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| 1 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 2 | The seamless model for three-dimensional datum transformation显示文摘With extensive applications of space geodesy, three-dimensional datum transformation model has been necessarily used to transform the coordinates in the different coordinate systems.Its essence is to predict the coordinates of non-common points in the second coordinate system based on their coordinates in the first coordinate system and the coordinates of common points in two coordinate systems.Traditionally, the computation of seven transformation parameters and the transformation of noncommon points are individually implemented, in which the errors of coordinates are taken into account only in the second system although the coordinates in both two systems are inevitably contaminated by the random errors.Moreover, the coordinate errors of non-common points are disregarded when they are transformed using the solved transformation parameters.Here we propose the seamless (rigorous) datum transformation model to compute the transformation parameters and transform the non-common points integratively, considering the errors of all coordinates in both coordinate systems.As a result, a nonlinear coordinate transformation model is formulated.Based on the Gauss-Newton algorithm and the numerical characteristics of transformation parameters, two linear versions of the established nonlinear model are individually derived.Then the least-squares collocation (prediction) method is employed to trivially solve these linear models.Finally, the simulation experiment is carried out to demonstrate the performance and benefits of the presented method.The results show that the presented method can significantly improve the precision of the coordinate transformation, especially when the non-common points are strongly correlated with the common points used to compute the transformation parameters. | LI BoFeng SHEN YunZhong LI WeiXiao | 2012 | Science China Earth Sciences2012，55，12： | 19 |
| 3 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 4 | Type Two Cytokines Predominance of Human Lung Cancer and Its Reverse by Traditional Chinese Medicine TTMP显示文摘Type 2 cytokines are usually predominant in tumor patients and associated with tumor progression. To explore whether reversing of type 2 predominance could be a promising strategy in tumor immunotherapy, PBMCs of 35 lung cancer patients and 19 healthy subjects were prepared and subjected to be examined for cytokine secretion and gene expression. Tetra-Methylpyrazine (TTMP), extracted from a traditional Chinese medicinal herb which has been used in clinic to reverse the Th2 status of cancer patients in China, was added to PBMC culture.Determined by RT-PCR, the positive percentages of mRNA expression of type 1 cytokines (8.6% for IFN-γ and 11.4% for IL-2) were lower than those of type 2 cytokines (71.4% for IL-4, 60% for IL-6 and 80% for IL-10) in patients' PBMCs. The potential of gene expressing (measured as relative intensity to the ratio of β-actin) in the patients for type 1 cytokines was also in a low level (0.111 for IFN-γ, 0.119 for IL-2) in comparison with a relative high level for type 2 cytokines (0.319 for IL-4, 0.303 for IL-6 and 0.377 for IL-10). Meanwhile, both positive percentage and relative intensity of gene expression were lower for a type 1 cytokine-related transcription factor T-bet (31.4% and 0.142, respectively) than those for type 2 cytokine-related GATA3 (85.7% and 0.378,respectively). The blood serum levels of IFN-γ and IL-2 in the patients were slightly lower but not significantly when compared with healthy control. In contrast, the levels IL-4 and IL-6 in patients were significantly higher than those in healthy subjects by ELISA analysis. TTMP could enhance supernatant concentration and gene expression levels of IFN-γ, IL-2 and T-bet, but reduced those of type 2 cytokines. These results demonstrate that the lung cancer patients had a predominant expression of type 2 cytokines and TTMP could reverse the type 2 dominant status, which might offer an alternative therapeutic regime for lung cancer patients. Cellular & Molecular Immunology. 2004;1(1):63-70. | HaimingWei RuiSun WeiXiao JinboFeng ChunyanZhen XiaoqunXu ZhigangTian | 2004 | Cellular & Molecular Immunology2004，1，1： | 10 |
