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68篇 您的检索式：作者名="White GE"

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	题名	作者	年代	出处	被引量
1	Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML.	Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge	2020	Signal Transduction and Targeted Therapy2020，5，1：	3
2	Tratment of spinal cord trauma by selective hypothermic perfusion显示文摘	Albin MS White RJ Locke GE	1965	Surg Forum1965，16，：	1
3	Antimicrobial-resistant Campylobacter species from retail raw meats显示文摘	GE B WHITE D G McDERMOTT P F	2003	Appl Environ Microbiol2003，69，：	1
4	Identification and characterization of integron-mediated antibiotic resistance among Shiga toxin-producing Escherichia coli isolates显示文摘	Zhao S White D G Ge B	2001	Appl Environ Microbiol2001，67，4：	1
5	Long-term subjective memory function in ventricular fibrillation out-of-hospital cardiac arrest survivors resuscitated by early defibrillation显示文摘	Buncha TJ White RD Smith GE	2004	Rcsuscitation2004，60，2：	1
6	Employed adults with asthma who have frequent workplace exposures显示文摘	White GE Mazurek JM Storey E	2014	J Asthma2014，7，16：	1
7	Class preparation for fractured anterior teeth restored with composite resin restorations显示文摘	Eid H White GE	2003	J Clin Pediatr Dent2003，27，3：	1
8	Elevated intramuscular compartment pressures do not influence outcome after tibial fracture显示文摘	White TO Howell GE Will EM	2003	J Trauma2003，55，6：	1
9	Polyethylene ribbon fibers: a new alternative for t~storing badly destroyed primary incisol 显示文摘	Island G White GE	2005	J Clin Pedia/rDent2005，29，2：	1
10	Long-term subjective memory function in ventricular fibrillation out-of-hospital cardiac arrest survivors resuscitated by early defibrillation显示文摘	Buncha TJ White RD Smith GE	2004	Resuscitation2004，60，2：	1
11	Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling显示文摘	White GE Tan TC John AE	2010	Cardiovasc Res2010，85，4：	1
12	Fluorogenic PCR based quantitative detection of a murine pathogen, Helicobacter hepaticus 显示文摘	Ge Z White DA Whary MT	2001	Clin Microbiol2001，39，7：	1
13	Long-term subjective memory function in ventricular fibrillation out-of-hospital cardiac arrest survivors resuscitated by early defibrillation 显示文摘	Bunch TJ White RD Smith GE	2004	Resuscitation2004，60，2：	1
14	Calreticulin binding affinity for glycosylated laminin显示文摘	McDonnell JM Jones GE White TK	1996	J Biol Chem1996，271，14：	1
15	An in vitro evaluation of microleakage in class I preparations using 5th, 6th and 7th gener- ation composite bonding agents 显示文摘	Kallenos TN A1-Badawi E White GE	2005	J Clin Pediatr Dent2005，29，4：	1
16	Cold - water immersion and other forms of cryotherapy: physiological changes potentially affecting recovery from high - intensity exercise 显示文摘	White GE Wells GD	2013	Extreme physiology & medicine2013，2，1：	1
17	Cardiovascular Safety in Patients Receiving Roflumilast for the Treatment of COPD显示文摘	White WB Cooke GE Kowey PR	2013	Chest2013，144，3：	1
18	Longa2term subjective memory function in ventricular fibrillation out2 ofa2 hospital cardiac arrest survivors resuscitated by early defibrillation显示文摘	Buncha TJ White RD Smith GE	2004	Rcsuscitation2004，60，2：	1
19	Identification of integron-mediated antibiotic resistance among Shige Toxin-producing Escherichia coli isolates显示文摘	Shaohua Zhao David G White Beilei Ge	2001	Appl Environ Microbiol2001，67，4：	1
20	Angioscopic thromboembolectomy: preliminary observations with a recent technique显示文摘	White GH White RA Kopchok GE et aI	1988	J Vasc Surg1988，7，2：	1

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