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| 1 | Reduction and characterization of bioaerosols in a wastewater treatment station via ventilation显示文摘Bioaerosols from wastewater treatment processes are a significant subgroup of atmospheric aerosols. In the present study,airborne microorganisms generated from a wastewater treatment station(WWTS) that uses an oxidation ditch process were diminished by ventilation.Conventional sampling and detection methods combined with cloning/sequencing techniques were applied to determine the groups,concentrations,size distributions,and species diversity of airborne microorganisms before and after ventilation. There were 3021 ± 537 CFU/m3 of airborne bacteria and 926 ± 132 CFU/m3 of airborne fungi present in the WWTS bioaerosol.Results showed that the ventilation reduced airborne microorganisms significantly compared to the air in the WWTS. Over 60% of airborne bacteria and airborne fungi could be reduced after4 hr of air exchange. The highest removal(92.1% for airborne bacteria and 89.1% for fungi) was achieved for 0.65–1.1 μm sized particles. The bioaerosol particles over 4.7 μm were also reduced effectively. Large particles tended to be lost by gravitational settling and small particles were generally carried away,which led to the relatively easy reduction of bioaerosol particles0.65–1.1 μm and over 4.7 μm in size. An obvious variation occurred in the structure of the bacterial communities when ventilation was applied to control the airborne microorganisms in enclosed spaces. | Xuesong Guo Pianpian Wu Wenjie Ding Weiyi Zhang Lin Li | 2014 | Journal of Environmental Sciences2014，26，8： | 6 |
| 2 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 3 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 4 | Microstructure and properties of novel Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloy conductors processed by die casting,hot extrusion and cold drawing显示文摘In order to overcome the trade-off between the strength and electrical conductivity of aluminum alloy conductors,the new Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloys were prepared by die casting,high temperature homogenization treatment,hot extrusion and cold drawing.Adding Sc and Y eliminated the dendrite segregation of the as-cast Al-0.2 Ce alloy and promoted the formation of equiaxed grains with the average grain size of 142.5μm.The Al-0.2 Ce-0.2 Sc-0.1 Y alloy inherited the great tensile properties of Al-0.2 Ce-0.2 Sc alloy and the high electrical conductivity of Al-0.2 Ce-0.1 Y alloy simultaneously.After cold drawing and annealing at 200℃for 5 h,the ultimate tensile strength of Al-0.2 Ce-0.2 Sc-0.1 Y alloy reached 200 MPa and 198 MPa,the elongation reached 6.8%and 8.5%,and the electrical conductivity reached 61.01%and 61.77%,respectively.The main second phase of Al-0.2 Ce-0.2 Sc-0.1 Y alloy after hot extrusion were Al_(13)Fe_3 Ce containing a few Y and Si atoms.The larger size and proportion of the second phase greatly reduced the concentration of solute Fe and Si atoms and the addition of Y significantly decreased the density of defects after cold drawing compared to Al-0.2 Ce-0.2 Sc alloy,which improved electrical conductivity of the alloy.Furthermore,the dispersed and coherent nano-size Al_3 Sc precipitions of Al-0.2 Ce-0.2 Sc-0.1 Y alloy greatly improved strength,elongation and heat resistance.Compared with Al-0.2 Ce-0.2 Sc alloy,the lower density of dislocation,stacking fault and subgrain boundary and the larger size of Al_3 Sc precipitions with enrichment of Y atoms enable the Al-0.2 Ce-0.2 Sc-0.1 Y alloy to maintain high strength,elongation and electrical conductivity after annealing. | Weiyi Wang Qinglin Pan Geng Lin Xiaoping Wang Yuqiao Sun Xiangdong Wang Ji Ye Yuanwei Sun Yi Yu Fuqing Jiang Jun Li Yaru Liu | 2020 | Journal of Materials Science & Technology2020，58，23： | 4 |
| 5 | Long-term exposure to decabrominated diphenyl ether mpairs CD8 T-cell function in adult mice显示文摘 | Weihong Zeng Ying Wang Zhicui Liu Asma Khanniche Qingliang Hu Yan Feng Weiyi Ye Jianglong Yang Shujun Wang Lin Zhou Hao Shen Yan Wang | 2014 | Cellular & Molecular Immunology2014，11，4： | 3 |
| 6 | Boosted photoreduction of diluted CO_(2) through oxygen vacancy engineering in NiO nanoplatelets显示文摘Converting carbon dioxide(CO_(2))to diverse value-added products through photocatalysis can validly alleviate the critical issues of greenhouse effect and energy shortages simultaneously.In particular,based on practical considerations,exploring novel catalysts to achieve efficient photoreduction of diluted CO_(2) is necessary and urgent.However,this process is extremely challenging owing to the disturbance of competitive adsorption at low CO_(2) concentration.Herein,we delicately synthesize oxygen vacancy-laden NiO nanoplatelets(r-NiO)via calcination under Ar protection to reduce diluted CO_(2) through visible light irradiation(>400 nm)assisted by a Ru-based photosensitizer.Benefitting from the strongly CO_(2) adsorption energy of oxygen vacancies,which was confirmed by density functional calculations,the r-NiO catalysts exhibit higher activity and selectivity(6.28×10^(3)µmol·h^(−1)·g^(−1);82.11%)for diluted CO_(2)-to-CO conversion than that of the normal NiO(3.94×10^(3)µmol·h^(−1)·g^(−1);65.26%).Besides,the presence of oxygen vacancies can also promote the separation of electron-hole pairs.Our research demonstrates that oxygen vacancies could act as promising candidates for photocatalytic CO_(2) reduction,offering fundamental guidance for the actual photoreduction of diluted CO_(2) in the future. | Weiyi Chen Xueming Liu Bin Han Shujie Liang Hong Deng Zhang Lin | 2021 | Nano Research2021，14，3： | 2 |