| 5 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 6 | Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration显示文摘The design of orthopedic biomaterials has gradually shifted from“immune-friendly”to“immunomodulatory,”in which the biomaterials are able to modulate the inflammatory response via macrophage polarization in a local immune microenvironment that favors osteogenesis and implant-to-bone osseointegration.Despite the well-known effects of bioactive metallic ions on osteogenesis,how extracellular metallic ions manipulate immune cells in bone tissue microenvironments toward osteogenesis and subsequent bone formation has rarely been studied.Herein,we investigate the osteoimmunomodulatory effect of an extracellular bioactive cation(Mg^(2+))in the bone tissue microenvironment using custom-made poly lactic-co-glycolic acid(PLGA)/MgO-alendronate microspheres that endow controllable release of magnesium ions.The results suggest that the Mg^(2+)-controlled tissue microenvironment can effectively induce macrophage polarization from the M0 to M2 phenotype via the enhancement of anti-inflammatory(IL-10)and pro-osteogenic(BMP-2 and TGF-β1)cytokines production.It also generates a favorable osteoimmune microenvironment that facilitates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.The in vivo results further verify that a large amount of bony tissue,with comparable bone mineral density and mechanical properties,has been generated at an early post-surgical stage in rat intramedullary bone defect models.This study demonstrates that the concept of in situ immunomodulated osteogenesis can be realized in a controlled magnesium tissue microenvironment. | Zhengjie Lin Danni Shen Weixiao Zhou Yufeng Zheng Tiantian Kong Xuanyong Liu Shuilin Wu Paul K.Chu Ying Zhao Jun Wu Kenneth M.C.Cheung Kelvin W.K.Yeung | 2021 | Bioactive Materials2021，6，8： | 5 |
| 7 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 8 | Shaking table comparative test and associated study of a stepped wall-frame structure显示文摘A new structural system c alled a stepped wall-frame structure is proposed in this study to solve the bottom yielding problem of RC frames, which widely occurred during previous earthquakes such as the Wenchuan and Yushu earthquakes in China. A 1/5 scale ordinary RC frame model and a stepped wall-frame model were subjected to shake table motions together to study the seismic behavior of the new structural system. This paper presents the dynamic characteristics, the seismic responses and the failure and collapse mechanism of the two models under low, moderate and high intensity shaking. The test results and further analysis demonstrate that the seismic performance of stepped wall-frame structures is superior to ordinary RC frames in terms of the well-controlled deformation pattern and more uniformly distributed damage. The stepped wall can effectively suppress the bottom yielding mechanism, and is simple, economical and practical for engineering practice. | Xu Weixiao Sun Jingjiang Yang Weisong Du Ke | 2014 | Earthquake Engineering and Engineering Vibration2014，13，3： | 3 |
| 9 | Revisiting the role of delta-1-pyrroline-5-carboxylate synthetase in drought-tolerant crop breeding显示文摘The delta-1-pyrroline-5-carboxylate synthetase(P5CS)gene exercises a protective function in stressed plants.However,the relationship between proline accumulation caused by P5CS and abiotic stress tolerance in plants is not always clear,as P5CS overexpression has been reported to repress plant growth under normal conditions in several reports.We re-evaluated the role of P5CS in drought-tolerant rice breeding by expressing the AtP5CS1 and feedback-inhibition-removed AtP5CS1(AtP5CS1^(F128A))genes under the regulation of an ABA-inducible promoter to avoid the potential side effects of P5CS overexpression under normal conditions.ABA-inducible AtP5CS1 and AtP5CS1^(F128A) increased seedling growth in a nutrient solution(under osmotic stress)and grain yield in pot plants.However,the evidently deleterious effects of AtP5CS1 on grain quality,tiller number,and grain yield in the field indicated the unsuitability of P5CS for drought-tolerance breeding. | Xuanjun Feng Yue Hu Weixiao Zhang Rongqian Xie Huarui Guan Hao Xiong Li Jia Xuemei Zhang Hanmei Zhou Dan Zheng Ying Wen Qingjun Wang Fengkai Wu Jie Xu Yanli Lu | 2022 | The Crop Journal2022，10，4： | 2 |
