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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Phenotyping Parents of Mapping Populations of Rice for Heat Tolerance during Anthesis显示文摘 | Jagadish S V K Craufurd P Q Wheeler T R | 2008 | Crop Science2008，，3： | 2 |
| 3 | Meat tenderness and muscle growth: is there any relationship? 显示文摘 | Koohmaraie M Kent M P Shackelford S D Veiseth E Wheeler T L | 2002 | Meat Science2002，62，： | 1 |
| 4 | A new single nucleotide polymorphism in CAPN1 extends the current tenderness marker test to include cattle of Boa indicus,Boa taurus,and crossbred descent显示文摘 | Casas E Wheeler T L | 2005 | J Anita Sci2005，83，： | 1 |
| 5 | Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults 显示文摘 | Taaffe DR Duret C Wheeler S | 1999 | J Am Geriatr Soc1999，47，10： | 1 |
| 6 | Corporation headquarters relocation and changes in metropolitan corporation dominance, 1980-1987 显示文摘 | Holloway S R Wheeler J O | 1991 | Economic Geography1991，67，1： | 1 |
| 7 | T lymphocyte subpopulations in idiopathic thrombocytopenic purpura (ITP) 显示文摘 | Scott C S Wheeler R Ford P | 1983 | Scand J Haematol1983，40，： | 1 |
| 8 | Urine detection of survivin and diagnosis of bladder cancer显示文摘 | Smith S D Wheeler M A Plescia J | 2001 | JAMA2001，285，： | 1 |
| 9 | An elastoplastic critical state framework for unsaturated soil显示文摘 | WHEELER S J SIVAKUMAR V | 1995 | Geotechnique1995，45，1： | 1 |
| 10 | An Elasto -plastic CriticalState Framework for Unsaturated Soil显示文摘 | WHEELER S J SIVAKUMAR V | 1995 | C eotechnique1995，45，1： | 1 |
| 11 | Sepsis in the Pediatric Cardiac Intensive Care Unit显示文摘 | Wheeler D S Jeffries H E Zimmerman J J | 2011 | WorldJPediatr Congenit Heart Surg2011，2，3： | 1 |
| 12 | An anisotropic elastoplastic model for soft clays 显示文摘 | WHEELER S J NAATANEN A KARSTUNEN M | 2003 | Canadian Geotechnical Journal2003，40，2： | 1 |
| 13 | The “Shaken Self,: Product Choicesas a Means of Restoring Self - view Confidence 显示文摘 | Gao L Wheeler S C Shiv B | 2009 | Journal ofConsumer Research2009，36，1： | 1 |
| 14 | The effects of Piedmontese inheritance and myostatin genotype on the palatalility of longissimus thoracic,guteus medius,semimembranosus and biceps femoris 显示文摘 | Wheeler T L Shackelford S D Casas E | 2001 | Animal Science2001，79，12： | 1 |
| 15 | A new single nucleotide polymorphism in CAPN1 extends the current tenderness marker test to include cattle of Bos indicus,Bos taurus,and crossbred descent显示文摘 | WHITE S N CASAS E WHEELER T L | 2005 | J Anim Sci2005，，83： | 1 |
| 16 | Genetic variation in anti-herbivore chemical defenses in an invasive plant显示文摘 | Wang Y Siemann E Wheeler G S Zhu L Gu X Ding J | | 0，，： | 1 |
| 17 | The cartilage specific microRNA-140 targets histone deacetylate 4 in mouse cells显示文摘 | Tuddenham L Wheeler G Ntounia-Fousara S | | 0，，： | 1 |
| 18 | An anisotropic elasto-plastic model for soft clays显示文摘 | Wheeler S J Naatanen A Karstunen M | 2003 | Canadian Geotechnical Journal2003，40，40： | 1 |
| 19 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils 显示文摘 | Wheeler S J Sharma R S Buisson M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 20 | Zidovudine-induced diaphragmatic contractile dysfunction:impact of an antioxidant diet显示文摘 | Wheeler S Maxwell-Bawden A Herb R A | 2005 | Respirology2005，10，2： | 1 |
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