| 7 | Molecular cloning and mRNA expression of duck invariant chain显示文摘 | Dalian Zhong Weiyi Yu Min Bao Zhiben Xu Lin Li Jing Liu | 2005 | Veterinary Immunology and Immunopathology2005，，3： | 1 |
| 8 | Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution显示文摘Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic interest.Despite numerous studies,the mechanisms underlying its adaptation and evolution remain enigmatic.Here,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded geographically.We complete a chromosome-level assembly and annotation of the E.onukii genome,showing notable expansions of gene families associated with adaptation to chemoreception and detoxification.Genomic signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse regions.Patterns of genetic variations among 54 E.onukii samples unveil the population structure and evolutionary history across different tea-growing regions in China.Our results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of E.onukii.This work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management. | Qian Zhao Longqing Shi Weiyi He Jinyu Li Shijun You Shuai Chen Jing Lin Yibin Wang Liwen Zhang Guang Yang Liette Vasseur Minsheng You | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 9 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 10 | Human miR-31 targets radixin and inhibits migration and invasion ofglioma cells显示文摘 | Dasong Hua Dong Ding Xu Han Weiyi Zhang Na Zhao Gregory Foltz Qing Lan Qiang Huang Biaoyang Lin | 2012 | Oncology Reports2012，，3： | 1 |
| 11 | Isotope effect of the phonons mean free path in graphene by micro-Raman measurement显示文摘The isotope labeled graphene was synthesized in the concentration of 13 C carbon atom in 1%, 25%, 50%, 75% and 99%. The isotope effect on the phonon behavior in graphene was investigated based on the micro-Raman analysis of 13 C isotope labeled graphene samples. We found that the phonon scattering is affected by the isotopic carbon atom as a point defect. Based on the experiment results, the Klemens-Callaway model and uncertainty principle were used to obtain the mean free path of the G and D phonons. The results agree with the thermal conductivity measurement by non-contact optical method and with other theoretical calculations. | ZHANG CanKun LI QiongYu TIAN Bo HUANG ZhiYi LIN WeiYi LI HongYang HE DaHai ZHOU YingHui CAI WeiWei | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 1 |
| 12 | Design of Research Platform on Telerobot System Based on Virtual Reality Technology显示文摘 | Chen Junjie Huang Weiyi Song Aiguo Xi Weiyang Lin Chun | 2004 | Journal of Southeast University (S1003-7985)2004，20，1： | 1 |
| 13 | The Role of the financial early-warning system in strengthening financial supervision and the deposit insurance mechanism显示文摘 | | 2000 | Review of Pacific Basin Financial Markets and Policies2000，，3： | 1 |
| 14 | An integrative protocol for one‑step PCR amplicon library construction and accurate demultiplexing of pooled sequencing data显示文摘High-throughput sequencing of amplicons has been widely used to precisely and efficiently identify species compositions and analyze community structures,greatly promoting biological studies involving large amounts of complex samples,especially those involving environmental and pathogen-monitoring ones.Commercial library preparation kits for amplicon sequencing,which generally require multiple steps,including adapter ligation and indexing,are expensive and time-consuming,especially for applications at a large scale.To overcome these limitations,a“one-step PCR approach”has been previously proposed for constructions of amplicon libraries using long fusion primers.However,efficient amplifications of target genes and accurate demultiplexing of pooled sequencing data remain to be addressed.To tackle these,we present an integrative protocol for one-step PCR amplicon library construction(OSPALC).High-quality reads have been generated by this approach to reliably identify species compositions of mock bacterial communities and environmental samples.With this protocol,the amplicon library is constructed through one regular PCR with long primers,and the total cost per DNA/cDNA sample decreases to just 7%of the typical cost via the multi-step PCR approach.Empirically tested primers and optimized PCR conditions to construct OSPALC libraries for 16S rDNA V4 regions are demonstrated as a case study.Tools to design primers targeting at any genomic regions are also presented.In principle,OSPALC can be readily applied to construct amplicon libraries of any target genes using DNA or RNA samples,and will facilitate research in numerous fields. | Jiahao Ni Jiao Pan Yaohai Wang Tianhao Chen Xinshi Feng Yichen Li Tongtong Lin Michael Lynch Hongan Long Weiyi Li | 2023 | Marine Life Science & Technology2023，5，4： | 1 |