| 10 | Civil Aircraft Assisted Space-Air-Ground Integrated Networks: Architecture Design and Coverage Analysis显示文摘In this paper, we propose a novel AIenabled space-air-ground integrated networks(SAGIN). This new integrated networks architecture consists of LEO satellites and civil aircrafts carrying aerial base stations, called 'civil aircraft assisted SAGIN(CAA-SAGIN)'. The assistance of civil aircrafts can reduce the stress of satellite networks, improve the performance of SAGIN, decrease the construction cost and save space resources. Taking the Chinese mainland as an example, this paper has analyzed the distribution of civil aircrafts, and obtained the coverage characteristics of civil aircraft assisted networks(CAAN). Taking Starlink as the benchmark, this paper has calculated the service gap of CAAN, and designed the joint coverage constellation. The simulation results prove that the number of satellites in CAASAGIN can be greatly reduced with the assistance of civil aircrafts at the same data rate. | Shuxun Li Qian Chen Zhe Li Weixiao Meng Cheng Li | 2022 | China Communications2022，19，1： | 2 |
| 11 | An active vibration control method based on energy-fuzzy for cantilever structures excited by aerodynamic loads显示文摘In wind tunnel tests for the full-model fixed with sting,the low structural damping of the long cantilever sting results in destructive low-frequency and large-amplitude vibration.In order to obtain high-quality wind tunnel test data and ensure the safety of wind tunnel tests,an energy-fuzzy adaptive PD(Proportion Differentiation)control method is proposed.This method is used for active vibration control of a cantilever structure under variable aerodynamic load excitation,and real-time adjustment of parameters is achieved according to the system characteristics of vibration energy.Meanwhile,a real-time method is proposed to estimate the real-time vibration energy through the vibration acceleration signal,and the average exciting power of aerodynamic load is obtained by deducting the part of the power contributed by the vibration suppressor from the total power.Furthermore,an energy-fuzzy adaptive PD controller is proposed to achieve adaptive control to the changes of the aerodynamic load.Besides,the subsonic and transonic experiments were carried out in wind tunnel,the results revealed that comparing to fixed gain PD controllers,the energy-fuzzy adaptive PD controller maintains higher performance. | Wei LIU Weixiao LIU Mengde ZHOU Linlin TANG Qinqin WANG Zhengquan WEN Zhuang YAO Xiaojing YUAN | 2021 | Chinese Journal of Aeronautics2021，34，9： | 2 |
| 12 | AIR IMPINGEMENT DRYING CHARACTERISTICS AND QUALITY OF CARROT CUBES显示文摘 | HONG‐WEIXIAO HAILIN WEN‐XIAYANG | 2009 | Journal of Food Process Engineering2009，，5： | 2 |
| 13 | Defect engineering in molybdenum-based electrode materials for energy storage显示文摘Molybdenum-based materials have stepped into the spotlight as promising electrodes for energy storage systems due to their abundant valence states,low cost,and high theoretical capacity.However,the performance of conventional molybdenum-based electrode materials has been limited by slow diffusion dynamics and deficient thermodynamics.Applying defect engineering to molybdenum-based electrode materials is a viable method for overcoming these intrinsic limitations to realize superior electrochemical performance for energy storage.Herein,we systematically review recent progress in defect engineering for molybdenum-based electrode materials,including vacancy modulation,doping engineering,topochemical substitution,and amorphization.In particular,the essential optimization mechanisms of defect engineering in molybdenum-based electrode materials are pre-sented:accelerating ion diffusion,enhancing electron transfer,adjusting potential,and maintaining structural stability.We also discuss the existing challenges and future objectives for defect engineering in molybdenum-based electrode materials to realize high-energy and high-power energy storage devices. | Weixiao Wang Fangyu Xiong Shaohua Zhu Jinghui Chen Jun Xie Qinyou An | 2022 | eScience2022，2，3： | 2 |
