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| 1 | Cloning and Characterization of miRNAs and Their Targets, Including a Novel miRNA-Targeted NBS-LRR Protein Class Gene in Apple (Golden Delicious)显示文摘MicroRNA (miRNA ) 在植物作为基因表示的一个重要管理者出现了。146 miRNAs 从苹果被识别(Malus domestica cv。金色美味) 由定序的生物信息的分析和 RNA 图书馆。从这些, 135 被保存, 11 是新奇 miRNAs。目标分析预言了新奇 miRNAs 之一, Md-miRLn11 (Malus domestica microRNA Ln11 ) ,指向了一个苹果核苷酸绑定地点(NBS ) 充满白氨酸的重复(LRR ) 班蛋白质编码基因(Md-NBS ) 。5 赛跑试金证实了 Md-miRLn11 的能力在 1112-nt 位置劈开 Md-NBS。Md-miRLn11 和 Md-NBS 的表示的分析在在 40 个苹果变化的最佳侵略时期期间证明在抵抗变化的 Md-NBS 基因的表示比在易受影响的变化高,与为 Md-miRLn11 的一个反的模式。从抵抗苹果变化 JiGuan 的幼苗被用来执行 Agrobacterium 渗入试金,然后与苹果叶点疾病接种。结果在 JiGuan 苹果显示出疾病抵抗的清楚的衰落。相反,与 Md-NBS 基因渗入的易受影响的变化富士在疾病抵抗显示出重要增加。基于上述结果,我们建议 Md-miRLn11 特别地在病原体感染的条件下面调整 Md-NBS 基因表示,并且指向 P 环地点的 Md-miRLn11 可以在木质的植物调整许多 NBSLRR 蛋白质类基因。 | Chao Ma You Lu Songlin Bai Wennan Zhang Xuwei Duan Dong Meng Zhigang Wang Aide Wang Zongshan Zhou Tianzhong Li | 2014 | Molecular Plant2014，7，1： | 19 |
| 2 | Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy显示文摘The phosphatidylinositol 3-kinase(PI3K) pathway is frequently activated in human cancers.Class I PI3 Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate(PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate(PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin(m TOR) to play key roles in carcinogenesis. Therefore, PI3 K has become an important anticancer drug target, and currently there is very high interest in the pharmaceutical development of PI3 K inhibitors. Idelalisib has been approved in USA and Europe as the first-in-class PI3 K inhibitor for cancer therapy. Dozens of other PI3 K inhibitors including BKM120 and ZSTK474 are being evaluated in clinical trials. Multifaceted studies on these PI3 K inhibitors are being performed, such as single and combinational efficacy, resistance, biomarkers,etc. This review provides an introduction to PI3 K and summarizes key advances in the development of PI3 K inhibitors. | Wennan Zhao Yuling Qiu Dexin Kong | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 19 |
| 3 | Flexible smart sensing skin for“Fly-by-Feel”morphing aircraft显示文摘Flexible smart sensing skin is a key enabling technology for the future'Fly-by-Feel'control of morphing aircraft.It represents the next-generation skin of aircraft that can exhibit a more powerful sensing function than a conventional one and could be mounted on arbitrary curvilinear surfaces,especially for advanced autonomic,morphing aircraft.Recent significant technical advances in flexible electronics have overcome many historic drawbacks of conventional smart skin,e.g.,only a limited number of discrete block sensors can be integrated due to the inevitable structural damage and heavy guidelines.Herein,we review the key developments in flexible sensors technology and highlight both the state-of-the-art devices and the potential applications for the measurement of aircraft.We begin with the importance of flexible smart skin for morphing aircraft and then expand to the latest progress in various types of flexible sensors.Then we highlight flexible sensors as smart skin to measure aerodynamic parameters and monitor the structural health,and further to achieve the Fly-by-Feel control.Finally,the challenges and opportunities on flexible smart sensing skin are discussed,from the functional design to practical applications. | HUANG YongAn ZHU Chen XIONG WenNan WANG Yu JIANG YongGang QIU Lei GUO DongLiang HOU Chao JIANG Shan YANG ZhaoXi WANG Bo WANG Lu YIN ZhouPing | 2022 | Science China(Technological Sciences)2022，65，1： | 6 |
