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2篇 您的检索式：作者名="Wencheng Xue"

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		题名	作者	年代	出处	被引量
	1	Mutating Escherichia coli caused multiple organ dysfunction syndrome显示文摘Pathogenic Escherichia coli is of great concern in the clinical setting.But few reports have demonstrated the variation in disease course.We present a severe case of multiple organ dysfunction syndrome caused by E.coli infection.Pathogens isolated from blood and urine samples harboured many virulence factors.Whole‐genome sequencing and conventional analyses showed that the isolates experienced beneficial variations,both genetically and phenotypically,during the disease course.These findings showed that E.coli can cause sys-temic symptoms and informed us of the importance of assessing the reasons for such variations in pathogens occurring in vivo.	Lihua Qi Wencheng Xue Xuelin Liu Shaofu Qiu Jie Liu	2023	iLABMED2023，1，3：	0
	2	Serum albumin complexed with ellagic acid from pomegranate peel and its metabolite urolithin B显示文摘As one of fruit waste by-products,the pomegranate peel is rich in bioactive compounds such as ellagic acid.Ellagic acid and its main gut microbial metabolite urolithin B have been reported to exhibit numerous biological activities and widely used as dietary supplements in the past decades.Interaction of these two compounds to serum albumin(SA)might affect their metabolism,efficacy,and body distribution.The interaction of ellagic acid and urolithin B with SA was investigated and BSA interference on the anti-cancer activity of these two compounds was also evaluated.Results of spectra experiments showed that ellagic acid and urolithin B could form complexes with bovine serum albumin(BSA)and urolithin B has a higher binding force and number of binding sites than ellagic acid when forming a complex with BSA.The results of molecular docking and molecular dynamics simulations suggested that ellagic acid and urolithin B tended to bind in site I rather than site II.The MTT assay results indicated that the IC_(50) value of ellagic acid decreased from 123.58μM to 55.91μM,while the IC_(50) value of urolithin B decreased from 83.67μM to 47.40μM.Ellagic acid and urolithin B can form complexes with serum albumin and the anti-cancer activity of ellagic acid and urolithin B was enhanced when combined with BSA.	Peiyu Xue Guangjie Zhang Hongmei Zhao Wencheng Wang Jie Zhang Li Ren	2022	Food Bioscience2022，46，2：	0

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