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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Quantitative Changes in Microtubule Distribution Correlate with Guard Cell Function in Arabidopsis显示文摘放射状地安排的外皮的微导管是警卫房间的一个突出的特征。我们观察了与共焦的显微镜学表示 GFP 导管素(GFP-TUA6 ) 的警卫房间并且当时,在微导管的外观发现了可认识的变化开或靠近的 stomata (Eisinger 等, 2012 ) 。在现在的学习,荧光分发的分析作为 stomata 在警卫房间以内在微导管捆的山峰紧张显示出戏剧的增加开。这增加随能被归因于 polymerized 导管素的全部的荧光的增加被相关。邻近的人行道房间没在山峰紧张或综合荧光看类似的变化有气孔的孔什么时候变化了。标注 RFP 的结束绑定蛋白质 1 的成像(EB1 ) 和在一样的房间表示的标注 YFP 的导管素表明有种结束的微导管的数字仍然保持不变,尽管 polymerized 导管素的全部的数量是更高的在比在关上的警卫房间开。一起拿,这些结果显示在微导管的变化穿被相关与并且为正常要求警卫房间功能被变化在聚类的微导管或捆绑描绘的组织。 | William R. Eisinger Viktor Kirik Charlotte Lewis David W. Ehrhardt Winslow R. Briggs | 2012 | Molecular Plant2012，5，3： | 4 |
| 4 | Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA显示文摘 | Christopher A Koczor William Lewis | 2010 | Expert Opinion on Drug Metabolism & Toxicology2010，，12： | 2 |
| 5 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes显示文摘 | Xiaodan Zhang William S. Harmsen Teresa A. Mettler W. Ray Kim Rosebud O. Roberts Terry M. Therneau Lewis R. Roberts Roongruedee Chaiteerakij | 2014 | Hepatology2014，，6： | 2 |
| 7 | The Australian corneal graft registry 1996 report 显示文摘 | Williams KA Muehlberg SM Lewis RF | 1997 | Adelaide: Mercury Press1997，4750，： | 1 |
| 8 | Transgenic expression of the deoxynucleotide carrier cau- ses mitochondrial damage that is enhanced by NRTIs for AIDS 显示文摘 | William Lewis Chad P Haase Yoon K Miller | 2005 | Laboratory Investigation2005，85，8： | 1 |
| 9 | The impact of excess heat events in Maricopa County, Arizona: 2000–2005显示文摘 | Fuyuen Y. Yip W. Dana Flanders Amy Wolkin David Engelthaler William Humble Antonio Neri Lauren Lewis Lorraine Backer Carol Rubin | 2008 | International Journal of Biometeorology2008，，8： | 1 |
| 10 | Anterior hyaloiolal fibrovascular proliferation after diabetic vitrectomy显示文摘 | Lewis H Abranis GW Williams GA | 1987 | Am J Ophthalmol1987，104，： | 1 |
| 11 | Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases显示文摘 | Edward G. McIver Justin Bryans Kristian Birchall Jasveen Chugh Thomas Drake Stephen J. Lewis Joanne Osborne Ela Smiljanic-Hurley William Tsang Ahmad Kamal Alison Levy Michelle Newman Debra Taylor J. Simon C. Arthur Kristopher Clark Philip Cohen | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，23： | 1 |
| 12 | How successful is corneal transplantation? A report from the Australian corneal graft register显示文摘 | WILLIAMS KA MUEHIBERG SM LEWIS RF | 1995 | Eye1995，9，： | 1 |
| 13 | Drilling Straight Down显示文摘 | Brusco G Lewis P Williams M | 2004 | Oilfield Review2004，16，3： | 1 |
| 14 | The neutral volatile components of cider apple juices显示文摘 | Williams A A Lewis M J Tucknott O G | 1980 | Food Chemistry1980，6，2： | 1 |
| 15 | Diseases of the submandibular gland as demonstrated using high resolution ultrasound 显示文摘 | Alyas F Lewis K Williams M | 2005 | Br J Ra- diol2005，78，928： | 1 |
| 16 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 17 | A natural flavonoid present in unripe plantain banana pulp ( Musa sapientum L. var. paradisiaca ) protects the gastric mucosa from aspirin-induced erosions显示文摘 | David A Lewis William N Fields Graham P Shaw | 1999 | Journal of Ethnopharmacology1999，，3： | 1 |
| 18 | Properties and an anisotropic model of cancellous bone from the proximal tibial epiphysis 显示文摘 | William JL Lewis JL | 1982 | J Biomech Eng1982，104，1： | 1 |
| 19 | How successful is corneal transplantation?A report from the Australian corneal graft register显示文摘 | Williams KA Muehiberg SM Lewis RF | 1995 | Eye1995，9，： | 1 |
| 20 | Quality simulation along river systems(QUASAR):model theory and development显示文摘 | WHITEHEAD P G WILLIAMS R J LEWIS D R | 1997 | Science of the Total Environment1997，194，： | 1 |
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