thedens DR Weiss R | | 0，，： | 1 |
| 16 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | J Am Acad Dermatol1997，37，： | 1 |
| 17 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | J Am Acad Dermatol1997，37，21： | 1 |
| 18 | Fiveyear colon surveillance after screening colonoscopy显示文摘 | Lieberman DA Weiss DG Harford WV | | Gastroenterology0，133，4： | 1 |
| 19 | Use ofcolonoscopy to screen asymptomatic adults for colorectalcancer 显示文摘 | Lieberman DA Weiss DG Bond JH | 2000 | N Engl J Med2000，343，3： | 1 |
| 20 | Mechaisms mediating renal sympathetic activation to leptin in obesity 显示文摘 | Morgan DA Thedens DR Weiss R | 2008 | Am J Physiol Regnl Integr Comp Physiol2008，295，6： | 1 |
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