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46篇 您的检索式：作者名="Wilhelm MJ"

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	题名	作者	年代	出处	被引量
1	Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.	Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters	2013	World Journal of Gastroenterology2013，19，36：	3
2	Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes 显示文摘	Baba HA Schmid C Wilhelm MJ	1997	Transplantation1997，64，7：	1
3	A model of gradual onset brain death for transplant-associated studies in rats显示文摘	Wilhelm MJ Kusaka M	2000	Transplantation2000，69，3：	1
4	Activation of in- flammatory mediators in rat renal isografts by donor brain death显示文摘	Kusaka M PratschkeJ Wilhelm MJ	2000	Transplantation2000，3，：	1
5	Accelerated rejection of renal allografts from brain-dead donors显示文摘	PratschkeJ Wilhelm MJ Kusaka M		0，，2：	1
6	Activation of inflammatory mediators in rat renal isografts by donor brain death显示文摘	Kusaka M Pratschke J Wilhelm MJ		0，，3：	1
7	A model of gradual onset brain death for transplant-associated studies in rats 显示文摘	Pratsehke J Wilhelm MJ Kusaka M	2000	Transplantation2000，69，3：	1
8	Health-related quality oflife in hyperparathyroidism measurably improves after parathyroid-ectomy 显示文摘	Quiros RM Alef MJ Wilhelm SM ef al	2003	Surgery2003，134，4：	1
9	Accelerated rejection of renal allografts from brain-dead donors 显示文摘	Pratschke J Wilhelm MJ Kusaka M	2000	Ann Surg2000，232，2：	1
10	A model of gradual onset brain death for transplant- associated studies in rats显示文摘	Pratschke J Wilhelm MJ Kusaka M	2000	Transplantation2000，69，21：	1
11	A model of gradual onset brain death for transplant-associated studies in rats显示文摘	Pratschke J Wilhelm MJ Kusaka M	2000	Transplantion2000，69，3：	1
12	Activation of inflammatory mediators in rat renal isografts by donor brain death显示文摘	Kusaka M Pratschke J Wilhelm MJ	2000	Transplantation2000，3，：	1
13	Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes 显示文摘	Baba HA Schmid C Wilhelm MJ	1997	Transplantation1997，64，7：	1
14	A model of gradual onset brain death for transplant-associated studies in rats显示文摘	Pratschke J Wilhelm MJ Kusaka M	2000	Transplantation2000，69，3：	1
15	Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes显示文摘	Baba HA Schmid C Wilhelm MJ etal	1997	Transplantation1997，64，7：	1
16	A model of gradual onset brain death for transplant-associated studies in rats显示文摘	Pratschke J Wilhelm MJ Kusaka M	2000	Transplantation2000，69，3：	1
17	A model of gradual onset brain death for transplant-associated studies in rats显示文摘	Pratschke J Wilhelm MJ KusakaM	2000	Transplantation2000，69，3：	1
18	Health-related quality of life in hyperparathyroidism measurably im- proves after parathyroidectomy显示文摘	Ouiros RM Alef MJ Wilhelm SM	2003	Surgery2003，134，：	1
19	Chronic rejection: Increasing evidence for the importance of allogen- independent factors 显示文摘	Wilhelm MJ Kttsaka M Pratschke J	1998	Transplant Proc1998，30，5：	1
20	A model of grad- ual onset brain death for transplant-associated studies in rats 显示文摘	Pratsehke J Wilhelm MJ Kusaka M	2000	Transplantation2000，69，：	1

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