| 14 | Remote-controlled flexible pose measurement system and method for a moving target in wind tunnel显示文摘The measurement of position and attitude parameters for the isolated target from a highspeed aircraft is a great challenge in the field of wind tunnel simulation technology.This paper proposes a remote-controlled flexible pose measurement system in wind tunnel conditions for the separation of a target from an aircraft.The position and attitude parameters of a moving object are obtained by utilizing a single camera with a focal length and camera orientation that can be changed based on different measurement conditions.Using this proposed system and method, both the flexibility and efficiency of the pose measurement system can be enhanced in wind tunnel conditions to meet the measurement requirements of different objects and experiments, which is also useful for the development of an intelligent position and attitude measurement system.The position and the focal length of the camera also can be controlled remotely during measurements to enlarge both the vertical and horizontal measurement range of this system.Experiments are conducted in the laboratory to measure the position and attitude of moving objects with high flexibility and efficiency,and the measurement precision of the measurement system is also verified through experiments. | Wei LIU Xin MA Ling CHEN Zhenyuan JIA Weixiao LIU Xiao LI Jiakun ZHANG Jiwen LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 2 |
| 15 | Performant Au hydrogenation catalyst cooperated with Cu-doped Al_(2)O_(3) for selective conversion of furfural to furfuryl alcohol at ambient pressure显示文摘Catalytic hydrogenation of furfural to furfuryl alcohol is an important upgrading process for valorization of biomass-derived furanyl platform molecules.However,selective hydrogenation of a,b-unsaturated aldehydes like furfural to the corresponding alcohols at ambient pressure remains challenging in sustainable chemistry.Till date heterogeneous Au hydrogenation catalyst has been scarcely reported for this reaction due to the low reactivity of Au for H_(2)dissociation.In this work,we showed that Au nanoparticles(loading:0.2 wt%)with a mean size of about 3 nm supported on Cu-doped Al_(2)O_(3)can efficiently hydrogenate furfural to furfuryl alcohol in liquid phase at ambient pressure.We demonstrated that doping a small amount of Cu(2 mol%)to g-Al_(2)O_(3)may modify the Lewis acidity-basicity of Al_(2)O_(3)and simultaneously induce the presence of sufficient Cu^(+) species on surface,which facilitated the hydrogen transfer from i-PrOH to furfural.Moreover,we observed an enhanced reactivity of Au toward molecular H_(2)via cooperation with the Lewis acidic-basic Cu_(2)O-Al_(2)O_(3)support.Hence,100%yield to furfuryl alcohol with a productivity of 0.98 g_(FA),h^(-1),g^(-1)_(cat.)at 120C and 0.1 MPa H_(2)can be obtained.The prepared Au/Cu-Al_(2)O_(3)catalyst was found reusable and was effective to the concentrated furfural solution,as well as several typical unsaturated aldehydes. | Junjie Chen Weixiao Sun Yongxing Wang Wenhao Fang | 2021 | Green Energy & Environment2021，6，4： | 2 |
| 16 | Oxygenated, nitrated, methyl and parent polycyclic aromatic hydrocarbons in rivers of Haihe River System, China: Occurrence, possible formation, and source and fate in a water-shortage area显示文摘 | Meng Qiao Weixiao Qi Huijuan Liu Jiuhui Qu | 2014 | Science of the Total Environment2014，，： | 1 |
| 17 | Self-assembly of single-walled carbon nanotube based on diazoresin显示文摘 | Bo Li Tingbing Cao Weixiao Cao | 2003 | Synthetic Met- als2003，132，1： | 1 |
| 18 | Resource allocation algorithm for multi-user MIMO-OFDM downlink with correlated channels显示文摘To minimize transmitting power,an adaptive resource allocation algorithm is proposed for multi-user multiple input multiple output-orthogonal frequency division multiplexing(MIMO-OFDM)downlink with correlated channels,which,based on the user’s grouping according to their spatial correlations,combines the shared manner and the exclusive manner to allocate sub-carriers.Between different groups the shared manner with a null steering method based on group marginal users is applied,whereas within a group the exclusive manner is applied.The simulations show that the power efficiency and spectral efficiency are improved;the base station transmitting antenna number and the computational complexity is decreased. | Chengwen ZHANG Zhongzhao ZHANG Weixiao MENG | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，3： | 1 |
| 19 | Local mean decomposition combined with SVD and application in telemetry vibration signal processing 显示文摘 | Li Zhenxing Dai Weixiao | 2013 | Applied Mechanics and Materials2013，347，2： | 1 |
| 20 | Sparse underwater acoustic OFDM channel estimation based on superimposed train- ing显示文摘 | Zhao Junyi Meng Weixiao Jia Shilou | 2009 | Journal of Marine Science and Application2009，，8： | 1 |
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