| 4 | Conformable,programmable and step-linear sensor array for large-range wind pressure measurement on curved surface显示文摘The wind pressure measurement,especially on curved surfaces is imperative in revealing flow characteristics.The flexible sensor with high linear sensitivity over large pressure range is still a significant challenge,especially for commutatively positive and negative pressure measurement.Here,we propose a conformable,range-programmable capacitive sensor that can extremely extend the measuring range but with high linear sensitivity.The key point is to precisely control the reference pressure of the flexible capacitive sensor array through microchannel network.The proposed sensor with reference pressure 0 kPa keeps stable at a highly-linear sensitivity of 0.28 kPa-1 in an initial measurement regime from 0 to 3 kPa,beyond which the linearity changes significantly.Via the tunable reference pressure,the linear ranges can be customized arbitrarily according to different flight conditions and measured positions,but without any deterioration of sensitivity.The theoretical model is built for the flexible capacitive sensor with tunable reference pressure,agreeing well with the experimental and finite element method results.Additionally,the bending effect is discovered when the flexible sensor is conformed on curved surfaces.This surface-mounted sensor skin is tested on a plate and is integrated with acquisition circuits on a standard airfoil NACA0012 in a wind tunnel and compares with the standard destructive method of pressure taps.It shows great potential applications in measuring wind pressure on curved surfaces,such as for'Fly-by-Feel'of unmanned aerial vehicles and wind tunnel test. | XIONG WenNan GUO DongLiang YANG ZhaoXi ZHU Chen HUANG YongAn | 2020 | Science China(Technological Sciences)2020，63，10： | 5 |
| 5 | Forms of potassium and chlorine from oxy-fuel co-combustion of lignite coal and corn stover显示文摘In this work,the forms of potassium and chlorine from oxy-fuel co-combustion of lignite coal and corn stover under atmospheric pressure were investigated.In order to check transitional stage,the feedstocks were combusted stepwise,first by pyrolysis to form coke under N2 environment and later by coke combustion into the ash at 850℃ in O_(2)/CO_(2) atmosphere.The results show that an increase in blend ratio from 15%to 40%results in an increase in water-soluble potassium in the feedstock and the ashes from 0.15%to 0.4%and 0.015%to 0.038%in weight respectively.The water-soluble potassium is present mainly as KCl and K2SO4.For ammonium acetate soluble potassium,a similar trend to water-soluble potassium is presented but with a much lower content of potassium.The bound potassium in the fuel matrix exists,likely in the form of AlKSi_(2)O_(6).Chlorides are present mainly in the form of KCl which is the dominant water-soluble compound. | Chansa Oris Zhongyang Luo Wennan Zhang Chunjiang Yu | 2019 | Carbon Resources Conversion2019，2，2： | 2 |
| 6 | Influence of uniaxial tensile pre-strain on forming limit curve by using biaxial tensile test显示文摘This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove. | Wennan YUAN Min WAN Xiangdong WU Bolin MA Xu LU Bing YANG | 2020 | Chinese Journal of Aeronautics2020，33，8： | 2 |
| 7 | Enhanced INS/Wi-Fi Integration for Indoor Vehicle Navigation显示文摘 | Wennan Chai Cheng Chen Ezzaldeen Edwan Jieying Zhang Otmar Loffeld | 2012 | 通讯和计算机(中英文版)2012，9，11： | 2 |
| 8 | Automation and optimization of liquid-phase microextraction by gas chromatography显示文摘 | Gangfeng Ouyang Wennan Zhao Janusz Pawliszyn | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 9 | Fluid-dynamic boundary layers in CFB boilers显示文摘 | Wennan Zhang Filip Johnsson Bo Leckner | 1995 | Chemical Engineering Science1995，，2： | 1 |
| 10 | Auto-mation and optimization of liquid-phase microextraction by gaschromatography显示文摘 | Gangfeng Ouyanga Wennan Zhao Janusz Pawliszyn | 2007 | J Chromatography A2007，1138，： | 1 |
| 11 | Oscillation transient energy function applied to the design of a TCSC fuzzy logic damping controller to suppress power system interarea mode oscillations 显示文摘 | Fang D Z Xiaodong Y Wennan S | 2003 | IEE Proceedings : Generation Transmission and Distribu- tion2003，150，23： | 1 |
| 12 | Automotive fuels from biomass via gasification显示文摘 | Zhang Wennan | 2009 | FuelProcessingTechnology2009，91，8： | 1 |
