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| 1 | Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus显示文摘 | Alexander J. Thompson Andrew J. Muir Mark S. Sulkowski Dongliang Ge Jacques Fellay Kevin V. Shianna Thomas Urban Nezam H. Afdhal Ira M. Jacobson Rafael Esteban Fred Poordad Eric J. Lawitz Jonathan McCone Mitchell L. Shiffman Greg W. Galler William M. Lee | 2010 | Gastroenterology2010,,1: | 7 |
| 2 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018,63,16: | 4 |
| 3 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011,21,5: | 3 |
| 4 | BUSINESS DIRECTIONS AND MATERIALS CHALLENGES FOR THE AIRCRAFT ENGINE INDUSTRY显示文摘BUSINESSDIRECTIONSANDMATERIALSCHALLENGESFORTHEAIRCRAFTENGINEINDUSTRYJ.C.Williams(GEAircraftEngines,Cincinnati,OH45215-6301,US... | J.C. Williams(GE Aircraft Engines, Cincinnati, OH 45215-6301, USA Manuscript received 26 August 1996) | 1996 | Acta Metallurgica Sinica(English Letters)1996,9,6: | 2 |
| 5 | Leaming representations by back-propagating errors显示文摘 | Rumelhart DE Hinton GE Williams RJ | 1986 | Nature1986,323,: | 1 |
| 6 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013,22,: | 1 |
| 7 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics显示文摘 | Stacker SA Caesar C Baldwin ME Thornton GE Williams RA Prevo R | 2001 | Nat Med2001,7,2: | 1 |
| 8 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis显示文摘 | David H. Adams Jeffrey J. Popma Michael J. Reardon Steven J. Yakubov Joseph S. Coselli G. Michael Deeb Thomas G. Gleason Maurice Buchbinder James Hermiller Neal S. Kleiman Stan Chetcuti John Heiser William Merhi George Zorn Peter Tadros Newell Robinson Ge | 2014 | The New England Journal of Medicine2014,,19: | 1 |
| 9 | Hereditary hypoc eruloplasminemia显示文摘 | Edwards CQ Williams DM Cartwright GE | 1979 | Clin Genet1979,15,4: | 1 |
| 10 | Prenatal screening for Down's syndrome with use of maternal serum markers显示文摘 | JE Haddow GE Palomaki GJ Knight J Williams A Pulkkinen JA Canick DN Saller and GB Bowers | 1992 | N Engl J Med1992,,: | 1 |
| 11 | Classification of premalignant pancreatic cancer mass-spectrometry data using decision tree ensembles 显示文摘 | Ge G William W | 2008 | BMC Bioinformatics2008,9,: | 1 |
| 12 | Nieo- tinic acetylcholine receptors of muscle and neuronal(al-phc~7)types coexpressed in a small cell lung carcinoma 显示文摘 | Sciamanna MA Griesmann GE Williams CL | 1997 | J Neurochem1997,69,6: | 1 |
| 13 | Prenatal screening for open neuraltube defects in Maine 显示文摘 | Palomaki GE Williams JR Haddow JE | 1999 | N Engl J Med1999,340,13: | 1 |
| 14 | Safety of zoster vaccine in elderly adults following documented herpes zoster 显示文摘 | Morrison VA Oxman MN Levin MJ Schmader KE Guatelli JC Betts RF Gelb LD Pachucki CT Keay SK Menzies B Griffin MR Kauffman CA Marques AR Toney JF Simberkoff MS Serrao R Arbeit RD Gnann JW Greenberg RN Holodniy M Keitel WA Yeh SS Davis LE Crawford GE Neuzil KM Johnson GR ZhangJH Harbecke R Chan IS Keller PM Williams HM Boardman KD Silber JL Annunziato PW Shingles Prevention Study Group | 2013 | J Infect Dis2013,208,4: | 1 |
| 15 | A prospective study of psychologi- cal predict - ors of lumbar surgery outcome 显示文摘 | Paula MT William GE Bruce F | 2010 | Spine2010,25,: | 1 |
| 16 | A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults 显示文摘 | Oxman MN Levin MJ Johnson GR Schmader KE Straus SE Gelb LD Arbeit RD Simberkoff MS Gershon AA Davis LE Weinberg A Boardman KD Williams HM Zhang JH Peduzzi PN Beisel CE Morrison VA Guatelli JC Brooks PA Kauffman CA Pachucki CT Neuzil KM Betts RF Wright PF Griffin MR Brunell P Soto NE Marques AR Keay SK Goodman RP Cotton DJ Gnann JW Jr Loutit J Holodniy M Keitel WA Crawford GE Yeh SS Lobo Z Toney JF Greenberg RN Keller PM Harbecke R Hayward AR Irwin MR Kyriakides TC Chan CY Chan IS Wang WW Annunziato PW Silber JL Shingles Prevention Study Group | 2005 | New Engl J Med2005,352,22: | 1 |
| 17 | Pharmacologic profile of a novel potent direct-acting dopamine agonist,(+)-4-propyl-9-hydroxynaphthoxazine显示文摘 | Martin GE Williams M Pettibone DJ | 1984 | J Pharmacol Exp Ther1984,230,: | 1 |
| 18 | Polarization tomography for P-wave velocity structure in southern California显示文摘 | Hu Ge William Menke | 1994 | J Geophys Res1994,99,15: | 1 |
| 19 | Nonsteriodal anti-inflamma- tory drugs as adjuncts in the management of periodontal diseases and peri-implantitis 显示文摘 | Salvi GE Williams RC Offenbacher S | 1997 | Curr Opin Periodontol1997,4,: | 1 |
| 20 | Cyclin D1 gene ex-pression in human cervical neoplasia 显示文摘 | Nichols GE Williams ME Gaffey MG | 2009 | J Mad Pathol2009,9,4: | 1 |