| 15 | CVD synthesis of nitrogen-doped graphene using urea显示文摘This work provides an effective low-cost synthesis and in-depth mechanistic study of high quality large-area nitrogen-doped graphene(NG) films. These films were synthesized using urea as nitrogen source and methane as carbon source, and were characterized by scanning electron microscopy(SEM), Raman spectroscopy and X-ray photoelectron spectroscopy(XPS). The N doping level was determined to be 3.72 at.%, and N atoms were suggested to mainly incorporated in a pyrrolic N configuration. All distinct Raman peaks display a shift due to the nitrogen-doping and compressive strain. The increase in urea concentration broadens the D and 2D peak's Full Width at Half Maximum(FWHM), due to the decrease of mean free path of phonons. The N-doped graphene exhibited an n-type doping behavior with a considerably high carrier mobility of about 74.1 cm2/(V s), confirmed by electrical transport measurements. | ZHANG CanKun LIN WeiYi ZHAO ZhiJuan ZHUANG PingPing ZHAN LinJie ZHOU YingHui CAI WeiWei | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 1 |
| 16 | Using the traditional model to evaluate the active force of the human lateral rectus muscle显示文摘The information on the force of extraocular muscles(EOMs)is beneficial for strabismus diagnosis and surgical planning,and a direct and simple method is important for surgeons to obtain these forces.Based on the traditional model,a numerical simulation method was proposed to achieve this aim,and then the active force of the lateral rectus(LR)muscle was successfully simulated when the eye rotated every angle from 0°to 30°in the horizontal plane from the nasal to the temporal side.In order to verify these simulations,the results were compared with the previous experimental data.The comparison shows that the simulation results diverged much more than the experimental data in the range of 0°–10°.The errors were corrected to make the simulation results closer to the experimental data.Finally,a general empirical equation was proposed to evaluate the active force of the LR muscle by fitting these data,which represent the relationship between the simulation forces and the contractive amounts of the LR muscle. | GAO ZhiPeng CHEN WeiYi JING Lin FENG PengFei WU XiaoGang GUO HongMei | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，5： | 0 |
| 17 | Design and Development Based on Embedded System显示文摘The demand for equipment has been unable to meet the current and future high performance application and development needs with the rapid development of electronic technology and upgrading of traditional industries in China. At the same time, intense market competition and technical competition require that the development cycle of the product to be as short as possible. Obviously, the software and hardware of embedded system are becoming more important foundation of technological innovation in various fi elds. The embedded system is a combination of advanced computer technology, semiconductor technology, electronic technology and the specific application of various industries. This determines that it must be a technology-intensive, capital-intensive, highly fragmented and innovative knowledge integration system. The embedded type is based on the application of computer technology-based hardware and software can be tailored to adapt to the application system on the function, reliability, cost, size, power and other strict requirements of the special computer system. The emergence of consumer appliances and cheap microprocessors embedded systems will form larger application areas in daily life to as the embedded system usually has low power consumption, small size and high integration. Embedded employment is widely embedded in the social needs of large talent. The content of the paper is clear in the embedded control system overview - development - application writing ideas in three chapters gradually. Chapter 1 introduces the defi nition, frame, characteristic, development history, current situation and prospect of the embedded control system in detail. The development of the embedded control system mainly discusses the development steps and methods. The third chapter embedded control system. This paper discusses the practical application of embedded control system in public life. As the application of these research results in the fi nal summary of the various aspects of the system capacity and analysis of the existing problems for further research to provide a direction and valuable experience. | Huiguo Peng Weiyong Yao Weiyi Lin | 2018 | Insight-Engineering and Technology2018，1，1： | 0 |
