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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 3 | Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model of Cerebral Ischemia显示文摘Leukemia inhibitory factor(LIF) contributes to the neuroprotection by neural stem cells(NSCs) after ischemic stroke. Our aim was to explore whether LIFtransfected NSCs(LIF-NSCs) can ameliorate brain injury and promote neuroprotection in a rat model of cerebral ischemia. To accomplish this goal, we transfected NSCs with a lentivirus carrying the LIF gene to stably overexpress LIF. The LIF-NSCs reduced caspase 3 activation under conditions of oxygen-glucose deprivation in vitro.Transient cerebral ischemia was induced in rats by 2 h of middle cerebral artery occlusion(MCAo), and LIF-NSCs were intravenously injected at 6 h post-ischemia. LIF-NSC treatment reduced the infarction volume and improved neurological recovery. Moreover, LIF-NSCs improved glial cell regeneration and ameliorated white matter injuryin the MCAo rats. The NSCs acted as carriers and increased the expression of LIF in the lesions to protect against cerebral infarction, suggesting that LIF-NSCs could be a potential treatment for cerebral infarction. | Lili Tian Wenli Zhu Yuanchu Liu Ye Gong Aowei Lv Zhen Wang Xiaoli Ding Shaowu Li Ying Fu Yi Lin Yaping Yan | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 4 | Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy显示文摘Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted. | Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 5 | ZrO2 nanoparticles anchored on nitrogen-doped carbon nanosheets as efficient catalyst for electrochemical CO2 reduction显示文摘Electrochemical reduction of CO2 to produce value-added feedstock chemicals using high-performance electrocatalysts is a promising protocol to address the excessive CO2 in the atmosphere and the energy crisis. However, the high overpotential, low current density, and poor product selectivity for CO2 electroreduction greatly impede their practical applications. In this work, we develop an efficient catalyst for CO2 reduction to CO consisting of well-dispersed ZrO2 nanoparticles tightly anchored on nitrogendoped carbon nanosheets(ZrO2/N-C) for the first time. Importantly, the ZrO2 nanoparticles possess oxygen vacancies and defects, which regulate the electronic structure of catalyst and thus greatly enhance the electrocatalytic activity. Specifically, ZrO2/N-C demonstrates a high CO Faradaic efficiency(FE) of 64% at-0.4 V vs. the reversible hydrogen electrode(RHE) and a respectable current density of ~2.6 m A cm-2 in CO2-saturated 0.5 M KHCO 3 solution. This work opens a new avenue for developing excellent catalysts for CO2 electroreduction with metal oxide/heteroatom-doped carbon composite structure. | Zhengpei Miao Pei Hu Chuanye Nie Huan Xie Wenli Fu Qing Li | 2019 | Journal of Energy Chemistry2019，28，11： | 3 |
| 6 | Amorphous NiO_(n)coupled with trace PtO_(x)toward superior electrocatalytic overall water splitting in alkaline seawater media显示文摘Developing corrosion resistance bifunctional electrocatalysts with high activity and stability toward both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),especially electrolysis in seawater,is of prime significance but still pressingly challenging.Herein,in-situ introduced PtO_(x)on the derivative amorphous NiO_(n)is prepared via heat treatment of Ni ZIFL nanosheets on nickel foam under low temperature(PtO_(x)-NiO_(n)/NF).The synthesized PtO_(x)-NiO_(n)/NF possesses suprahydrophilic and aerophilic surface,then in favor of intimate contact between the electrode and electrolyte and release of the generated gas bubbles during the electrocatalysis.As a result,the in-situ PtO_(x)-NiO_(n)/NF electrode presents outstanding bifunctional activity,which only requires extremely low overpotentials of 32 and 240 mV to reach a current density of 10 mA·cm^(-2)for HER and OER,respectively,which exceeds most of the electrocatalysts previously developed and even suppresses commercial Pt/C and RuO_(2)electrodes.As for two-electrode cell organized by PtO_(x)-NiO_(n)/NF,the voltages down to 1.57 and 1.58 V are necessary to drive 10 mA·cm^(-2)with remarkable durability in 1 M KOH and alkaline seawater,respectively,along with remarkable stability.Moreover,a low cell voltage of 1.88 V is needed to achieve 1,000 mA·cm^(-2)toward water-splitting under industrial conditions.This study provides a new idea for designing in-situ amorphous metal oxide bifunctional electrocatalyst with strong Pt–support interaction for overall water splitting. | Wenli Yu Hongru Liu Ying Zhao Yunlei Fu Weiping Xiao Bin Dong Zexing Wu Yongming Chai Lei Wang | 2023 | Nano Research2023，16，5： | 2 |
