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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage显示文摘 | Wen R Cheng T Li Y | 1996 | J Neurosci1996，16，19： | 2 |
| 4 | Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine显示文摘 | Manome Y Kunieda T Wen P Y | 1998 | Hum Gene Ther1998，，： | 2 |
| 5 | 显示文摘 | SHIMADAA T WEN C TANIGUCHIC N | 2004 | J Power Sources2004，131，： | 1 |
| 6 | Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma:Application to the pharmacokinetics study 显示文摘 | Yu S Liu L Wen T | 2008 | J Chromatogr B2008，861，： | 1 |
| 7 | Targeting Toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients 显示文摘 | Ren T Wen ZK Liu ZM etal | 2008 | Cancer Invest2008，26，5： | 1 |
| 8 | Reliability analysis for rotor rubbing 显示文摘 | Zhang Y M Wen B C Leung Y T | 2002 | ASME Journal for Vibration and Acoustics2002，124，1： | 1 |
| 9 | Indentation penetration and perforation of composite laminates and sandwich panels under quasi-static and projectile loading显示文摘 | Wen H M Reddy T Y Reid S R | 1998 | Key Eng Mater1998，，1： | 1 |
| 10 | Processing of biocompatible porous Ti and Mg显示文摘 | WEN C E MABUCHI M YAMADA Y SHIMOJIMA K CHINO Y ASAHINA T | 2001 | Scripta Materialia2001，45，10： | 1 |
| 11 | The influence of green innovation performance on corporate advantage in Taiwan显示文摘 | Chen Y S Lai S B Wen C T | 2006 | Journal of Business Ethics2006，67，： | 1 |
| 12 | Changes in serum adiponectin con- centrations and endothelial function after intensive insulin treat- ment in people with newly diagnosed type 2 diabetes: A pilot study显示文摘 | Li F Zhao T Y Wen X R | 2011 | Original Research Article Diabetes Research and Clini-cal Practice2011，94，2： | 1 |
| 13 | Processing and mechanical properties of autogenous titanium implant materials 显示文摘 | WEN C E YAMADA ~ SHIMOJIMA K CHINO Y ASAHINA T MABUCHI M | 2002 | Journal of Materials Science: Materials in Medicine2002，13，4： | 1 |
| 14 | Viral vector-mediated trans- duction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth显示文摘 | Tanaka T Manome Y Wen P | 1997 | Nat Med1997，3，4： | 1 |
| 15 | Parallel PSM/ FDM Hybrid Simulation of Ground Motions from the 1999 Chi-Chi,Taiwan,Earthquake显示文摘 | Furumura T Koketsu K Wen K L | | 0，，09： | 1 |
| 16 | Desulfurization and denitrogena- tion from flue gas using Fenton reagent显示文摘 | ZHAO Y WEN X GUO T | 2014 | Fuel Processing Technol- ogy2014，128，12： | 1 |
| 17 | Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis 显示文摘 | Wang T Wen C~ Yan CH | 2013 | Osteoarthritis Cartilage2013，21，4： | 1 |
| 18 | Overexpression of HMGBI in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 ( Wafl/Cipl ) up-regulation via a p53-independent, Spl-dependent pathway 显示文摘 | Li Q Li J Wen T | 2014 | Oncotarget2014，5，15： | 1 |
| 19 | Vibration fracture properties of a lightweight Mg-Li-Zn alloy 显示文摘 | Song J M Wen T X Wang J Y | 2007 | Scripta Materialia2007，56，： | 1 |
| 20 | A common variant inMTNR1B* encoding melatonin receptor IB, is associated withtype 2 diabetes and fasting plasma glucose in Han Chineseindividuals显示文摘 | Ro nn T Wen J Yang Z | 2009 | Diabetologia2009，52，5： | 1 |
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