| 18 | Electron transition manipulation under graphene-mediated plasmonic engineering nanostructure显示文摘Monolayer graphene has attracted enormous attention owing to its unique electronic and optical properties.However,achieving an effective approach without applying electrical bias for manipulating the charge transfer based on graphene is elusive to date.Herein,we realized the manipulation of excitons’transition from emitter to the graphene surface with plasmonic engineering nanostructures and firstly obtained large enhancements for photon emission on the graphene surface.The localized plasmons generated from the plasmonic nanostructures of shell-isolated nanoparticle coupling to ultra-flat Au substrate would dictate a consistent junction geometry while enhancing the optical field and dominating the electron transition pathways,which may cause obvious perturbations for molecular radiation behaviors.Additionally,the three-dimensional finite-difference time-domain and time-dependent density functional theory were also carried out to simulate the distributions of electromagnetic field and energy levels of hybrid nanostructure respectively and the results agreed well with the experimental data.Therefore,this work paves a novel approach for tunning graphene charge/energy transfer processes,which may hold great potential for applications in photonic devices based on graphene. | Huaizhou Jin Jing-Yu Wang Xia-Guang Zhang Weiyi Lin Weiwei Cai Yue-Jiao Zhang Zhi-Lin Yang Fan-Li Zhang Jian-Feng Li | 2023 | Nano Research2023，16，4： | 0 |
| 19 | Design and Development Based on Embedded System显示文摘The demand for equipment has been unable to meet the current and future high performance application and development needs with the rapid development of electronic technology and upgrading of traditional industries in China.At the same time,intense market competition and technical competition require that the development cycle of the product to be as short as possible.Obviously,the software and hardware of embedded system are becoming more important foundation of technological innovation in various fi elds.The embedded system is a combination of advanced computer technology,semiconductor technology,electronic technology and the specific application of various industries.This determines that it must be a technology-intensive,capital-intensive,highly fragmented and innovative knowledge integration system.The embedded type is based on the application of computer technology-based hardware and software can be tailored to adapt to the application system on the function,reliability,cost,size,power and other strict requirements of the special computer system.The emergence of consumer appliances and cheap microprocessors embedded systems will form larger application areas in daily life to as the embedded system usually has low power consumption,small size and high integration.Embedded employment is widely embedded in the social needs of large talent.The content of the paper is clear in the embedded control system overview-development-application writing ideas in three chapters gradually.Chapter 1 introduces the defi nition,frame,characteristic,development history,current situation and prospect of the embedded control system in detail.The development of the embedded control system mainly discusses the development steps and methods.The third chapter embedded control system.This paper discusses the practical application of embedded control system in public life.As the application of these research results in the fi nal summary of the various aspects of the system capacity and analysis of the existing problems for further research to provide a direction and valuable experience. | Huiguo Peng Weiyong Yao Weiyi Lin | 2017 | Control and Systems Engineering2017，1，1： | 0 |
| 20 | Halide vapor phase epitaxy of monolayer molybdenum diselenide single crystals显示文摘Single-crystalline transition metal dichalcogenides(TMD)films are of potential application in future electronics and optoelectronics.In this work,a halide vapor phase epitaxy(HVPE)strategy was proposed and demonstrated for the epitaxy of molybdenum diselenide(MoSe_(2))single crystals,in which metal halide vapors were in-situ produced by the chlorination of molybdenum as sources for the TMD growth.Combined with the epitaxial sapphire substrate,unidirectional domain alignment was successfully achieved and monolayer single-crystal MoSe_(2) films have been demonstrated on a 2-inch wafer for the first time.A series of characterizations ranging from centimeter to nanometer scales have been implemented to demonstrate the high quality and uniformity of the MoSe_(2).This work provides a universal strategy for the growth of TMD single-crystal films. | Taotao Li Yang Yang Liqi Zhou Wenjie Sun Weiyi Lin Lei Liu Xilu Zou Si Gao Yuefeng Nie Yi Shi Xinran Wang | 2023 | National Science Open2023，2，4： | 0 |
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