| 7 | An image-reconstruction algorithm based on revised regularization method for eleclrical-capacitance tomography显示文摘 | Zhao Jinchuang Fu Wenli | 2002 | Meas Sci and Technol2002，13，4： | 1 |
| 8 | Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders:From Bench to Bedside显示文摘Neuromyelitis optica(NMO)/NMO spectrum disorder(NMOSD)is a chronic,recurrent,antibodymediated,inflammatory demyelinating disease of the central nervous system,characterized by optic neuritis and transverse myelitis.The binding of NMO-IgG with astrocytic aquaporin-4(AQP4)functions directly in the pathogenesis of>60%of NMOSD patients,and causes astrocyte loss,secondary inflammatory infiltration,demyelination,and neuron death,potentially leading to paralysis and blindness.Current treatment options,including immunosuppressive agents,plasma exchange,and B-cell depletion,are based on small retrospective case series and open-label studies.It is noteworthy that monoclonal antibody(mAb)therapy is a better option for autoimmune diseases due to its high efficacy and tolerability.Although the pathophysiological mechanisms of NMOSD remain unknown,increasingly,therapeutic studies have focused on mAbs,which target B cell depletion,complement and inflammation cascade inactivation,bloodbrain-barrier protection,and blockade of NMO-IgG-AQP4 binding.Here,we review the targets,characteristics,mechanisms of action,development,and potential efficacy of mAb trials in NMOSD,including preclinical and experimental investigations. | Wenli Zhu Yaling Zhang Zhen Wang Ying Fu Yaping Yan | 2020 | Neuroscience Bulletin2020，36，10： | 1 |
| 9 | A New Class of p-Ary Sequence Families with Low Correlation Property via m-Sequence显示文摘For an odd prime p which is congruent to 3 module 4 and an odd integer k,we investigate the upper bound on the magnitude of cross correlation values of a p-ary m-sequence s(t) and its decimated sequences s(dt + l) for a decimation value d.Using the above upper bound of the magnitude of cross correlation values of pary m-sequence and its decimated sequences,we construct a new class of p-ary sequence families with low correlation property via m-sequence. | REN Wenli FU Fangwei | 2016 | Chinese Journal of Electronics2016，25，4： | 1 |
| 10 | A Novel Image Reconstruction Algorithm for electrical Capacitance Tomography显示文摘 | Jinchuang Zhao Wenli Fu Qingyu Gan | 2005 | Journal of Information and Computational Science2005，2，1： | 1 |
| 11 | Online Parameter Estimation of the Ni-MH Batteries Based on Statistical Methods 显示文摘 | PIAO Changhao FU Wenli LEI Gaihui | 2009 | Energies2009，3，2： | 1 |
| 12 | FBFN-based adaptive repetitive control of nonlinearly parameterized systems显示文摘An adaptive repetitive control scheme is presented for a class of nonlinearly parameterized systems based on the fuzzy basis function network (FBFN).The parameters of the fuzzy rules are tuned with adaptive schemes.To attenuate chattering effectively,the discontinuous control term is approximated by an adaptive PI control structure.The bound of the discontinuous control term is assumed to be unknown and estimated by an adaptive mechanism.Based on the Lyapunov stability theory,an adaptive repetitive control law is proposed to guarantee the closed-loop stability and the tracking performance.By means of FBFNs,which avoid the nonlinear parameterization from entering into the adaptive repetitive control,the controller singularity problem is solved.The proposed approach does not require an exact structure of the system dynamics,and the proposed controller is utilized to control a model of permanent-magnet linear synchronous motor subject to significant disturbances and parameter uncertainties.The simulation results demonstrate the effectiveness of the proposed method. | Wenli Sun Hong Cai Fu Zhao | 2013 | Journal of Systems Engineering and Electronics2013，24，6： | 0 |
| 13 | Tonghua Liu:A life dedicated to clinical pathology显示文摘Professor Tonghua Liu(刘彤华)was an academician of the Chinese Academy of Engineering,a renowned medical scientist,pathologist,medical educator and professor of the Pathology Department in Peking Union Medical College Hospital(PUMCH)(Fig.1).She passed away from illness on July 8th,2018 at PUMCH.She was 89(PUMCH,2018).Prof.Liu was born on November 13th,1929 in Wuxi,Jiangsu Province.She studied at the Medical School of Saint John's University in Shanghai from 1947 to 1953(Fang et al.,2009). | Lin Dong Tanping Fu Junyi Pang Zhiyong Liang Wenli Duan | 2019 | Protein & Cell2019，10，12： | 0 |