| 13 | Effect of Chemical Cross-linking on Properties of Gelatin/Hyaluronic Acid Composite Hydrogels显示文摘 | Zhihua Zhou Zhongmin Yang Tianlong Huang Lihua Liu Qingquan Liu Yanmin Zhao Wennan Zeng Qingfeng Yi Dafu Cao | 2013 | Polymer-Plastics Technology and Engineering2013，，1： | 1 |
| 14 | Programmable robotized‘transfer-and-jet’printing for large,3D curved electronics on complex surfaces显示文摘Large,3D curved electronics are a trend of the microelectronic industry due to their unique ability to conformally coexist with complex surfaces while retaining the electronic functions of 2D planar integrated circuit technologies.However,these curved electronics present great challenges to the fabrication processes.Here,we propose a reconfigurable,mask-free,conformal fabrication strategy with a robot-like system,called robotized‘transfer-and-jet’printing,to assemble diverse electronic devices on complex surfaces.This novel method is a ground-breaking advance with the unique capability to integrate rigid chips,flexible electronics,and conformal circuits on complex surfaces.Critically,each process,including transfer printing,inkjet printing,and plasma treating,are mask-free,digitalized,and programmable.The robotization techniques,including measurement,surface reconstruction and localization,and path programming,break through the fundamental constraints of 2D planar microfabrication in the context of geometric shape and size.The transfer printing begins with the laser lift-off of rigid chips or flexible electronics from donor substrates,which are then transferred onto a curved surface via a dexterous robotic palm.Then the robotic electrohydrodynamic printing directly writes submicrometer structures on the curved surface.Their permutation and combination allow versatile conformal microfabrication.Finally,robotized hybrid printing is utilized to successfully fabricate a conformal heater and antenna on a spherical surface and a flexible smart sensing skin on a winged model,where the curved circuit,flexible capacitive and piezoelectric sensor arrays,and rigid digital–analog conversion chips are assembled.Robotized hybrid printing is an innovative printing technology,enabling additive,noncontact and digital microfabrication for 3D curved electronics. | YongAn Huang Hao Wu Chen Zhu Wennan Xiong Furong Chen Lin Xiao Jianpeng Liu Kaixin Wang Huayang Li Dong Ye Yongqing Duan Jiankui Chen Hua Yang Wenlong Li Kun Bai Zhouping Yin Han Ding | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 1 |
| 15 | Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cy- lindrospermopsin显示文摘 | Banker R Carmeli S Wennan M | 2001 | J Toxicol Environ Health PT A2001，62，4： | 1 |
| 16 | Trans- mission line fault location for single-phase-to-earth fault on non- direct-ground neutral system显示文摘 | ZHANG Qingchao ZHANG Yao SONG Wennan | 1998 | IEEE Transactions on Power Delivery1998，13，4： | 1 |
| 17 | Stimulation of the P2X 7 receptor kills rat retinal ganglion cells in vivo显示文摘 | Huiling Hu Wennan Lu Mei Zhang Xiulan Zhang Arthur J. Argall Shaun Patel Ga Eun Lee Yong-Chul Kim Kenneth A. Jacobson Alan M. Laties Claire H. Mitchell | 2010 | Experimental Eye Research2010，，3： | 1 |
| 18 | Oscillation transient energy function applied to the design of a TCSC fuzzy logic damping controller to suppress power system interarea mode oscillations显示文摘 | Fang D Z Xiaodong Y Wennan S | 2003 | IEEE Proceedings:Generation Transmission and Distribution2003，150，2： | 1 |
| 19 | Comer Detection and Interpretation on Planar Curves Using Fuzzy Reasoning 显示文摘 | Li Liyuan Chen Wennan | 1999 | IEEE Trans on Pattern Analysis Machine Intelligence1999，21，11： | 1 |
| 20 | Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function显示文摘Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment. | Zhen Xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu Siyi Xu Tianbin Chen Jing Chen Qishui Ou | 2021 | Cellular & Molecular Immunology2021，18，2： | 1 |
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