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| 1 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Splenic Artery Aneurysms: Two Decades Experience at Mayo Clinic显示文摘 | Maher A. Abbas William M. Stone Richard J. Fowl Peter Gloviczki W. Andrew Oldenburg Peter C. Pairolero John W. Hallett Thomas C. Bower Jean M. Panneton Kenneth J. Cherry | 2002 | Annals of Vascular Surgery2002，，： | 2 |
| 4 | The minimally invasive management of visceral artery aneurysms and pseudoaneurysms显示文摘 | Grant T. Fankhauser William M. Stone Sailendra G. Naidu Gustavo S. Oderich Joseph J. Ricotta Haraldur Bjarnason Samuel R. Money | 2011 | Journal of Vascular Surgery2011，，4： | 2 |
| 5 | Recent developments in neuropsychological endophenotypes for schizophrenia: Development of the MATRICS battery, liability syndromes and the near future显示文摘Cognitive deficits are now recognized widely as core features of schizophrenia, and as major contributors to the clinical outcome of the disorder. They are also studied widely as 'endophenotypes', reflecting a growing consensus that schizophrenia is a broader, more multidimensional illness than the diagnostic criteria required for its formal diagnosis. This evolving view of cognition underlies its utilization in recent initiatives for intervention and assessment in schizophrenia. Two of these initiatives are reviewed in this paper. The first focuses on the development and validation of the MATRICS Cognitive Consensus Battery, a standardized battery of neuropsychological tests developed to assess the effectiveness of cognitive enhancing treatments in schizophrenia. A part of this effort includes the identification of performance-based, 'co-primary' measures of functional capacity that are related to cognition, and that are likely to show improvement at least partly as a function of improved cognition. The second initiative involves efforts to utilize neuropsychological deficits in the identification, validation and remediation of a liability syndrome for schizophrenia ('schizotaxia'). The discussion of this effort focuses on the development of a syndrome that is both measurable and meaningful clinically, and that may provide useful intervention targets. The utilization of cognition in both of these initiatives underscores its functional importance in the clinical outcome of schizophrenia. Moreover, it helps to illuminate indicators of liability for schizophrenia that might be amenable to remediation. | STONE William S HSI Xiaolu | 2011 | Chinese Science Bulletin2011，56，32： | 1 |
| 6 | Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association显示文摘 | Michael Miller Neil J. Stone Christie Ballantyne Vera Bittner Michael H. Criqui Henry N. Ginsberg Anne Carol Goldberg William James Howard Marc S. Jacobson Penny M. Kris-Etherton Terry A. Lennie Moshe Levi Theodore Mazzone Subramanian Pennathur | 2011 | Circulation2011，，20： | 1 |
| 7 | Thrombocytopenia in the critically ill patient 显示文摘 | Bogdonoff DL Williams ME Stone DJ | 1990 | J Crit Care1990，5，2： | 1 |
| 8 | Development of gamma (γ)-tocopherol as colorectal cancer chemopreventive agent显示文摘 | Sharon Campbell William Stone Sarah Whaley | 2003 | Critical Reviews in Oncology/Hematology2003，47，3： | 1 |
| 9 | Comparison of disk dif-fusion ,Vitek 2,and broth microdilution antimicrobial susceptibilitytest results for unusual species of Enterobacteriaceae 显示文摘 | Stone ND 0 ’ Hara CM Williams PP | 2007 | J ClinMicrobiol2007，45，2： | 1 |
| 10 | Long - term reduction in ^137Cs concentration in food crops on coral atolls resulting from potassium treatment显示文摘 | WILLIAM L ROBISON STONE E L HAMILTON T F | 2006 | J Environ Radioact2006，88，3： | 1 |
| 11 | Partitioning of platinum-group elements and Au in the Fe?Ni?Cu?S system: experiments on the fractional crystallization of sulfide melt显示文摘 | Michael E. Fleet Stephen L. Chryssoulis William E. Stone Christopher G. Weisener | 1993 | Contributions to Mineralogy and Petrology1993，，1： | 1 |
| 12 | Health Care Provider Knowledge and Practices Regarding Folic Acid, United States, 2002–2003显示文摘 | Jennifer L. Williams Stephen M. Abelman Elizabeth M. Fassett Cheryl E. Stone Joann R. Petrini Karla Damus Joseph Mulinare | 2006 | Maternal and Child Health Journal2006，，1： | 1 |
| 13 | All in the family:the BTB/POZ,KRAB,and SCAN domains显示文摘 | Collins T Stone JR Williams AJ | 2001 | Mol Cell Biol2001，21，： | 1 |
| 14 | Thrombocytopenia in the critically ill patient显示文摘 | Bogdonoff DL Williams ME Stone DJ | 1990 | J Crit Care1990，5，2： | 1 |
| 15 | All in the family:the BTB/POZ, KRAB, and SCAN domains 显示文摘 | Collins T Stone J R Williams A J | 2001 | Molecular and Cellular Biology2001，21，11： | 1 |
| 16 | Behavior of 1/6-scale model bridge columns subjected to inelastic cyclic loading 显示文摘 | Cheok G S Stone William C | 1990 | ACI Structural Journal1990，87，6： | 1 |
| 17 | Thrombocytopenia in the critically ill patient显示文摘 | Bogdonoff DL Williams ME Stone DJ | 1990 | J Crit Care1990，5，2： | 1 |
| 18 | Lymphocytic choriomeningitis in the newborn : probable transplacental infection显示文摘 | Komrower GM Williams BL Stones PB | 1955 | Lancet1955，1，： | 1 |
| 19 | Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease:a randomized trial显示文摘 | Stone GW Midei M Newman W Sanz M Hermiller JB Williams J | 2008 | JAMA2008，299，16： | 1 |
| 20 | Consequences of Electroencephalographic-suppressive Doses of Propofol in Conjunction with Deep Hypothermic Circulatory Arrest显示文摘 | J. Gilbert Stone William L. Young Zvi S. Marans Robert A. Solomon Craig R. Smith Subhash C. Jamdar Noeleen Ostapkovich Jaime Diaz | 1996 | Anesthesiology1996，，3： | 1 |
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