| 14 | A study of function mechanism of hemxamethyl tetra-amine in gelation process of uranium显示文摘The UO2 ceramic microspheres are the most important materials in the spherical fuel elements for high temperature reactor (HTR). A process for preparation of UO2 kernels known as total gelation process of uranium (TGU) was developed as the production process of 10 mW HTR at Tsinghua University. The TGU process is based on the traditional sol-gel process, external gelation process and internal gelation process of uranium (EGU and IGU), which implies that the gelation action is initiated both by ammonia out of the gel particles and hemxamethyl tetra-amine (HMTA) inside the gel particles. The gelation behavior and the properties of uranium microspheres were investigated of the solution with and without HMTA. It is observed that good spherical particles can be obtained without HMTA in the sol, which indicates a more controllable and industrialized route will be set up. Contrasts between this route and the traditional EGU were also listed. | GUO Wenli LIANG Tongxiang ZHAO Xingyu HAO Shaochang FU Xiaoming | 2006 | Rare Metals2006，25，z1： | 0 |
| 15 | An Improved Rate Control Method Based on Modification at Scene Change for H.264显示文摘This paper presents an improved rate control method for H.264. First, the scene changes are detected by the average absolute difference of the brightness histograms between the adja-cent frames. Then, the bit allocation and quantization parameters are adjusted, using a certain threshold. In addition, the calculation of the mean absolute difference (MAD) is modified in an alterna-tive way, which makes the rate distortion optimization (RDO) more accurate. Extensive simulation results show that the pro-posed method, compared with G012, can improve the average peak signal-to-noise ratio (PSNR) and moderate the image quality. | RU Guobao GAO Wenli FU Jianfeng | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 0 |
| 16 | The innate interfacial elastic strain field of a transformable B2 precipitate embedded in an amorphous matrix显示文摘When a transformable B2 precipitate is embedded in an amorphous matrix,it is often experimentally observed that the crystalline-amorphous interface not only serves as an initiation site for the martensitic transformation due to local stress concentrations,but also as an inhibitor to stabilize the transformation,the latter being attributed to the“confinement effect”exerted by the amorphous matrix,according to the Eshelby solution.These two seemingly incongruous factors are examined in this study using molecular dynamics simulations from an atomic interaction perspective.An innate strain gradient in the vicinity of the crystalline-amorphous interface is identified.The actual interface,the compressive/dilatative transition,and the interfacial maximum strain are investigated to differentiate from the conventional“interface”located within a distance of a few nanometers.Our innate interfacial elastic strain field model is applicable for the design of materials with a higher degree of martensitic transformation and controllable stress concentration,even in cryogenic environments. | Xiaoling Fu Yujun Lin Mixun Zhu Kai Wang Jiaqing Wu Xing Tong Wenli Song Ming Jen Tan Yuanzheng Yang Jun Shen Gang Wang Chan Hung Shek Robert O.Ritchie | 2023 | npj Computational Materials2023，，1： | 0 |
| 17 | Qi Fang:Affective interweave with patients显示文摘It is terribly wrong to make patients serve doctors,which means they are treated as sources of medical experience.Poctors should treat patients equally.Less educated and inarticulate patients need more help,care and love.Patients'interest is always the priority,including,not to abuse doctors'power for personal gains,or to gain anything directly or indirectly from patients.To win a patient's trust,we have to understand him or her,his or her understanding about the illness.'Professor Qi Fang(方圻)always repeated those views,which have profound implications(Fang,2002). | Tanping Fu Wenli Duan Mingyan Chen Shuyang Zhang | 2022 | Protein & Cell2022，13，11： | 0 |
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