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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | 采用间接复位、钢板固定、不植骨的方法治疗稳定的股骨干髓内假体周围骨折显示文摘背景:间接复位技术相对于较早期的开放复位技术具有能够提高骨愈合率及减少植骨的优势,我们对以间接复位治疗股骨干假体周围骨折的结果进行了研究。
方法:连续对50例稳定的股骨干髓内假体周围骨折(Vancourvr B1型)进行治疗,根据病例记录包括切开复位、间接复位、外侧单钢板固定且不行同种异体或其他植骨。4例术后早期死亡,5例随访时间短,对其余41例(平均年龄72岁)进行了平均24个月的随访,并进行临床和影像学评估。
结果:所有骨折平均12周(7~23周)愈合,对位满意。1例有1根钢丝断裂,2例有1枚螺钉断裂,骨折最终愈合且无明显的内置物松动和对位不良。1例发生围手术期深部感染。41例中30例行走功能恢复到骨折前的状态。
结论:结果证实间接复位骨膜外侧单钢板固定且不进行植骨的方法对于稳定的股骨干髓内假体周围骨折的疗效是应该肯定的。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | WILLIAM M. RICCI BRETT R. BOLHOFNER TIMOTHY LOFTUS CHRISTOPHER COX SCOTT MITCHELL JOSEPH BORRELLI JR 董强(译) 马宝通(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 3 | Serum Metabolic Profiling in Inflammatory Bowel Disease显示文摘 | Horace Williams James Willsmore I. Cox David Walker Jeremy Cobbold Simon Taylor-Robinson Timothy Orchard | 2012 | Digestive Diseases and Sciences2012，，8： | 2 |
| 4 | Trade show guidelines for smaller firms 显示文摘 | Williams J D Gopalakrishna S Cox J M | 1993 | Industrial Marketing Management1993，，4： | 1 |
| 5 | Causes of spherical ab-erration induced by laser refractive surgery显示文摘 | Yoon G Macrae S Williams DR Cox IG | 2005 | J Cataract Re-fract Surg2005，31，1： | 1 |
| 6 | 显示文摘 | WILLIAMS D H COX J P L DOIG A | 1991 | J Am Chem Soc1991，113，18： | 1 |
| 7 | Separate effects of the microkeratome incision and laser ablation on the eye's wave aberration显示文摘 | Porter J MacRae S Yoon G Roberts C Cox IG Williams DR | 2003 | Am J Ophthalmol2003，136，2： | 1 |
| 8 | Bacterial respiratory tract infections are promoted by systemic hyperglycemia after severe burn injury in pediatric patients显示文摘 | Robert Kraft David N. Herndon Ronald P. Mlcak Celeste C. Finnerty Robert A. Cox Felicia N. Williams Marc G. Jeschke | 2014 | Burns2014，，3： | 1 |
| 9 | Naturally acquired antibodies against Haemophilus influenzae type a in Aboriginal adults,Canada显示文摘 | Nix EB Williams K Cox AD | 2015 | Emerg Infect Dis2015，21，2： | 1 |
| 10 | Pearls and pitfalls of allergy di- agnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force显示文摘 | Cox L Williams B Sicherer S | 2008 | Ann Allergy Asthma Immunol2008，101，6： | 1 |
| 11 | Effect of rotation and translation on the expected benefit of an ideal method to correct the eye's higher-order aberrations显示文摘 | Guirao A Williams DR Cox IG | | 0，，5： | 1 |
| 12 | Row spacing, plant density, and nitrogen effects on corn silage 显示文摘 | William J Cox Debbie J R Cherney | 2001 | Agronomy Journal2001，93，： | 1 |
| 13 | The roles of perceived teacher support, motivational climate, and psychological need satisfaction in students' physical education motivation 显示文摘 | Cox A Williams L | 2008 | Journal of Sport and Exercise Psychology2008，30，： | 1 |
| 14 | Separate effects of the microkeratome incision and laser abla-tion on the eye,s wave aberration 显示文摘 | Porter J MacRae S Yoon G Roberts C Cox IG Williams DR | 2003 | Am J Ophthalmol2003，136，2： | 1 |
| 15 | Extrinsic life goals and health risk behaviors in adolescents显示文摘 | Williams GC Cox EM Hedberg V | 2000 | Journal of Applied Social Psychology2000，30，： | 1 |
| 16 | Emollients, education and quality of life: the RCPCH care pathway for children with eczema 显示文摘 | Cox H Lloyd K Williams H | 2011 | Arch Dis Child2011，96，2： | 1 |
| 17 | Separate effects of the microkeratome incision and laser ablation on the eye' s wave aberration显示文摘 | Porter J MacRae S Yoon G Roberts C Cox IG Williams DR | 2003 | Am J Ophthalmol2003，136，2： | 1 |
| 18 | Frequent salad vegetable consumption is associated with a reduction in the risk of diabetes mellitus显示文摘 | Williams DE Wareham NJ Cox SD | 1999 | J Clin Epidemio11999，52，4： | 1 |
| 19 | 3',4'Bisdifiuoromethoxycinnamoylanthranilate(FT061):an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy显示文摘 | Williams S J Zammit S C Cox A J | 2013 | Bioorg Med Chem Lett2013，23，24： | 1 |
| 20 | Contribution of behavior therapy and biofeedback to laxative therapy in the treatment of pediatric encopresis显示文摘 | Daniel J. Cox James Sutphen Steve Borowitz Boris Kovatchev William Ling | 1998 | Annals of Behavioral Medicine1998，，2： | 1 |
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